Maintenance of pluripotency in human embryonic stem cells is STAT3 independent

Stem Cells

Volumn 22, Issue 4, 2004, Pages 522-530

  Humphrey, Rohan K ^a   Beattie, Gillian M ^a   Lopez, Ana D ^a   Bucay, Nathan ^a   King, Charles C ^a   Firpo, Meri T ^b   Rose John, Stefan ^c   Hayek, Alberto ^a  

^a UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF KIEL   (Germany)

Author keywords

Gp130; Human embryonic stem cells; LIF; Pluripotency; STAT3

Indexed keywords

CYTOKINE; GLYCOPROTEIN GP 130; INTERLEUKIN 6; JANUS KINASE; LEUKEMIA INHIBITORY FACTOR; MITOGEN ACTIVATED PROTEIN KINASE 1; OCTAMER TRANSCRIPTION FACTOR 4; PROTEIN; PROTEIN KINASE B; PROTEIN NANOG; PROTEIN TRA 1 60; STAT PROTEIN; STAT3 PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL DIFFERENTIATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; EMBRYO CELL; EMBRYO STEM CELL; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PLURIPOTENT STEM CELL; PROTEIN EXPRESSION; PROTEIN FAMILY; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; STEM CELL;

ANIMALIA; JANUS; MURINAE;

EID: 3542996260     PISSN: 10665099     EISSN: None     Source Type: Journal    
DOI: 10.1634/stemcells.22-4-522     Document Type: Article

References (34)

1. Heinrich PC, Behrmann I, Haan S et al. Principles of interleukin (IL)-6-type cytokine signalling and its regulation. Biochem J 2003;374:1-20.
2. Smith AG. Embryo-derived stem cells: of mice and men. Annu Rev Cell Dev Biol 2001;17:435-462.
3. Nichols J, Chambers I, Smith A. Derivation of germline competent embryonic stem cells with a combination of interleukin-6 and soluble interleukin-6 receptor. Exp Cell Res 1994;215:237-239.
4. Yoshida K, Chambers I, Nichols J et al. Maintenance of the pluripotential phenotype of embryonic stem cells through direct activation of gp130 signalling pathways. Mech Dev 1994;45:163-171.
5. Burdon T, Smith A, Savatier P. Signalling, cell cycle and pluripotency in embryonic stem cells. Trends Cell Biol 2002;12:432-438.
6. Nichols J, Chambers I, Taga T et al. Physiological rationale for responsiveness of mouse embryonic stem cells to gp 130 cytokines. Development 2001;128:2333-2339.
7. Van Snick J. Interleukin-6: an overview. Annu Rev Immunol 1990;8:253-278.
8. Owczarek CM, Layton MJ, Metcalf D et al. Inter-species chimeras of leukaemia inhibitory factor define a major human receptor-binding determinant. EMBO J 1993; 12:3487-3495.
9. Thomson JA, Itskovitz-Eldor J, Shapiro SS et al. Embryonic stem cell lines derived from human blastocysts. Science 1998;282:1145-1147.
10. Reubinoff BE, Pera MF, Fong CY et al. Embryonic stem cell lines from human blastocysts: somatic differentiation in vitro. Nat Biotechnol 2000;18:399-404.
11. Rose-John S. GP130 stimulation and the maintenance of stem cells. Trends Biotechnol 2002;20:417.
12. Taga T, Kishimoto T. Gp 130 and the interleukin-6 family of cytokines. Annu Rev Immunol 1997;15:797-819.
13. Fischer M, Goldschmitt J, Peschel C et al. I. A bioactive designer cytokine for human hematopoietic progenitor cell expansion. Nat Biotechnol 1997;15:142-145.
14. Viswanathan S, Benatar T, Rose-John S et al. Ligand/receptor signaling threshold (LIST) model accounts for gp130-mediated embryonic stem cell self-renewal responses to LIF and HIL-6. STEM CELLS 2002;20:119-138.
15. Abeyta M, Clark A, Rodriguez R et al. Unique gene expression signatures of independently derived human embryonic stem cell lines. Hum Mol Gen 2004;13:601-608.
16. Xu C, Inokuma MS, Denham J et al. Feeder-free growth of undifferentiated human embryonic stem cells. Nat Biotechnol 2001;19:971-974.
17. Kallen KJ, Grotzinger J, Lelievre E et al. Receptor recognition sites of cytokines are organized as exchangeable modules: transfer of the leukemia inhibitory factor receptor-binding site from ciliary neurotrophic factor to interleukin-6. J Biol Chem 1999;274:11859-11867.
18. Matthews V, Schuster B, Schutze S et al. Cellular cholesterol depletion triggers shedding of the human interleukin-6 receptor by ADAM10 and ADAM17 (TACE). J Biol Chem 2003;278:38829-38839.
19. Sonnenburg ED, Gao T, Newton AC. The phosphoinositide-dependent kinase, PDK-1, phosphorylates conventional protein kinase C isozymes by a mechanism that is independent of phosphoinositide 3-kinase. J Biol Chem 2001;276: 45289-45297.
20. Ernst M, Oates A, Dunn AR. Gp130-mediated signal transduction in embryonic stem cells involves activation of Jak and Ras/mitogen-activated protein kinase pathways. J Biol Chem 1996;271:30136-30143.
21. Matsuda T, Nakamura T, Nakao K et al. STAT3 activation is sufficient to maintain an undifferentiated state of mouse embryonic stem cells. EMBO J 1999;18:4261-4269.
22. Dani C, Chambers I, Johnstone S et al. Paracrine induction of stem cell renewal by LIF-deficient cells: a new ES cell regulatory pathway. Dev Biol 1998;203:149-162.
23. Vassilieva S, Guan K, Pich U et al. Establishment of SSEA-1- and Oct-4-expressing rat embryonic stem-like cell lines and effects of cytokines of the IL-6 family on clonal growth. Exp Cell Res 2000;258:361-373.
24. Thomson JA, Kalishman J, Golos TG et al. Isolation of a primate embryonic stem cell line. Proc Natl Acad Sci USA 1995;92:7844-7848.
25. Shamblott MJ, Axelman J, Wang S et al. Derivation of pluripotent stem cells from cultured human primordial germ cells. Proc Natl Acad Sci U S A 1998;95:13726-13731.
26. Schuringa JJ, van der Schaaf S, Vellenga E et al. LIF-induced STAT3 signaling in murine versus human embryonal carcinoma (EC) cells. Exp Cell Res 2002;274:119-129.
27. Stewart CL, Kaspar P, Brunet LJ et al. Blastocyst implantation depends on maternal expression of leukaemia inhibitory factor. Nature 1992;359:76-79.
28. Li M, Sendtner M, Smith A. Essential function of LIF receptor in motor neurons. Nature 1995;378:724-727.
29. Ware CB, Horowitz MC, Renshaw BR et al. Targeted disruption of the low-affinity leukemia inhibitory factor receptor gene causes placental, skeletal, neural and metabolic defects and results in perinatal death. Development 1995;121:1283-1299.
30. Yoshida K, Taga T, Saito M et al. Targeted disruption of gp130, a common signal transducer for the interleukin 6 family of cytokines leads to myocardial and hematological disorders. Proc Natl Acad Sci U S A 1996;93:407-411.
31. Nakashima K, Wiese S, Yanagisawa M et al. Developmental requirement of gp130 signaling in neuronal survival and astrocyte differentiation. J Neurosci 1999;19:5429-5434.
32. Chambers I, Colby D, Robertson M et al Functional expression cloning of Nanog, a pluripotency sustaining factor in embryonic stem cells. Cell 2003;113:643-655.
33. Mitsui K, Tokuzawa Y, Itoh H et al. The homeoprotein Nanog is required for maintenance of pluripotency in mouse epiblast and ES cells. Cell 2003:113:631-642.
34. Constantinescu S. Stemness, fusion and renewal of hematopoietic and embryonic stem cells. J Cell Mol Med 2003;7:103-112.