-
1
-
-
77952561299
-
Bile acids as regulators of hepatic lipid and glucose metabolism
-
Trauner M, Claudel T, Fickert P, Moustafa T, Wagner M. Bile acids as regulators of hepatic lipid and glucose metabolism. Dig Dis 2010;28:220–224.
-
(2010)
Dig Dis
, vol.28
, pp. 220-224
-
-
Trauner, M.1
Claudel, T.2
Fickert, P.3
Moustafa, T.4
Wagner, M.5
-
2
-
-
84905257719
-
Bile acid signaling in metabolic disease and drug therapy
-
Li T, Chiang JY. Bile acid signaling in metabolic disease and drug therapy. Pharmacol Rev 2014;66:948–983.
-
(2014)
Pharmacol Rev
, vol.66
, pp. 948-983
-
-
Li, T.1
Chiang, J.Y.2
-
3
-
-
70349430938
-
Bile acids: regulation of synthesis
-
Chiang JY. Bile acids: regulation of synthesis. J Lipid Res 2009;50:1955–1966.
-
(2009)
J Lipid Res
, vol.50
, pp. 1955-1966
-
-
Chiang, J.Y.1
-
4
-
-
0036175425
-
Ghrelin drives GH secretion during fasting in man
-
Muller AF, Lamberts SW, Janssen JA, Hoffland LJ, Koestsveld PV, Bidlingmaier M, et al. Ghrelin drives GH secretion during fasting in man. Eur J Endocrinol 2002;146:203–207.
-
(2002)
Eur J Endocrinol
, vol.146
, pp. 203-207
-
-
Muller, A.F.1
Lamberts, S.W.2
Janssen, J.A.3
Hoffland, L.J.4
Koestsveld, P.5
Bidlingmaier, M.6
-
5
-
-
34249677947
-
FGF21: a missing link in the biology of fasting
-
Reitman ML. FGF21: a missing link in the biology of fasting. Cell Metab 2007;5:405–407.
-
(2007)
Cell Metab
, vol.5
, pp. 405-407
-
-
Reitman, M.L.1
-
6
-
-
84868249301
-
Orphan nuclear receptor small heterodimer partner negatively regulates growth hormone-mediated induction of hepatic gluconeogenesis through inhibition of signal transducer and activator of transcription 5 (STAT5) Transactivation
-
Kim YD, Li T, Ahn SW, Kim DK, Lee JM, Hwang SL, et al. Orphan nuclear receptor small heterodimer partner negatively regulates growth hormone-mediated induction of hepatic gluconeogenesis through inhibition of signal transducer and activator of transcription 5 (STAT5) Transactivation. J Biol Chem 2012;287:37098–37108.
-
(2012)
J Biol Chem
, vol.287
, pp. 37098-37108
-
-
Kim, Y.D.1
Li, T.2
Ahn, S.W.3
Kim, D.K.4
Lee, J.M.5
Hwang, S.L.6
-
7
-
-
0003269455
-
A G protein-coupled receptor responsive to bile acids
-
Kawamata Y, Fujii R, Hosoya M, Harada M, Yoshida H, Miwa M, et al. A G protein-coupled receptor responsive to bile acids. J Biol Chem 2003;278:9435–9440.
-
(2003)
J Biol Chem
, vol.278
, pp. 9435-9440
-
-
Kawamata, Y.1
Fujii, R.2
Hosoya, M.3
Harada, M.4
Yoshida, H.5
Miwa, M.6
-
8
-
-
0036432845
-
Identification of membrane-type receptor for bile acids (M-BAR)
-
Maruyama T, Miyamoto Y, Nakamura T, Tamai Y, Okada H, Sugiyama E, et al. Identification of membrane-type receptor for bile acids (M-BAR). Biochem Biophys Res Commun 2002;298:714–719.
-
(2002)
Biochem Biophys Res Commun
, vol.298
, pp. 714-719
-
-
Maruyama, T.1
Miyamoto, Y.2
Nakamura, T.3
Tamai, Y.4
Okada, H.5
Sugiyama, E.6
-
9
-
-
70349255713
-
The membrane-bound bile acid receptor TGR5 is localized in the epithelium of human gallbladders
-
Keitel V, Cupisti K, Ullmer C, Knoefel WT, Kubitz R, Häussinger D. The membrane-bound bile acid receptor TGR5 is localized in the epithelium of human gallbladders. Hepatology 2009;50:861–870.
-
(2009)
Hepatology
, vol.50
, pp. 861-870
-
-
Keitel, V.1
Cupisti, K.2
Ullmer, C.3
Knoefel, W.T.4
Kubitz, R.5
Häussinger, D.6
-
10
-
-
44649092024
-
Expression and function of the bile acid receptor TGR5 in Kupffer cells
-
Keitel V, Donner M, Winandy S, et al. Expression and function of the bile acid receptor TGR5 in Kupffer cells. Biochem Biophys Res Commun 2008;372:78–84.
-
(2008)
Biochem Biophys Res Commun
, vol.372
, pp. 78-84
-
-
Keitel, V.1
Donner, M.2
Winandy, S.3
-
11
-
-
33947383769
-
The G-protein coupled bile salt receptor TGR5 is expressed in liver sinusoidal endothelial cells
-
Keitel V, Reinehr R, Gatsios P, Rupprecht C, Görg B, Selbach O, et al. The G-protein coupled bile salt receptor TGR5 is expressed in liver sinusoidal endothelial cells. Hepatology 2007;45:695–704.
-
(2007)
Hepatology
, vol.45
, pp. 695-704
-
-
Keitel, V.1
Reinehr, R.2
Gatsios, P.3
Rupprecht, C.4
Görg, B.5
Selbach, O.6
-
12
-
-
13844299425
-
Bile acids promote glucagon-like peptide-1 secretion through TGR5 in a murine enteroendocrine cell line STC-1
-
Katsuma S, Hirasawa A, Tsujimoto G. Bile acids promote glucagon-like peptide-1 secretion through TGR5 in a murine enteroendocrine cell line STC-1. Biochem Biophys Res Commun 2005;329:386–390.
-
(2005)
Biochem Biophys Res Commun
, vol.329
, pp. 386-390
-
-
Katsuma, S.1
Hirasawa, A.2
Tsujimoto, G.3
-
13
-
-
61949416918
-
Medical treatment of primary sclerosing cholangitis: a role for novel bile acids and other (post-)transcriptional modulators?
-
Beuers U, Kullak-Ublick GA, Pusl T, Rauws ER, Rust C. Medical treatment of primary sclerosing cholangitis: a role for novel bile acids and other (post-)transcriptional modulators? Clin Rev Allergy Immunol 2009;36:52–61.
-
(2009)
Clin Rev Allergy Immunol
, vol.36
, pp. 52-61
-
-
Beuers, U.1
Kullak-Ublick, G.A.2
Pusl, T.3
Rauws, E.R.4
Rust, C.5
-
14
-
-
31444454037
-
Bile acids induce energy expenditure by promoting intracellular thyroid hormone activation
-
Watanabe M, Houten SM, Mataki C, Christoffolete MA, Kim BW, Sato H, et al. Bile acids induce energy expenditure by promoting intracellular thyroid hormone activation. Nature 2006;439:484–489.
-
(2006)
Nature
, vol.439
, pp. 484-489
-
-
Watanabe, M.1
Houten, S.M.2
Mataki, C.3
Christoffolete, M.A.4
Kim, B.W.5
Sato, H.6
-
15
-
-
69149083245
-
TGR5-mediated bile acid sensing controls glucose homeostasis
-
Thomas C, Gioiello A, Noriega L, Strehle A, Oury J, Rizzo G, et al. TGR5-mediated bile acid sensing controls glucose homeostasis. Cell Metab 2009;10:167–177.
-
(2009)
Cell Metab
, vol.10
, pp. 167-177
-
-
Thomas, C.1
Gioiello, A.2
Noriega, L.3
Strehle, A.4
Oury, J.5
Rizzo, G.6
-
16
-
-
33751066787
-
Targeted disruption of G protein-coupled bile acid receptor 1 (Gpbar1/M-Bar) in mice
-
Maruyama T, Tanaka K, Suzuki J, Miyoshi H, Harada N, Nakamura T, et al. Targeted disruption of G protein-coupled bile acid receptor 1 (Gpbar1/M-Bar) in mice. J Endocrinol 2006;191:197–205.
-
(2006)
J Endocrinol
, vol.191
, pp. 197-205
-
-
Maruyama, T.1
Tanaka, K.2
Suzuki, J.3
Miyoshi, H.4
Harada, N.5
Nakamura, T.6
-
17
-
-
33748757234
-
Targeted deletion of Gpbar1 protects mice from cholesterol gallstone formation
-
Vassileva G, Golovko A, Markowitz L, Abbondanzo SJ, Zeng M, Yang S, et al. Targeted deletion of Gpbar1 protects mice from cholesterol gallstone formation. Biochem J 2006;398:423–430.
-
(2006)
Biochem J
, vol.398
, pp. 423-430
-
-
Vassileva, G.1
Golovko, A.2
Markowitz, L.3
Abbondanzo, S.J.4
Zeng, M.5
Yang, S.6
-
18
-
-
84884982788
-
The receptor TGR5 protects the liver from bile acid overload during liver regeneration in mice
-
Péan N, Doignon I, Garcin I, Besnard A, Julien B, Liu B, et al. The receptor TGR5 protects the liver from bile acid overload during liver regeneration in mice. Hepatology 2013;58:1451–1460.
-
(2013)
Hepatology
, vol.58
, pp. 1451-1460
-
-
Péan, N.1
Doignon, I.2
Garcin, I.3
Besnard, A.4
Julien, B.5
Liu, B.6
-
19
-
-
77950806433
-
SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation
-
Hirschey MD, Shimazu T, Goetzman E, Jing E, Schwer B, Lombard DB, et al. SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation. Nature 2010;464:121–125.
-
(2010)
Nature
, vol.464
, pp. 121-125
-
-
Hirschey, M.D.1
Shimazu, T.2
Goetzman, E.3
Jing, E.4
Schwer, B.5
Lombard, D.B.6
-
20
-
-
0346492572
-
CD36 deficiency increases insulin sensitivity in muscle, but induces insulin resistance in the liver in mice
-
Goudriaan JR, Dahlmans VE, Teusink B, Ouwens DM, Febbraio M, Maassen JA, et al. CD36 deficiency increases insulin sensitivity in muscle, but induces insulin resistance in the liver in mice. J Lipid Res 2003;44:2270–2277.
-
(2003)
J Lipid Res
, vol.44
, pp. 2270-2277
-
-
Goudriaan, J.R.1
Dahlmans, V.E.2
Teusink, B.3
Ouwens, D.M.4
Febbraio, M.5
Maassen, J.A.6
-
21
-
-
84993913350
-
Selective liver targeting of antivirals by recombinant chylomicrons—a new therapeutic approach to hepatitis B
-
Rensen PCN, van Dijk MCM, Havenaar EC, Bijsterbosch MK, Kruijt JK, van Berkel TJ. Selective liver targeting of antivirals by recombinant chylomicrons—a new therapeutic approach to hepatitis B. Nat Med 1995;1:221–225.
-
(1995)
Nat Med
, vol.1
, pp. 221-225
-
-
Rensen, P.C.N.1
van Dijk, M.C.M.2
Havenaar, E.C.3
Bijsterbosch, M.K.4
Kruijt, J.K.5
van Berkel, T.J.6
-
22
-
-
0032699670
-
Peroxisome proliferator-activated receptor alpha mediates the adaptive response to fasting
-
Kersten S, Seydoux J, Peters JM, Gonzalez FJ, Desvergne B, Wahli W. Peroxisome proliferator-activated receptor alpha mediates the adaptive response to fasting. J Clin Invest 1999;103:1489–1498.
-
(1999)
J Clin Invest
, vol.103
, pp. 1489-1498
-
-
Kersten, S.1
Seydoux, J.2
Peters, J.M.3
Gonzalez, F.J.4
Desvergne, B.5
Wahli, W.6
-
23
-
-
84862909056
-
Glucose and insulin induction of bile acid synthesis: mechanisms and implication in diabetes and obesity
-
Li T, Francl JM, Boehme S, Ochoa A, Zhang Y, Klaassen CD, et al. Glucose and insulin induction of bile acid synthesis: mechanisms and implication in diabetes and obesity. J Biol Chem 2012;287:1861–1873.
-
(2012)
J Biol Chem
, vol.287
, pp. 1861-1873
-
-
Li, T.1
Francl, J.M.2
Boehme, S.3
Ochoa, A.4
Zhang, Y.5
Klaassen, C.D.6
-
24
-
-
84891439386
-
Retinoic acid-related orphan receptor alpha regulates diurnal rhythm and fasting induction of sterol 12alpha-hydroxylase in bile acid synthesis
-
Pathak P, Li T, Chiang JY. Retinoic acid-related orphan receptor alpha regulates diurnal rhythm and fasting induction of sterol 12alpha-hydroxylase in bile acid synthesis. J Biol Chem 2013;288:37154–37165.
-
(2013)
J Biol Chem
, vol.288
, pp. 37154-37165
-
-
Pathak, P.1
Li, T.2
Chiang, J.Y.3
-
25
-
-
33344457703
-
Codependence of growth hormone-responsive, sexually dimorphic hepatic gene expression on signal transducer and activator of transcription 5b and hepatic nuclear factor 4alpha
-
Holloway MG, Laz EV, Waxman DJ. Codependence of growth hormone-responsive, sexually dimorphic hepatic gene expression on signal transducer and activator of transcription 5b and hepatic nuclear factor 4alpha. Mol Endocrinol 2006;20:647–660.
-
(2006)
Mol Endocrinol
, vol.20
, pp. 647-660
-
-
Holloway, M.G.1
Laz, E.V.2
Waxman, D.J.3
-
26
-
-
65949095803
-
Autophagy regulates lipid metabolism
-
Singh R, Kaushik S, Wang Y, Xiang Y, Novak I, Komatsu M, et al. Autophagy regulates lipid metabolism. Nature 2009;458:1131–1135.
-
(2009)
Nature
, vol.458
, pp. 1131-1135
-
-
Singh, R.1
Kaushik, S.2
Wang, Y.3
Xiang, Y.4
Novak, I.5
Komatsu, M.6
-
27
-
-
78650850032
-
GH-dependent STAT5 signaling plays an important role in hepatic lipid metabolism
-
Barclay JL, Nelson CN, Ishikawa M, Murray LA, Kerr LM, McPhee TR, et al. GH-dependent STAT5 signaling plays an important role in hepatic lipid metabolism. Endocrinology 2011;152:181–192.
-
(2011)
Endocrinology
, vol.152
, pp. 181-192
-
-
Barclay, J.L.1
Nelson, C.N.2
Ishikawa, M.3
Murray, L.A.4
Kerr, L.M.5
McPhee, T.R.6
-
28
-
-
84880836117
-
Disruption of JAK2 in adipocytes impairs lipolysis and improves fatty liver in mice with elevated GH
-
Nordstrom SM, Tran JL, Sos BC, Wagner KU, Weiss EJ. Disruption of JAK2 in adipocytes impairs lipolysis and improves fatty liver in mice with elevated GH. Mol Endocrinol 2013;27:1333–1342.
-
(2013)
Mol Endocrinol
, vol.27
, pp. 1333-1342
-
-
Nordstrom, S.M.1
Tran, J.L.2
Sos, B.C.3
Wagner, K.U.4
Weiss, E.J.5
-
29
-
-
84873342775
-
Gut microbiota regulates bile acid metabolism by reducing the levels of tauro-beta-muricholic acid, a naturally occurring FXR antagonist
-
Sayin SI, Wahlström A, Felin J, Jäntti S, Marschall HU, Bamberg K, et al. Gut microbiota regulates bile acid metabolism by reducing the levels of tauro-beta-muricholic acid, a naturally occurring FXR antagonist. Cell Metab 2013;17:225–235.
-
(2013)
Cell Metab
, vol.17
, pp. 225-235
-
-
Sayin, S.I.1
Wahlström, A.2
Felin, J.3
Jäntti, S.4
Marschall, H.U.5
Bamberg, K.6
-
30
-
-
84891760775
-
Human insulin resistance is associated with increased plasma levels of 12alpha-hydroxylated bile acids
-
Haeusler RA, Astiarraga B, Camastra S, Accili D, Ferrannini E. Human insulin resistance is associated with increased plasma levels of 12alpha-hydroxylated bile acids. Diabetes 2013;62:4184–4191.
-
(2013)
Diabetes
, vol.62
, pp. 4184-4191
-
-
Haeusler, R.A.1
Astiarraga, B.2
Camastra, S.3
Accili, D.4
Ferrannini, E.5
-
31
-
-
84946866183
-
TGR5 contributes to glucoregulatory improvements after vertical sleeve gastrectomy in mice
-
, Oct 28., [Epub ahead of print
-
McGavigan AK, Garibay D, Henseler ZM, Chen J, Bettaieb A, Haj FG, et al. TGR5 contributes to glucoregulatory improvements after vertical sleeve gastrectomy in mice. Gut 2015 Oct 28. pii: gutjnl-2015-309871. doi: 10.1136/gutjnl-2015-309871. [Epub ahead of print]
-
(2015)
Gut
-
-
McGavigan, A.K.1
Garibay, D.2
Henseler, Z.M.3
Chen, J.4
Bettaieb, A.5
Haj, F.G.6
-
32
-
-
84923031534
-
Nutrient-sensing nuclear receptors coordinate autophagy
-
Lee JM, Wagner M, Xiao R, Kim KH, Feng D, Lazar MA, Moore DD. Nutrient-sensing nuclear receptors coordinate autophagy. Nature 2014;516:112–115.
-
(2014)
Nature
, vol.516
, pp. 112-115
-
-
Lee, J.M.1
Wagner, M.2
Xiao, R.3
Kim, K.H.4
Feng, D.5
Lazar, M.A.6
Moore, D.D.7
-
33
-
-
84921822489
-
Reduced autophagy in livers of fasted, fat-depleted, ghrelin-deficient mice: reversal by growth hormone
-
Zhang Y, Fang F, Goldstein JL, Brown MS, Zhao TJ. Reduced autophagy in livers of fasted, fat-depleted, ghrelin-deficient mice: reversal by growth hormone. Proc Natl Acad Sci U S A 2015;112:1226–1231.
-
(2015)
Proc Natl Acad Sci U S A
, vol.112
, pp. 1226-1231
-
-
Zhang, Y.1
Fang, F.2
Goldstein, J.L.3
Brown, M.S.4
Zhao, T.J.5
-
34
-
-
76049093949
-
PGC-1alpha negatively regulates hepatic FGF21 expression by modulating the heme/Rev-Erb(alpha) axis
-
Estall JL, Ruas JL, Choi CS, Laznik D, Badman M, Maratos-Flier E, et al. PGC-1alpha negatively regulates hepatic FGF21 expression by modulating the heme/Rev-Erb(alpha) axis. Proc Natl Acad Sci U S A 2009;106:22510–22515.
-
(2009)
Proc Natl Acad Sci U S A
, vol.106
, pp. 22510-22515
-
-
Estall, J.L.1
Ruas, J.L.2
Choi, C.S.3
Laznik, D.4
Badman, M.5
Maratos-Flier, E.6
-
35
-
-
45649085226
-
Inhibition of growth hormone signaling by the fasting-induced hormone FGF21
-
Inagaki T, Lin VY, Goetz R, Mohammadi M, Mangelsdorf DJ, Kliewer SA. Inhibition of growth hormone signaling by the fasting-induced hormone FGF21. Cell Metab 2008;8:77–83.
-
(2008)
Cell Metab
, vol.8
, pp. 77-83
-
-
Inagaki, T.1
Lin, V.Y.2
Goetz, R.3
Mohammadi, M.4
Mangelsdorf, D.J.5
Kliewer, S.A.6
-
36
-
-
77954881744
-
Preventive effects of chronic exogenous growth hormone levels on diet-induced hepatic steatosis in rats
-
Qin Y, Tian YP. Preventive effects of chronic exogenous growth hormone levels on diet-induced hepatic steatosis in rats. Lipids Health Dis 2010;9:78.
-
(2010)
Lipids Health Dis
, vol.9
, pp. 78
-
-
Qin, Y.1
Tian, Y.P.2
-
37
-
-
66149089158
-
The circadian clock components CRY1 and CRY2 are necessary to sustain sex dimorphism in mouse liver metabolism
-
Bur IM, Cohen-Solal AM, Carmignac D, Abecassis PY, Chauvet N, Martin AO, et al. The circadian clock components CRY1 and CRY2 are necessary to sustain sex dimorphism in mouse liver metabolism. J Biol Chem 2009;284:9066–9073.
-
(2009)
J Biol Chem
, vol.284
, pp. 9066-9073
-
-
Bur, I.M.1
Cohen-Solal, A.M.2
Carmignac, D.3
Abecassis, P.Y.4
Chauvet, N.5
Martin, A.O.6
-
38
-
-
77952562273
-
Gender-dependent effect of Gpbar1 genetic deletion on the metabolic profiles of diet-induced obese mice
-
Vassileva G, Hu W, Hoos L, Tetzloff G, Yang S, Liu L, et al. Gender-dependent effect of Gpbar1 genetic deletion on the metabolic profiles of diet-induced obese mice. J Endocrinol 2010;205:225–232.
-
(2010)
J Endocrinol
, vol.205
, pp. 225-232
-
-
Vassileva, G.1
Hu, W.2
Hoos, L.3
Tetzloff, G.4
Yang, S.5
Liu, L.6
-
39
-
-
1242297067
-
Presence of protein-bound unconjugated bile acids in the cytoplasmic fraction of rat brain
-
Mano N, Goto T, Uchida M, Nishimura K, Ando M, Kobayashi N, Goto J. Presence of protein-bound unconjugated bile acids in the cytoplasmic fraction of rat brain. J Lipid Res 2004;45:295–300.
-
(2004)
J Lipid Res
, vol.45
, pp. 295-300
-
-
Mano, N.1
Goto, T.2
Uchida, M.3
Nishimura, K.4
Ando, M.5
Kobayashi, N.6
Goto, J.7
-
40
-
-
84875848761
-
The TGR5 receptor mediates bile acid-induced itch and analgesia
-
Alemi F, Kwon E, Poole DP, Lieu T, Lyo V, Cattaruzza F, et al. The TGR5 receptor mediates bile acid-induced itch and analgesia. J Clin Invest 2013;123:1513–1530.
-
(2013)
J Clin Invest
, vol.123
, pp. 1513-1530
-
-
Alemi, F.1
Kwon, E.2
Poole, D.P.3
Lieu, T.4
Lyo, V.5
Cattaruzza, F.6
-
41
-
-
79951675823
-
Immediate neuroendocrine signaling after partial hepatectomy through acute portal hyperpressure and cholestasis
-
Doignon I, Julien B, Serrière-Lanneau V, Garcin I, Alonso G, Nicou A, et al. Immediate neuroendocrine signaling after partial hepatectomy through acute portal hyperpressure and cholestasis. J Hepatol 2011;54:481–488.
-
(2011)
J Hepatol
, vol.54
, pp. 481-488
-
-
Doignon, I.1
Julien, B.2
Serrière-Lanneau, V.3
Garcin, I.4
Alonso, G.5
Nicou, A.6
-
42
-
-
3042703073
-
Pituitary control of lipoprotein and bile acid metabolism in male rats: growth hormone effects are not mediated by prolactin
-
Matasconi M, Angelin B, Rudling M. Pituitary control of lipoprotein and bile acid metabolism in male rats: growth hormone effects are not mediated by prolactin. Am J Physiol Endocrinol Metab 2004;287:E114–E119.
-
(2004)
Am J Physiol Endocrinol Metab
, vol.287
, pp. E114-E119
-
-
Matasconi, M.1
Angelin, B.2
Rudling, M.3
-
43
-
-
0030987347
-
Growth hormone and bile acid synthesis. Key role for the activity of hepatic microsomal cholesterol 7alpha-hydroxylase in the rat
-
Rudling M, Parini P, Angelin B. Growth hormone and bile acid synthesis. Key role for the activity of hepatic microsomal cholesterol 7alpha-hydroxylase in the rat. J Clin Invest 1997;99:2239–2245.
-
(1997)
J Clin Invest
, vol.99
, pp. 2239-2245
-
-
Rudling, M.1
Parini, P.2
Angelin, B.3
|