The role of PARP in DNA repair and its therapeutic exploitation

British Journal of Cancer

Volumn 105, Issue 8, 2011, Pages 1114-1122

  Javle, M ^a   Curtin, N J ^b  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^b NEWCASTLE UNIVERSITY   (United Kingdom)

Author keywords

BRCA1; BRCA2; DNA repair; homologous recombination; Poly (ADP ribose) polymerases

Indexed keywords

3 AMINOBENZAMIDE; 8 FLUORO 3,4 DIHYDRO 2 [4 (METHYLAMINOMETHYL)PHENYL]PYRROLO[3,4,5 E,F][2]BENZAZEPIN 6(5H) ONE; ANTINEOPLASTIC AGENT; BMN 763; CARBOPLATIN; CEP 9722; CISPLATIN; E 7016; GEMCITABINE; GPI 21016; INIPARIB; INO 1001; MK 4827; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE INHIBITOR; OLAPARIB; PF 0367338; TEMOZOLOMIDE; TOPOTECAN; UNCLASSIFIED DRUG; VELIPARIB;

ANTINEOPLASTIC ACTIVITY; BONE MARROW SUPPRESSION; BRAIN CANCER; BREAST CANCER; CANCER COMBINATION CHEMOTHERAPY; CANCER RADIOTHERAPY; CANCER SUSCEPTIBILITY; CLINICAL TRIAL (TOPIC); CYTOTOXICITY; DNA REPAIR; DRUG DOSE ESCALATION; DRUG POTENTIATION; FATIGUE; GENE MUTATION; GLIOBLASTOMA; HOMOLOGOUS RECOMBINATION; HUMAN; IN VITRO STUDY; IN VIVO STUDY; LYMPHOBLASTOMA; MEDULLOBLASTOMA; MELANOMA; MOOD DISORDER; NEUROBLASTOMA; OVARY CANCER; PRIORITY JOURNAL; PROSTATE CANCER; REVIEW; SOLID TUMOR; SOMNOLENCE; THROMBOCYTOPENIA; TRIPLE NEGATIVE BREAST CANCER;

ANTINEOPLASTIC AGENTS; CLINICAL TRIALS AS TOPIC; DNA REPAIR; ENZYME INHIBITORS; HUMANS; POLY(ADP-RIBOSE) POLYMERASES; RADIATION-SENSITIZING AGENTS;

EID: 80053966336     PISSN: 00070920     EISSN: 15321827     Source Type: Journal    
DOI: 10.1038/bjc.2011.382     Document Type: Review

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