Butyrate and trichostatin A attenuate nuclear factor κB activation and tumor necrosis factor α secretion and increase prostaglandin E2 secretion in human peripheral blood mononuclear cells

Nutrition Research

Volumn 28, Issue 5, 2008, Pages 321-328

  Usami, Makoto ^a   Kishimoto, Kazunori ^a   Ohata, Atsushi ^a   Miyoshi, Makoto ^a,b   Aoyama, Michiko ^a   Fueda, Yuri ^a   Kotani, Joji ^c  

^a KOBE UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b KAGAWA PREFECTURAL UNIVERSITY OF HEALTH SCIENCES   (Japan)

^c HYOGO COLLEGE OF MEDICINE   (Japan)

Author keywords

Histone deacetylase inhibitor; Human peripheral blood mononuclear cells; Nuclear factor B; Prostaglandin E2; Short chain fatty acids; Tumor necrosis factor

Indexed keywords

CYCLOOXYGENASE 2 INHIBITOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDOMETACIN; N [2 (CYCLOHEXYLOXY) 4 NITRO PHENYL] METHANESULFONAMIDE; NORDIHYDROGUAIARETIC ACID; PROSTAGLANDIN E2; TRIBUTYRIN; TRICHOSTATIN A; TUMOR NECROSIS FACTOR ALPHA;

ADULT; ARTICLE; CYTOKINE PRODUCTION; DOWN REGULATION; FEMALE; HUMAN; HUMAN CELL; MALE; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; PROTEIN SECRETION;

ADULT; ANTI-INFLAMMATORY AGENTS; COLON; DINOPROSTONE; ENZYME INHIBITORS; FATTY ACIDS, VOLATILE; FEMALE; HUMANS; HYDROXAMIC ACIDS; IMMUNOLOGIC FACTORS; INFLAMMATION; LEUKOCYTES, MONONUCLEAR; MALE; NF-KAPPA B; PRODRUGS; TRIGLYCERIDES; TUMOR NECROSIS FACTOR-ALPHA; YOUNG ADULT;

EID: 42949171444     PISSN: 02715317     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.nutres.2008.02.012     Document Type: Article

References (27)

1. Buetler B., and Grau G.E. Tumor necrosis factor in the pathogenesis of infectious disease. Crit Care Med 21 Suppl (1992) S423-S435
2. Lin E., Calvano S.E., and Lowry S.F. Inflammatory cytokines and the cell response in injury. Surgery 127 (2000) 117-126
3. Grimble R.F. Interaction between nutrients, pro-inflammatory cytokines and inflammation. Clin Sci 91 (1996) 121-130
4. van der Poll T., and van Deventer S.J. Cytokines and anticytokines in the pathogenesis of sepsis. Infect Dis Clin North Am 14 (1999) 413-426
5. Quivy V., and Lint C.V. Regulation at multiple levels of NF-kB-mediated transcription by protein acetylation. Biochem Pharm 68 (2004) 1221-1229
6. Suuronen T., Huuskonen J., Pihlaja R., Kyrylenko S., and Salminen A. Regulation of microglial inflammatory response by histone deacetylase inhibitors. J Neurochem 87 (2003) 407-416
7. Roy C.C., Kien C.L., Bouthillier L., and Levy E. Short-chain fatty acids: ready for prime time?. Nutr Clin Prac 21 (2006) 651-666
8. Della Ragione F., Criniti V., Della Pietra V., Borriello A., Oliva A., Indaco S., et al. Genes modulated by histone acetylation as new effectors of butyrate activity. FEBS Lett 499 (2001) 199-204
9. Taniura S., Kamitani H., Watanabe T., and Eling T.E. Transcriptional regulation of cyclooxygenase-1 by histone deacetylase inhibitors in normal human astrocyte cells. J Biol Chem 277 (2002) 16823-16830
10. Park G.Y., Joo M., Pedchenko T., Blackwell T.S., and Christman J.W. Regulation of macrophage cyclooxygenase-2 gene expression by modifications of histone H3. Am J Physiol Lung Cell Mol Physiol 286 (2004) L956-L962
11. Segain J.P., Raingeard de la Bletiere D., Bourreille A., Leray V., Gervois N., Rosales C., et al. Butyrate inhibits inflammatory responses through NFkappaB inhibition: implications for Crohn's disease. Gut 47 (2000) 397-403
12. Saemann M.D., Bohmig G.A., Osterreicher C.H., Burtscher H., Parolini O., Diakos C., et al. Anti-inflammatory effects of sodium butyrate on human monocytes: potent inhibition of IL-12 and up-regulation of IL-10 production. FASEBJ 14 (2000) 2380-2382
13. Nancey S., Bienvenu J., Coffin B., Andre F., Descos L., and Flourié B. Butyrate strongly inhibits in vivo stimulated release of cytokines in blood. Dig Dis Sci 47 (2002) 921-928
14. Cavaglieeri C.R., Nishiyama A., Fernandes L.C., Curi R., Miles E.A., and Calder P.C. Differential effects of short-chain fatty acids on proliferation and production of pro- and anti-inflammatory cytokines by cultured lymphocytes. Life Sci 73 (2003) 1683-1690
15. 2 production and modulates immune function. J Surg Res 78 (1998) 1-6
16. 2 inhibits IL-18-induced ICAM-1 and B7.2 expression through EP2/EP4 receptors in human peripheral blood mononuclear cells. J Immmunol 168 (2002) 4446-4454
17. Drozdowski L.A., Dixon W.T., McBurney M.I., and Thomson A.B. Short-chain fatty acids and total parenteral nutrition affect intestinal gene expression. JPEN 26 (2002) 145-150
18. Ohata A., Usami M., and Miyoshi M. Short-chain fatty acids alter tight junction permeability in intestinal monolayer cells via lipoxygenase activation. Nutrition 21 (2005) 838-847
19. Egorin M.J., Yuan Z.M., Sentz D.L., Plaisance K., and Eiseman J.L. Plasma pharmacokinetics of butyrate after intravenous administration of sodium butyrate or oral administration of tributyrin or sodium butyrate to mice and rats. Cancer Chemother Pharmacol 43 (1999) 445-453
20. Lowry O.H., Rosenbrough N.J., Farr A.l., and Randoall R. Protein measurement with the folin phenol reagent. J Biol Chem 193 (1951) 265-275
21. James M.J., Penglis P.S., Caughey G.E., Demasi M., and Cleland L.G. Eicosanoid production by human monocytes: does COX-2 contribute to a self-limiting inflammatory response?. Inflamm Res 50 (2001) 249-253
22. Davie J.R. Inhibition of histone deacetylase activity by butyrate. J Nutr 133 (2003) S2485-S2493
23. Carozzi S., Nasini M.G., Caviglia P.M., Schelotto C., Santoni O., and Atti M. Acetate free biofiltration. Effects on peripheral blood monocyte activation and cytokine release. Asaio J 38 (1992) 52-54
24. Poul E.L., Loison C., Struyf S., Springael J.Y., Lannoy V., Decobecq M.E., et al. Functional characterization of human receptors for short chain fatty acids and their role in polymorphonuclear cell activation. J Biol Chem 278 (2003) 25481-25489
25. Nilsson N.E., Kotarsky K., Owman C., and Olde B. Identification of a free fatty acid receptor, FFA2R, expressed on leukocytes and activated by short-chain fatty acids. Biochem Biophys Res Commun 303 (2003) 1047-1052
26. Conley B.A., Egorin M.J., Tait N., Rosen D.M., Sausville E.A., Dover G., et al. Phase I study of the orally administered butyrate prodrug, tributyrin, in patients with solid tumors. Clin Cancer Res 4 (1998) 629-634
27. Bengmark S. Probiotics, prebiotics, and synbiotics in the intensive care unit. In: Shikora S.A., Martindale R.G., and Schwaitzberg S.D. (Eds). Nutritional considerations in the intensive care unit (2002), Kendall/Hunt, A.S.P.E.N. Dubuque 383-399