SIRT5 Regulates both Cytosolic and Mitochondrial Protein Malonylation with Glycolysis as a Major Target

Molecular Cell

Volumn 59, Issue 2, 2015, Pages 321-332

  Nishida, Yuya ^a   Rardin, Matthew J ^b   Carrico, Chris ^a   He, Wenjuan ^a   Sahu, Alexandria K ^b   Gut, Philipp ^a   Najjar, Rami ^c   Fitch, Mark ^d   Hellerstein, Marc ^d,e   Gibson, Bradford W ^b   Verdin, Eric ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b BUCK INSTITUTE FOR RESEARCH ON AGING   (United States)

^c CELL SIGNALING TECHNOLOGY   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e KINEMED INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTISERUM; GLUTAMIC ACID; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; GLYCOLYTIC ENZYME; LYSINE; MITOCHONDRIAL PROTEIN; SIRTUIN 5; MALONIC ACID DERIVATIVE; SIRT5 PROTEIN, MOUSE; SIRTUIN;

ACYLATION; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CYTOSOL; DIET RESTRICTION; ENZYME ACTIVITY; GLYCOLYSIS; HUMAN; HUMAN CELL; LIVER CELL; MITOCHONDRION; MOUSE; NONHUMAN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN MALONYLATION; PROTEOMICS; QUANTITATIVE ANALYSIS; SIGNAL TRANSDUCTION; WILD TYPE; AMINO ACID SUBSTITUTION; ANIMAL; CHEMISTRY; DEFICIENCY; ENZYME ACTIVE SITE; GENE SILENCING; GENETICS; HEK293 CELL LINE; KNOCKOUT MOUSE; LIVER; METABOLISM; MOLECULAR MIMICRY;

ANIMALIA; MUS;

ACYLATION; AMINO ACID SUBSTITUTION; ANIMALS; CATALYTIC DOMAIN; CYTOSOL; GENE KNOCKDOWN TECHNIQUES; GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASES; GLYCOLYSIS; HEK293 CELLS; HUMANS; LIVER; MALONATES; METABOLIC NETWORKS AND PATHWAYS; MICE; MICE, KNOCKOUT; MITOCHONDRIAL PROTEINS; MOLECULAR MIMICRY; SIRTUINS;

EID: 84937517955     PISSN: 10972765     EISSN: 10974164     Source Type: Journal    
DOI: 10.1016/j.molcel.2015.05.022     Document Type: Article

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