Inhibition of Poly(ADP-ribose) Polymerase-1 Enhances Gene Expression of Selected Sirtuins and APP Cleaving Enzymes in Amyloid Beta Cytotoxicity

Molecular Neurobiology

Volumn 55, Issue 6, 2018, Pages 4612-4623

  Wencel, Przemysław L ^a   Lukiw, Walter J ^b   Strosznajder, Joanna B ^a   Strosznajder, Robert Piotr ^a  

^a MOSSAKOWSKI MEDICAL RESEARCH CENTRE   (Poland)

^b LOUISIANA STATE UNIVERSITY HEALTH SCIENCES CENTER   (United States)

Author keywords

Alzheimer s disease; Amyloid; APP; Neuroprotection; PARPs; Poly(ADP ribose) polymerases; Secretases; SIRTs; Sirtuins

Indexed keywords

ADAM10 ENDOPEPTIDASE; AMYLOID BETA PROTEIN[1-42]; AMYLOID PRECURSOR PROTEIN; BETA SECRETASE 1; GAMMA SECRETASE; MESSENGER RNA; N (5,6 DIHYDRO 6 OXO 2 PHENANTHRIDINYL) 2 DIMETHYLAMINOACETAMIDE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE 1; OLIGOMER; PEPTIDE; PRESENILIN 1; PRESENILIN 2; SIRTUIN 1; SIRTUIN 2; SIRTUIN 3; SIRTUIN 4; SIRTUIN 5; SIRTUIN 6; AMYLOID BETA PROTEIN; N-(OXO-5,6-DIHYDROPHENANTHRIDIN-2-YL)-N,N-DIMETHYLACETAMIDE HYDROCHLORIDE; NICOTINAMIDE ADENINE DINUCLEOTIDE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE INHIBITOR; PHENANTHRENE DERIVATIVE; SECRETASE; SIRTUIN;

ANIMAL CELL; APP CLEAVING ENZYME GENE; ARTICLE; BACE1 GENE; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; ENZYME DEGRADATION; ENZYME INHIBITION; GENE; GENE EXPRESSION REGULATION; NONHUMAN; PARP1 GENE; PARP3 GENE; PC12 CELL LINE; POLY(ADENOSINE DIPHOSPHATE) RIBOSYLATION; PROTEIN CLEAVAGE; PROTEIN DNA BINDING; PROTEIN METABOLISM; PROTEIN SUBUNIT; PSEN1 GENE; PSEN2 GENE; RAT; SIRT GENE; SIRT1 GENE; SIRT2 GENE; SIRT3 GENE; SIRT4 GENE; SIRT5 GENE; SIRT6 GENE; STABLE TRANSFECTION; TRANSCRIPTION REGULATION; UPREGULATION; ANIMAL; BIOLOGICAL MODEL; CELL DEATH; CELL SURVIVAL; DRUG EFFECT; GENETIC TRANSCRIPTION; GENETICS; METABOLISM; MITOCHONDRION; PC12 CELL LINE (PHEOCHROMOCYTOMA);

AMYLOID BETA-PEPTIDES; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; CELL DEATH; CELL SURVIVAL; GENE EXPRESSION REGULATION; MITOCHONDRIA; MODELS, BIOLOGICAL; NAD; PC12 CELLS; PHENANTHRENES; POLY(ADP-RIBOSE) POLYMERASE INHIBITORS; POLY(ADP-RIBOSE) POLYMERASES; RATS; RNA, MESSENGER; SIRTUINS; TRANSCRIPTION, GENETIC;

EID: 85023201538     PISSN: 08937648     EISSN: 15591182     Source Type: Journal    
DOI: 10.1007/s12035-017-0646-8     Document Type: Article

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