Amyloid-beta interaction with mitochondria

International Journal of Alzheimer's Disease

Volumn , Issue , 2011, Pages

  Eckert, Anne ^a   Pagani, Lucia ^a  

^a UNIVERSITY OF BASEL   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; REACTIVE OXYGEN METABOLITE;

ALZHEIMER DISEASE; HUMAN; MITOCHONDRIAL MEMBRANE; MITOCHONDRION; NONHUMAN; OXIDATIVE PHOSPHORYLATION; PRIORITY JOURNAL; PROTEIN INTERACTION; PROTEIN LOCALIZATION; REVIEW;

EID: 79955454688     PISSN: None     EISSN: 20900252     Source Type: Journal    
DOI: 10.4061/2011/925050     Document Type: Review

References (129)

1. Rhein V., Song X., Wiesner A., Ittner L. M., Baysang G., Meier F., Ozmen L., Bluethmann H., Drse S., Brandt U., Savaskan E., Czech C., Gtz J., Eckert A., Amyloid- and tau synergistically impair the oxidative phosphorylation system in triple transgenic Alzheimer's disease mice Proceedings of the National Academy of Sciences of the United States of America 2010 106 47 20057 20062
2. Eckert A., Hauptmann S., Scherping I., Meinhardt J., Rhein V., Drse S., Brandt U., Fndrich M., Mller W. E., Gtz J., Oligomeric and fibrillar species of -amyloid (A 42) both impair mitochondrial function in P301L tau transgenic mice Journal of Molecular Medicine 2008 86 11 1255 1267
3. Hauptmann S., Scherping I., Drse S., Brandt U., Schulz K. L., Jendrach M., Leuner K., Eckert A., Mller W. E., Mitochondrial dysfunction: an early event in Alzheimer pathology accumulates with age in AD transgenic mice Neurobiology of Aging 2009 30 10 1574 1586
4. Lustbader J. W., Cirilli M., Lin C., ABAD directly links Abeta to mitochondrial toxicity in Alzheimer's disease Science 2004 304 448 452 (Pubitemid 38495942)
5. Su B., Wang X., Nunomura A., Moreira P. I., Lee H. G., Perry G., Smith M. A., Zhu X., Oxidative stress signaling in Alzheimer's disease Current Alzheimer Research 2008 5 6 525 532
6. Wang X., Su BO., Siedlak S. L., Moreira P. I., Fujioka H., Wang Y., Casadesus G., Zhu X., Amyloid- overproduction causes abnormal mitochondrial dynamics via differential modulation of mitochondrial fission/fusion proteins Proceedings of the National Academy of Sciences of the United States of America 2008 105 49 19318 19323
7. Moreira P. I., Santos M. S., Oliveira C. R., Alzheimer's disease: a lesson from mitochondrial dysfunction Antioxidants and Redox Signaling 2007 9 10 1621 1630 (Pubitemid 47462966)
8. Moreira P. I., Santos M. S., Oliveira C. R., Shenk J. C., Nunomura A., Smith M. A., Zhu X., Perry G., Alzheimer disease and the role of free radicals in the pathogenesis of the disease CNS and Neurological DisordersDrug Targets 2008 7 1 3 10 (Pubitemid 351516211)
9. Mller W. E., Eckert A., Kurz C., Eckert G. P., Leuner K., Mitochondrial dysfunction: common final pathway in brain aging and Alzheimer's diseasetherapeutic aspects Molecular Neurobiology 2010 41 159 171
10. Leuner K., Hauptmann S., Abdel-Kader R., Scherping I., Keil U., Strosznajder J. B., Eckert A., Mller W. E., Mitochondrial dysfunction: the first domino in brain aging and Alzheimer's disease? Antioxidants and Redox Signaling 2007 9 10 1659 1675 (Pubitemid 47462969)
11. Eckert A., Schulz K. L., Rhein V., Gtz J., Convergence of amyloid-beta and tau pathologies on mitochondria in vivo Molecular Neurobiology 2010 41 107 114
12. Pavlov P. F., Wiehager B., Sakai J., Mitochondrial {gamma}-secretase participates in the metabolism of mitochondria-associated amyloid precursor protein The FASEB Journal 2011 25 78 88
13. Anandatheerthavarada H. K., Biswas G., Robin M. A., Avadhani N. G., Mitochondrial targeting and a novel transmembrane arrest of Alzheimer's amyloid precursor protein impairs mitochondrial function in neuronal cells Journal of Cell Biology 2003 161 1 41 54 (Pubitemid 36459078)
14. Sambamurti K., Refolo L. M., Shioi J., Pappolla M. A., Robakis N. K., The Alzheimer's amyloid precursor is cleaved intracellularly in the trans-golgi network or in a post-golgi compartment Annals of the New York Academy of Sciences 1992 674 118 128 (Pubitemid 23077400)
15. Allinson T. M. J., Parkin E. T., Turner A. J., Hooper N. M., ADAMs family members as amyloid precursor protein alpha-secretases Journal of Neuroscience Research 2003 74 3 342 352 (Pubitemid 37362810)
16. Gtz J., Ittner L. M., Animal models of Alzheimer's disease and frontotemporal dementia Nature Reviews Neuroscience 2008 9 7 532 544 (Pubitemid 351873467)
17. Edbauer D., Winkler E., Regula J. T., Pesold B., Steiner H., Haass C., Reconstitution of -secretase activity Nature Cell Biology 2003 5 5 486 488
18. Selkoe D. J., Alzheimer's disease is a synaptic failure Science 2002 298 5594 789 791 (Pubitemid 35231524)
19. Haass C., Hung A. Y., Schlossmacher M. G., Teplow D. B., Selkoe D. J., -Amyloid peptide and a 3-kDa fragment are derived by distinct cellular mechanisms Journal of Biological Chemistry 1993 268 5 3021 3024 (Pubitemid 23070917)
20. Vassar R., Bennett B. D., Babu-Khan S., Kahn S., Mendiaz E. A., Denis P., Teplow D. B., Ross S., Amarante P., Loeloff R., Luo YI., Fisher S., Fuller J., Edenson S., Lile J., Jarosinski M. A., Biere A. L., Curran E., Burgess T., Louis J. C., Collins F., Treanor J., Rogers G., Citron M., -Secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE Science 1999 286 5440 735 741
21. Ulery P. G., Beers J., Mikhailenko I., Tanzi R. E., Rebeck G. W., Hyman B. T., Strickland D. K., Modulation of -amyloid precursor protein processing by the low density lipoprotein receptor-related protein (LRP). Evidence that LRP contributes to the pathogenesis of Alzheimer's disease Journal of Biological Chemistry 2000 275 10 7410 7415 (Pubitemid 30146296)
22. Cam J. A., Zerbinatti C. V., Li Y., Bu G., Rapid endocytosis of the low density lipoprotein receptor-related protein modulates cell surface distribution and processing of the -amyloid precursor protein Journal of Biological Chemistry 2005 280 15 15464 15470 (Pubitemid 40562905)
23. Cam J. A., Zerbinatti C. V., Knisely J. M., Hecimovic S., Li Y., Bu G., The low density lipoprotein receptor-related protein 1B retains -amyloid precursor protein at the cell surface and reduces amyloid- peptide production Journal of Biological Chemistry 2004 279 28 29639 29646 (Pubitemid 38915847)
24. Li Y., Lu W., Marzolo M. P., Bu G., Differential functions of members of the low density lipoprotein receptor family suggested by their distinct endocytosis rates Journal of Biological Chemistry 2001 276 21 18000 18006
25. Andersen O. M., Reiche J., Schmidt V., Gotthardt M., Spoelgen R., Behlke J., Von Arnim C. A. F., Breiderhoff T., Jansen P., Wu X., Bales K. R., Cappai R., Masters C. L., Gliemann J., Mufson E. J., Hyman B. T., Paul S. M., Nykjsr A., Willnow T. E., Neuronal sorting protein-related receptor sorLA/LR11 regulates processing of the amyloid precursor protein Proceedings of the National Academy of Sciences of the United States of America 2005 102 38 13461 13466 (Pubitemid 41420870)
26. Spoelgen R., Von Arnim C. A. F., Thomas A. V., Peltan I. D., Koker M., Deng A., Irizarry M. C., Andersen O. M., Willnow T. E., Hyman B. T., Interaction of the cytosolic domains of sorLA/LR11 with the amyloid precursor protein (APP) and -secretase -site APP-cleaving enzyme Journal of Neuroscience 2006 26 2 418 428 (Pubitemid 43237105)
27. Devi L., Prabhu B. M., Galati D. F., Avadhani N. G., Anandatheerthavarada H. K., Accumulation of amyloid precursor protein in the mitochondrial import channels of human Alzheimer's disease brain is associated with mitochondrial dysfunction Journal of Neuroscience 2006 26 35 9057 9068 (Pubitemid 44319397)
28. Manczak M., Anekonda T. S., Henson E., Park B. S., Quinn J., Reddy P. H., Mitochondria are a direct site of A accumulation in Alzheimer's disease neurons: implications for free radical generation and oxidative damage in disease progression Human Molecular Genetics 2006 15 9 1437 1449
29. Takahashi R. H., Nam E. E., Edgar M., Gouras G. K., Alzheimer -amyloid peptides: normal and abnormal localization Histology and Histopathology 2002 17 1 239 246 (Pubitemid 34116427)
30. Caspersen C., Wang N., Yao J., Sosunov A., Chen XI., Lustbader J. W., Xu H. W., Stern D., McKhann G., Yan S. D., Mitochondrial A : a potential focal point for neuronal metabolic dysfunction in Alzheimer's disease FASEB Journal 2005 19 14 2040 2041 (Pubitemid 41759758)
31. Fernndez-Vizarra P., Fernndez A. P., Castro-Blanco S., Serrano J., Bentura M. L., Martnez-Murillo R., Martinez A., Rodrigo J., Intra- and extracellular A and PHF in clinically evaluated cases of Alzheimer's disease Histology and Histopathology 2004 19 3 823 844 (Pubitemid 38855065)
32. Fujiwara T., Oda K., Yokota S., Takatsuki A., Ikehara Y., Brefeldin A causes disassembly of the Golgi complex and accumulation of secretory proteins in the endoplasmic reticulum Journal of Biological Chemistry 1988 263 34 18545 18552 (Pubitemid 19005133)
33. Glabe C. G., Kayed R., Common structure and toxic function of amyloid oligomers implies a common mechanism of pathogenesis Neurology 2006 66 2 S74 S78
34. Reddy P. H., Beal M. F., Amyloid beta, mitochondrial dysfunction and synaptic damage: implications for cognitive decline in aging and Alzheimer's disease Trends in Molecular Medicine 2008 14 2 45 53
35. Simmons M. A., Schneider C. R., Amyloid peptides act directly on single neurons Neuroscience Letters 1993 150 2 133 136 (Pubitemid 23153670)
36. Arispe N., Rojas E., Pollard H. B., Alzheimer disease amyloid protein forms calcium channels in bilayer membranes: blockade by tromethamine and aluminum Proceedings of the National Academy of Sciences of the United States of America 1993 90 2 567 571 (Pubitemid 23028904)
37. Alikhani N., Ankarcrona M., Glaser E., Mitochondria and Alzheimer's disease: amyloid- peptide uptake and degradation by the presequence protease, hPreP Journal of Bioenergetics and Biomembranes 2009 41 5 447 451
38. Hansson Petersen C. A., Alikhani N., Behbahani H., Wiehager B., Pavlov P. F., Alafuzoff I., Leinonen V., Ito A., Winblad B., Glaser E., Ankarcrona M., The amyloid -peptide is imported into mitochondria via the TOM import machinery and localized to mitochondrial cristae Proceedings of the National Academy of Sciences of the United States of America 2008 105 35 13145 13150
39. Mattson M. P., Magnus T., Ageing and neuronal vulnerability Nature Reviews Neuroscience 2006 7 4 278 294
40. Balaban R. S., Nemoto S., Finkel T., Mitochondria, oxidants, and aging Cell 2005 120 4 483 495 (Pubitemid 40269763)
41. Benzi G., Pastoris O., Marzatico F., Villa R. F., Dagani F., Curti D., The mitochondrial electron transfer alteration as a factor involved in the brain aging Neurobiology of Aging 1992 13 3 361 368
42. Reddy P. H., Mitochondrial dysfunction in aging and Alzheimer's disease: strategies to protect neurons Antioxidants and Redox Signaling 2007 9 10 1647 1658 (Pubitemid 47462968)
43. Moreira P. I., Duarte A. I., Santos M. S., Rego A. C., Oliveira C. R., An integrative view of the role of oxidative stress, mitochondria and insulin in Alzheimer's disease Journal of Alzheimer's Disease 2009 16 4 741 761
44. Sirk D., Zhu Z., Wadia J. S., Shulyakova N., Phan N., Fong J., Mills L. R., Chronic exposure to sub-lethal beta-amyloid (A ) inhibits the import of nuclear-encoded proteins to mitochondria in differentiated PC12 cells Journal of Neurochemistry 2007 103 5 1989 2003 (Pubitemid 350126630)
45. Okamoto K., Shaw J. M., Mitochondrial morphology and dynamics in yeast and multicellular eukaryotes Annual Review of Genetics 2005 39 503 536 (Pubitemid 43011125)
46. Chen H., Chomyn A., Chan D. C., Disruption of fusion results in mitochondrial heterogeneity and dysfunction Journal of Biological Chemistry 2005 280 28 26185 26192 (Pubitemid 41022214)
47. Chen H., Detmer S. A., Ewald A. J., Griffin E. E., Fraser S. E., Chan D. C., Mitofusins Mfn1 and Mfn2 coordinately regulate mitochondrial fusion and are essential for embryonic development Journal of Cell Biology 2003 160 2 189 200 (Pubitemid 36254953)
48. Chen H., McCaffery J. M., Chan D. C., Mitochondrial fusion protects against neurodegeneration in the cerebellum Cell 2007 130 3 548 562 (Pubitemid 47198302)
49. Baloh R. H., Schmidt R. E., Pestronk A., Milbrandt J., Altered axonal mitochondrial transport in the pathogenesis of Charcot-Marie-Tooth disease from mitofusin 2 mutations Journal of Neuroscience 2007 27 2 422 430 (Pubitemid 46106016)
50. Hoppins S., Lackner L., Nunnari J., The machines that divide and fuse mitochondria Annual Review of Biochemistry 2007 76 751 780
51. Wang X., Su BO., Lee H. G., Li X., Perry G., Smith M. A., Zhu X., Impaired balance of mitochondrial fission and fusion in Alzheimer's disease Journal of Neuroscience 2009 29 28 9090 9103
52. Su B., Wang X., Bonda D., Perry G., Smith M., Zhu X., Abnormal mitochondrial dynamicsa novel therapeutic target for Alzheimer's disease? Molecular Neurobiology 2010 41 87 96
53. Wang X., Su BO., Fujioka H., Zhu X., Dynamin-like protein 1 reduction underlies mitochondrial morphology and distribution abnormalities in fibroblasts from sporadic Alzheimer's disease patients American Journal of Pathology 2008 173 2 470 482
54. Cho D. H., Nakamura T., Fang J., Cieplak P., Godzik A., Gu Z., Lipton S. A., S-nitrosylation of Drp1 mediates beta-amyloid-related mitochondrial fission and neuronal injury Science 2009 324 5923 102 105
55. Querfurth H. W., LaFerla F. M., Alzheimer's disease New England Journal of Medicine 2010 362 4 329 344
56. Schuessel K., Schfer S., Bayer T. A., Czech C., Pradier L., Mller-Spahn F., Mller W. E., Eckert A., Impaired Cu/Zn-SOD activity contributes to increased oxidative damage in APP transgenic mice Neurobiology of Disease 2005 18 1 89 99 (Pubitemid 40092899)
57. Keil U., Bonert A., Marques C. A., Scherping I., Weyermann J., Strosznajder J. B., Mller-Spahn F., Haass C., Czech C., Pradier L., Mller W. E., Eckert A., Amyloid -induced changes in nitric oxide production and mitochondrial activity lead to apoptosis Journal of Biological Chemistry 2004 279 48 50310 50320 (Pubitemid 39577847)
58. Gillardon F., Rist W., Kussmaul L., Vogel J., Berg M., Danzer K., Kraut N., Hengerer B., Proteomic and functional alterations in brain mitochondria from Tg2576 mice occur before amyloid plaque deposition Proteomics 2007 7 4 605 616 (Pubitemid 46362624)
59. Eckert A., Hauptmann S., Scherping I., Rhein V., Mller-Spahn F., Gtz J., Mller W. E., Soluble beta-amyloid leads to mitochondrial defects in amyloid precursor protein and tau transgenic mice Neurodegenerative Diseases 2008 5 3-4 157 159 (Pubitemid 351347837)
60. Rhein V., Baysang G., Rao S., Meier F., Bonert A., Mller-Spahn F., Eckert A., Amyloid-beta leads to impaired cellular respiration, energy production and mitochondrial electron chain complex activities in human neuroblastoma cells Cellular and Molecular Neurobiology 2009 29 6-7 1063 1071
61. Oddo S., Caccamo A., Shepherd J. D., Murphy M. P., Golde T. E., Kayed R., Metherate R., Mattson M. P., Akbari Y., LaFerla F. M., Triple-transgenic model of Alzheimer's Disease with plaques and tangles: intracellular A and synaptic dysfunction Neuron 2003 39 3 409 421 (Pubitemid 36937044)
62. Yao J., Irwin R. W., Zhao L., Nilsen J., Hamilton R. T., Brinton R. D., Mitochondrial bioenergetic deficit precedes Alzheimer's pathology in female mouse model of Alzheimer's disease Proceedings of the National Academy of Sciences of the United States of America 2009 106 34 14670 14675
63. Du H., Guo L., Fang F., Chen D., A Sosunov A., M McKhann G., Yan Y., Wang C., Zhang H., Molkentin J. D., Gunn-Moore F. J., Vonsattel J. P., Arancio O., Chen J. X., Yan S. D., Cyclophilin D deficiency attenuates mitochondrial and neuronal perturbation and ameliorates learning and memory in Alzheimer's disease Nature Medicine 2008 14 10 1097 1105
64. Du H., Guo L., Zhang W., Rydzewska M., Yan S., Cyclophilin D deficiency improves mitochondrial function and learning/memory in aging Alzheimer disease mouse model. Neurobiology of Aging. In press
65. Halestrap A. P., McStay G. P., Clarke S. J., The permeability transition pore complex: another view Biochimie 2002 84 2-3 153 166
66. Zamzami N., Larochette N., Kroemer G., Mitochondrial permeability transition in apoptosis and necrosis Cell Death and Differentiation 2005 12 2 1478 1480 (Pubitemid 41553982)
67. Crompton M., Barksby E., Johnson N., Capano M., Mitochondrial intermembrane junctional complexes and their involvement in cell death Biochimie 2002 84 2-3 143 152
68. Halestrap A. P., Calcium, mitochondria and reperfusion injury: a pore way to die Biochemical Society Transactions 2006 34 2 232 237
69. Bernardi P., Krauskopf A., Basso E., Petronilli V., Blachly-Dyson E., Di Lisa F., Forte M. A., The mitochondrial permeability transition from in vitro artifact to disease target FEBS Journal 2006 273 2077 2099
70. Kinnally K. W., Peixoto P. M., Ryu S. -Y., Dejean L. M., Is mPTP the gatekeeper for necrosis, apoptosis, or both? Biochimica et Biophysica Acta. In press
71. Liu X., Kim C. N., Yang J., Jemmerson R., Wang X., Induction of apoptotic program in cell-free extracts: requirement for dATP and cytochrome c Cell 1996 86 1 147 157 (Pubitemid 26256586)
72. Zou H., Henzel W. J., Liu X., Lutschg A., Wang X., Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3 Cell 1997 90 3 405 413 (Pubitemid 27347231)
73. Susin S. A., Lorenzo H. K., Zamzami N., Marzo I., Brenner C., Larochette N., Prvost M. C., Alzari P. M., Kroemer G., Mitochondrial release of caspase-2 and -9 during the apoptotic process Journal of Experimental Medicine 1999 189 2 381 393 (Pubitemid 29063259)
74. Adrain C., Creagh E. M., Martin S. J., Apoptosis-associated release of Smac/DIABLO from mitochondria requires active caspases and is blocked by Bcl-2 EMBO Journal 2001 20 23 6627 6636 (Pubitemid 33134193)
75. Li L. Y., Luo X., Wang X., Endonuclease G is an apoptotic DNase when released from mitochondria Nature 2001 412 6842 95 99 (Pubitemid 32851517)
76. Eliseev R. A., Filippov G., Velos J., VanWinkle B., Goldman A., Rosier R. N., Gunter T. E., Role of cyclophilin D in the resistance of brain mitochondria to the permeability transition Neurobiology of Aging 2007 28 10 1532 1542 (Pubitemid 47238534)
77. Hajnczky G., Hoek J. B., Cell signaling: mitochondrial longevity pathways Science 2007 315 5812 607 609 (Pubitemid 46214696)
78. Perry E. K., Perry R. H., Tomlinson B. E., Coenzyme A-acetylating enzymes in Alzheimer's disease: possible cholinergic 'compartment' of pyruvate dehydrogenase Neuroscience Letters 1980 18 1 105 110 (Pubitemid 10122792)
79. Sorbi S., Bird E. D., Blass J. P., Decreased pyruvate dehydrogenase complex activity in Huntington and Alzheimer brain Annals of Neurology 1983 13 1 72 78 (Pubitemid 13224203)
80. Gibson G. E., Sheu K. F. R., Blass J. P., Abnormalities of mitochondrial enzymes in Alzheimer disease Journal of Neural Transmission 1998 105 8-9 855 870 (Pubitemid 28539834)
81. Gibson G. E., Sheu K. F. R., Blass J. P., Baker A., Carlson K. C., Harding B., Perrino P., Reduced activities of thiamine-dependent enzymes in the brains and peripheral tissues of patients with Alzheimer's disease Archives of Neurology 1988 45 8 836 840
82. Sheu K. F. R., Cooper A. J. L., Koike K., Koike M., Lindsay J. G., Blass J. P., Abnormality of the -ketoglutarate dehydrogenase complex in fibroblasts from familial Alzheimer's disease Annals of Neurology 1994 35 3 312 318
83. Mastrogiacoma F., Lindsay J. G., Bettendorff L., Rice J., Kish S. H., Brain protein and alpha-ketoglutarate dehydrogenase complex activity in Alzheimer's disease Annals of Neurology 1996 39 592 598 (Pubitemid 26143597)
84. Ko L. W., Sheu K. F. R., Thaler H. T., Markesbery W. R., Blass J. P., Selective loss of KGDHC-enriched neurons in Alzheimer temporal cortex: does mitochondrial variation contribute to selective vulnerability? Journal of Molecular Neuroscience 2001 17 3 361 369 (Pubitemid 34123953)
85. Gibson G. E., Starkov A., Blass J. P., Ratan R. R., Beal M. F., Cause and consequence: mitochondrial dysfunction initiates and propagates neuronal dysfunction, neuronal death and behavioral abnormalities in age-associated neurodegenerative diseases Biochimica et Biophysica Acta 2010 1802 1 122 134
86. Casley C. S., Canevari L., Land J. M., Clark J. B., Sharpe M. A., -Amyloid inhibits integrated mitochondrial respiration and key enzyme activities Journal of Neurochemistry 2002 80 1 91 100 (Pubitemid 34614581)
87. Yan S. D., Fu J., Soto C., Chen XI., Zhu H., Al-Mohanna F., Collison K., Zhu A., Stern E., Saido T., Tohyama M., Ogawa S., Roher A., Stern D., An intracellular protein that binds amyloid- peptide and mediates neurotoxicity in Alzheimer's disease Nature 1997 389 6652 689 695 (Pubitemid 27458947)
88. Wen G. Y., Yang S. Y., Kaczmarski W., He X. Y., Pappas K. S., Presence of hydroxysteroid dehydrogenase type 10 in amyloid plaques (APs) of Hsiao's APP-Sw transgenic mouse brains, but absence in APs of Alzheimer's disease brains Brain Research 2002 954 1 115 122 (Pubitemid 35223447)
89. He X. Y., Wen G. Y., Merz G., Lin D., Yang Y. Z., Mehta P., Schulz H., Yang S. Y., Abundant type 10 17 -hydroxysteroid dehydrogenase in the hippocampus of mouse Alzheimer's disease model Molecular Brain Research 2002 99 1 46 53 (Pubitemid 34178500)
90. Aleardi A. M., Benard G., Augereau O., Malgat M., Talbot J. C., Mazat J. P., Letellier T., Dachary-Prigent J., Solaini G. C., Rossignol R., Gradual alteration of mitochondrial structure and function by -amyloids: importance of membrane viscosity changes, energy deprivation, reactive oxygen species production, and cytochrome c release Journal of Bioenergetics and Biomembranes 2005 37 4 207 225 (Pubitemid 41420458)
91. Shoffner J. M., Brown M. D., Torroni A., Lott M. T., Cabell M. F., Mirra S. S., Beal M. F., Yang C. C., Gearing M., Salvo R., Watts R. L., Juncos J. L., Hansen L. A., Crain B. J., Fayad M., Reckord C. L., Wallace D. C., Mitochondrial DNA variants observed in Alzheimer disease and Parkinson disease patients Genomics 1993 17 1 171 184 (Pubitemid 23205074)
92. Brown M. D., Shoffher J. M., Kim Y. L., Jun A. S., Graham B. H., Cabell M. F., Gurley D. S., Wallace D. C., Mitochondrial DNA sequence analysis of four Alzheimer's and Parkinson's disease patients American Journal of Medical Genetics 1996 61 3 283 289
93. Hutchin T., Cortopassi G., A mitochondrial DNA clone is associated with increased risk for Alzheimer disease Proceedings of the National Academy of Sciences of the United States of America 1995 92 15 6892 6895
94. Tysoe C., Robinson D., Brayne C., Dening T., Paykel E. S., Huppert F. A., Rubinsztein D. C., The tRNAGln 4336 mitochondrial DNA variant is not a high penetrance mutation which predisposes to dementia before the age of 75 years Journal of Medical Genetics 1996 33 12 1002 1006
95. Egensperger R., Ksel S., Schnopp N. M., Mehraein P., Graeber M. B., Association of the mitochondrial tRNA(A4336G) mutation with Alzheimer's and Parkinson's diseases Neuropathology and Applied Neurobiology 1997 23 4 315 321 (Pubitemid 27352842)
96. Coskun P. E., Beal M. F., Wallace D. C., Alzheimer's brains harbor somatic mtDNA control-region mutations that suppress mitochondrial transcription and replication Proceedings of the National Academy of Sciences of the United States of America 2004 101 29 10726 10731 (Pubitemid 38955810)
97. Sudoh S., Frosch M. P., Wolf B. A., Differential effects of proteases involved in intracellular degradation of amyloid beta-protein between detergent-soluble and -insoluble pools in CHO-695 cells Biochemistry 2002 41 4 1091 1099 (Pubitemid 34083761)
98. Sthl A., Moberg P., Ytterberg J., Panfilov O., Von Lwenhielm H. B., Nilsson F., Glaser E., Isolation and identification of a novel mitochondrial metalloprotease (PreP) that degrades targeting presequences in plants Journal of Biological Chemistry 2002 277 44 41931 41939 (Pubitemid 35257506)
99. Sthl A., Nilsson S., Lundberg P., Bhushan S., Biversthl H., Moberg P., Morisset M., Vener A., Mler L., Langel U., Glaser E., Two novel targeting peptide degrading proteases, PrePs, in mitochondria and chloroplasts, so similar and still different Journal of Molecular Biology 2005 349 4 847 860 (Pubitemid 40725958)
100. Moberg P., Sth A., Bhushan S., Wright S. J., Eriksson A., Bruce B. D., Glaser E., Characterization of a novel zinc metalloprotease involved in degrading targeting peptides in mitochondria and chloroplasts Plant Journal 2003 36 5 616 628 (Pubitemid 37496490)
101. Taylor S. W., Fahy E., Zhang B., Glenn G. M., Warnock D. E., Wiley S., Murphy A. N., Gaucher S. P., Capaldi R. A., Gibson B. W., Ghosh S. S., Characterization of the human heart mitochondrial proteome Nature Biotechnology 2003 21 3 281 286 (Pubitemid 36314812)
102. Falkevall A., Alikhani N., Bhushan S., Pavlov P. F., Busch K., Johnson K. A., Eneqvist T., Tjernberg L., Ankarcrona M., Glaser E., Degradation of the amyloid beta-protein by the novel mitochondrial peptidasome Journal of Biological Chemistry 2006 281 39 29096 29104 (Pubitemid 44507053)
103. Parker W. D., Filley C. M., Parks J. K., Cytochrome oxidase deficiency in Alzheimer's disease Neurology 1990 40 8 1302 1303 (Pubitemid 20244999)
104. Parker W. D., Parks J. K., Cytochrome c oxidase in Alzheimer's disease brain: purification and characterization Neurology 1995 45 3 I 482 486
105. Cardoso S. M., Santana I., Swerdlow R. H., Oliveira C. R., Mitochondria dysfunction of Alzheimer's disease cybrids enhances A toxicity Journal of Neurochemistry 2004 89 6 1417 1426 (Pubitemid 38802663)
106. Kish S. J., Bergeron C., Rajput A., Dozic S., Mastrogiacomo F., Chang-L. J., Wilson J. M., DiStefano L. M., Nobrega J. N., Brain cytochrome oxidase in Alzheimer's disease Journal of Neurochemistry 1992 59 2 776 779
107. Mark R. J., Pang Z., Geddes J. W., Uchida K., Mattson M. P., Amyloid -peptide impairs glucose transport in hippocampal and cortical neurons: involvement of membrane lipid peroxidation Journal of Neuroscience 1997 17 3 1046 1054 (Pubitemid 27043963)
108. Mattson M. P., Pathways towards and away from Alzheimer's disease Nature 2004 430 7000 631 639 (Pubitemid 39061671)
109. Bubber P., Haroutunian V., Fisch G., Blass J. P., Gibson G. E., Mitochondrial abnormalities in Alzheimer brain: mechanistic implications Annals of Neurology 2005 57 5 695 703 (Pubitemid 40628858)
110. Yan S. D., Shi Y., Zhu A., Fu J., Zhu H., Zhu Y., Gibson L., Stern E., Collison K., Al-Mohanna F., Ogawa S., Roher A., Clarke S. G., Stern D. M., Role of ERAB/L-3-hydroxyacyl-coenzyme A dehydrogenase type II activity in A -induced cytotoxicity Journal of Biological Chemistry 1999 274 4 2145 2156
111. Keil U., Hauptmann S., Bonert A., Scherping I., Eckert A., Mller W. E., Mitochondrial dysfunction induced by disease relevant AbetaPP and tau protein mutations Journal of Alzheimer's Disease 2006 9 2 139 146 (Pubitemid 44078641)
112. Lin M. T., Beal M. F., Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases Nature 2006 443 7113 787 795 (Pubitemid 44622683)
113. Nunomura A., Perry G., Aliev G., Hirai K., Takeda A., Balraj E. K., Jones P. K., Ghanbari H., Wataya T., Shimohama S., Chiba S., Atwood C. S., Petersen R. B., Smith M. A., Oxidative damage is the earliest event in Alzheimer disease Journal of Neuropathology and Experimental Neurology 2001 60 8 759 767 (Pubitemid 32678256)
114. Reddy P. H., Beal M. F., Are mitochondria critical in the pathogenesis of Alzheimer's disease? Brain Research Reviews 2005 49 3 618 632 (Pubitemid 41546661)
115. Moreira P. I., Carvalho C., Zhu X., Smith M. A., Perry G., Mitochondrial dysfunction is a trigger of Alzheimer's disease pathophysiology Biochimica et Biophysica Acta 2010 1802 1 2 10
116. Parker W. D., Cytochrome oxidase deficiency in Alzheimer's disease Annals of the New York Academy of Sciences 1991 640 59 64
117. Maurer I., Zierz S., Mller H. J., A selective defect of cytochrome c oxidase is present in brain of Alzheimer disease patients Neurobiology of Aging 2000 21 3 455 462 (Pubitemid 30349116)
118. Russell R. L., Siedlak S. L., Raina A. K., Bautista J. M., Smith M. A., Perry G., Increased neuronal glucose-6-phosphate dehydrogenase and sulfhydryl levels indicate reductive compensation to oxidative stress in Alzheimer disease Archives of Biochemistry and Biophysics 1999 370 2 236 239 (Pubitemid 29491430)
119. Swerdlow R. H., Mitochondria in cybrids containing mtDNA from persons with mitochondriopathies Journal of Neuroscience Research 2007 85 15 3416 3428 (Pubitemid 350058530)
120. Newman M., Musgrave F. I., Lardelli M., Alzheimer disease: amyloidogenesis, the presenilins and animal models Biochimica et Biophysica Acta 2007 1772 3 285 297 (Pubitemid 46275437)
121. Richartz E., Noda S., Schott K., Gnthner A., Lewczuk P., Bartels M., Increased serum levels of CD95 in Alzheimer's disease Dementia and Geriatric Cognitive Disorders 2002 13 3 178 182 (Pubitemid 34224937)
122. Zarkovic K., 4-Hydroxynonenal and neurodegenerative diseases Molecular Aspects of Medicine 2003 24 4-5 293 303 (Pubitemid 36945029)
123. Hirai K., Aliev G., Nunomura A., Fujioka H., Russell R. L., Atwood C. S., Johnson A. B., Kress Y., Vinters H. V., Tabaton M., Shimohama S., Cash A. D., Siedlak S. L., Harris P. L. R., Jones P. K., Petersen R. B., Perry G., Smith M. A., Mitochondrial abnormalities in Alzheimer's disease Journal of Neuroscience 2001 21 9 3017 3023 (Pubitemid 32323483)
124. Abdel-Kader R., Hauptmann S., Keil U., Scherping I., Leuner K., Eckert A., Mller W. E., Stabilization of mitochondrial function by Ginkgo biloba extract (EGb 761) Pharmacological Research 2007 56 6 493 502 (Pubitemid 350148165)
125. Eckert A., Keil U., Kressmann S., Schindowski K., Leutner S., Leutz S., Mller W. E., Effects of EGb 761 Ginkgo biloba extract on mitochondrial function and oxidative stress Pharmacopsychiatry 2003 36 supplement 1 S15 S23
126. Eckert A., Keil U., Scherping I., Hauptmann S., Mller W. E., Stabilization of mitochondrial membrane potential and improvement of neuronal energy metabolism by Ginkgo biloba extract EGb 761 Annals of the New York Academy of Sciences 2005 1056 474 485 (Pubitemid 43031000)
127. Rhein V., Giese M., Baysang G., Meier F., Rao S., Schulz K. L., Hamburger M., Eckert A., Ginkgo biloba extract ameliorates oxidative phosphorylation performance and rescues A -induced failure PLos One 2010 5 8
128. Bastianetto S., Ramassamy C., Dor S., Christen Y., Poirier J., Quirion R., The ginkgo biloba extract (EGb 761) protects hippocampal neurons against cell death induced by -amyloid European Journal of Neuroscience 2000 12 6 1882 1890 (Pubitemid 30348827)
129. Yao Z., Drieu K., Papadopoulos V., The Ginkgo biloba extract EGb 761 rescues the PC12 neuronal cells from beta-amyloid-induced cell death by inhibiting the formation of beta-amyloid-derived diffusible neurotoxic ligands Brain Research 2001 889 181 190 (Pubitemid 32146280)