Ongoing activation of autoantigen-specific B cells in primary biliary cirrhosis

Hepatology

Volumn 60, Issue 5, 2014, Pages 1708-1716

  Zhang, Jun ^a   Zhang, Weici ^a   Leung, Patrick S C ^a   Bowlus, Christopher L ^a   Dhaliwal, Sandeep ^a   Coppel, Ross L ^b   Ansari, Aftab A ^c   Yang, Guo Xiang ^a   Wang, Jinjun ^a   Kenny, Thomas P ^a   He, Xiao Song ^a   Mackay, Ian R ^b   Gershwin, M Eric ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b MONASH UNIVERSITY   (Australia)

^c EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGEN; CHEMOKINE RECEPTOR CCR10; CHEMOKINE RECEPTOR CXCR7; IMMUNOGLOBULIN A; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; POLYCLONAL ANTIBODY; TETANUS TOXOID; XENOBIOTIC AGENT; AUTOANTIGEN; CCR10 PROTEIN, HUMAN; CHEMOKINE RECEPTOR CXCR; CXCR7 PROTEIN, HUMAN; DIHYDROLIPOAMIDE ACETYLTRANSFERASE;

ADULT; AGED; ANTIGEN SPECIFICITY; ARTICLE; AUTOANTIGEN SPECIFIC B CELL; B LYMPHOCYTE; B LYMPHOCYTE ACTIVATION; BLOOD SAMPLING; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; ENZYME LINKED IMMUNOSPOT ASSAY; FEMALE; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IN VIVO STUDY; LYMPHOCYTE SUBPOPULATION; MAJOR CLINICAL STUDY; MALE; MEMORY CELL; PERIPHERAL BLOOD MONONUCLEAR CELL; PHENOTYPE; PLASMABLAST; PRIMARY BILIARY CIRRHOSIS; PRIMARY SCLEROSING CHOLANGITIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; TISSUE SPECIFICITY; VERY ELDERLY; ANTIBODY SPECIFICITY; BILIARY CIRRHOSIS; CASE CONTROL STUDY; IMMUNOGLOBULIN PRODUCING CELL; IMMUNOLOGY; METABOLISM; MIDDLE AGED; YOUNG ADULT;

ADULT; AGED; AGED, 80 AND OVER; ANTIBODY SPECIFICITY; ANTIBODY-PRODUCING CELLS; AUTOANTIGENS; B-LYMPHOCYTES; CASE-CONTROL STUDIES; DIHYDROLIPOYLLYSINE-RESIDUE ACETYLTRANSFERASE; FEMALE; HUMANS; LIVER CIRRHOSIS, BILIARY; MALE; MIDDLE AGED; RECEPTORS, CCR10; RECEPTORS, CXCR; YOUNG ADULT;

EID: 84922223191     PISSN: 02709139     EISSN: 15273350     Source Type: Journal    
DOI: 10.1002/hep.27313     Document Type: Article

References (39)

1. Gardam S, Brink R. Non-canonical NF-kappaB signaling initiated by BAFF influences B cell biology at multiple junctures. Front Immunol 2014;4:509.
2. Bergmann B, Grimsholm O, Thorarinsdottir K, Ren W, Jirholt P, Gjertsson I, et al. Memory B cells in mouse models. Scand J Immunol 2013;78:149-156.
3. Wrammert J, Smith K, Miller J, Langley WA, Kokko K, Larsen C, et al. Rapid cloning of high-affinity human monoclonal antibodies against influenza virus. Nature 2008;453:667-671.
4. Kunkel EJ, Butcher EC. Chemokines and the tissue-specific migration of lymphocytes. Immunity 2002;16:1-4.
5. He XS, Sasaki S, Narvaez CF, Zhang C, Liu H, Woo JC, et al. Plasmablast-derived polyclonal antibody response after influenza vaccination. J Immunol Methods 2011;365:67-75.
6. Chen RC, Naiyanetr P, Shu SA, Wang J, Yang GX, Kenny TP, et al. Antimitochondrial antibody heterogeneity and the xenobiotic etiology of primary biliary cirrhosis. Hepatology 2013;57:1498-1508.
7. Wang J, Budamagunta MS, Voss JC, Kurth MJ, Lam KS, Lu L, et al. Antimitochondrial antibody recognition and structural integrity of the inner lipoyl domain of the E2 subunit of pyruvate dehydrogenase complex. J Immunol 2013;191:2126-2133.
8. Leung PS, Lam K, Kurth MJ, Coppel RL, Gershwin ME. Xenobiotics and autoimmunity: does acetaminophen cause primary biliary cirrhosis? Trends Mol Med 2012;18:577-582.
9. Lindor KD, Gershwin ME, Poupon R, Kaplan M, Bergasa NV, Heathcote EJ, American Association for Study of Liver Diseases. Primary biliary cirrhosis. Hepatology 2009;50:291-308.
10. Chapman R, Fevery J, Kalloo A, Nagorney DM, Boberg, KM, Shneider B, et al., American Association for the Study of Liver Diseases. Diagnosis and management of primary sclerosing cholangitis. 2010;Hepatology 51:660-678.
11. Wang Q, Selmi C, Zhou X, Qiu D, Li Z, Miao Q, et al. Epigenetic considerations and the clinical reevaluation of the overlap syndrome between primary biliary cirrhosis and autoimmune hepatitis. J Autoimmun 2013;41:140-145.
12. Tartakovsky F, Worman HJ. Detection of Gp210 autoantibodies in primary biliary cirrhosis using a recombinant protein containing the predominant autoepitope. Hepatology 1995;21:495-500.
13. Leung PS, Iwayama T, Coppel RL, Gershwin ME. Site-directed mutagenesis of lysine within the immunodominant autoepitope of PDC-E2. Hepatology 1990;12:1321-1328.
14. Wang J, Yang GX, Zhang W, Lu L, Tsuneyama K, Kronenberg M, et al. Escherichia coli infection induces autoimmune cholangitis and antimitochondrial antibodies in NOD.B6 (Idd10/Idd18) mice. Clin Exp Immunol 2014;175:192-201.
15. Wakabayashi K, Lian ZX, Leung PS, Moritoki Y, Tsuneyama K, Kurth MJ, et al. Loss of tolerance in C57BL/6 mice to the autoantigen E2 subunit of pyruvate dehydrogenase by a xenobiotic with ensuing biliary ductular disease. Hepatology 2008;48:531-540.
16. Lee FE, Halliley JL, Walsh EE, Moscatiello AP, Kmush BL, Falsey AR, et al. Circulating human antibody-secreting cells during vaccinations and respiratory viral infections are characterized by high specificity and lack of bystander effect. J Immunol 2011;186:5514-5521.
17. Slocombe T, Brown S, Miles K, Gray M, Barr TA, Gray D. Plasma cell homeostasis: the effects of chronic antigen stimulation and inflammation. J Immunol 2013;191:3128-3138.
18. Amanna IJ, Carlson NE, Slifka MK. Duration of humoral immunity to common viral and vaccine antigens. N Engl J Med 2007;357:1903-1915.
19. Takahashi T, Miura T, Nakamura J, Yamada S, Miura T, Yanagi M, et al. Plasma cells and the chronic nonsuppurative destructive cholangitis of primary biliary cirrhosis. Hepatology 2012;55:846-855.
20. Duan B, Morel L. Role of B-1a cells in autoimmunity. Autoimmun Rev 2006;5:403-408.
21. Tazawa H, Irei T, Tanaka Y, Igarashi Y, Tashiro H, Ohdan H. Blockade of invariant TCR-CD1d interaction specifically inhibits antibody production against blood group A carbohydrates. Blood 2013;122:2582-2590.
22. Jacobi AM, Mei H, Hoyer BF, Mumtaz IM, Thiele K, Radbruch A, et al. HLA-DRhigh/CD27high plasmablasts indicate active disease in patients with systemic lupus erythematosus. Ann Rheum Dis 2010;69:305-308.
23. Ten Boekel E, Siegert CE, Vrielink GJ, Van Dam VC, Ceelen A, De Kieviet W. Analyses of CD27++ plasma cells in peripheral blood from patients with bacterial infections and patients with serum antinuclear antibodies. J Clin Immunol 2007;27:467-476.
24. Kunkel EJ, Kim CH, Lazarus NH, Vierra MA, Soler D, Bowman EP, et al. CCR10 expression is a common feature of circulating and mucosal epithelial tissue IgA Ab-secreting cells. J Clin Invest 2003;111:1001-1010.
25. Sanchez-Martin L, Sanchez-Mateos P, Cabanas C. CXCR7 impact on CXCL12 biology and disease. Trends Mol Med 2013;19:12-22.
26. Wald O, Pappo O, Safadi R, Dagan-Berger M, Beider K, Wald H, et al. Involvement of the CXCL12/CXCR4 pathway in the advanced liver disease that is associated with hepatitis C virus or hepatitis B virus. Eur J Immunol 2004;34:1164-1174.
27. Terada R, Yamamoto K, Hakoda T, Shimada N, Okano N, Baba N, et al. Stromal cell-derived factor-1 from biliary epithelial cells recruits CXCR4-positive cells: implications for inflammatory liver diseases. Lab Invest 2003;83:665-672.
28. Shimoda S, Selmi C, Gershwin ME. Fractalkine and other chemokines in primary biliary cirrhosis. Int J Hepatol 2012;2012:102839.
29. Eksteen B, Miles A, Curbishley SM, Tselepis C, Grant AJ, Walker LS, et al. Epithelial inflammation is associated with CCL28 production and the recruitment of regulatory T cells expressing CCR10. J Immunol 2006;177:593-603.
30. Lleo A, Liao J, Invernizzi P, Zhao M, Bernuzzi F, Ma L, et al. Immunoglobulin M levels inversely correlate with CD40 ligand promoter methylation in patients with primary biliary cirrhosis. Hepatology 2012;55:153-160.
31. Smyk D, Rigopoulou EI, Baum H, Burroughs AK, Vergani D, Bogdanos DP. Autoimmunity and environment: am I at risk? Clin Rev Allergy Immunol 2012;42:199-212.
32. McNally RJ, James PW, Ducker S, James OF. Seasonal variation in the patient diagnosis of primary biliary cirrhosis: further evidence for an environmental component to etiology. Hepatology 2011;54:2099-2103.
33. Leung PS, Wang J, Naiyanetr P, Kenny TP, Lam KS, Kurth MJ, et al. Environment and primary biliary cirrhosis: electrophilic drugs and the induction of AMA. J Autoimmun 2013;41:79-86.
34. Amano K, Leung PS, Rieger R, Quan C, Wang X, Marik J, et al. Chemical xenobiotics and mitochondrial autoantigens in primary biliary cirrhosis: identification of antibodies against a common environmental, cosmetic, and food additive, 2-octynoic acid. J Immunol 2005;174:5874-5883.
35. Jin Q, Moritoki Y, Lleo A, Tsuneyama K, Invernizzi P, Moritoki H, et al. Comparative analysis of portal cell infiltrates in antimitochondrial autoantibody-positive versus antimitochondrial autoantibody-negative primary biliary cirrhosis. Hepatology 2012;55:1495-1506.
36. Lleo A, Selmi C, Invernizzi P, Podda M, Coppel RL, Mackay IR, et al. Apotopes and the biliary specificity of primary biliary cirrhosis. Hepatology 2009;49:871-879.
37. Scholz JL, Cancro MP. Resolve, revise, and relax: the 3 Rs of B cell repertoire adjustment. Immunol Lett 2012;143:2-8.
38. Gershwin ME, Selmi C, Worman HJ, Gold EB, Watnik M, Utts J, et al. Risk factors and comorbidities in primary biliary cirrhosis: a controlled interview-based study of 1032 patients. Hepatology 2005;42:1194-1202.
39. Stravitz RT, Lefkowitch JH, Fontana RJ, Gershwin ME, Leung PS, Sterling RK, et al. Autoimmune acute liver failure: proposed clinical and histological criteria. Hepatology 2011;53:517-526.