Metabolic engineering of CHO cells for the development of a robust protein production platform

PLoS ONE

Volumn 12, Issue 8, 2017, Pages

  Gupta, Sanjeev Kumar ^a,b   Srivastava, Santosh K ^a   Sharma, Ankit ^a   Nalage, Vaibhav H H ^a   Salvi, Darshita ^a   Kushwaha, Hiralal ^a   Chitnis, Nikhil B ^a   Shukla, Pratyoosh ^b  

^a Ipca Laboratories Ltd   (India)

^b MAHARSHI DAYANAND UNIVERSITY   (India)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; LACTIC ACID; PYRUVATE CARBOXYLASE; CARBON; GLUTAMINE; LACTIC ACID DERIVATIVE; MONOCLONAL ANTIBODY; OLIGONUCLEOTIDE; POLYSACCHARIDE; PYRUVIC ACID;

ANIMAL CELL; ARTICLE; BIOACCUMULATION; CELL CLONE; CELL CULTURE; CELL DENSITY; CELL ENERGY; CELL ISOLATION; CELL KINETICS; CHO CELL LINE; CITRIC ACID CYCLE; CONTROLLED STUDY; ENERGY METABOLISM; LONGEVITY; METABOLIC ENGINEERING; NONHUMAN; PROTEIN EXPRESSION; PROTEIN SYNTHESIS; PROTEIN TRANSPORT; PYC2 GENE; ANIMAL; BIOREACTOR; CHEMISTRY; CRICETULUS; CYTOPLASM; CYTOSOL; ENZYMOLOGY; GENE DOSAGE; GLYCOSYLATION; HAMSTER; METABOLISM; MITOCHONDRION; OXIDATION REDUCTION REACTION; SACCHAROMYCES CEREVISIAE;

ANIMALS; ANTIBODIES, MONOCLONAL; BIOREACTORS; CARBON; CHO CELLS; CITRIC ACID CYCLE; CRICETINAE; CRICETULUS; CYTOPLASM; CYTOSOL; ENERGY METABOLISM; GENE DOSAGE; GLUCOSE; GLUTAMINE; GLYCOSYLATION; LACTATES; LACTIC ACID; METABOLIC ENGINEERING; MITOCHONDRIA; OLIGONUCLEOTIDES; OXIDATION-REDUCTION; POLYSACCHARIDES; PYRUVATE CARBOXYLASE; PYRUVIC ACID; SACCHAROMYCES CEREVISIAE;

EID: 85026500742     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0181455     Document Type: Article

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