Nicotinamide mononucleotide attenuates brain injury after intracerebral hemorrhage by activating Nrf2/HO-1 signaling pathway

Scientific Reports

Volumn 7, Issue 1, 2017, Pages

  Wei, Chun Chun ^a   Kong, Yuan Yuan ^a   Li, Guo Qiang ^a   Guan, Yun Feng ^a   Wang, Pei ^a,b   Miao, Chao Yu ^a,c  

^a SECOND MILITARY MEDICAL UNIVERSITY   (China)

^b YANTAI UNIVERSITY   (China)

^c BEIJING INSTITUTE FOR BRAIN DISORDERS   (China)

Author keywords

[No Author keywords available]

Indexed keywords

AUTACOID; BIOLOGICAL MARKER; HEME OXYGENASE 1; NICOTINAMIDE ADENINE DINUCLEOTIDE; NICOTINAMIDE NUCLEOTIDE; PROTECTIVE AGENT; TRANSCRIPTION FACTOR NRF2;

ANIMAL; BRAIN HEMORRHAGE; BRAIN INJURY; CELL DEATH; COMPLICATION; DISEASE MODEL; DRUG EFFECT; IMMUNOHISTOCHEMISTRY; METABOLISM; MICROGLIA; MOUSE; NEUROPROTECTION; NEUTROPHIL CHEMOTAXIS; OXIDATIVE STRESS; PATHOLOGY; SIGNAL TRANSDUCTION; TIME FACTOR;

ANIMALS; BIOMARKERS; BRAIN INJURIES; CELL DEATH; CEREBRAL HEMORRHAGE; DISEASE MODELS, ANIMAL; HEME OXYGENASE-1; IMMUNOHISTOCHEMISTRY; INFLAMMATION MEDIATORS; MICE; MICROGLIA; NAD; NEUROPROTECTION; NEUTROPHIL INFILTRATION; NF-E2-RELATED FACTOR 2; NICOTINAMIDE MONONUCLEOTIDE; OXIDATIVE STRESS; PROTECTIVE AGENTS; SIGNAL TRANSDUCTION; TIME FACTORS;

EID: 85018791337     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/s41598-017-00851-z     Document Type: Article

References (55)

1. Keep, R. F., et al. Intracerebral haemorrhage: Mechanisms of injury and therapeutic targets. Lancet Neurol 11, 720-731 (2012).
2. Zhou, Y., et al. Inflammation in intracerebral hemorrhage: From mechanisms to clinical translation. Prog Neurobiol 115, 25-44 (2014).
3. Mracsko, E., et al. Neuroinflammation after intracerebral hemorrhage. Front Cell Neurosci 8, 388 (2014).
4. Mendelow, A. D., et al. Early surgery versus initial conservative treatment in patients with spontaneous supratentorial intracerebral haematomas in the International Surgical Trial in Intracerebral Haemorrhage (STICH): A randomised trial. Lancet 365, 387-397 (2005).
5. Rich, P. R. The molecular machinery of Keilin's respiratory chain. Biochem Soc Trans 31, 1095-1105 (2003).
6. Houtkooper, R. H., et al. The secret life of NAD+: An old metabolite controlling new metabolic signaling pathways. Endocr Rev 31, 194-223 (2010).
7. Garten, A., et al. Physiological and pathophysiological roles of NAMPT and NAD metabolism. Nat Rev Endocrinol 11, 535-546 (2015).
8. Zhang, D. X., et al. The potential regulatory roles of NAD(+) and its metabolism in autophagy. Metabolism 65, 454-462 (2016).
9. Wang, S., et al. Cellular NAD depletion and decline of SIRT1 activity play critical roles in PARP-1-mediated acute epileptic neuronal death in vitro. Brain Res 1535, 14-23 (2013).
10. Alano, C. C., et al. NAD+ depletion is necessary and sufficient for poly(ADP-ribose) polymerase-1-mediated neuronal death. J Neurosci 30, 2967-2978 (2010).
11. Wang, S. N., et al. Neuroprotective Efficacy of an Aminopropyl Carbazole Derivative P7C3-A20 in Ischemic Stroke. CNS Neurosci Ther 22, 782-788 (2016).
12. Wang, S. N., et al. Targeting Nicotinamide Phosphoribosyltransferase as a Potential Therapeutic Strategy to Restore Adult Neurogenesis. CNS Neurosci Ther 22, 431-439 (2016).
13. Wang, P., et al. Nicotinamide phosphoribosyltransferase protects against ischemic stroke through SIRT1-dependent adenosine monophosphate-activated kinase pathway. Ann Neurol 69, 360-374 (2011).
14. Wang, P., et al. Induction of autophagy contributes to the neuroprotection of nicotinamide phosphoribosyltransferase in cerebral ischemia. Autophagy 8, 77-87 (2012).
15. Zhao, Y., et al. Extracellular visfatin has nicotinamide phosphoribosyltransferase enzymatic activity and is neuroprotective against ischemic injury. CNS Neurosci Ther 20, 539-547 (2014).
16. Rongvaux, A., et al. Pre-B-cell colony-enhancing factor, whose expression is up-regulated in activated lymphocytes, is a nicotinamide phosphoribosyltransferase, a cytosolic enzyme involved in NAD biosynthesis. Eur J Immunol 32, 3225-3234 (2002).
17. Yoshino, J., et al. Nicotinamide mononucleotide, a key NAD(+) intermediate, treats the pathophysiology of diet-A nd age-induced diabetes in mice. Cell Metab 14, 528-536 (2011).
18. de Picciotto, N. E., et al. Nicotinamide mononucleotide supplementation reverses vascular dysfunction and oxidative stress with aging in mice. Aging Cell (2016).
19. Caton, P. W., et al. Nicotinamide mononucleotide protects against pro-inflammatory cytokine-mediated impairment of mouse islet function. Diabetologia 54, 3083-3092 (2011).
20. Long, A. N., et al. Effect of nicotinamide mononucleotide on brain mitochondrial respiratory deficits in an Alzheimer's diseaserelevant murine model. BMC Neurol 15, 19 (2015).
21. Wang, X., et al. Nicotinamide mononucleotide protects against beta-amyloid oligomer-induced cognitive impairment and neuronal death. Brain Res 1643, 1-9 (2016).
22. Harlan, B. A., et al. Enhancing NAD+ Salvage Pathway Reverts the Toxicity of Primary Astrocytes Expressing Amyotrophic Lateral Sclerosis-linked Mutant Superoxide Dismutase 1 (SOD1). J Biol Chem 291, 10836-10846 (2016).
23. Stein, L. R., et al. Specific ablation of Nampt in adult neural stem cells recapitulates their functional defects during aging. EMBO J 33, 1321-1340 (2014).
24. Zhao, Y., et al. Regenerative Neurogenesis After Ischemic Stroke Promoted by Nicotinamide Phosphoribosyltransferase-Nicotinamide Adenine Dinucleotide Cascade. Stroke 46, 1966-1974 (2015).
25. Park, J. H., et al. Nicotinamide mononucleotide inhibits post-ischemic NAD(+) degradation and dramatically ameliorates brain damage following global cerebral ischemia. Neurobiol Dis 95, 102-110 (2016).
26. Wang, P., et al. NAMPT as a Therapeutic Target against Stroke. Trends Pharmacol Sci 36, 891-905 (2015).
27. Nayernia, Z., et al. New insights on NOX enzymes in the central nervous system. Antioxid Redox Signal 20, 2815-2837 (2014).
28. Chen, H., et al. Oxidative stress in ischemic brain damage: Mechanisms of cell death and potential molecular targets for neuroprotection. Antioxid Redox Signal 14, 1505-1517 (2011).
29. Libby, P. Fanning the flames: Inflammation in cardiovascular diseases. Cardiovasc Res 107, 307-309 (2015).
30. Gerhardt, T., et al. Monocyte trafficking across the vessel wall. Cardiovasc Res 107, 321-330 (2015).
31. Sozzani, S., et al. Chemokines as effector and target molecules in vascular biology. Cardiovasc Res 107, 364-372 (2015).
32. Keep, R. F., et al. Vascular disruption and blood-brain barrier dysfunction in intracerebral hemorrhage. Fluids Barriers CNS 11, 18 (2014).
33. Alam, J., et al. Nrf2, a Cap'n'Collar transcription factor, regulates induction of the heme oxygenase-1 gene. J Biol Chem 274, 26071-26078 (1999).
34. Piantadosi, C. A., et al. Heme oxygenase-1 regulates cardiac mitochondrial biogenesis via Nrf2-mediated transcriptional control of nuclear respiratory factor-1. Circ Res 103, 1232-1240 (2008).
35. Zhang, R. Y., et al. A fluorometric assay for high-throughput screening targeting nicotinamide phosphoribosyltransferase. Anal Biochem 412, 18-25 (2011).
36. Formentini, L., et al. Detection and pharmacological modulation of nicotinamide mononucleotide (NMN) in vitro and in vivo. Biochem Pharmacol 77, 1612-1620 (2009).
37. Wang, P., et al. Perivascular adipose tissue-derived visfatin is a vascular smooth muscle cell growth factor: Role of nicotinamide mononucleotide. Cardiovasc Res 81, 370-380 (2009).
38. Han, X., et al. AMPK activation protects cells from oxidative stress-induced senescence via autophagic flux restoration and intracellular NAD(+) elevation. Aging Cell 15, 416-427 (2016).
39. Yoon, M. J., et al. SIRT1-Mediated eNAMPT Secretion from Adipose Tissue Regulates Hypothalamic NAD+ and Function in Mice. Cell Metab 21, 706-717 (2015).
40. Mylroie, H., et al. PKCepsilon-CREB-Nrf2 signalling induces HO-1 in the vascular endothelium and enhances resistance to inflammation and apoptosis. Cardiovasc Res 106, 509-519 (2015).
41. Van Gool, F., et al. Intracellular NAD levels regulate tumor necrosis factor protein synthesis in a sirtuin-dependent manner. Nat Med 15, 206-210 (2009).
42. Esposito, E., et al. The NAMPT inhibitor FK866 reverts the damage in spinal cord injury. J Neuroinflammation 9, 66 (2012).
43. Tullius, S. G., et al. NAD+ protects against EAE by regulating CD4+ T-cell differentiation. Nat Commun 5, 5101 (2014).
44. Audrito, V., et al. Extracellular nicotinamide phosphoribosyltransferase (NAMPT) promotes M2 macrophage polarization in chronic lymphocytic leukemia. Blood 125, 111-123 (2015).
45. Ganji, S. H., et al. Niacin inhibits fat accumulation, oxidative stress, inflammatory cytokine IL-8 in cultured hepatocytes: Impact on non-alcoholic fatty liver disease. Metabolism 64, 982-990 (2015).
46. Barratt, H. E., et al. Mouse intracerebral hemorrhage models produce different degrees of initial and delayed damage, axonal sprouting, recovery. J Cereb Blood Flow Metab 34, 1463-1471 (2014).
47. Zhang, Y., et al. Stereotactic Administration of Edaravone Ameliorates Collagenase-Induced Intracerebral Hemorrhage in Rat. CNS Neurosci Ther 22, 824-835 (2016).
48. Matsushita, H., et al. A retinoic acid receptor agonist Am80 rescues neurons, attenuates inflammatory reactions, improves behavioral recovery after intracerebral hemorrhage in mice. J Cereb Blood Flow Metab 31, 222-234 (2011).
49. Chen, M., et al. Atorvastatin prevents advanced glycation end products (AGEs)-induced cardiac fibrosis via activating peroxisome proliferator-activated receptor gamma (PPAR-gamma). Metabolism 65, 441-453 (2016).
50. Zhang, X., et al. Beyond knockout: A novel homodimerization-targeting MyD88 inhibitor prevents and cures type 1 diabetes in NOD mice. Metabolism 65, 1267-1277 (2016).
51. Wang, P., et al. ARRB1/beta-arrestin-1 mediates neuroprotection through coordination of BECN1-dependent autophagy in cerebral ischemia. Autophagy 10, 1535-1548 (2014).
52. Li, D. J., et al. Exercise-stimulated FGF23 promotes exercise performance via controlling the excess reactive oxygen species production and enhancing mitochondrial function in skeletal muscle. Metabolism 65, 747-756 (2016).
53. Wang, P., et al. Intracellular NAMPT-NAD+-SIRT1 cascade improves post-ischaemic vascular repair by modulating Notch signalling in endothelial progenitors. Cardiovasc Res 104, 477-488 (2014).
54. Wang, P., et al. Depletion of NAD pool contributes to impairment of endothelial progenitor cell mobilization in diabetes. Metabolism 65, 852-862 (2016).
55. Wang, P., et al. Loss of AMP-Activated Protein Kinase-alpha2 Impairs the Insulin-Sensitizing Effect of Calorie Restriction in Skeletal Muscle. Diabetes 61, 1051-1061 (2012).