-
1
-
-
84869797922
-
IL-6 trans-signaling via the soluble IL-6 receptor: importance for the pro-inflammatory activities of IL-6
-
Rose-John, S. IL-6 trans-signaling via the soluble IL-6 receptor: importance for the pro-inflammatory activities of IL-6. Int. J. Biol. Sci. 8, 1237–1247 (2012).
-
(2012)
Int. J. Biol. Sci.
, vol.8
, pp. 1237-1247
-
-
Rose-John, S.1
-
2
-
-
0022499547
-
Complementary DNA for a novel human interleukin (BSF-2) that induces B lymphocytes to produce immunoglobulin
-
Hirano, T. et al. Complementary DNA for a novel human interleukin (BSF-2) that induces B lymphocytes to produce immunoglobulin. Nature 324, 73–76 (1986).
-
(1986)
Nature
, vol.324
, pp. 73-76
-
-
Hirano, T.1
-
3
-
-
0023432812
-
Interferon beta 2/B-cell stimulatory factor type 2 shares identity with monocyte-derived hepatocyte-stimulating factor and regulates the major acute phase protein response in liver cells
-
Gauldie, J., Richards, C., Harnish, D., Lansdorp, P. & Baumann, H. Interferon beta 2/B-cell stimulatory factor type 2 shares identity with monocyte-derived hepatocyte-stimulating factor and regulates the major acute phase protein response in liver cells. Proc. Natl. Acad. Sci. U S A 84, 7251–7255 (1987).
-
(1987)
Proc. Natl. Acad. Sci. U S A
, vol.84
, pp. 7251-7255
-
-
Gauldie, J.1
Richards, C.2
Harnish, D.3
Lansdorp, P.4
Baumann, H.5
-
4
-
-
0023582926
-
Molecular cloning and expression of hybridoma growth factor in Escherichia coli
-
Brakenhoff, J.P., de Groot, E.R., Evers, R.F., Pannekoek, H. & Aarden, L.A. Molecular cloning and expression of hybridoma growth factor in Escherichia coli. J. Immunol. 139, 4116–4121 (1987).
-
(1987)
J. Immunol.
, vol.139
, pp. 4116-4121
-
-
Brakenhoff, J.P.1
de Groot, E.R.2
Evers, R.F.3
Pannekoek, H.4
Aarden, L.A.5
-
5
-
-
0022801346
-
Structure and expression of cDNA and genes for human interferon-beta-2, a distinct species inducible by growth-stimulatory cytokines
-
Zilberstein, A., Ruggieri, R., Korn, J.H. & Revel, M. Structure and expression of cDNA and genes for human interferon-beta-2, a distinct species inducible by growth-stimulatory cytokines. EMBO J. 5, 2529–2537 (1986).
-
(1986)
EMBO J.
, vol.5
, pp. 2529-2537
-
-
Zilberstein, A.1
Ruggieri, R.2
Korn, J.H.3
Revel, M.4
-
6
-
-
0022447204
-
Structural analysis of the sequence coding for an inducible 26-kDa protein in human fibroblasts
-
Haegeman, G., Content, J., Volckaert, G., Derynck, R., Tavernier, J. & Fiers, W. Structural analysis of the sequence coding for an inducible 26-kDa protein in human fibroblasts. Eur. J. Biochem. 159, 625–632 (1986).
-
(1986)
Eur. J. Biochem.
, vol.159
, pp. 625-632
-
-
Haegeman, G.1
Content, J.2
Volckaert, G.3
Derynck, R.4
Tavernier, J.5
Fiers, W.6
-
7
-
-
80052358980
-
Therapeutic strategies for the clinical blockade of IL-6/gp130 signaling
-
Jones, S.A., Scheller, J. & Rose-John, S. Therapeutic strategies for the clinical blockade of IL-6/gp130 signaling. J. Clin. Invest. 121, 3375–3383 (2011).
-
(2011)
J. Clin. Invest.
, vol.121
, pp. 3375-3383
-
-
Jones, S.A.1
Scheller, J.2
Rose-John, S.3
-
8
-
-
84941941387
-
Interleukin-6: Biology, signaling and strategies of blockade
-
Schaper, F. & Rose-John, S. Interleukin-6: Biology, signaling and strategies of blockade. Cytokine Growth Factor Rev. 26, 475–487 (2015).
-
(2015)
Cytokine Growth Factor Rev.
, vol.26
, pp. 475-487
-
-
Schaper, F.1
Rose-John, S.2
-
9
-
-
79955650634
-
The pro- and anti-inflammatory properties of the cytokine interleukin-6
-
Scheller, J., Chalaris, A., Schmidt-Arras, D. & Rose-John, S. The pro- and anti-inflammatory properties of the cytokine interleukin-6. Biochim. Biophys. Acta 1813, 878–888 (2011).
-
(2011)
Biochim. Biophys. Acta
, vol.1813
, pp. 878-888
-
-
Scheller, J.1
Chalaris, A.2
Schmidt-Arras, D.3
Rose-John, S.4
-
10
-
-
0027303256
-
Structure-function analysis of interleukin-6 utilizing human/murine chimeric molecules. Involvement of two separate domains in receptor binding
-
van Dam, M. et al. Structure-function analysis of interleukin-6 utilizing human/murine chimeric molecules. Involvement of two separate domains in receptor binding. J. Biol. Chem. 268, 15285–15290 (1993).
-
(1993)
J. Biol. Chem.
, vol.268
, pp. 15285-15290
-
-
van Dam, M.1
-
11
-
-
0025134958
-
The three carboxy-terminal amino acids of human interleukin-6 are essential for its biological activity
-
Kruttgen, A. et al. The three carboxy-terminal amino acids of human interleukin-6 are essential for its biological activity. FEBS Lett. 273, 95–98 (1990).
-
(1990)
FEBS Lett.
, vol.273
, pp. 95-98
-
-
Kruttgen, A.1
-
12
-
-
0027964206
-
Identification of two novel regions of human IL-6 responsible for receptor binding and signal transduction
-
Ehlers, M. et al. Identification of two novel regions of human IL-6 responsible for receptor binding and signal transduction. J. Immunol. 153, 1744–1753 (1994).
-
(1994)
J. Immunol.
, vol.153
, pp. 1744-1753
-
-
Ehlers, M.1
-
13
-
-
0028127741
-
Development of a human interleukin-6 receptor antagonist
-
Brakenhoff, J.P. et al. Development of a human interleukin-6 receptor antagonist. J. Biol. Chem. 269, 86–93 (1994).
-
(1994)
J. Biol. Chem.
, vol.269
, pp. 86-93
-
-
Brakenhoff, J.P.1
-
14
-
-
0028202123
-
Generation of interleukin-6 receptor antagonists by molecular-modeling guided mutagenesis of residues important for gp130 activation
-
Savino, R. et al. Generation of interleukin-6 receptor antagonists by molecular-modeling guided mutagenesis of residues important for gp130 activation. EMBO J. 13, 1357–1367 (1994).
-
(1994)
EMBO J.
, vol.13
, pp. 1357-1367
-
-
Savino, R.1
-
15
-
-
0027398766
-
The soluble interleukin-6 receptor is generated by shedding
-
Mullberg, J. et al. The soluble interleukin-6 receptor is generated by shedding. Eur. J. Immunol. 23, 473–480 (1993).
-
(1993)
Eur. J. Immunol.
, vol.23
, pp. 473-480
-
-
Mullberg, J.1
-
16
-
-
0027074343
-
Protein kinase C activity is rate limiting for shedding of the interleukin-6 receptor
-
Mullberg, J., Schooltink, H., Stoyan, T., Heinrich, P.C. & Rose-John, S. Protein kinase C activity is rate limiting for shedding of the interleukin-6 receptor. Biochem. Biophys. Res. Commun. 189, 794–800 (1992).
-
(1992)
Biochem. Biophys. Res. Commun.
, vol.189
, pp. 794-800
-
-
Mullberg, J.1
Schooltink, H.2
Stoyan, T.3
Heinrich, P.C.4
Rose-John, S.5
-
17
-
-
0024274123
-
Molecular cloning of mouse protein kinase C (PKC) cDNA from Swiss 3T3 fibroblasts
-
Rose-John, S., Dietrich, A. & Marks, F. Molecular cloning of mouse protein kinase C (PKC) cDNA from Swiss 3T3 fibroblasts. Gene 74, 465–471 (1988).
-
(1988)
Gene
, vol.74
, pp. 465-471
-
-
Rose-John, S.1
Dietrich, A.2
Marks, F.3
-
18
-
-
34548856204
-
Apoptosis is a natural stimulus of IL6R shedding and contributes to the proinflammatory trans-signaling function of neutrophils
-
Chalaris, A. et al. Apoptosis is a natural stimulus of IL6R shedding and contributes to the proinflammatory trans-signaling function of neutrophils. Blood 110, 1748–1755 (2007).
-
(2007)
Blood
, vol.110
, pp. 1748-1755
-
-
Chalaris, A.1
-
19
-
-
0028270409
-
The soluble human IL-6 receptor. Mutational characterization of the proteolytic cleavage site
-
Mullberg, J. et al. The soluble human IL-6 receptor. Mutational characterization of the proteolytic cleavage site. J. Immunol. 152, 4958–4968 (1994).
-
(1994)
J. Immunol.
, vol.152
, pp. 4958-4968
-
-
Mullberg, J.1
-
20
-
-
0141866756
-
Cellular cholesterol depletion triggers shedding of the human interleukin-6 receptor by ADAM10 and ADAM17 (TACE)
-
Matthews, V. et al. Cellular cholesterol depletion triggers shedding of the human interleukin-6 receptor by ADAM10 and ADAM17 (TACE). J. Biol. Chem. 278, 38829–38839 (2003).
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 38829-38839
-
-
Matthews, V.1
-
21
-
-
85011850275
-
Proteolytic origin of the soluble human IL-6R in vivo and a decisive role of N-glycosylation
-
Riethmueller, S. et al. Proteolytic origin of the soluble human IL-6R in vivo and a decisive role of N-glycosylation. PLoS Biol. 15, e2000080 (2017).
-
(2017)
PLoS Biol.
, vol.15
-
-
Riethmueller, S.1
-
22
-
-
84967333718
-
Cleavage site localization differentially controls interleukin-6 receptor proteolysis by ADAM10 and ADAM17
-
Riethmueller, S. et al. Cleavage site localization differentially controls interleukin-6 receptor proteolysis by ADAM10 and ADAM17. Sci. Rep. 6, 25550 (2016).
-
(2016)
Sci. Rep.
, vol.6
, pp. 25550
-
-
Riethmueller, S.1
-
23
-
-
0026828552
-
Isolation of an mRNA encoding a soluble form of the human interleukin-6 receptor
-
Lust, J.A., Donovan, K.A., Kline, M.P., Greipp, P.R., Kyle, R.A. & Maihle, N.J. Isolation of an mRNA encoding a soluble form of the human interleukin-6 receptor. Cytokine 4, 96–100 (1992).
-
(1992)
Cytokine
, vol.4
, pp. 96-100
-
-
Lust, J.A.1
Donovan, K.A.2
Kline, M.P.3
Greipp, P.R.4
Kyle, R.A.5
Maihle, N.J.6
-
24
-
-
84944909402
-
Shedding of endogenous interleukin-6 receptor (IL-6R) is governed by a disintegrin and metalloproteinase (ADAM) proteases while a full-length IL-6R isoform localizes to circulating microvesicles
-
Schumacher, N. et al. Shedding of endogenous interleukin-6 receptor (IL-6R) is governed by a disintegrin and metalloproteinase (ADAM) proteases while a full-length IL-6R isoform localizes to circulating microvesicles. J. Biol. Chem. 290, 26059–26071 (2015).
-
(2015)
J. Biol. Chem.
, vol.290
, pp. 26059-26071
-
-
Schumacher, N.1
-
25
-
-
0028226196
-
Soluble receptors for cytokines and growth factors: generation and biological function
-
Rose-John, S. & Heinrich, P.C. Soluble receptors for cytokines and growth factors: generation and biological function. Biochem. J. 300, 281–290 (1994).
-
(1994)
Biochem. J.
, vol.300
, pp. 281-290
-
-
Rose-John, S.1
Heinrich, P.C.2
-
26
-
-
84945930543
-
The soluble interleukin-6 receptor and related proteins
-
Rose-John, S. The soluble interleukin-6 receptor and related proteins. Best Pract. Res. Clin. Endocrinol. Metab. 29, 787–797 (2015).
-
(2015)
Best Pract. Res. Clin. Endocrinol. Metab.
, vol.29
, pp. 787-797
-
-
Rose-John, S.1
-
27
-
-
33645233489
-
Differential expression of CD126 and CD130 mediates different STAT-3 phosphorylation in CD4+CD25- and CD25high regulatory T cells
-
Oberg, H.H., Wesch, D., Grussel, S., Rose-John, S. & Kabelitz, D. Differential expression of CD126 and CD130 mediates different STAT-3 phosphorylation in CD4+CD25- and CD25high regulatory T cells. Int. Immunol. 18, 555–563 (2006).
-
(2006)
Int. Immunol.
, vol.18
, pp. 555-563
-
-
Oberg, H.H.1
Wesch, D.2
Grussel, S.3
Rose-John, S.4
Kabelitz, D.5
-
28
-
-
0025303609
-
Studies on the structure and regulation of the human hepatic interleukin-6 receptor
-
Rose-John, S. et al. Studies on the structure and regulation of the human hepatic interleukin-6 receptor. Eur. J. Biochem. 190, 79–83 (1990).
-
(1990)
Eur. J. Biochem.
, vol.190
, pp. 79-83
-
-
Rose-John, S.1
-
29
-
-
0030614539
-
I. A bioactive designer cytokine for human hematopoietic progenitor cell expansion
-
Fischer, M. et al. I. A bioactive designer cytokine for human hematopoietic progenitor cell expansion. Nat. Biotechnol. 15, 142–145 (1997).
-
(1997)
Nat. Biotechnol.
, vol.15
, pp. 142-145
-
-
Fischer, M.1
-
30
-
-
84920285641
-
IL-6 biology: implications for clinical targeting in rheumatic disease
-
Calabrese, L.H. & Rose-John, S. IL-6 biology: implications for clinical targeting in rheumatic disease. Nat. Rev. Rheumatol. 10, 720–727 (2014).
-
(2014)
Nat. Rev. Rheumatol.
, vol.10
, pp. 720-727
-
-
Calabrese, L.H.1
Rose-John, S.2
-
31
-
-
0036310997
-
Differential response of neuronal cells to a fusion protein of ciliary neurotrophic factor/soluble CNTF-receptor and leukemia inhibitory factor
-
Marz, P., Ozbek, S., Fischer, M., Voltz, N., Otten, U. & Rose-John, S. Differential response of neuronal cells to a fusion protein of ciliary neurotrophic factor/soluble CNTF-receptor and leukemia inhibitory factor. Eur. J. Biochem. 269, 3023–3031 (2002).
-
(2002)
Eur. J. Biochem.
, vol.269
, pp. 3023-3031
-
-
Marz, P.1
Ozbek, S.2
Fischer, M.3
Voltz, N.4
Otten, U.5
Rose-John, S.6
-
32
-
-
61849112508
-
Interleukin-6 and neural stem cells: more than gliogenesis
-
Islam, O., Gong, X., Rose-John, S. & Heese, K. Interleukin-6 and neural stem cells: more than gliogenesis. Mol. Biol. Cell 20, 188–199 (2009).
-
(2009)
Mol. Biol. Cell
, vol.20
, pp. 188-199
-
-
Islam, O.1
Gong, X.2
Rose-John, S.3
Heese, K.4
-
33
-
-
0035852678
-
Distinct role of gp130 activation in promoting self-renewal divisions by mitogenically stimulated murine hematopoietic stem cells
-
Audet, J., Miller, C.L., Rose-John, S., Piret, J.M. & Eaves, C.J. Distinct role of gp130 activation in promoting self-renewal divisions by mitogenically stimulated murine hematopoietic stem cells. Proc. Natl. Acad. Sci. U S A 98, 1757–1762 (2001).
-
(2001)
Proc. Natl. Acad. Sci. U S A
, vol.98
, pp. 1757-1762
-
-
Audet, J.1
Miller, C.L.2
Rose-John, S.3
Piret, J.M.4
Eaves, C.J.5
-
34
-
-
0032846613
-
Novel path to activation of vascular smooth muscle cells: up-regulation of gp130 creates an autocrine activation loop by IL-6 and its soluble receptor
-
Klouche, M., Bhakdi, S., Hemmes, M. & Rose-John, S. Novel path to activation of vascular smooth muscle cells: up-regulation of gp130 creates an autocrine activation loop by IL-6 and its soluble receptor. J. Immunol. 163, 4583–4589 (1999).
-
(1999)
J. Immunol.
, vol.163
, pp. 4583-4589
-
-
Klouche, M.1
Bhakdi, S.2
Hemmes, M.3
Rose-John, S.4
-
35
-
-
0036219910
-
Ligand/receptor signaling threshold (LIST) model accounts for gp130-mediated embryonic stem cell self-renewal responses to LIF and HIL-6
-
Viswanathan, S., Benatar, T., Rose-John, S., Lauffenburger, D.A. & Zandstra, P.W. Ligand/receptor signaling threshold (LIST) model accounts for gp130-mediated embryonic stem cell self-renewal responses to LIF and HIL-6. Stem Cells 20, 119–138 (2002).
-
(2002)
Stem Cells
, vol.20
, pp. 119-138
-
-
Viswanathan, S.1
Benatar, T.2
Rose-John, S.3
Lauffenburger, D.A.4
Zandstra, P.W.5
-
36
-
-
3542996260
-
Maintenance of pluripotency in human embryonic stem cells is STAT3 independent
-
Humphrey, R.K. et al. Maintenance of pluripotency in human embryonic stem cells is STAT3 independent. Stem Cells 22, 522–530 (2004).
-
(2004)
Stem Cells
, vol.22
, pp. 522-530
-
-
Humphrey, R.K.1
-
37
-
-
0035160256
-
Soluble gp130 is the natural inhibitor of soluble interleukin-6 receptor transsignaling responses
-
Jostock, T. et al. Soluble gp130 is the natural inhibitor of soluble interleukin-6 receptor transsignaling responses. Eur. J. Biochem. 268, 160–167 (2001).
-
(2001)
Eur. J. Biochem.
, vol.268
, pp. 160-167
-
-
Jostock, T.1
-
38
-
-
38949164424
-
Transgenic blockade of interleukin 6 transsignaling abrogates inflammation
-
Rabe, B. et al. Transgenic blockade of interleukin 6 transsignaling abrogates inflammation. Blood 111, 1021–1028 (2008).
-
(2008)
Blood
, vol.111
, pp. 1021-1028
-
-
Rabe, B.1
-
39
-
-
84962016526
-
The role of interleukin-6 signaling in nervous tissue
-
Rothaug, M., Becker-Pauly, C. & Rose-John, S. The role of interleukin-6 signaling in nervous tissue. Biochim. Biophys. Acta 1863, 1218–1227 (2016).
-
(2016)
Biochim. Biophys. Acta
, vol.1863
, pp. 1218-1227
-
-
Rothaug, M.1
Becker-Pauly, C.2
Rose-John, S.3
-
40
-
-
33745598848
-
Forced dimerization of gp130 leads to constitutive STAT3 activation, cytokine-independent growth, and blockade of differentiation of embryonic stem cells
-
Stuhlmann-Laeisz, C. et al. Forced dimerization of gp130 leads to constitutive STAT3 activation, cytokine-independent growth, and blockade of differentiation of embryonic stem cells. Mol. Biol. Cell 17, 2986–2995 (2006).
-
(2006)
Mol. Biol. Cell
, vol.17
, pp. 2986-2995
-
-
Stuhlmann-Laeisz, C.1
-
41
-
-
84915755914
-
GP130 activation induces myeloma and collaborates with MYC
-
Dechow, T. et al. GP130 activation induces myeloma and collaborates with MYC. J. Clin. Invest. 124, 5263–5274 (2014).
-
(2014)
J. Clin. Invest.
, vol.124
, pp. 5263-5274
-
-
Dechow, T.1
-
42
-
-
18244419398
-
Extramedullary expansion of hematopoietic progenitor cells in interleukin (IL)-6-sIL-6R double transgenic mice
-
Peters, M. et al. Extramedullary expansion of hematopoietic progenitor cells in interleukin (IL)-6-sIL-6R double transgenic mice. J. Exp. Med. 185, 755–766 (1997).
-
(1997)
J. Exp. Med.
, vol.185
, pp. 755-766
-
-
Peters, M.1
-
43
-
-
0032194108
-
In vivo and in vitro activities of the gp130-stimulating designer cytokine Hyper-IL-6
-
Peters, M., Blinn, G., Solem, F., Fischer, M., Meyer zum Buschenfelde, K.H. & Rose-John, S. In vivo and in vitro activities of the gp130-stimulating designer cytokine Hyper-IL-6. J. Immunol. 161, 3575–3581 (1998).
-
(1998)
J. Immunol.
, vol.161
, pp. 3575-3581
-
-
Peters, M.1
Blinn, G.2
Solem, F.3
Fischer, M.4
Meyer zum Buschenfelde, K.H.5
Rose-John, S.6
-
44
-
-
84924560120
-
The IL-6/gp130/STAT3 signaling axis: recent advances towards specific inhibition
-
Garbers, C., Aparicio-Siegmund, S. & Rose-John, S. The IL-6/gp130/STAT3 signaling axis: recent advances towards specific inhibition. Curr. Opin. Immunol. 34, 75–82 (2015).
-
(2015)
Curr. Opin. Immunol.
, vol.34
, pp. 75-82
-
-
Garbers, C.1
Aparicio-Siegmund, S.2
Rose-John, S.3
-
45
-
-
0024529891
-
The complex pattern of cytokines in serum from patients with meningococcal septic shock
-
Waage, A., Brandtzaeg, P., Halstensen, A., Kierulf, P. & Espevik, T. The complex pattern of cytokines in serum from patients with meningococcal septic shock. J. Exp. Med. 169, 333–338 (1989).
-
(1989)
J. Exp. Med.
, vol.169
, pp. 333-338
-
-
Waage, A.1
Brandtzaeg, P.2
Halstensen, A.3
Kierulf, P.4
Espevik, T.5
-
46
-
-
84864229482
-
The interleukin 6 pathway and atherosclerosis
-
Scheller, J. & Rose-John, S. The interleukin 6 pathway and atherosclerosis. Lancet 380, 338 (2012).
-
(2012)
Lancet
, vol.380
, pp. 338
-
-
Scheller, J.1
Rose-John, S.2
-
47
-
-
84903461123
-
The interleukin-6 receptor Asp358Ala single nucleotide polymorphism rs2228145 confers increased proteolytic conversion rates by ADAM proteases
-
Garbers, C. et al. The interleukin-6 receptor Asp358Ala single nucleotide polymorphism rs2228145 confers increased proteolytic conversion rates by ADAM proteases. Biochim. Biophys. Acta 1842, 1485–1494 (2014).
-
(2014)
Biochim. Biophys. Acta
, vol.1842
, pp. 1485-1494
-
-
Garbers, C.1
-
48
-
-
84876828211
-
Functional IL6R 358Ala allele impairs classical IL-6 receptor signaling and influences risk of diverse inflammatory diseases
-
Ferreira, R.C. et al. Functional IL6R 358Ala allele impairs classical IL-6 receptor signaling and influences risk of diverse inflammatory diseases. PLoS Genet. 9, e1003444 (2013).
-
(2013)
PLoS Genet.
, vol.9
-
-
Ferreira, R.C.1
-
49
-
-
84896495791
-
A new era for the treatment of inflammatory autoimmune diseases by interleukin-6 blockade strategy
-
Tanaka, T., Narazaki, M., Ogata, A. & Kishimoto, T. A new era for the treatment of inflammatory autoimmune diseases by interleukin-6 blockade strategy. Semin. Immunol. 26, 88–96 (2014).
-
(2014)
Semin. Immunol.
, vol.26
, pp. 88-96
-
-
Tanaka, T.1
Narazaki, M.2
Ogata, A.3
Kishimoto, T.4
-
50
-
-
85021014942
-
The role of IL-6 in host defense against infections: Immunobiology and Clinical Implications
-
&,) [Epub ahead of print].
-
Rose-John, S., Winthrop, K.L. & Calabrese, L.H. The role of IL-6 in host defense against infections: Immunobiology and Clinical Implications. Nat. Rev. Rheumatol. (2017) [Epub ahead of print].
-
(2017)
Nat. Rev. Rheumatol.
-
-
Rose-John, S.1
Winthrop, K.L.2
Calabrese, L.H.3
-
51
-
-
84877275257
-
Tocilizumab monotherapy versus adalimumab monotherapy for treatment of rheumatoid arthritis (ADACTA): a randomised, double-blind, controlled phase 4 trial
-
Gabay, C. et al. Tocilizumab monotherapy versus adalimumab monotherapy for treatment of rheumatoid arthritis (ADACTA): a randomised, double-blind, controlled phase 4 trial. Lancet 381, 1541–1550 (2013).
-
(2013)
Lancet
, vol.381
, pp. 1541-1550
-
-
Gabay, C.1
-
52
-
-
20444489218
-
Design of effective immunotherapy for human autoimmunity
-
Feldmann, M. & Steinman, L. Design of effective immunotherapy for human autoimmunity. Nature 435, 612–619 (2005).
-
(2005)
Nature
, vol.435
, pp. 612-619
-
-
Feldmann, M.1
Steinman, L.2
-
53
-
-
84922552290
-
TNF antagonists opened the way to personalized medicine in rheumatoid arthritis
-
Breedveld, F. TNF antagonists opened the way to personalized medicine in rheumatoid arthritis. Mol. Med. 20(suppl. 1), S7–9 (2014).
-
(2014)
Mol. Med.
, vol.20
, pp. S7-9
-
-
Breedveld, F.1
-
54
-
-
84865377662
-
Therapeutic targeting of interleukin-6 trans-signaling does not affect the outcome of experimental tuberculosis
-
Sodenkamp, J. et al. Therapeutic targeting of interleukin-6 trans-signaling does not affect the outcome of experimental tuberculosis. Immunobiology 217, 996–1004 (2012).
-
(2012)
Immunobiology
, vol.217
, pp. 996-1004
-
-
Sodenkamp, J.1
-
55
-
-
84872182482
-
IL-6 controls the innate immune response against Listeria monocytogenes via classical IL-6 signaling
-
Hoge, J. et al. IL-6 controls the innate immune response against Listeria monocytogenes via classical IL-6 signaling. J. Immunol. 190, 703–711 (2013).
-
(2013)
J. Immunol.
, vol.190
, pp. 703-711
-
-
Hoge, J.1
-
56
-
-
83355163340
-
Inhibition of classic signaling is a novel function of soluble glycoprotein 130 (sgp130), which is controlled by the ratio of interleukin 6 and soluble interleukin 6 receptor
-
Garbers, C. et al. Inhibition of classic signaling is a novel function of soluble glycoprotein 130 (sgp130), which is controlled by the ratio of interleukin 6 and soluble interleukin 6 receptor. J. Biol. Chem. 286, 42959–42970 (2011).
-
(2011)
J. Biol. Chem.
, vol.286
, pp. 42959-42970
-
-
Garbers, C.1
-
57
-
-
18344410191
-
Blockade of interleukin 6 trans signaling suppresses T-cell resistance against apoptosis in chronic intestinal inflammation: evidence in crohn disease and experimental colitis in vivo
-
Atreya, R. et al. Blockade of interleukin 6 trans signaling suppresses T-cell resistance against apoptosis in chronic intestinal inflammation: evidence in crohn disease and experimental colitis in vivo. Nat. Med. 6, 583–588 (2000).
-
(2000)
Nat. Med.
, vol.6
, pp. 583-588
-
-
Atreya, R.1
-
58
-
-
33747774200
-
STAT3 activation via interleukin 6 trans-signalling contributes to ileitis in SAMP1/Yit mice
-
Mitsuyama, K. et al. STAT3 activation via interleukin 6 trans-signalling contributes to ileitis in SAMP1/Yit mice. Gut 55, 1263–1269 (2006).
-
(2006)
Gut
, vol.55
, pp. 1263-1269
-
-
Mitsuyama, K.1
-
59
-
-
79953756112
-
Stat3/Socs3 activation by IL-6 transsignaling promotes progression of pancreatic intraepithelial neoplasia and development of pancreatic cancer
-
Lesina, M. et al. Stat3/Socs3 activation by IL-6 transsignaling promotes progression of pancreatic intraepithelial neoplasia and development of pancreatic cancer. Cancer Cell 19, 456–469 (2011).
-
(2011)
Cancer Cell
, vol.19
, pp. 456-469
-
-
Lesina, M.1
-
60
-
-
84931575213
-
Inhibition of IL-6 signaling significantly reduces primary tumor growth and recurrencies in orthotopic xenograft models of pancreatic cancer
-
Goumas, F.A. et al. Inhibition of IL-6 signaling significantly reduces primary tumor growth and recurrencies in orthotopic xenograft models of pancreatic cancer. Int. J. Cancer 137, 1035–1046 (2015).
-
(2015)
Int. J. Cancer
, vol.137
, pp. 1035-1046
-
-
Goumas, F.A.1
-
61
-
-
84874830783
-
The role of IL-6 trans-signaling in vascular leakage: implications for ovarian hyperstimulation syndrome in a murine model
-
Wei, L.H. et al. The role of IL-6 trans-signaling in vascular leakage: implications for ovarian hyperstimulation syndrome in a murine model. J. Clin. Endocrinol. Metab. 98, E472–484 (2013).
-
(2013)
J. Clin. Endocrinol. Metab.
, vol.98
, pp. E472-484
-
-
Wei, L.H.1
-
62
-
-
0042834261
-
Soluble IL-6 receptor governs IL-6 activity in experimental arthritis: blockade of arthritis severity by soluble glycoprotein 130
-
Nowell, M.A. et al. Soluble IL-6 receptor governs IL-6 activity in experimental arthritis: blockade of arthritis severity by soluble glycoprotein 130. J. Immunol. 171, 3202–3209 (2003).
-
(2003)
J. Immunol.
, vol.171
, pp. 3202-3209
-
-
Nowell, M.A.1
-
63
-
-
33646469222
-
Functional characterization of a soluble gp130 isoform and its therapeutic capacity in an experimental model of inflammatory arthritis
-
Richards, P.J. et al. Functional characterization of a soluble gp130 isoform and its therapeutic capacity in an experimental model of inflammatory arthritis. Arthritis Rheum. 54, 1662–1672 (2006).
-
(2006)
Arthritis Rheum.
, vol.54
, pp. 1662-1672
-
-
Richards, P.J.1
-
64
-
-
84885126530
-
Interleukin-6 trans-signaling exacerbates inflammation and renal pathology in lupus-prone mice
-
Tsantikos, E. et al. Interleukin-6 trans-signaling exacerbates inflammation and renal pathology in lupus-prone mice. Arthritis Rheum. 65, 2691–2702 (2013).
-
(2013)
Arthritis Rheum.
, vol.65
, pp. 2691-2702
-
-
Tsantikos, E.1
-
65
-
-
20144375594
-
The IL-6R alpha chain controls lung CD4+CD25+ Treg development and function during allergic airway inflammation in vivo
-
Doganci, A. et al. The IL-6R alpha chain controls lung CD4+CD25+ Treg development and function during allergic airway inflammation in vivo. J. Clin. Invest. 115, 313–325 (2005).
-
(2005)
J. Clin. Invest.
, vol.115
, pp. 313-325
-
-
Doganci, A.1
-
66
-
-
84941301482
-
Allergen-induced IL-6 trans-signaling activates gammadelta T cells to promote type 2 and type 17 airway inflammation
-
Ullah, M.A. et al. Allergen-induced IL-6 trans-signaling activates gammadelta T cells to promote type 2 and type 17 airway inflammation. J. Allergy Clin. Immunol. 136, 1065–1073 (2015).
-
(2015)
J. Allergy Clin. Immunol.
, vol.136
, pp. 1065-1073
-
-
Ullah, M.A.1
-
67
-
-
79957656408
-
Selective blockade of interleukin-6 trans-signaling improves survival in a murine polymicrobial sepsis model
-
Barkhausen, T. et al. Selective blockade of interleukin-6 trans-signaling improves survival in a murine polymicrobial sepsis model. Crit. Care Med. 39, 1407–1413 (2011).
-
(2011)
Crit. Care Med.
, vol.39
, pp. 1407-1413
-
-
Barkhausen, T.1
-
68
-
-
79251578016
-
IL-6 trans-signaling modulates TLR4-dependent inflammatory responses via STAT3
-
Greenhill, C.J. et al. IL-6 trans-signaling modulates TLR4-dependent inflammatory responses via STAT3. J. Immunol. 186, 1199–1208 (2011).
-
(2011)
J. Immunol.
, vol.186
, pp. 1199-1208
-
-
Greenhill, C.J.1
-
69
-
-
84893676729
-
Trans-signaling is a dominant mechanism for the pathogenic actions of interleukin-6 in the brain
-
Campbell, I.L. et al. Trans-signaling is a dominant mechanism for the pathogenic actions of interleukin-6 in the brain. J. Neurosci. 34, 2503–2513 (2014).
-
(2014)
J. Neurosci.
, vol.34
, pp. 2503-2513
-
-
Campbell, I.L.1
-
70
-
-
84924580495
-
Inflammation-induced IL-6 functions as a natural brake on macrophages and limits GN
-
Luig, M. et al. Inflammation-induced IL-6 functions as a natural brake on macrophages and limits GN. J. Am. Soc. Nephrol. 26, 1597–1607 (2015).
-
(2015)
J. Am. Soc. Nephrol.
, vol.26
, pp. 1597-1607
-
-
Luig, M.1
-
71
-
-
84954436047
-
IL-6 trans-signaling drives murine crescentic GN
-
Braun, G.S. et al. IL-6 trans-signaling drives murine crescentic GN. J. Am. Soc. Nephrol. 27, 132–142 (2016).
-
(2016)
J. Am. Soc. Nephrol.
, vol.27
, pp. 132-142
-
-
Braun, G.S.1
-
72
-
-
84856221966
-
Transsignaling of interleukin-6 crucially contributes to atherosclerosis in mice
-
Schuett, H. et al. Transsignaling of interleukin-6 crucially contributes to atherosclerosis in mice. Arterioscler. Thromb. Vasc. Biol. 32, 281–290 (2012).
-
(2012)
Arterioscler. Thromb. Vasc. Biol.
, vol.32
, pp. 281-290
-
-
Schuett, H.1
-
73
-
-
84924415012
-
Blocking IL-6 trans-signaling prevents high-fat diet-induced adipose tissue macrophage recruitment but does not improve insulin resistance
-
Kraakman, M.J. et al. Blocking IL-6 trans-signaling prevents high-fat diet-induced adipose tissue macrophage recruitment but does not improve insulin resistance. Cell Metab. 21, 403–416 (2015).
-
(2015)
Cell Metab.
, vol.21
, pp. 403-416
-
-
Kraakman, M.J.1
-
74
-
-
78751549236
-
IL-6 trans-signaling in formation and progression of malignant ascites in ovarian cancer
-
Lo, C.W. et al. IL-6 trans-signaling in formation and progression of malignant ascites in ovarian cancer. Cancer Res. 71, 424–434 (2011).
-
(2011)
Cancer Res.
, vol.71
, pp. 424-434
-
-
Lo, C.W.1
-
75
-
-
84874606609
-
IL-6 trans-signaling promotes pancreatitis-associated lung injury and lethality
-
Zhang, H. et al. IL-6 trans-signaling promotes pancreatitis-associated lung injury and lethality. J. Clin. Invest. 123, 1019–1031 (2013).
-
(2013)
J. Clin. Invest.
, vol.123
, pp. 1019-1031
-
-
Zhang, H.1
-
76
-
-
84960338835
-
IL6 trans-signaling promotes KRAS-driven lung carcinogenesis
-
Brooks, G.D. et al. IL6 trans-signaling promotes KRAS-driven lung carcinogenesis. Cancer Res. 76, 866–876 (2016).
-
(2016)
Cancer Res.
, vol.76
, pp. 866-876
-
-
Brooks, G.D.1
-
77
-
-
85006018001
-
IL-6 trans-signaling is essential for the development of hepatocellular carcinoma in mice
-
Bergmann, J. et al. IL-6 trans-signaling is essential for the development of hepatocellular carcinoma in mice. Hepatology 65, 89–103 (2017).
-
(2017)
Hepatology
, vol.65
, pp. 89-103
-
-
Bergmann, J.1
-
78
-
-
85029293897
-
Therapeutic targeting of the IL-6 trans-signalling/mTORC1 axis in pulmonary emphysema
-
[Epub ahead of print].
-
Ruwanpura, S.M. et al. Therapeutic targeting of the IL-6 trans-signalling/mTORC1 axis in pulmonary emphysema. Am. J. Respir. Crit. Care Med. (2016) [Epub ahead of print].
-
(2016)
Am. J. Respir. Crit. Care Med.
-
-
Ruwanpura, S.M.1
-
79
-
-
58649108302
-
IL-6 and Stat3 are required for survival of intestinal epithelial cells and development of colitis-associated cancer
-
Grivennikov, S. et al. IL-6 and Stat3 are required for survival of intestinal epithelial cells and development of colitis-associated cancer. Cancer Cell 15, 103–113 (2009).
-
(2009)
Cancer Cell
, vol.15
, pp. 103-113
-
-
Grivennikov, S.1
-
80
-
-
77949326158
-
Essential roles of IL-6 trans-signaling in colonic epithelial cells, induced by the IL-6/soluble-IL-6 receptor derived from lamina propria macrophages, on the development of colitis-associated premalignant cancer in a murine model
-
Matsumoto, S. et al. Essential roles of IL-6 trans-signaling in colonic epithelial cells, induced by the IL-6/soluble-IL-6 receptor derived from lamina propria macrophages, on the development of colitis-associated premalignant cancer in a murine model. J. Immunol. 184, 1543–1551 (2010).
-
(2010)
J. Immunol.
, vol.184
, pp. 1543-1551
-
-
Matsumoto, S.1
|