메뉴 건너뛰기




Volumn 2, Issue 5, 2017, Pages

Bile acids initiate cholestatic liver injury by triggering a hepatocyte-specific inflammatory response

Author keywords

[No Author keywords available]

Indexed keywords


EID: 85022085353     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/jci.insight.90780     Document Type: Article
Times cited : (193)

References (39)
  • 1
    • 84922758254 scopus 로고    scopus 로고
    • Bile acids as metabolic regulators
    • Li T, Chiang JY. Bile acids as metabolic regulators. Curr Opin Gastroenterol. 2015;31(2):159-165.
    • (2015) Curr Opin Gastroenterol , vol.31 , Issue.2 , pp. 159-165
    • Li, T1    Chiang, JY.2
  • 2
    • 77955591462 scopus 로고    scopus 로고
    • Hepatocyte death: a clear and present danger
    • Malhi H, Guicciardi ME, Gores GJ. Hepatocyte death: a clear and present danger. Physiol Rev. 2010;90(3):1165-1194.
    • (2010) Physiol Rev , vol.90 , Issue.3 , pp. 1165-1194
    • Malhi, H1    Guicciardi, ME2    Gores, GJ.3
  • 3
    • 0032919402 scopus 로고    scopus 로고
    • Toxic bile salts induce rodent hepatocyte apoptosis via direct activation of Fas
    • Faubion WA, et al. Toxic bile salts induce rodent hepatocyte apoptosis via direct activation of Fas. J Clin Invest. 1999;103(1):137-145.
    • (1999) J Clin Invest , vol.103 , Issue.1 , pp. 137-145
    • Faubion, WA1
  • 4
    • 0035914341 scopus 로고    scopus 로고
    • The bile acid glycochenodeoxycholate induces trail-receptor 2/DR5 expression and apoptosis
    • Higuchi H, et al. The bile acid glycochenodeoxycholate induces trail-receptor 2/DR5 expression and apoptosis. J Biol Chem. 2001;276(42):38610-38618.
    • (2001) J Biol Chem , vol.276 , Issue.42 , pp. 38610-38618
    • Higuchi, H1
  • 5
    • 32044467118 scopus 로고    scopus 로고
    • 24-norUrsodeoxycholic acid is superior to ursodeoxycholic acid in the treatment of sclerosing cholangitis in Mdr2 (Abcb4) knockout mice
    • Fickert P, et al. 24-norUrsodeoxycholic acid is superior to ursodeoxycholic acid in the treatment of sclerosing cholangitis in Mdr2 (Abcb4) knockout mice. Gastroenterology. 2006;130(2):465-481.
    • (2006) Gastroenterology , vol.130 , Issue.2 , pp. 465-481
    • Fickert, P1
  • 6
    • 83255185056 scopus 로고    scopus 로고
    • Effect of bile duct ligation on bile acid composition in mouse serum and liver
    • Zhang Y, Hong JY, Rockwell CE, Copple BL, Jaeschke H, Klaassen CD. Effect of bile duct ligation on bile acid composition in mouse serum and liver. Liver Int. 2012;32(1):58-69.
    • (2012) Liver Int , vol.32 , Issue.1 , pp. 58-69
    • Zhang, Y1    Hong, JY2    Rockwell, CE3    Copple, BL4    Jaeschke, H5    Klaassen, CD.6
  • 7
    • 84888859028 scopus 로고    scopus 로고
    • Plasma biomarkers of liver injury and inflammation demonstrate a lack of apoptosis during obstructive cholestasis in mice
    • Woolbright BL, Antoine DJ, Jenkins RE, Bajt ML, Park BK, Jaeschke H. Plasma biomarkers of liver injury and inflammation demonstrate a lack of apoptosis during obstructive cholestasis in mice. Toxicol Appl Pharmacol. 2013;273(3):524-531.
    • (2013) Toxicol Appl Pharmacol , vol.273 , Issue.3 , pp. 524-531
    • Woolbright, BL1    Antoine, DJ2    Jenkins, RE3    Bajt, ML4    Park, BK5    Jaeschke, H.6
  • 8
    • 84921976620 scopus 로고    scopus 로고
    • Bile acid-induced necrosis in primary human hepatocytes and in patients with obstructive cholestasis
    • Woolbright BL, et al. Bile acid-induced necrosis in primary human hepatocytes and in patients with obstructive cholestasis. Toxicol Appl Pharmacol. 2015;283(3):168-177.
    • (2015) Toxicol Appl Pharmacol , vol.283 , Issue.3 , pp. 168-177
    • Woolbright, BL1
  • 9
    • 0034086273 scopus 로고    scopus 로고
    • Bile duct ligation in rats induces biliary expression of cytokine-induced neutrophil chemoattractant
    • Saito JM, Maher JJ. Bile duct ligation in rats induces biliary expression of cytokine-induced neutrophil chemoattractant. Gastroenterology. 2000;118(6):1157-1168.
    • (2000) Gastroenterology , vol.118 , Issue.6 , pp. 1157-1168
    • Saito, JM1    Maher, JJ.2
  • 10
    • 0042766884 scopus 로고    scopus 로고
    • Neutrophils aggravate acute liver injury during obstructive cholestasis in bile duct-ligated mice
    • Gujral JS, Farhood A, Bajt ML, Jaeschke H. Neutrophils aggravate acute liver injury during obstructive cholestasis in bile duct-ligated mice. Hepatology. 2003;38(2):355-363.
    • (2003) Hepatology , vol.38 , Issue.2 , pp. 355-363
    • Gujral, JS1    Farhood, A2    Bajt, ML3    Jaeschke, H.4
  • 11
    • 78650793157 scopus 로고    scopus 로고
    • Bile acids induce inflammatory genes in hepatocytes: a novel mechanism of inflammation during obstructive cholestasis
    • Allen K, Jaeschke H, Copple BL. Bile acids induce inflammatory genes in hepatocytes: a novel mechanism of inflammation during obstructive cholestasis. Am J Pathol. 2011;178(1):175-186.
    • (2011) Am J Pathol , vol.178 , Issue.1 , pp. 175-186
    • Allen, K1    Jaeschke, H2    Copple, BL.3
  • 12
    • 84896726055 scopus 로고    scopus 로고
    • Chemokine-chemokine receptor CCL2-CCR2 and CX3CL1-CX3CR1 axis may play a role in the aggravated inflammation in primary biliary cirrhosis
    • Sasaki M, Miyakoshi M, Sato Y, Nakanuma Y. Chemokine-chemokine receptor CCL2-CCR2 and CX3CL1-CX3CR1 axis may play a role in the aggravated inflammation in primary biliary cirrhosis. Dig Dis Sci. 2014;59(2):358-364.
    • (2014) Dig Dis Sci , vol.59 , Issue.2 , pp. 358-364
    • Sasaki, M1    Miyakoshi, M2    Sato, Y3    Nakanuma, Y.4
  • 13
    • 80155130601 scopus 로고    scopus 로고
    • Serum IL-6 and IL-8 in infants with biliary atresia in comparison to intrahepatic cholestasis
    • El-Faramawy AA, El-Shazly LB, Abbass AA, Ismail HA. Serum IL-6 and IL-8 in infants with biliary atresia in comparison to intrahepatic cholestasis. Trop Gastroenterol. 2011;32(1):50-55.
    • (2011) Trop Gastroenterol , vol.32 , Issue.1 , pp. 50-55
    • El-Faramawy, AA1    El-Shazly, LB2    Abbass, AA3    Ismail, HA.4
  • 14
    • 0141814990 scopus 로고    scopus 로고
    • Tumor necrosis factor alpha-dependent up-regulation of Lrh-1 and Mrp3(Abcc3) reduces liver injury in obstructive cholestasis
    • Bohan A, Chen WS, Denson LA, Held MA, Boyer JL. Tumor necrosis factor alpha-dependent up-regulation of Lrh-1 and Mrp3(Abcc3) reduces liver injury in obstructive cholestasis. J Biol Chem. 2003;278(38):36688-36698.
    • (2003) J Biol Chem , vol.278 , Issue.38 , pp. 36688-36698
    • Bohan, A1    Chen, WS2    Denson, LA3    Held, MA4    Boyer, JL.5
  • 15
    • 67651156353 scopus 로고    scopus 로고
    • CCR2 promotes hepatic fibrosis in mice
    • Seki E, et al. CCR2 promotes hepatic fibrosis in mice. Hepatology. 2009;50(1):185-197.
    • (2009) Hepatology , vol.50 , Issue.1 , pp. 185-197
    • Seki, E1
  • 16
    • 84886689508 scopus 로고    scopus 로고
    • IL-17A synergistically enhances bile acid-induced inflammation during obstructive cholestasis
    • O'Brien KM, Allen KM, Rockwell CE, Towery K, Luyendyk JP, Copple BL. IL-17A synergistically enhances bile acid-induced inflammation during obstructive cholestasis. Am J Pathol. 2013;183(5):1498-1507.
    • (2013) Am J Pathol , vol.183 , Issue.5 , pp. 1498-1507
    • O'Brien, KM1    Allen, KM2    Rockwell, CE3    Towery, K4    Luyendyk, JP5    Copple, BL.6
  • 17
    • 80052164116 scopus 로고    scopus 로고
    • Cytoplasmic DNA innate immune pathways
    • Barber GN. Cytoplasmic DNA innate immune pathways. Immunol Rev. 2011;243(1):99-108.
    • (2011) Immunol Rev , vol.243 , Issue.1 , pp. 99-108
    • Barber, GN.1
  • 18
    • 77950275298 scopus 로고    scopus 로고
    • Circulating mitochondrial DAMPs cause inflammatory responses to injury
    • Zhang Q, et al. Circulating mitochondrial DAMPs cause inflammatory responses to injury. Nature. 2010;464(7285):104-107.
    • (2010) Nature , vol.464 , Issue.7285 , pp. 104-107
    • Zhang, Q1
  • 19
    • 0028816461 scopus 로고
    • Ursodeoxycholate (UDCA) inhibits the mitochondrial membrane permeability transition induced by glycochenodeoxycholate: a mechanism of UDCA cytoprotection
    • Botla R, Spivey JR, Aguilar H, Bronk SF, Gores GJ. Ursodeoxycholate (UDCA) inhibits the mitochondrial membrane permeability transition induced by glycochenodeoxycholate: a mechanism of UDCA cytoprotection. J Pharmacol Exp Ther. 1995;272(2):930-938.
    • (1995) J Pharmacol Exp Ther , vol.272 , Issue.2 , pp. 930-938
    • Botla, R1    Spivey, JR2    Aguilar, H3    Bronk, SF4    Gores, GJ.5
  • 20
    • 84920954598 scopus 로고    scopus 로고
    • Sodium taurocholate cotransporting polypeptide (SLC10A1) deficiency: conjugated hypercholanemia without a clear clinical phenotype
    • Vaz FM, et al. Sodium taurocholate cotransporting polypeptide (SLC10A1) deficiency: conjugated hypercholanemia without a clear clinical phenotype. Hepatology. 2015;61(1):260-267.
    • (2015) Hepatology , vol.61 , Issue.1 , pp. 260-267
    • Vaz, FM1
  • 21
    • 84933178894 scopus 로고    scopus 로고
    • Impaired uptake of conjugated bile acids and hepatitis b virus pres1-binding in na(+) -taurocholate cotransporting polypeptide knockout mice
    • Slijepcevic D, et al. Impaired uptake of conjugated bile acids and hepatitis b virus pres1-binding in na(+) -taurocholate cotransporting polypeptide knockout mice. Hepatology. 2015;62(1):207-219.
    • (2015) Hepatology , vol.62 , Issue.1 , pp. 207-219
    • Slijepcevic, D1
  • 22
    • 10744225137 scopus 로고    scopus 로고
    • Resistance of rat hepatocytes against bile acid-induced apoptosis in cholestatic liver injury is due to nuclear factor-kappa B activation
    • Schoemaker MH, et al. Resistance of rat hepatocytes against bile acid-induced apoptosis in cholestatic liver injury is due to nuclear factor-kappa B activation. J Hepatol. 2003;39(2):153-161.
    • (2003) J Hepatol , vol.39 , Issue.2 , pp. 153-161
    • Schoemaker, MH1
  • 23
    • 84959173279 scopus 로고    scopus 로고
    • Therapeutic targets for cholestatic liver injury
    • Woolbright BL, Jaeschke H. Therapeutic targets for cholestatic liver injury. Expert Opin Ther Targets. 2016;20(4):463-475.
    • (2016) Expert Opin Ther Targets , vol.20 , Issue.4 , pp. 463-475
    • Woolbright, BL1    Jaeschke, H.2
  • 24
    • 52949125148 scopus 로고    scopus 로고
    • Role of TLR9 in hepatic stellate cells and experimental liver fibrosis
    • Gäbele E, et al. Role of TLR9 in hepatic stellate cells and experimental liver fibrosis. Biochem Biophys Res Commun. 2008;376(2):271-276.
    • (2008) Biochem Biophys Res Commun , vol.376 , Issue.2 , pp. 271-276
    • Gäbele, E1
  • 25
    • 0027227827 scopus 로고
    • Glycochenodeoxycholate-induced lethal hepatocellular injury in rat hepatocytes. Role of ATP depletion and cytosolic free calcium
    • Spivey JR, Bronk SF, Gores GJ. Glycochenodeoxycholate-induced lethal hepatocellular injury in rat hepatocytes. Role of ATP depletion and cytosolic free calcium. J Clin Invest. 1993;92(1):17-24.
    • (1993) J Clin Invest , vol.92 , Issue.1 , pp. 17-24
    • Spivey, JR1    Bronk, SF2    Gores, GJ.3
  • 26
    • 84864815555 scopus 로고    scopus 로고
    • Tauro-β-muricholic acid restricts bile acid-induced hepatocellular apoptosis by preserving the mitochondrial membrane potential
    • Denk GU, et al. Tauro-β-muricholic acid restricts bile acid-induced hepatocellular apoptosis by preserving the mitochondrial membrane potential. Biochem Biophys Res Commun. 2012;424(4):758-764.
    • (2012) Biochem Biophys Res Commun , vol.424 , Issue.4 , pp. 758-764
    • Denk, GU1
  • 27
    • 84869852834 scopus 로고    scopus 로고
    • Current pharmacotherapy for cholestatic liver disease
    • Carey EJ, Lindor KD. Current pharmacotherapy for cholestatic liver disease. Expert Opin Pharmacother. 2012;13(17):2473-2484.
    • (2012) Expert Opin Pharmacother , vol.13 , Issue.17 , pp. 2473-2484
    • Carey, EJ1    Lindor, KD.2
  • 28
    • 84926421958 scopus 로고    scopus 로고
    • 24-nor-ursodeoxycholic acid ameliorates inflammatory response and liver fibrosis in a murine model of hepatic schistosomiasis
    • Sombetzki M, et al. 24-nor-ursodeoxycholic acid ameliorates inflammatory response and liver fibrosis in a murine model of hepatic schistosomiasis. J Hepatol. 2015;62(4):871-878.
    • (2015) J Hepatol , vol.62 , Issue.4 , pp. 871-878
    • Sombetzki, M1
  • 29
    • 84890453194 scopus 로고    scopus 로고
    • Experimental sepsis-induced mitochondrial biogenesis is dependent on autophagy, TLR4, and TLR9 signaling in liver
    • Carchman EH, et al. Experimental sepsis-induced mitochondrial biogenesis is dependent on autophagy, TLR4, and TLR9 signaling in liver. FASEB J. 2013;27(12):4703-4711.
    • (2013) FASEB J , vol.27 , Issue.12 , pp. 4703-4711
    • Carchman, EH1
  • 30
    • 33645128199 scopus 로고    scopus 로고
    • Early growth response factor-1 is critical for cholestatic liver injury
    • Kim ND, Moon JO, Slitt AL, Copple BL. Early growth response factor-1 is critical for cholestatic liver injury. Toxicol Sci. 2006;90(2):586-595.
    • (2006) Toxicol Sci , vol.90 , Issue.2 , pp. 586-595
    • Kim, ND1    Moon, JO2    Slitt, AL3    Copple, BL.4
  • 31
    • 84906535982 scopus 로고    scopus 로고
    • Roles for chemokines in liver disease
    • e1
    • Marra F, Tacke F. Roles for chemokines in liver disease. Gastroenterology. 2014;147(3):577-594.e1.
    • (2014) Gastroenterology , vol.147 , Issue.3 , pp. 577-594
    • Marra, F1    Tacke, F.2
  • 32
    • 33644855120 scopus 로고    scopus 로고
    • Kupffer cells abrogate cholestatic liver injury in mice
    • Gehring S, et al. Kupffer cells abrogate cholestatic liver injury in mice. Gastroenterology. 2006;130(3):810-822.
    • (2006) Gastroenterology , vol.130 , Issue.3 , pp. 810-822
    • Gehring, S1
  • 33
    • 84959871331 scopus 로고    scopus 로고
    • Hepatocyte mitochondrial DNA drives nonalcoholic steatohepatitis by activation of TLR9
    • Garcia-Martinez I, et al. Hepatocyte mitochondrial DNA drives nonalcoholic steatohepatitis by activation of TLR9. J Clin Invest. 2016;126(3):859-864.
    • (2016) J Clin Invest , vol.126 , Issue.3 , pp. 859-864
    • Garcia-Martinez, I1
  • 34
    • 84900558520 scopus 로고    scopus 로고
    • Altered expression and function of canalicular transporters during early development of cholestatic liver injury in Abcb4-deficient mice
    • Cai SY, Mennone A, Soroka CJ, Boyer JL. Altered expression and function of canalicular transporters during early development of cholestatic liver injury in Abcb4-deficient mice. Am J Physiol Gastrointest Liver Physiol. 2014;306(8):G670-G676.
    • (2014) Am J Physiol Gastrointest Liver Physiol , vol.306 , Issue.8 , pp. G670-G676
    • Cai, SY1    Mennone, A2    Soroka, CJ3    Boyer, JL.4
  • 35
    • 60449097716 scopus 로고    scopus 로고
    • ATP8B1 deficiency disrupts the bile canalicular membrane bilayer structure in hepatocytes, but FXR expression and activity are maintained
    • Cai SY, Gautam S, Nguyen T, Soroka CJ, Rahner C, Boyer JL. ATP8B1 deficiency disrupts the bile canalicular membrane bilayer structure in hepatocytes, but FXR expression and activity are maintained. Gastroenterology. 2009;136(3):1060-1069.
    • (2009) Gastroenterology , vol.136 , Issue.3 , pp. 1060-1069
    • Cai, SY1    Gautam, S2    Nguyen, T3    Soroka, CJ4    Rahner, C5    Boyer, JL.6
  • 36
    • 84890932260 scopus 로고    scopus 로고
    • Adenosine is required for sustained inflammasome activation via the A2A receptor and the HIF-1α pathway
    • Ouyang X, et al. Adenosine is required for sustained inflammasome activation via the A2A receptor and the HIF-1α pathway. Nat Commun. 2013;4:2909.
    • (2013) Nat Commun , vol.4 , pp. 2909
    • Ouyang, X1
  • 37
    • 72249123155 scopus 로고    scopus 로고
    • ERK1/2-dependent vascular endothelial growth factor signaling sustains cyst growth in polycystin-2 defective mice
    • e7
    • Spirli C, et al. ERK1/2-dependent vascular endothelial growth factor signaling sustains cyst growth in polycystin-2 defective mice. Gastroenterology. 2010;138(1):360-371.e7.
    • (2010) Gastroenterology , vol.138 , Issue.1 , pp. 360-371
    • Spirli, C1
  • 38
    • 61949472508 scopus 로고    scopus 로고
    • Innate immune recognition of infected apoptotic cells directs T(H)17 cell differentiation
    • Torchinsky MB, Garaude J, Martin AP, Blander JM. Innate immune recognition of infected apoptotic cells directs T(H)17 cell differentiation. Nature. 2009;458(7234):78-82.
    • (2009) Nature , vol.458 , Issue.7234 , pp. 78-82
    • Torchinsky, MB1    Garaude, J2    Martin, AP3    Blander, JM.4
  • 39
    • 84899019345 scopus 로고    scopus 로고
    • Neutrophil migration through extracellular matrix
    • Jennings RT, Knaus UG. Neutrophil migration through extracellular matrix. Methods Mol Biol. 2014;1124:209-218.
    • (2014) Methods Mol Biol , vol.1124 , pp. 209-218
    • Jennings, RT1    Knaus, UG.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.