N-glycosylation as novel strategy to improve pharmacokinetic properties of bispecific single-chain diabodies

Journal of Biological Chemistry

Volumn 283, Issue 12, 2008, Pages 7804-7812

  Stork, Roland ^a   Zettlitz, Kirstin A ^a,c   Müller, Dafne ^a   Rether, Miriam ^a   Hanisch, Franz Georg ^b   Kontermann, Roland E ^a  

^a UNIVERSITY OF STUTTGART   (Germany)

^b UNIVERSITY OF COLOGNE   (Germany)

^c TECHNICAL UNIVERSITY OF MUNICH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODIES; BINDING SITES; ESTERIFICATION; GLYCOSYLATION; INTERNET; MOLECULES; PHARMACOKINETICS; POLYETHYLENE GLYCOLS;

ANTIGEN BINDINGS; BIFUNCTIONAL MOLECULES; CIRCULATION TIMES; CYTOTOXIC; DIABODY; GLYCOSYLATED; HEK293 CELLS; NOVEL STRATEGIES; PHARMACOKINETIC PROPERTIES; RECOMBINANT ANTIBODIES; SMALL SIZES; T CELLS; TARGET CELLS; TUMOR CELLS;

DRUG PRODUCTS;

ANTIGEN; CARCINOEMBRYONIC ANTIBODY; CARCINOEMBRYONIC ANTIGEN; IMMUNOGLOBULIN G1 ANTIBODY; INTERLEUKIN 2; MACROGOL; RECOMBINANT ANTIBODY; SINGLE CHAIN FRAGMENT VARIABLE ANTIBODY; BISPECIFIC ANTIBODY; IMMUNOGLOBULIN G; MACROGOL DERIVATIVE;

ANIMAL EXPERIMENT; ANTIBODY SPECIFICITY; ANTIGEN BINDING; ANTIGEN EXPRESSION; ANTIGEN SPECIFICITY; AREA UNDER THE CURVE; ARTICLE; BINDING AFFINITY; CARBOXY TERMINAL SEQUENCE; CELL STRAIN HEK293; CIRCULATION TIME; CONTROLLED STUDY; CYTOKINE RELEASE; CYTOTOXIC T LYMPHOCYTE; DRUG ACTIVITY; DRUG BINDING; DRUG CONJUGATION; EFFECTOR CELL; EMBRYO; FEMALE; GENETIC TRANSFECTION; GLYCOSYLATION; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; TARGET CELL; TUMOR CELL; ANIMAL; CELL LINE; GENETICS; IMMUNOLOGY; PROTEIN PROCESSING;

ANIMALS; ANTIBODIES, BISPECIFIC; CELL LINE; FEMALE; GLYCOSYLATION; IMMUNOGLOBULIN G; INTERLEUKIN-2; MICE; POLYETHYLENE GLYCOLS; PROTEIN MODIFICATION, TRANSLATIONAL; T-LYMPHOCYTES, CYTOTOXIC;

EID: 43149096504     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M709179200     Document Type: Article

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