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Volumn 124, Issue 12, 2014, Pages 5263-5274

GP130 activation induces myeloma and collaborates with MYC

(24)  Dechow, Tobias a   Steidle, Sabine a   Götze, Katharina S a,b   Rudelius, Martina a,c   Behnke, Kerstin a   Pechloff, Konstanze a,b   Kratzat, Susanne a   Bullinger, Lars d   Fend, Falko e   Soberon, Valeria a   Mitova, Nadya a   Li, Zhoulei a   Thaler, Markus a   Bauer, Jan a   Pietschmann, Elke a   Albers, Corinna a   Grundler, Rebekka a   Schmidt Supprian, Marc a   Ruland, Jürgen a   Peschel, Christian a,b   more..


Author keywords

[No Author keywords available]

Indexed keywords

GLYCOPROTEIN GP 130; JANUS KINASE; MYC PROTEIN; STAT3 PROTEIN; IL6ST PROTEIN, HUMAN; IL6ST PROTEIN, MOUSE; MYC PROTEIN, HUMAN; MYC PROTEIN, MOUSE; STAT3 PROTEIN, HUMAN; STAT3 PROTEIN, MOUSE;

EID: 84915755914     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI69094     Document Type: Article
Times cited : (31)

References (56)
  • 2
    • 85027950818 scopus 로고    scopus 로고
    • Update on risk stratification and treatment of newly diagnosed multiple myeloma
    • Kapoor P, Rajkumar SV. Update on risk stratification and treatment of newly diagnosed multiple myeloma. Int J Hematol. 2011;94(4):310-320.
    • (2011) Int J Hematol , vol.94 , Issue.4 , pp. 310-320
    • Kapoor, P.1    Rajkumar, S.V.2
  • 3
    • 79952781038 scopus 로고    scopus 로고
    • Medical Progress Multiple Myeloma
    • Palumbo A, Anderson K. Medical Progress Multiple Myeloma. New Engl J Med. 2011;364(11):1046-1060.
    • (2011) New Engl J Med , vol.364 , Issue.11 , pp. 1046-1060
    • Palumbo, A.1    Anderson, K.2
  • 5
    • 74049162897 scopus 로고    scopus 로고
    • International Myeloma Working Group molecular classification of multiple myeloma: Spotlight review
    • Fonseca R, et al. International Myeloma Working Group molecular classification of multiple myeloma: spotlight review. Leukemia. 2009;23(12):2210-2221.
    • (2009) Leukemia , vol.23 , Issue.12 , pp. 2210-2221
    • Fonseca, R.1
  • 6
    • 84867158927 scopus 로고    scopus 로고
    • Molecular pathogenesis of multiple myeloma and its premalignant precursor
    • Kuehl WM, Bergsagel PL. Molecular pathogenesis of multiple myeloma and its premalignant precursor. J Clin Invest. 2012;122(10):3456-3463.
    • (2012) J Clin Invest , vol.122 , Issue.10 , pp. 3456-3463
    • Kuehl, W.M.1    Bergsagel, P.L.2
  • 7
    • 84905705842 scopus 로고    scopus 로고
    • Promiscuous MYC locus rearrangements hijack enhancers but mostly super-enhancers to dysregulate MYC expression in multiple myeloma
    • Affer M, et al. Promiscuous MYC locus rearrangements hijack enhancers but mostly super-enhancers to dysregulate MYC expression in multiple myeloma. Leukemia. 2014;28(8):1725-1735.
    • (2014) Leukemia , vol.28 , Issue.8 , pp. 1725-1735
    • Affer, M.1
  • 8
    • 0028946686 scopus 로고
    • Signaling mechanisms through cytokine receptors that share signal transducing receptor components
    • Taga T, Kishimoto T. Signaling mechanisms through cytokine receptors that share signal transducing receptor components. Curr Opin Immunol. 1995;7(1):17-23.
    • (1995) Curr Opin Immunol , vol.7 , Issue.1 , pp. 17-23
    • Taga, T.1    Kishimoto, T.2
  • 9
    • 0029080019 scopus 로고
    • Membrane-bound and soluble interleukin-6 receptor: Studies on structure, regulation of expression, and signal transduction
    • Heinrich PC, et al. Membrane-bound and soluble interleukin-6 receptor: studies on structure, regulation of expression, and signal transduction. Ann N Y Acad Sci. 1995;762:222-236.
    • (1995) Ann N Y Acad Sci , vol.762 , pp. 222-236
    • Heinrich, P.C.1
  • 10
    • 0034023759 scopus 로고    scopus 로고
    • The Jak-STAT pathway
    • Imada K, Leonard WJ. The Jak-STAT pathway. Mol Immunol. 2000;37(1-2):1-11.
    • (2000) Mol Immunol , vol.37 , Issue.1-2 , pp. 1-11
    • Imada, K.1    Leonard, W.J.2
  • 11
    • 34547106018 scopus 로고    scopus 로고
    • Understanding multiple myeloma pathogenesis in the bone marrow to identify new therapeutic targets
    • Hideshima T, Mitsiades C, Tonon G, Richardson PG, Anderson KC. Understanding multiple myeloma pathogenesis in the bone marrow to identify new therapeutic targets. Nat Rev Cancer. 2007;7(8):585-598.
    • (2007) Nat Rev Cancer , vol.7 , Issue.8 , pp. 585-598
    • Hideshima, T.1    Mitsiades, C.2    Tonon, G.3    Richardson, P.G.4    Anderson, K.C.5
  • 12
    • 79952452004 scopus 로고    scopus 로고
    • The novel JAK inhibitor AZD1480 blocks STAT3 and FGFR3 signaling, resulting in suppression of human myeloma cell growth and survival
    • Scuto A, et al. The novel JAK inhibitor AZD1480 blocks STAT3 and FGFR3 signaling, resulting in suppression of human myeloma cell growth and survival. Leukemia. 2011;25(3):538-550.
    • (2011) Leukemia , vol.25 , Issue.3 , pp. 538-550
    • Scuto, A.1
  • 13
    • 83555174315 scopus 로고    scopus 로고
    • The novel JAK inhibitor CYT387 suppresses multiple signalling pathways, prevents proliferation and induces apoptosis in phenotypically diverse myeloma cells
    • Monaghan KA, Khong T, Burns CJ, Spencer A. The novel JAK inhibitor CYT387 suppresses multiple signalling pathways, prevents proliferation and induces apoptosis in phenotypically diverse myeloma cells. Leukemia. 2011;25(12):1891-1899.
    • (2011) Leukemia , vol.25 , Issue.12 , pp. 1891-1899
    • Monaghan, K.A.1    Khong, T.2    Burns, C.J.3    Spencer, A.4
  • 14
    • 33644866173 scopus 로고    scopus 로고
    • Novel therapeutic strategies targeting growth factor signalling cascades in multiple myeloma
    • Yasui H, Hideshima T, Richardson PG, Anderson KC. Novel therapeutic strategies targeting growth factor signalling cascades in multiple myeloma. Br J Haematol. 2006;132(4):385-397.
    • (2006) Br J Haematol , vol.132 , Issue.4 , pp. 385-397
    • Yasui, H.1    Hideshima, T.2    Richardson, P.G.3    Anderson, K.C.4
  • 15
    • 33750298971 scopus 로고    scopus 로고
    • Pyridone 6, a pan-Janus-activated kinase inhibitor, induces growth inhibition of multiple myeloma cells
    • Pedranzini L, et al. Pyridone 6, a pan-Janus-activated kinase inhibitor, induces growth inhibition of multiple myeloma cells. Cancer Res. 2006;66(19):9714-9721.
    • (2006) Cancer Res , vol.66 , Issue.19 , pp. 9714-9721
    • Pedranzini, L.1
  • 16
    • 0037022341 scopus 로고    scopus 로고
    • IL-6 transgenic mouse model for extraosseous plasmacytoma
    • Kovalchuk AL, et al. IL-6 transgenic mouse model for extraosseous plasmacytoma. Proc Natl Acad Sci U S A. 2002;99(3):1509-1514.
    • (2002) Proc Natl Acad Sci U S A , vol.99 , Issue.3 , pp. 1509-1514
    • Kovalchuk, A.L.1
  • 17
    • 0022380768 scopus 로고
    • The c-myc oncogene driven by immunoglobulin enhancers induces lymphoid malignancy in transgenic mice
    • Adams JM, et al. The c-myc oncogene driven by immunoglobulin enhancers induces lymphoid malignancy in transgenic mice. Nature. 1985;318(6046):533-538.
    • (1985) Nature , vol.318 , Issue.6046 , pp. 533-538
    • Adams, J.M.1
  • 18
    • 34047136169 scopus 로고    scopus 로고
    • The differentiation and stress response factor XBP-1 drives multiple myeloma pathogenesis
    • Carrasco DR, et al. The differentiation and stress response factor XBP-1 drives multiple myeloma pathogenesis. Cancer Cell. 2007;11(4):349-360.
    • (2007) Cancer Cell , vol.11 , Issue.4 , pp. 349-360
    • Carrasco, D.R.1
  • 19
    • 19444385692 scopus 로고    scopus 로고
    • Stat3 regulates genes common to both wound healing and cancer
    • Dauer DJ, et al. Stat3 regulates genes common to both wound healing and cancer. Oncogene. 2005;24(21):3397-3408.
    • (2005) Oncogene , vol.24 , Issue.21 , pp. 3397-3408
    • Dauer, D.J.1
  • 20
    • 79951494668 scopus 로고    scopus 로고
    • Initial genome sequencing and analysis of multiple myeloma
    • Chapman MA, et al. Initial genome sequencing and analysis of multiple myeloma. Nature. 2011;471(7339):467-472.
    • (2011) Nature , vol.471 , Issue.7339 , pp. 467-472
    • Chapman, M.A.1
  • 21
    • 33745779502 scopus 로고    scopus 로고
    • The molecular classification of multiple myeloma
    • Zhan F, et al. The molecular classification of multiple myeloma. Blood. 2006;108(6):2020-2028.
    • (2006) Blood , vol.108 , Issue.6 , pp. 2020-2028
    • Zhan, F.1
  • 22
    • 0027958212 scopus 로고
    • Proliferative responses and binding properties of hematopoietic cells transfected with low-affinity receptors for leukemia inhibitory factor, oncostatin M, and ciliary neurotrophic factor
    • Gearing DP, et al. Proliferative responses and binding properties of hematopoietic cells transfected with low-affinity receptors for leukemia inhibitory factor, oncostatin M, and ciliary neurotrophic factor. Proc Natl Acad Sci U S A. 1994;91(3):1119-1123.
    • (1994) Proc Natl Acad Sci U S A , vol.91 , Issue.3 , pp. 1119-1123
    • Gearing, D.P.1
  • 23
    • 33745598848 scopus 로고    scopus 로고
    • Forced dimerization of gp130 leads to constitutive STAT3 activation, cytokine-independent growth, and blockade of differentiation of embryonic stem cells
    • Stuhlmann-Laeisz C, et al. Forced dimerization of gp130 leads to constitutive STAT3 activation, cytokine-independent growth, and blockade of differentiation of embryonic stem cells. Mol Biol Cell. 2006;17(7):2986-2995.
    • (2006) Mol Biol Cell , vol.17 , Issue.7 , pp. 2986-2995
    • Stuhlmann-Laeisz, C.1
  • 24
    • 0043091984 scopus 로고    scopus 로고
    • The oncogenic fusion protein nucleophosmin-anaplastic lymphoma kinase (NPM-ALK) induces two distinct malignant phenotypes in a murine retroviral transplantation model
    • Miething C, et al. The oncogenic fusion protein nucleophosmin-anaplastic lymphoma kinase (NPM-ALK) induces two distinct malignant phenotypes in a murine retroviral transplantation model. Oncogene. 2003;22(30):4642-4647.
    • (2003) Oncogene , vol.22 , Issue.30 , pp. 4642-4647
    • Miething, C.1
  • 26
    • 40849151008 scopus 로고    scopus 로고
    • Report of the European Myeloma Network on multiparametric flow cytometry in multiple myeloma and related disorders
    • Rawstron AC, et al. Report of the European Myeloma Network on multiparametric flow cytometry in multiple myeloma and related disorders. Haematologica. 2008;93(3):431-438.
    • (2008) Haematologica , vol.93 , Issue.3 , pp. 431-438
    • Rawstron, A.C.1
  • 28
    • 73949153879 scopus 로고    scopus 로고
    • INCB16562, a JAK1/2 selective inhibitor, is efficacious against multiple myeloma cells and reverses the protective effects of cytokine and stromal cell support
    • Li J, et al. INCB16562, a JAK1/2 selective inhibitor, is efficacious against multiple myeloma cells and reverses the protective effects of cytokine and stromal cell support. Neoplasia. 2010;12(1):28-38.
    • (2010) Neoplasia , vol.12 , Issue.1 , pp. 28-38
    • Li, J.1
  • 29
    • 0037082497 scopus 로고    scopus 로고
    • Stromal cell lines from mouse aorta-gonads-mesonephros subregions are potent supporters of hematopoietic stem cell activity
    • Oostendorp RA, et al. Stromal cell lines from mouse aorta-gonads-mesonephros subregions are potent supporters of hematopoietic stem cell activity. Blood. 2002;99(4):1183-1189.
    • (2002) Blood , vol.99 , Issue.4 , pp. 1183-1189
    • Oostendorp, R.A.1
  • 30
    • 1342288971 scopus 로고    scopus 로고
    • Opinion - Comparative biology of mouse versus human cells: Modelling human cancer in mice
    • Rangarajan A, Weinberg RA. Opinion - Comparative biology of mouse versus human cells: modelling human cancer in mice. Nat Rev Cancer. 2003;3(12):952-959.
    • (2003) Nat Rev Cancer , vol.3 , Issue.12 , pp. 952-959
    • Rangarajan, A.1    Weinberg, R.A.2
  • 31
    • 77954058175 scopus 로고    scopus 로고
    • Myc suppression of Nfkb2 accelerates lymphomagenesis
    • Keller U, et al. Myc suppression of Nfkb2 accelerates lymphomagenesis. BMC Cancer. 2010;10:348.
    • (2010) BMC Cancer , vol.10 , pp. 348
    • Keller, U.1
  • 32
    • 77949681500 scopus 로고    scopus 로고
    • Skp2 directs Myc-mediated suppression of p27Kip1 yet has modest effects on Myc-driven lymphomagenesis
    • Old JB, et al. Skp2 directs Myc-mediated suppression of p27Kip1 yet has modest effects on Myc-driven lymphomagenesis. Mol Cancer Res. 2010;8(3):353-362.
    • (2010) Mol Cancer Res , vol.8 , Issue.3 , pp. 353-362
    • Old, J.B.1
  • 33
    • 77956588949 scopus 로고    scopus 로고
    • Aurora kinases A and B are up-regulated by Myc and are essential for maintenance of the malignant state
    • den Hollander J, et al. Aurora kinases A and B are up-regulated by Myc and are essential for maintenance of the malignant state. Blood. 2010;116(9):1498-1505.
    • (2010) Blood , vol.116 , Issue.9 , pp. 1498-1505
    • Den Hollander, J.1
  • 34
    • 35948946514 scopus 로고    scopus 로고
    • FoxO transcription factors suppress Myc-driven lymphomagenesis via direct activation of Arf
    • Bouchard C, Lee S, Paulus-Hock V, Loddenkemper C, Eilers M, Schmitt CA. FoxO transcription factors suppress Myc-driven lymphomagenesis via direct activation of Arf. Genes Dev. 2007;21(21):2775-2787.
    • (2007) Genes Dev , vol.21 , Issue.21 , pp. 2775-2787
    • Bouchard, C.1    Lee, S.2    Paulus-Hock, V.3    Loddenkemper, C.4    Eilers, M.5    Schmitt, C.A.6
  • 35
    • 0030041147 scopus 로고    scopus 로고
    • Multiple myeloma cell adhesion-induced interleukin-6 expression in bone marrow stromal cells involves activation of NF-κB
    • Chauhan D, et al. Multiple myeloma cell adhesion-induced interleukin-6 expression in bone marrow stromal cells involves activation of NF-κB. Blood. 1996;87(3):1104-1112.
    • (1996) Blood , vol.87 , Issue.3 , pp. 1104-1112
    • Chauhan, D.1
  • 36
    • 0023849455 scopus 로고
    • Autocrine generation and requirement of BSF-2/IL-6 for human multiple myelomas
    • Kawano M, et al. Autocrine generation and requirement of BSF-2/IL-6 for human multiple myelomas. Nature. 1988;332(6159):83-85.
    • (1988) Nature , vol.332 , Issue.6159 , pp. 83-85
    • Kawano, M.1
  • 37
    • 0030057701 scopus 로고    scopus 로고
    • Soluble interleukin-6 receptor as a prognostic factor in multiple myeloma
    • Finnish Leukaemia Group
    • Pulkki K, Pelliniemi TT, Rajamaki A, Tienhaara A, Laakso M, Lahtinen R. Soluble interleukin-6 receptor as a prognostic factor in multiple myeloma. Finnish Leukaemia Group. Br J Haematol. 1996;92(2):370-374.
    • (1996) Br J Haematol , vol.92 , Issue.2 , pp. 370-374
    • Pulkki, K.1    Pelliniemi, T.T.2    Rajamaki, A.3    Tienhaara, A.4    Laakso, M.5    Lahtinen, R.6
  • 38
    • 0024832002 scopus 로고
    • Serum levels of interleukin 6, a potent myeloma cell growth factor, as a reflect of disease severity in plasma cell dyscrasias
    • Bataille R, Jourdan M, Zhang XG, Klein B. Serum levels of interleukin 6, a potent myeloma cell growth factor, as a reflect of disease severity in plasma cell dyscrasias. J Clin Invest. 1989;84(6):2008-2011.
    • (1989) J Clin Invest , vol.84 , Issue.6 , pp. 2008-2011
    • Bataille, R.1    Jourdan, M.2    Zhang, X.G.3    Klein, B.4
  • 39
    • 9344259121 scopus 로고    scopus 로고
    • Human interleukin-6 receptor super-antagonists with high potency and wide spectrum on multiple myeloma cells
    • Sporeno E, et al. Human interleukin-6 receptor super-antagonists with high potency and wide spectrum on multiple myeloma cells. Blood. 1996;87(11):4510-4519.
    • (1996) Blood , vol.87 , Issue.11 , pp. 4510-4519
    • Sporeno, E.1
  • 40
    • 0032984589 scopus 로고    scopus 로고
    • Constitutive activation of Stat3 signaling confers resistance to apoptosis in human U266 myeloma cells
    • Catlett-Falcone R, et al. Constitutive activation of Stat3 signaling confers resistance to apoptosis in human U266 myeloma cells. Immunity. 1999;10(1):105-115.
    • (1999) Immunity , vol.10 , Issue.1 , pp. 105-115
    • Catlett-Falcone, R.1
  • 41
    • 9444273447 scopus 로고    scopus 로고
    • Combined disruption of both the MEK/ERK and the IL-6R/STAT3 pathways is required to induce apoptosis of multiple myeloma cells in the presence of bone marrow stromal cells
    • Chatterjee M, Stuhmer T, Herrmann P, Bommert K, Dorken B, Bargou RC. Combined disruption of both the MEK/ERK and the IL-6R/STAT3 pathways is required to induce apoptosis of multiple myeloma cells in the presence of bone marrow stromal cells. Blood. 2004;104(12):3712-3721.
    • (2004) Blood , vol.104 , Issue.12 , pp. 3712-3721
    • Chatterjee, M.1    Stuhmer, T.2    Herrmann, P.3    Bommert, K.4    Dorken, B.5    Bargou, R.C.6
  • 42
    • 0036839144 scopus 로고    scopus 로고
    • In the presence of bone marrow stromal cells human multiple myeloma cells become independent of the IL-6/gp130/STAT3 pathway
    • Chatterjee M, et al. In the presence of bone marrow stromal cells human multiple myeloma cells become independent of the IL-6/gp130/STAT3 pathway. Blood. 2002;100(9):3311-3318.
    • (2002) Blood , vol.100 , Issue.9 , pp. 3311-3318
    • Chatterjee, M.1
  • 43
    • 9144231336 scopus 로고    scopus 로고
    • Interleukin-6-dependent gene expression profiles in multiple myeloma INA-6 cells reveal a Bcl-2 family-independent survival pathway closely associated with Stat3 activation
    • Brocke-Heidrich K, et al. Interleukin-6-dependent gene expression profiles in multiple myeloma INA-6 cells reveal a Bcl-2 family-independent survival pathway closely associated with Stat3 activation. Blood. 2004;103(1):242-251.
    • (2004) Blood , vol.103 , Issue.1 , pp. 242-251
    • Brocke-Heidrich, K.1
  • 44
    • 0037408535 scopus 로고    scopus 로고
    • Analysis of signal transducer and activator of transcription 3 (Stat 3) pathway in multiple myeloma: Stat 3 activation and cyclin D1 dysregulation are mutually exclusive events
    • Quintanilla-Martinez L, et al. Analysis of signal transducer and activator of transcription 3 (Stat 3) pathway in multiple myeloma: Stat 3 activation and cyclin D1 dysregulation are mutually exclusive events. Am J Pathol. 2003;162(5):1449-1461.
    • (2003) Am J Pathol , vol.162 , Issue.5 , pp. 1449-1461
    • Quintanilla-Martinez, L.1
  • 45
    • 70350500225 scopus 로고    scopus 로고
    • STATs in cancer inflammation and immunity: A leading role for STAT3
    • Yu H, Pardoll D, Jove R. STATs in cancer inflammation and immunity: a leading role for STAT3. Nat Rev Cancer. 2009;9(11):798-809.
    • (2009) Nat Rev Cancer , vol.9 , Issue.11 , pp. 798-809
    • Yu, H.1    Pardoll, D.2    Jove, R.3
  • 47
    • 3042806890 scopus 로고    scopus 로고
    • Novel targeted deregulation of c-Myc cooperates with Bcl-X(L) to cause plasma cell neoplasms in mice
    • Cheung WC, et al. Novel targeted deregulation of c-Myc cooperates with Bcl-X(L) to cause plasma cell neoplasms in mice. J Clin Invest. 2004;113(12):1763-1773.
    • (2004) J Clin Invest , vol.113 , Issue.12 , pp. 1763-1773
    • Cheung, W.C.1
  • 48
    • 85014285855 scopus 로고    scopus 로고
    • Distinct IL-6 signal transduction leads to growth arrest and death in B cells or growth promotion and cell survival in myeloma cells
    • Cheung WC, Van Ness B. Distinct IL-6 signal transduction leads to growth arrest and death in B cells or growth promotion and cell survival in myeloma cells. Leukemia. 2002;16(6):1182-1188.
    • (2002) Leukemia , vol.16 , Issue.6 , pp. 1182-1188
    • Cheung, W.C.1    Van Ness, B.2
  • 49
    • 8844264524 scopus 로고    scopus 로고
    • The SCID-rab model: A novel in vivo system for primary human myeloma demonstrating growth of CD138-expressing malignant cells
    • Yata K, Yaccoby S. The SCID-rab model: a novel in vivo system for primary human myeloma demonstrating growth of CD138-expressing malignant cells. Leukemia. 2004;18(11):1891-1897.
    • (2004) Leukemia , vol.18 , Issue.11 , pp. 1891-1897
    • Yata, K.1    Yaccoby, S.2
  • 50
    • 38549131395 scopus 로고    scopus 로고
    • AID-dependent activation of a MYC transgene induces multiple myeloma in a conditional mouse model of post-germinal center malignancies
    • Chesi M, et al. AID-dependent activation of a MYC transgene induces multiple myeloma in a conditional mouse model of post-germinal center malignancies. Cancer Cell. 2008;13(2):167-180.
    • (2008) Cancer Cell , vol.13 , Issue.2 , pp. 167-180
    • Chesi, M.1
  • 51
    • 34249097128 scopus 로고    scopus 로고
    • Myc targets Cks1 to provoke the suppression of p27Kip1, proliferation and lymphomagenesis
    • Keller UB, et al. Myc targets Cks1 to provoke the suppression of p27Kip1, proliferation and lymphomagenesis. EMBO J. 2007;26(10):2562-2574.
    • (2007) EMBO J , vol.26 , Issue.10 , pp. 2562-2574
    • Keller, U.B.1
  • 52
    • 33646487924 scopus 로고    scopus 로고
    • The Bcr-Abl mutations T315I and Y253H do not confer a growth advantage in the absence of imatinib
    • Miething C, et al. The Bcr-Abl mutations T315I and Y253H do not confer a growth advantage in the absence of imatinib. Leukemia. 2006;20(4):650-657.
    • (2006) Leukemia , vol.20 , Issue.4 , pp. 650-657
    • Miething, C.1
  • 53
    • 84862070506 scopus 로고    scopus 로고
    • Cks1 is required for tumor cell proliferation but not sufficient to induce hematopoietic malignancies
    • Kratzat S, et al. Cks1 is required for tumor cell proliferation but not sufficient to induce hematopoietic malignancies. PLoS One. 2012;7(5):e37433.
    • (2012) PLoS One , vol.7 , Issue.5 , pp. e37433
    • Kratzat, S.1
  • 54
    • 80755140040 scopus 로고    scopus 로고
    • Deregulated apoptosis signaling in core-binding factor leukemia differentiates clinically relevant, molecular marker-independent subgroups
    • Luck SC, et al. Deregulated apoptosis signaling in core-binding factor leukemia differentiates clinically relevant, molecular marker-independent subgroups. Leukemia. 2011;25(11):1728-1738.
    • (2011) Leukemia , vol.25 , Issue.11 , pp. 1728-1738
    • Luck, S.C.1
  • 55
    • 27344435774 scopus 로고    scopus 로고
    • Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles
    • Subramanian A, et al. Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. Proc Natl Acad Sci U S A. 2005;102(43):15545-15550.
    • (2005) Proc Natl Acad Sci U S A , vol.102 , Issue.43 , pp. 15545-15550
    • Subramanian, A.1
  • 56
    • 0033925065 scopus 로고    scopus 로고
    • Simplified labeling approach for synthesizing 3-deoxy-3-[18F] fluorothymidine ([18F] FLT)
    • Machulla HJ, Blocher A, Kuntzsch M, Piert M, Wei R, Grierson J. Simplified labeling approach for synthesizing 3-deoxy-3-[18F] fluorothymidine ([18F] FLT). J Radioanal Nucl Chem. 2000;243(3):843-846.
    • (2000) J Radioanal Nucl Chem , vol.243 , Issue.3 , pp. 843-846
    • Machulla, H.J.1    Blocher, A.2    Kuntzsch, M.3    Piert, M.4    Wei, R.5    Grierson, J.6


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