Impaired Uptake of Conjugated Bile Acids and Hepatitis B Virus Pres1-Binding in Na+-Taurocholate Cotransporting Polypeptide Knockout Mice

Hepatology

Volumn 62, Issue 1, 2015, Pages 207-219

  Slijepcevic, Davor ^a   Kaufman, Christina ^b   Wichers, Catharina G K ^c   Gilglioni, Eduardo H ^a   Lempp, Florian A ^b   Duijst, Suzanne ^a   de Waart, Dirk R ^a   Oude Elferink, Ronald P J ^a   Mier, Walter ^b   Stieger, Bruno ^d   Beuers, Ulrich ^a   Urban, Stephan ^b,e   van de Graaf, Stan F J ^a  

^a ACADEMIC MEDICAL CENTER   (Netherlands)

^b UNIVERSITY HOSPITAL HEIDELBERG   (Germany)

^c UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^d UNIVERSITY HOSPITAL ZURICH   (Switzerland)

^e UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BILE ACID CONJUGATE; MYRCLUDEX B; PROTEIN INHIBITOR; SODIUM BILE ACID COTRANSPORTER; SOLUTE CARRIER ORGANIC ANION TRANSPORTER 1A4; UNCLASSIFIED DRUG; URSODEOXYCHOLIC ACID; COTRANSPORTER; L PROTEIN, HEPATITIS B VIRUS; LIPOPEPTIDE; MYRCLUDEX-B; ORGANIC ANION TRANSPORTER; SODIUM-BILE ACID COTRANSPORTER; TAUROCHOLIC ACID; VIRUS ENVELOPE PROTEIN;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BILE SECRETION; CONTROLLED STUDY; DIET SUPPLEMENTATION; DOWN REGULATION; ENTEROHEPATIC CIRCULATION; FEMALE; HEPATITIS B VIRUS; IN VIVO STUDY; LIVER CELL; MALE; MOUSE; NONHUMAN; PHENOTYPE; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN EXPRESSION; UPREGULATION; WILD TYPE; ANIMAL; BILE; BLOOD; CHEMISTRY; FECES; GENETICS; KNOCKOUT MOUSE; LIVER; METABOLISM; URINE;

ANIMALS; BILE; FECES; FEMALE; HEPATITIS B VIRUS; LIPOPEPTIDES; LIVER; MALE; MICE, KNOCKOUT; ORGANIC ANION TRANSPORTERS, SODIUM-DEPENDENT; PHENOTYPE; SYMPORTERS; TAUROCHOLIC ACID; URSODEOXYCHOLIC ACID; VIRAL ENVELOPE PROTEINS;

EID: 84933178894     PISSN: 02709139     EISSN: 15273350     Source Type: Journal    
DOI: 10.1002/hep.27694     Document Type: Article

References (27)

1. Hofmann AF. Bile acids: the good, the bad, and the ugly. News Physiol Sci 1999;14:24-29.
2. Meier PJ, Stieger B. Bile salt transporters. Annu Rev Physiol 2002;64:635-661.
3. +-bile acid cotransport system. Proc Natl Acad Sci USA 1991;88:10629-10633.
4. Stieger B. The role of the sodium-taurocholate cotransporting polypeptide (NTCP) and of the bile salt export pump (BSEP) in physiology and pathophysiology of bile formation. Handb Exp Pharmacol 2011;(201):205-259.
5. +-independent organic anion transporter. Proc Natl Acad Sci USA 1994;91:133-137.
6. Csanaky IL, Lu H, Zhang Y, Ogura K, Choudhuri S, Klaassen CD. Organic anion-transporting polypeptide 1b2 (Oatp1b2) is important for the hepatic uptake of unconjugated bile acids: studies in Oatp1b2-null mice. Hepatology 2011;53:272-281.
7. +-dependent taurocholate cotransporting protein NTCP. Biochem J 2012;441(3):1007-1015.
8. Kim RB, Leake B, Cvetkovic M, Roden MM, Nadeau J, Walubo A, et al. Modulation by drugs of human hepatic sodium-dependent bile acid transporter (sodium taurocholate cotransporting polypeptide) activity. J Pharmacol Exp Ther 1999;291:1204-1209.
9. Visser WE, Wong WS, van Mullem AA, Friesema EC, Geyer J, Visser TJ. Study of the transport of thyroid hormone by transporters of the SLC10 family. Mol Cell Endocrinol 2010;315:138-145.
10. Dawson PA, Lan T, Rao A. Bile acid transporters. J Lipid Res 2009;50:2340-2357.
11. +-bile acid cotransporter in extrahepatic cholestasis. Gastroenterology 1996;110:199-209.
12. Yan H, Zhong G, Xu G, He W, Jing Z, Gao Z, et al. Sodium taurocholate cotransporting polypeptide is a functional receptor for human hepatitis B and D virus. Elife 2012;1:e00049.
13. Ni Y, Lempp FA, Mehrle S, Nkongolo S, Kaufman C, Falth M, et al. Hepatitis B and D viruses exploit sodium taurocholate co-transporting polypeptide for species-specific entry into hepatocytes. Gastroenterology 2014;146:1070-1083.
14. Meier A, Mehrle S, Weiss TS, Mier W, Urban S. Myristoylated PreS1-domain of the hepatitis B virus L-protein mediates specific binding to differentiated hepatocytes. Hepatology 2013;58:31-42.
15. Schulze A, Schieck A, Ni Y, Mier W, Urban S. Fine mapping of pre-S sequence requirements for hepatitis B virus large envelope protein-mediated receptor interaction. J Virol 2010;84:1989-2000.
16. Oude Elferink RP, Ottenhoff R, van Wijland M, Smit JJ, Schinkel AH, Groen AK. Regulation of biliary lipid secretion by mdr2 P-glycoprotein in the mouse. J Clin Invest 1995;95:31-38.
17. Schieck A, Müller T, Schulze A, Haberkorn U, Urban S, Mier W. Solid-phase synthesis of the lipopeptide Myr-HBVpreS/2-78, a hepatitis B virus entry inhibitor. Molecules 2010;15:4773-4783.
18. +-taurocholate cotransport and its encoding mRNA in primary cultures of rat hepatocytes. Hepatology 1993;18:1162-1166.
19. Rippin SJ, Hagenbuch B, Meier PJ, Stieger B. Cholestatic expression pattern of sinusoidal and canalicular organic anion transport systems in primary cultured rat hepatocytes. Hepatology 2001;33:776-782.
20. Wagner M, Halilbasic E, Marschall HU, Zollner G, Fickert P, Langner C, et al. CAR and PXR agonists stimulate hepatic bile acid and bilirubin detoxification and elimination pathways in mice. Hepatology 2005;42:420-430.
21. Hagenbuch B, Meier PJ. The superfamily of organic anion transporting polypeptides. Biochim Biophys Acta 2003;1609:1-18.
22. Schieck A, Schulze A, Gahler C, Muller T, Haberkorn U, Alexandrov A, et al. Hepatitis B virus hepatotropism is mediated by specific receptor recognition in the liver and not restricted to susceptible hosts. Hepatology 2013;58:43-53.
23. Vaz FM, Paulusma CC, Huidekoper H, de Ru M, Lim C, Koster J, et al. Sodium taurocholate cotransporting polypeptide (SLC10A1) deficiency: conjugated hypercholanemia without a clear clinical phenotype. Hepatology 2015;61:260-267.
24. +-taurocholate co-transporting polypeptide (NTCP) and ileal apical sodium-dependent bile acid transporter (ASBT) and ethnic comparisons of functional variants of NTCP among Asian populations. Xenobiotica 2011;41:501-510.
25. van der Velden LM, Golynskiy MV, Bijsmans IT, van Mil SW, Klomp LW, Merkx M, et al. Monitoring bile acid transport in single living cells using a genetically encoded FRET sensor. Hepatology 2013;57(2):740-752.
26. +-bile acid cotransporter. J Clin Invest 1994;93:1326-1331.
27. van de Steeg E, Wagenaar E, van der Kruijssen CM, Burggraaff JE, de Waart DR, Elferink RP, et al. Organic anion transporting polypeptide 1a/1b-knockout mice provide insights into hepatic handling of bilirubin, bile acids, and drugs. J Clin Invest 2010;120:2942-2952.