메뉴 건너뛰기




Volumn 52, Issue 1, 2015, Pages 533-544

Beta-Amyloid Precursor Protein (βAPP) Processing in Alzheimer’s Disease (AD) and Age-Related Macular Degeneration (AMD)

Author keywords

42 amino acid amyloid beta (A 42); Age related macular degeneration (AMD); Alzheimer s disease (AD); Beta amyloid precursor protein ( APP); CNS inflammation; Drusen; Micro RNA (miRNA); Neurological disease; sAPP ; Senile plaques; Transmissibility; APP processing

Indexed keywords

ALUMINUM; AMYLOID BETA PROTEIN[1-42]; AMYLOID PRECURSOR PROTEIN; BETA SECRETASE; COMPLEMENT FACTOR H; GAMMA SECRETASE; MICRORNA; NEUROTOXIN; SOLUBLE AMYLOID PRECURSOR PROTEIN ALPHA; UNCLASSIFIED DRUG; AMYLOID BETA PROTEIN;

EID: 84937932912     PISSN: 08937648     EISSN: 15591182     Source Type: Journal    
DOI: 10.1007/s12035-014-8886-3     Document Type: Review
Times cited : (55)

References (110)
  • 1
    • 0032211830 scopus 로고    scopus 로고
    • The cell biology of beta-amyloid precursor protein and presenilin in Alzheimer’s disease
    • COI: 1:CAS:528:DyaK1MXmsV2m, PID: 9854312
    • Selkoe DJ (1998) The cell biology of beta-amyloid precursor protein and presenilin in Alzheimer’s disease. Trends Cell Biol 8:447–453
    • (1998) Trends Cell Biol , vol.8 , pp. 447-453
    • Selkoe, D.J.1
  • 2
    • 84861378458 scopus 로고    scopus 로고
    • Interaction between pathogenic proteins in neurodegenerative disorders
    • COI: 1:CAS:528:DC%2BC38Xht1SjsbzO, PID: 22176890
    • Jellinger KA (2012) Interaction between pathogenic proteins in neurodegenerative disorders. J Cell Mol Med 16:1166–1183
    • (2012) J Cell Mol Med , vol.16 , pp. 1166-1183
    • Jellinger, K.A.1
  • 3
    • 84911008081 scopus 로고    scopus 로고
    • Cellular membrane fluidity in amyloid precursor protein processing, Mol Neurobiol
    • Yang X, Sun GY, Eckert GP, Lee JC (2014) Cellular membrane fluidity in amyloid precursor protein processing. Mol Neurobiol. doi:10.1007/s12035-014-8652-6
    • (2014) Lee JC
    • Yang, X.1    Sun, G.Y.2    Eckert, G.P.3
  • 4
    • 84883750935 scopus 로고    scopus 로고
    • Alzheimer’s disease (AD) as a disorder of the plasma membrane
    • PID: 23424582
    • Lukiw WJ (2013) Alzheimer’s disease (AD) as a disorder of the plasma membrane. Front Physiol 4:24. doi:10.3389/fphys.2013.00024
    • (2013) Front Physiol , vol.4 , pp. 24
    • Lukiw, W.J.1
  • 5
    • 84899908763 scopus 로고    scopus 로고
    • Apolipoprotein E, amyloid-beta, and neuroinflammation in Alzheimer’s disease
    • COI: 1:CAS:528:DC%2BC2cXmvFCnsb8%3D, PID: 24652457
    • Dorey E, Chang N, Liu QY, Yang Z, Zhang W (2014) Apolipoprotein E, amyloid-beta, and neuroinflammation in Alzheimer’s disease. Neurosci Bull 30:317–330
    • (2014) Neurosci Bull , vol.30 , pp. 317-330
    • Dorey, E.1    Chang, N.2    Liu, Q.Y.3    Yang, Z.4    Zhang, W.5
  • 6
    • 0019489110 scopus 로고
    • Congophilic angiopathy in the pathogenesis of Alzheimer’s degeneration
    • COI: 1:STN:280:DyaL38%2FitlGhtA%3D%3D, PID: 6169353
    • Glenner GG, Henry JH, Fujihara S (1981) Congophilic angiopathy in the pathogenesis of Alzheimer’s degeneration. Ann Pathol 1:120–129
    • (1981) Ann Pathol , vol.1 , pp. 120-129
    • Glenner, G.G.1    Henry, J.H.2    Fujihara, S.3
  • 7
    • 84871860097 scopus 로고
    • Alzheimer’s disease: initial report of the purification and characterization of a novel cerebrovascular amyloid protein
    • Glenner GG, Wong CW (1984) Alzheimer’s disease: initial report of the purification and characterization of a novel cerebrovascular amyloid protein. Biochem Biophys Res Commun 425:534–539
    • (1984) Biochem Biophys Res Commun , vol.425 , pp. 534-539
    • Glenner, G.G.1    Wong, C.W.2
  • 8
    • 0024841776 scopus 로고
    • Amyloidosis of the nervous system
    • COI: 1:STN:280:DyaK3c7jt1Omug%3D%3D, PID: 2559163
    • Glenner GG, Murphy MA (1989) Amyloidosis of the nervous system. J Neurol Sci 94:1–28
    • (1989) J Neurol Sci , vol.94
    • Glenner, G.G.1    Murphy, M.A.2
  • 9
    • 63849119978 scopus 로고    scopus 로고
    • Georges Marinesco and the early research in neuropathology
    • COI: 1:STN:280:DC%2BD1M%2FltFeguw%3D%3D, PID: 19122036
    • Buda O, Arsene D, Ceausu M, Dermengiu D, Curca GC (2009) Georges Marinesco and the early research in neuropathology. Neurology 72:88–91
    • (2009) Neurology , vol.72 , pp. 88-91
    • Buda, O.1    Arsene, D.2    Ceausu, M.3    Dermengiu, D.4    Curca, G.C.5
  • 10
    • 0028856460 scopus 로고
    • An English translation of Alzheimer’s 1907 paper, “Uber eine eigenartige Erkankung der Hirnrinde
    • COI: 1:STN:280:DyaK28zkvVWktg%3D%3D, PID: 8713166
    • Alzheimer A, Stelzmann RA, Schnitzlein HN, Murtagh FR (1995) An English translation of Alzheimer’s 1907 paper, “Uber eine eigenartige Erkankung der Hirnrinde”. Clin Anat 8:429–431
    • (1995) Clin Anat , vol.8 , pp. 429-431
    • Alzheimer, A.1    Stelzmann, R.A.2    Schnitzlein, H.N.3    Murtagh, F.R.4
  • 11
    • 62249133805 scopus 로고    scopus 로고
    • Spatial correlations between beta-amyloid (Abeta) deposits and blood vessels in familial Alzheimer’s disease
    • COI: 1:CAS:528:DC%2BD1MXislSrtbs%3D, PID: 19169965
    • Armstrong RA (2008) Spatial correlations between beta-amyloid (Abeta) deposits and blood vessels in familial Alzheimer’s disease. Folia Neuropathol 46:241–248
    • (2008) Folia Neuropathol , vol.46 , pp. 241-248
    • Armstrong, R.A.1
  • 12
    • 36248963151 scopus 로고    scopus 로고
    • Recent advances in the development of amyloid imaging agents
    • COI: 1:CAS:528:DC%2BD2sXhsVOrtb3O, PID: 17979786
    • Furumoto S, Okamura N, Iwata R, Yanai K, Arai H, Kudo Y (2007) Recent advances in the development of amyloid imaging agents. Curr Top Med Chem 7:1773–1789
    • (2007) Curr Top Med Chem , vol.7 , pp. 1773-1789
    • Furumoto, S.1    Okamura, N.2    Iwata, R.3    Yanai, K.4    Arai, H.5    Kudo, Y.6
  • 13
    • 84869021291 scopus 로고    scopus 로고
    • Development of positron emission tomography β-amyloid plaque imaging agents
    • PID: 23026364
    • Mathis CA, Mason NS, Lopresti BJ, Klunk WE (2012) Development of positron emission tomography β-amyloid plaque imaging agents. Semin Nucl Med 42:423–432
    • (2012) Semin Nucl Med , vol.42 , pp. 423-432
    • Mathis, C.A.1    Mason, N.S.2    Lopresti, B.J.3    Klunk, W.E.4
  • 14
  • 15
    • 79960671469 scopus 로고    scopus 로고
    • Age related macular degeneration and drusen: neuroinflammation in the retina
    • COI: 1:CAS:528:DC%2BC3MXhtVOjs7rM, PID: 21740956
    • Buschini E, Piras A, Nuzzi R, Vercelli A (2011) Age related macular degeneration and drusen: neuroinflammation in the retina. Prog Neurobiol 95:14–25
    • (2011) Prog Neurobiol , vol.95 , pp. 14-25
    • Buschini, E.1    Piras, A.2    Nuzzi, R.3    Vercelli, A.4
  • 16
    • 0025899041 scopus 로고
    • Amyloid deposition as the central event in the aetiology of Alzheimer’s disease
    • COI: 1:CAS:528:DyaK3MXmslKktr8%3D, PID: 1763432
    • Hardy J, Allsop D (1991) Amyloid deposition as the central event in the aetiology of Alzheimer’s disease. Trends Pharmacol Sci 12:383–388
    • (1991) Trends Pharmacol Sci , vol.12 , pp. 383-388
    • Hardy, J.1    Allsop, D.2
  • 17
    • 84878946078 scopus 로고    scopus 로고
    • The amyloid precursor protein: a biochemical enigma in brain development, function and disease
    • COI: 1:CAS:528:DC%2BC3sXot1Krt74%3D, PID: 23684647
    • Nalivaeva NN, Turner AJ (2013) The amyloid precursor protein: a biochemical enigma in brain development, function and disease. FEBS Lett 587:2046–2054
    • (2013) FEBS Lett , vol.587 , pp. 2046-2054
    • Nalivaeva, N.N.1    Turner, A.J.2
  • 18
    • 84896695262 scopus 로고    scopus 로고
    • The dark sides of amyloid in Alzheimer’s disease pathogenesis
    • COI: 1:CAS:528:DC%2BC2cXitlenuro%3D, PID: 24491999
    • Sorrentino P, Iuliano A, Polverino A, Jacini F, Sorrentino G (2014) The dark sides of amyloid in Alzheimer’s disease pathogenesis. FEBS Lett 588:641–652
    • (2014) FEBS Lett , vol.588 , pp. 641-652
    • Sorrentino, P.1    Iuliano, A.2    Polverino, A.3    Jacini, F.4    Sorrentino, G.5
  • 19
    • 79958098579 scopus 로고    scopus 로고
    • Parallel findings in age-related macular degeneration and Alzheimer’s disease
    • PID: 21440663
    • Ohno-Matsui K (2011) Parallel findings in age-related macular degeneration and Alzheimer’s disease. Prog Retin Eye Res 30:217–238
    • (2011) Prog Retin Eye Res , vol.30 , pp. 217-238
    • Ohno-Matsui, K.1
  • 20
    • 84928768988 scopus 로고    scopus 로고
    • Prevalence and risk factors for age-related macular degeneration in the elderly Chinese population in south-western Taiwan: the Puzih eye study. Eye (Lond)
    • Huang EJ, Wu SH, Lai CH, Kuo CN, Wu PL, Chen CL, Chen CY, King YC, Wu PC (2014) Prevalence and risk factors for age-related macular degeneration in the elderly Chinese population in south-western Taiwan: the Puzih eye study. Eye (Lond). doi:10.1038/eye.2014.55
    • (2014) doi:10.1038/eye.2014.55
    • Huang, E.J.1    Wu, S.H.2    Lai, C.H.3    Kuo, C.N.4    Wu, P.L.5    Chen, C.L.6    Chen, C.Y.7    King, Y.C.8    Wu, P.C.9
  • 21
    • 84862859234 scopus 로고    scopus 로고
    • Prevalence and risk factors of early-stage age-related macular degeneration in patients examined at a health promotion center in Korea
    • PID: 22563220
    • Moon BG, Joe SG, Hwang JU, Kim HK, Choe J, Yoon YH (2012) Prevalence and risk factors of early-stage age-related macular degeneration in patients examined at a health promotion center in Korea. J Korean Med Sci 27:537–541
    • (2012) J Korean Med Sci , vol.27 , pp. 537-541
    • Moon, B.G.1    Joe, S.G.2    Hwang, J.U.3    Kim, H.K.4    Choe, J.5    Yoon, Y.H.6
  • 22
    • 84876784987 scopus 로고    scopus 로고
    • Origins of amyloid-β
    • COI: 1:CAS:528:DC%2BC3sXptlyhs74%3D, PID: 23627794
    • Tharp WG, Sarkar IN (2013) Origins of amyloid-β. BMC Genomics 14:290. doi:10.1186/1471-2164-14-290
    • (2013) BMC Genomics , vol.14 , pp. 290
    • Tharp, W.G.1    Sarkar, I.N.2
  • 23
    • 30944465646 scopus 로고    scopus 로고
    • The amyloid precursor protein and postnatal neurogenesis/neuroregeneration
    • COI: 1:CAS:528:DC%2BD28XoslOrsA%3D%3D, PID: 16406235
    • Chen Y, Tang BL (2006) The amyloid precursor protein and postnatal neurogenesis/neuroregeneration. Biochem Biophys Res Commun 341:1–5
    • (2006) Biochem Biophys Res Commun , vol.341
    • Chen, Y.1    Tang, B.L.2
  • 24
    • 77952515576 scopus 로고    scopus 로고
    • An overview of APP processing enzymes and products
    • COI: 1:CAS:528:DC%2BC3cXislyktrs%3D
    • Chow VW, Mattson MP, Wong PC, Gleichmann M (2010) An overview of APP processing enzymes and products. Neuromol Med 12:1–12
    • (2010) Neuromol Med , vol.12
    • Chow, V.W.1    Mattson, M.P.2    Wong, P.C.3    Gleichmann, M.4
  • 25
    • 15944418620 scopus 로고    scopus 로고
    • The aluminum-amyloid cascade hypothesis of Alzheimer’s disease
    • COI: 1:CAS:528:DC%2BD2MXotFaktrg%3D, PID: 15709481
    • Exley C (2005) The aluminum-amyloid cascade hypothesis of Alzheimer’s disease. Subcell Biochem 38:225–234
    • (2005) Subcell Biochem , vol.38 , pp. 225-234
    • Exley, C.1
  • 26
    • 84876375186 scopus 로고    scopus 로고
    • Aluminum involvement in the progression of Alzheimer’s disease
    • COI: 1:CAS:528:DC%2BC3sXlsVGrsb4%3D, PID: 23380995
    • Walton JR (2013) Aluminum involvement in the progression of Alzheimer’s disease. J Alzheimers Dis 35:7–43
    • (2013) J Alzheimers Dis , vol.35 , pp. 7-43
    • Walton, J.R.1
  • 27
    • 3342879300 scopus 로고    scopus 로고
    • Molecular shuttle chelation: the use of ascorbate, desferrioxamine and Feralex-G in combination to remove nuclear bound aluminum
    • COI: 1:CAS:528:DC%2BD2cXivVGns7w%3D, PID: 15206824
    • Kruck TP, Cui JG, Percy ME, Lukiw WJ (2004) Molecular shuttle chelation: the use of ascorbate, desferrioxamine and Feralex-G in combination to remove nuclear bound aluminum. Cell Mol Neurobiol 24:443–459
    • (2004) Cell Mol Neurobiol , vol.24 , pp. 443-459
    • Kruck, T.P.1    Cui, J.G.2    Percy, M.E.3    Lukiw, W.J.4
  • 29
    • 81855163383 scopus 로고    scopus 로고
    • Towards the prevention of potential aluminum toxic effects and an effective treatment for Alzheimer’s disease
    • COI: 1:CAS:528:DC%2BC3MXhsV2mtLvF, PID: 22099160
    • Percy ME, Kruck TP, Pogue AI, Lukiw WJ (2011) Towards the prevention of potential aluminum toxic effects and an effective treatment for Alzheimer’s disease. J Inorg Biochem 105:1505–1512
    • (2011) J Inorg Biochem , vol.105 , pp. 1505-1512
    • Percy, M.E.1    Kruck, T.P.2    Pogue, A.I.3    Lukiw, W.J.4
  • 30
    • 84901298455 scopus 로고    scopus 로고
    • Aluminum and its potential contribution to Alzheimer’s disease (AD)
    • PID: 24782759
    • Bhattacharjee S, Zhao Y, Hill JM, Percy ME, Lukiw WJ (2014) Aluminum and its potential contribution to Alzheimer’s disease (AD). Front Aging Neurosci 6:62. doi:10.3389/fnagi.2014.00062.eCollection 2014
    • (2014) Front Aging Neurosci , vol.6 , pp. 62
    • Bhattacharjee, S.1    Zhao, Y.2    Hill, J.M.3    Percy, M.E.4    Lukiw, W.J.5
  • 31
    • 84885957958 scopus 로고    scopus 로고
    • Expression of the phagocytosis-essential protein TREM2 is down-regulated by an aluminum-induced miRNA-34a
    • COI: 1:CAS:528:DC%2BC3sXps1yrur0%3D, PID: 23778113
    • Alexandrov PN, Zhao Y, Jones BM, Bhattacharjee S, Lukiw WJ (2013) Expression of the phagocytosis-essential protein TREM2 is down-regulated by an aluminum-induced miRNA-34a. J Inorg Biochem 128:267–269
    • (2013) J Inorg Biochem , vol.128 , pp. 267-269
    • Alexandrov, P.N.1    Zhao, Y.2    Jones, B.M.3    Bhattacharjee, S.4    Lukiw, W.J.5
  • 32
    • 0037015020 scopus 로고    scopus 로고
    • The Alzheimer’s A beta-peptide is deposited at sites of complement activation in pathologic deposits associated with aging and age-related macular degeneration
    • COI: 1:CAS:528:DC%2BD38XntFWqtL4%3D, PID: 12189211
    • Johnson LV, Leitner WP, Rivest AJ, Staples MK, Radeke MJ, Anderson DH (2002) The Alzheimer’s A beta-peptide is deposited at sites of complement activation in pathologic deposits associated with aging and age-related macular degeneration. Proc Natl Acad Sci U S A 99:11830–11835
    • (2002) Proc Natl Acad Sci U S A , vol.99 , pp. 11830-11835
    • Johnson, L.V.1    Leitner, W.P.2    Rivest, A.J.3    Staples, M.K.4    Radeke, M.J.5    Anderson, D.H.6
  • 33
    • 32444450909 scopus 로고    scopus 로고
    • Drusen deposits associated with aging and age-related macular degeneration contain nonfibrillar amyloid oligomers
    • COI: 1:CAS:528:DC%2BD28Xht1Sqsrs%3D, PID: 16453022
    • Luibl V, Isas JM, Kayed R, Glabe CG, Langen R, Chen J (2006) Drusen deposits associated with aging and age-related macular degeneration contain nonfibrillar amyloid oligomers. J Clin Invest 116:378–385
    • (2006) J Clin Invest , vol.116 , pp. 378-385
    • Luibl, V.1    Isas, J.M.2    Kayed, R.3    Glabe, C.G.4    Langen, R.5    Chen, J.6
  • 34
    • 0037975774 scopus 로고    scopus 로고
    • Amyloid-beta is found in drusen from some age-related macular degeneration retinas, but not in drusen from normal retinas
    • COI: 1:CAS:528:DC%2BD3sXkvVGjtb0%3D, PID: 12764254
    • Dentchev T, Milam AH, Lee VM, Trojanowski JQ, Dunaief JL (2003) Amyloid-beta is found in drusen from some age-related macular degeneration retinas, but not in drusen from normal retinas. Mol Vis 9:184–190
    • (2003) Mol Vis , vol.9 , pp. 184-190
    • Dentchev, T.1    Milam, A.H.2    Lee, V.M.3    Trojanowski, J.Q.4    Dunaief, J.L.5
  • 35
    • 0345760069 scopus 로고    scopus 로고
    • Characterization of beta amyloid assemblies in drusen: the deposits associated with aging and age-related macular degeneration
    • COI: 1:CAS:528:DC%2BD2cXjtVekug%3D%3D, PID: 14729357
    • Anderson DH, Talaga KC, Rivest AJ, Barron E, Hageman GS, Johnson LV (2004) Characterization of beta amyloid assemblies in drusen: the deposits associated with aging and age-related macular degeneration. Exp Eye Res 78:243–256
    • (2004) Exp Eye Res , vol.78 , pp. 243-256
    • Anderson, D.H.1    Talaga, K.C.2    Rivest, A.J.3    Barron, E.4    Hageman, G.S.5    Johnson, L.V.6
  • 37
    • 58149471506 scopus 로고    scopus 로고
    • Acute and chronic effects of intravitreally injected beta-amyloid on the neurotransmitter system in the retina
    • COI: 1:CAS:528:DC%2BD1MXktF2iug%3D%3D, PID: 19059454
    • Aruoma OI, Jen SS, Watts HR, George J, Gentleman SM, Anderson PJ, Jen LS (2009) Acute and chronic effects of intravitreally injected beta-amyloid on the neurotransmitter system in the retina. Toxicology 256:92–100
    • (2009) Toxicology , vol.256 , pp. 92-100
    • Aruoma, O.I.1    Jen, S.S.2    Watts, H.R.3    George, J.4    Gentleman, S.M.5    Anderson, P.J.6    Jen, L.S.7
  • 38
    • 84871855675 scopus 로고    scopus 로고
    • Attenuated inflammatory response in triggering receptor expressed on myeloid cells 2 (TREM2) knock-out mice following stroke
    • COI: 1:CAS:528:DC%2BC3sXpsFCruw%3D%3D, PID: 23301011
    • Sieber MW, Jaenisch N, Brehm M, Guenther M, Linnartz-Gerlach B, Neumann H (2013) Attenuated inflammatory response in triggering receptor expressed on myeloid cells 2 (TREM2) knock-out mice following stroke. PLoS ONE 8(1):e52982
    • (2013) PLoS ONE , vol.8 , Issue.1 , pp. 52982
    • Sieber, M.W.1    Jaenisch, N.2    Brehm, M.3    Guenther, M.4    Linnartz-Gerlach, B.5    Neumann, H.6
  • 40
    • 84884155361 scopus 로고    scopus 로고
    • Insights into TREM2 biology by network analysis of human brain gene expression data
    • COI: 1:CAS:528:DC%2BC3sXhtFSmsbnK, PID: 23855984
    • Forabosco P, Ramasamy A, Trabzuni D, Walker R, Smith C, Bras J et al (2013) Insights into TREM2 biology by network analysis of human brain gene expression data. Neurobiol Aging 34:2699–2714
    • (2013) Neurobiol Aging , vol.34 , pp. 2699-2714
    • Forabosco, P.1    Ramasamy, A.2    Trabzuni, D.3    Walker, R.4    Smith, C.5    Bras, J.6
  • 41
    • 84897954222 scopus 로고    scopus 로고
    • TREM2 and the neuro-immunology of Alzheimer’s disease
    • COI: 1:CAS:528:DC%2BC2cXisVCjtA%3D%3D, PID: 24355566
    • Hickman SE, El Khoury J (2014) TREM2 and the neuro-immunology of Alzheimer’s disease. Biochem Pharmacol 88:495–498
    • (2014) Biochem Pharmacol , vol.88 , pp. 495-498
    • Hickman, S.E.1    El Khoury, J.2
  • 42
    • 84939895008 scopus 로고    scopus 로고
    • The role of SORL1 in Alzheimer’s disease. Mol Neurobiol. doi:10.1007/s12035-014-8742-5
    • Yin RH, Yu JT, Tan L (2014) The role of SORL1 in Alzheimer’s disease. Mol Neurobiol. doi:10.1007/s12035-014-8742-5. PubMed PMID: 24833601
    • (2014) PubMed PMID: 24833601
    • Yin, R.H.1    Yu, J.T.2    Tan, L.3
  • 43
    • 33847043137 scopus 로고    scopus 로고
    • Expression of inflammatory genes in the primary visual cortex of late-stage Alzheimer’s disease
    • COI: 1:CAS:528:DC%2BD2sXhslCmsbg%3D, PID: 17301674
    • Cui JG, Hill JM, Zhao Y, Lukiw WJ (2007) Expression of inflammatory genes in the primary visual cortex of late-stage Alzheimer’s disease. Neuroreport 18:115–119
    • (2007) Neuroreport , vol.18 , pp. 115-119
    • Cui, J.G.1    Hill, J.M.2    Zhao, Y.3    Lukiw, W.J.4
  • 44
    • 40849093600 scopus 로고    scopus 로고
    • Genome-wide association studies in Alzheimer disease
    • PID: 18332245
    • Waring SC, Rosenberg RN (2008) Genome-wide association studies in Alzheimer disease. Arch Neurol 65:329–334
    • (2008) Arch Neurol , vol.65 , pp. 329-334
    • Waring, S.C.1    Rosenberg, R.N.2
  • 45
    • 84872069366 scopus 로고    scopus 로고
    • Variant TREM2 as risk factor for Alzheimer’s disease
    • COI: 1:CAS:528:DC%2BC3sXovVygsA%3D%3D, PID: 23151315
    • Neumann H, Daly MJ (2013) Variant TREM2 as risk factor for Alzheimer’s disease. N Engl J Med 368:182–184
    • (2013) N Engl J Med , vol.368 , pp. 182-184
    • Neumann, H.1    Daly, M.J.2
  • 46
    • 80051551540 scopus 로고    scopus 로고
    • Retinal amyloid peptides and complement factor H in transgenic models of Alzheimer’s disease
    • COI: 1:CAS:528:DC%2BC3MXovVWiurY%3D, PID: 21734608
    • Alexandrov PN, Pogue A, Bhattacharjee S, Lukiw WJ (2011) Retinal amyloid peptides and complement factor H in transgenic models of Alzheimer’s disease. Neuroreport 22:623–627
    • (2011) Neuroreport , vol.22 , pp. 623-627
    • Alexandrov, P.N.1    Pogue, A.2    Bhattacharjee, S.3    Lukiw, W.J.4
  • 47
    • 84885077268 scopus 로고    scopus 로고
    • TREM2 signaling, miRNA-34a and the extinction of phagocytosis
    • PID: 24009555
    • Zhao Y, Lukiw WJ (2013) TREM2 signaling, miRNA-34a and the extinction of phagocytosis. Front Cell Neurosci 7:131–135
    • (2013) Front Cell Neurosci , vol.7 , pp. 131-135
    • Zhao, Y.1    Lukiw, W.J.2
  • 48
    • 84897954222 scopus 로고    scopus 로고
    • TREM2 and the neuroimmunology of Alzheimer’s disease
    • PID: 24355566
    • Hickman SE, El Khoury J (2013) TREM2 and the neuroimmunology of Alzheimer’s disease. Biochem Pharmacol 88:495–498
    • (2013) Biochem Pharmacol , vol.88 , pp. 495-498
    • Hickman, S.E.1    El Khoury, J.2
  • 49
    • 84897401882 scopus 로고    scopus 로고
    • Regulating amyloidogenesis through the natural triggering receptor expressed inmyeloid/microglial cells 2 (TREM2)
    • PID: 24744699
    • Jones BM, Bhattacharjee S, Dua P, Hill JM, Zhao Y, Lukiw WJ (2014) Regulating amyloidogenesis through the natural triggering receptor expressed inmyeloid/microglial cells 2 (TREM2). Front Cell Neurosci 8:94
    • (2014) Front Cell Neurosci , vol.8 , pp. 94
    • Jones, B.M.1    Bhattacharjee, S.2    Dua, P.3    Hill, J.M.4    Zhao, Y.5    Lukiw, W.J.6
  • 50
    • 84880923645 scopus 로고    scopus 로고
    • TREM2 in Alzheimer’s disease
    • COI: 1:CAS:528:DC%2BC3sXhtFGls7fL, PID: 23407992
    • Jiang T, Yu JT, Zhu XC, Tan L (2013) TREM2 in Alzheimer’s disease. Mol Neurobiol 48:180–185
    • (2013) Mol Neurobiol , vol.48 , pp. 180-185
    • Jiang, T.1    Yu, J.T.2    Zhu, X.C.3    Tan, L.4
  • 51
    • 84901188020 scopus 로고    scopus 로고
    • Insights into the physiological function of the β-amyloid precursor protein: beyond Alzheimer’s disease
    • COI: 1:CAS:528:DC%2BC2cXotFentbY%3D, PID: 24517464
    • Dawkins E, Small DH (2014) Insights into the physiological function of the β-amyloid precursor protein: beyond Alzheimer’s disease. J Neurochem 129:756–769
    • (2014) J Neurochem , vol.129 , pp. 756-769
    • Dawkins, E.1    Small, D.H.2
  • 52
    • 84883540611 scopus 로고    scopus 로고
    • Antagonism of NF-κB-up-regulated micro RNAs (miRNAs) in sporadic Alzheimer’s disease (AD): anti-NF-κB vs. anti-miRNA strategies
    • PID: 23641256
    • Lukiw WJ (2013) Antagonism of NF-κB-up-regulated micro RNAs (miRNAs) in sporadic Alzheimer’s disease (AD): anti-NF-κB vs. anti-miRNA strategies. Front Genet 4:77–79
    • (2013) Front Genet , vol.4 , pp. 77-79
    • Lukiw, W.J.1
  • 53
    • 84885027485 scopus 로고    scopus 로고
    • Variability in micro RNA (miRNA) abundance, speciation and complexity amongst different human populations and potential relevance to Alzheimer’s disease (AD)
    • PID: 23986657
    • Lukiw WJ (2013) Variability in micro RNA (miRNA) abundance, speciation and complexity amongst different human populations and potential relevance to Alzheimer’s disease (AD). Front Cell Neurosci 7:133
    • (2013) Front Cell Neurosci , vol.7 , pp. 133
    • Lukiw, W.J.1
  • 54
    • 84858959323 scopus 로고    scopus 로고
    • Amyloid beta (Aβ) peptide modulators and other current treatment strategies for Alzheimer’s disease (AD). Expert Opin Emerg Drugs. doi:10.1517/14728214.2012.672559
    • Lukiw WJ (2012) Amyloid beta (Aβ) peptide modulators and other current treatment strategies for Alzheimer’s disease (AD). Expert Opin Emerg Drugs. doi:10.1517/14728214.2012.672559. PubMed Central PMCID: PMC3399957
    • (2012) PubMed Central PMCID: PMC3399957
    • Lukiw, W.J.1
  • 55
    • 33746233383 scopus 로고    scopus 로고
    • Synapse formation and function is modulated by the amyloid precursor protein
    • COI: 1:CAS:528:DC%2BD28XntFejsb8%3D, PID: 16822978
    • Priller C, Bauer T, Mitteregger G, Krebs B, Kretzschmar HA, Herms J (2006) Synapse formation and function is modulated by the amyloid precursor protein. J Neurosci 26:7212–7221
    • (2006) J Neurosci , vol.26 , pp. 7212-7221
    • Priller, C.1    Bauer, T.2    Mitteregger, G.3    Krebs, B.4    Kretzschmar, H.A.5    Herms, J.6
  • 57
    • 84863011840 scopus 로고    scopus 로고
    • The upside of APP at synapses
    • COI: 1:CAS:528:DC%2BC38Xjt1Wqsbk%3D, PID: 21199446
    • Hoe HS, Lee HK, Pak DT (2012) The upside of APP at synapses. CNS Neurosci Ther 18:47–56
    • (2012) CNS Neurosci Ther , vol.18 , pp. 47-56
    • Hoe, H.S.1    Lee, H.K.2    Pak, D.T.3
  • 58
    • 0042634362 scopus 로고    scopus 로고
    • Roles of amyloid precursor protein and its fragments in regulating neural activity, plasticity and memory
    • COI: 1:CAS:528:DC%2BD3sXmt1Wrs7s%3D, PID: 12927332
    • Turner PR, O’Connor K, Tate WP, Abraham WC (2003) Roles of amyloid precursor protein and its fragments in regulating neural activity, plasticity and memory. Prog Neurobiol 70:1–32
    • (2003) Prog Neurobiol , vol.70
    • Turner, P.R.1    O’Connor, K.2    Tate, W.P.3    Abraham, W.C.4
  • 61
    • 35648994883 scopus 로고    scopus 로고
    • Amyloid-beta precursor protein expression and modulation in human embryonic stem cells: a novel role for human chorionic gonadotropin
    • COI: 1:CAS:528:DC%2BD2sXht1Krur%2FM, PID: 17959150
    • Porayette P, Gallego MJ, Kaltcheva MM, Meethal SV, Atwood CS (2007) Amyloid-beta precursor protein expression and modulation in human embryonic stem cells: a novel role for human chorionic gonadotropin. Biochem Biophys Res Commun 364:522–527
    • (2007) Biochem Biophys Res Commun , vol.364 , pp. 522-527
    • Porayette, P.1    Gallego, M.J.2    Kaltcheva, M.M.3    Meethal, S.V.4    Atwood, C.S.5
  • 62
    • 58149459584 scopus 로고    scopus 로고
    • Abnormal cleavage of APP impairs its functions in cell adhesion and migration
    • COI: 1:CAS:528:DC%2BD1MXntlOrtw%3D%3D, PID: 19056463
    • Sheng B, Song B, Zheng Z, Zhou F, Lu G, Zhao N, Zhang X, Gong Y (2009) Abnormal cleavage of APP impairs its functions in cell adhesion and migration. Neurosci Lett 450:327–331
    • (2009) Neurosci Lett , vol.450 , pp. 327-331
    • Sheng, B.1    Song, B.2    Zheng, Z.3    Zhou, F.4    Lu, G.5    Zhao, N.6    Zhang, X.7    Gong, Y.8
  • 63
    • 84863263718 scopus 로고    scopus 로고
    • Role of APP and Aβ in synaptic physiology
    • COI: 1:CAS:528:DC%2BC38XkslCmur8%3D, PID: 21605029
    • Wang Z, Yang L, Zheng H (2012) Role of APP and Aβ in synaptic physiology. Curr Alzheimer Res 9:217–226
    • (2012) Curr Alzheimer Res , vol.9 , pp. 217-226
    • Wang, Z.1    Yang, L.2    Zheng, H.3
  • 64
    • 0024790562 scopus 로고
    • Evidence for the derivation of a peptide ligand from the amyloid beta-protein precursor of Alzheimer’s disease
    • COI: 1:CAS:528:DyaK3cXivVOm, PID: 2513585
    • Allsop D, Ikeda S, Glenner GG (1989) Evidence for the derivation of a peptide ligand from the amyloid beta-protein precursor of Alzheimer’s disease. Prog Clin Biol Res 317:893–902
    • (1989) Prog Clin Biol Res , vol.317 , pp. 893-902
    • Allsop, D.1    Ikeda, S.2    Glenner, G.G.3
  • 65
    • 0030779677 scopus 로고    scopus 로고
    • Cellular actions of beta-amyloid precursor protein and its soluble and fibrillogenic derivatives
    • COI: 1:CAS:528:DyaK2sXnt1yhu7g%3D, PID: 9354812
    • Mattson MP (1997) Cellular actions of beta-amyloid precursor protein and its soluble and fibrillogenic derivatives. Physiol Rev 77:1081–1132
    • (1997) Physiol Rev , vol.77 , pp. 1081-1132
    • Mattson, M.P.1
  • 66
    • 33750823234 scopus 로고    scopus 로고
    • A peptide zipcode sufficient for anterograde transport within amyloid precursor protein
    • COI: 1:CAS:528:DC%2BD28Xht1WmsLnF, PID: 17062754
    • Satpute-Krishnan P, Degiorgis JA, Conley MP, Jang M, Bearer EL (2006) A peptide zipcode sufficient for anterograde transport within amyloid precursor protein. Proc Natl Acad Sci 103:16532
    • (2006) Proc Natl Acad Sci , vol.103 , pp. 16532
    • Satpute-Krishnan, P.1    Degiorgis, J.A.2    Conley, M.P.3    Jang, M.4    Bearer, E.L.5
  • 69
    • 0035912767 scopus 로고    scopus 로고
    • Kinesin molecular motors: transport pathways, receptors, and human disease
    • COI: 1:CAS:528:DC%2BD3MXkslWmsLo%3D, PID: 11416178
    • Goldstein LS (2001) Kinesin molecular motors: transport pathways, receptors, and human disease. Proc Natl Acad Sci U S A 98:6999–7003
    • (2001) Proc Natl Acad Sci U S A , vol.98 , pp. 6999-7003
    • Goldstein, L.S.1
  • 70
    • 70350502866 scopus 로고    scopus 로고
    • Regulation of the physiological function and metabolism of AbetaPP by AbetaPP binding proteins
    • COI: 1:CAS:528:DC%2BD1MXht1CjsrbE, PID: 19584434
    • Taru H, Suzuki T (2009) Regulation of the physiological function and metabolism of AbetaPP by AbetaPP binding proteins. J Alzheimers Dis 18:253–265
    • (2009) J Alzheimers Dis , vol.18 , pp. 253-265
    • Taru, H.1    Suzuki, T.2
  • 73
    • 79959379335 scopus 로고    scopus 로고
    • Differential expression of miRNA-146a-regulated inflammatory genes in human primary neural, astroglial and microglial cells
    • COI: 1:CAS:528:DC%2BC3MXotVeksro%3D, PID: 21640790
    • Li YY, Cui JG, Dua P, Pogue AI, Bhattacharjee S, Lukiw WJ (2011) Differential expression of miRNA-146a-regulated inflammatory genes in human primary neural, astroglial and microglial cells. Neurosci Lett 499:109–113
    • (2011) Neurosci Lett , vol.499 , pp. 109-113
    • Li, Y.Y.1    Cui, J.G.2    Dua, P.3    Pogue, A.I.4    Bhattacharjee, S.5    Lukiw, W.J.6
  • 74
    • 84860364449 scopus 로고    scopus 로고
    • NF-кB-regulated micro RNAs (miRNAs) in primary human brain cells
    • COI: 1:CAS:528:DC%2BC38XmtlKit7w%3D, PID: 22138609
    • Lukiw WJ (2012) NF-кB-regulated micro RNAs (miRNAs) in primary human brain cells. Exp Neurol 235:484–490
    • (2012) Exp Neurol , vol.235 , pp. 484-490
    • Lukiw, W.J.1
  • 75
    • 4644263024 scopus 로고    scopus 로고
    • Potential roles for presenilin-1 in oxygen sensing and in glial-specific gene expression
    • COI: 1:CAS:528:DC%2BD2cXntFSgs78%3D, PID: 15486475
    • Cui JG, Fraser PE, St George-Hyslop P, Westaway D, Lukiw WJ (2004) Potential roles for presenilin-1 in oxygen sensing and in glial-specific gene expression. Neuroreport 15:2025–2028
    • (2004) Neuroreport , vol.15 , pp. 2025-2028
    • Cui, J.G.1    Fraser, P.E.2    St George-Hyslop, P.3    Westaway, D.4    Lukiw, W.J.5
  • 76
    • 79251559674 scopus 로고    scopus 로고
    • Docosahexaenoic acid-derived neuroprotectin D1 induces neuronal survival via secretase- and PPARγ-mediated mechanisms in Alzheimer’s disease models
    • COI: 1:CAS:528:DC%2BC3MXosVOgsA%3D%3D, PID: 21246057
    • Zhao Y, Calon F, Julien C, Winkler JW, Petasis NA, Lukiw WJ, Bazan NG (2011) Docosahexaenoic acid-derived neuroprotectin D1 induces neuronal survival via secretase- and PPARγ-mediated mechanisms in Alzheimer’s disease models. PLoS ONE 6:e15816
    • (2011) PLoS ONE , vol.6 , pp. 15816
    • Zhao, Y.1    Calon, F.2    Julien, C.3    Winkler, J.W.4    Petasis, N.A.5    Lukiw, W.J.6    Bazan, N.G.7
  • 77
    • 84880767415 scopus 로고    scopus 로고
    • Complement factor H related proteins (CFHRs)
    • COI: 1:CAS:528:DC%2BC3sXhtVCrtLnJ, PID: 23830046
    • Skerka C, Chen Q, Fremeaux-Bacchi V, Roumenina LT (2013) Complement factor H related proteins (CFHRs). Mol Immunol 56:170–180
    • (2013) Mol Immunol , vol.56 , pp. 170-180
    • Skerka, C.1    Chen, Q.2    Fremeaux-Bacchi, V.3    Roumenina, L.T.4
  • 78
    • 84906858173 scopus 로고    scopus 로고
    • Age-related macular degeneration: genetics and biology coming together. Annu Rev Genomics Hum Genet. doi:10.1146/annurev-genom-090413-025610
    • Fritsche LG, Fariss RN, Stambolian D, Abecasis GR, Curcio CA, Swaroop A (2014) Age-related macular degeneration: genetics and biology coming together. Annu Rev Genomics Hum Genet. doi:10.1146/annurev-genom-090413-025610. PubMed PMID: 24773320
    • (2014) PubMed PMID: 24773320
    • Fritsche, L.G.1    Fariss, R.N.2    Stambolian, D.3    Abecasis, G.R.4    Curcio, C.A.5    Swaroop, A.6
  • 82
    • 84873333444 scopus 로고    scopus 로고
    • Genetic mechanisms and age-related macular degeneration: common variants, rare variants, copy number variations, epigenetics, and mitochondrial genetics
    • PID: 23244519
    • Liu MM, Chan CC, Tuo J (2012) Genetic mechanisms and age-related macular degeneration: common variants, rare variants, copy number variations, epigenetics, and mitochondrial genetics. Hum Genomics 6:13. doi:10.1186/1479-7364-6-13
    • (2012) Hum Genomics , vol.6 , pp. 13
    • Liu, M.M.1    Chan, C.C.2    Tuo, J.3
  • 83
    • 57649119790 scopus 로고    scopus 로고
    • An NF-kB-sensitive micro RNA-146a-mediated inflammatory circuit in Alzheimer disease and in stressed human brain cells
    • COI: 1:CAS:528:DC%2BD1cXhtlCjsLfF, PID: 18801740
    • Lukiw WJ, Zhao Y, Cui JG (2008) An NF-kB-sensitive micro RNA-146a-mediated inflammatory circuit in Alzheimer disease and in stressed human brain cells. J Biol Chem 283:31315–31322
    • (2008) J Biol Chem , vol.283 , pp. 31315-31322
    • Lukiw, W.J.1    Zhao, Y.2    Cui, J.G.3
  • 84
    • 84868089393 scopus 로고    scopus 로고
    • Regulation of complement factor H (CFH) by multiple miRNAs in Alzheimer’s disease (AD) brain
    • COI: 1:CAS:528:DC%2BC38XhtlGmsLnL, PID: 22302353
    • Lukiw WJ, Alexandrov PN (2012) Regulation of complement factor H (CFH) by multiple miRNAs in Alzheimer’s disease (AD) brain. Mol Neurobiol 46:11–19
    • (2012) Mol Neurobiol , vol.46 , pp. 11-19
    • Lukiw, W.J.1    Alexandrov, P.N.2
  • 85
    • 0035966319 scopus 로고    scopus 로고
    • microRNAs: tiny regulators with great potential
    • COI: 1:CAS:528:DC%2BD38XjtlKmtg%3D%3D, PID: 11779458
    • Ambros V (2001) microRNAs: tiny regulators with great potential. Cell 107:823–826
    • (2001) Cell , vol.107 , pp. 823-826
    • Ambros, V.1
  • 86
    • 0035955374 scopus 로고    scopus 로고
    • Identification of novel genes coding for small expressed RNAs
    • COI: 1:CAS:528:DC%2BD3MXotVChtb8%3D, PID: 11679670
    • Lagos-Quintana M, Rauhut R, Lendeckel W, Tuschl T (2001) Identification of novel genes coding for small expressed RNAs. Science 294:853–858
    • (2001) Science , vol.294 , pp. 853-858
    • Lagos-Quintana, M.1    Rauhut, R.2    Lendeckel, W.3    Tuschl, T.4
  • 87
    • 84871695724 scopus 로고    scopus 로고
    • microRNA (miRNA) speciation in Alzheimer’s disease (AD) cerebrospinal fluid (CSF) and extracellular fluid (ECF)
    • COI: 1:CAS:528:DC%2BC3sXhsFOrurs%3D, PID: 23301201
    • Alexandrov PN, Dua P, Hill JM, Bhattacharjee S, Zhao Y, Lukiw WJ (2012) microRNA (miRNA) speciation in Alzheimer’s disease (AD) cerebrospinal fluid (CSF) and extracellular fluid (ECF). Int J Biochem Mol Biol 3:365–373
    • (2012) Int J Biochem Mol Biol , vol.3 , pp. 365-373
    • Alexandrov, P.N.1    Dua, P.2    Hill, J.M.3    Bhattacharjee, S.4    Zhao, Y.5    Lukiw, W.J.6
  • 88
    • 77955644289 scopus 로고    scopus 로고
    • Mammalian microRNAs predominantly act to decrease target mRNA levels
    • COI: 1:CAS:528:DC%2BC3cXhtVais7nN, PID: 20703300
    • Guo H, Ingolia NT, Weissman JS, Bartel DP (2010) Mammalian microRNAs predominantly act to decrease target mRNA levels. Nature 466:835–840
    • (2010) Nature , vol.466 , pp. 835-840
    • Guo, H.1    Ingolia, N.T.2    Weissman, J.S.3    Bartel, D.P.4
  • 89
    • 84859702614 scopus 로고    scopus 로고
    • Common micro RNAs (miRNAs) target complement factor H (CFH) regulation in Alzheimer’s disease (AD) and in age-related macular degeneration (AMD)
    • COI: 1:CAS:528:DC%2BC38XmtVOluro%3D, PID: 22509485
    • Lukiw WJ, Surjyadipta B, Dua P, Alexandrov PN (2012) Common micro RNAs (miRNAs) target complement factor H (CFH) regulation in Alzheimer’s disease (AD) and in age-related macular degeneration (AMD). Int J Biochem Mol Biol 3:105–116
    • (2012) Int J Biochem Mol Biol , vol.3 , pp. 105-116
    • Lukiw, W.J.1    Surjyadipta, B.2    Dua, P.3    Alexandrov, P.N.4
  • 91
    • 84871195094 scopus 로고    scopus 로고
    • Association between complementary factor H Y402H polymorphisms and age-related macular degeneration in Chinese: systematic review and meta-analysis
    • COI: 1:CAS:528:DC%2BC38XhvVSns77I, PID: 22762059
    • Quan YL, Zhou AY, Feng ZH (2012) Association between complementary factor H Y402H polymorphisms and age-related macular degeneration in Chinese: systematic review and meta-analysis. Int J Ophthalmol 5:242–246
    • (2012) Int J Ophthalmol , vol.5 , pp. 242-246
    • Quan, Y.L.1    Zhou, A.Y.2    Feng, Z.H.3
  • 92
    • 79551507173 scopus 로고    scopus 로고
    • Complement factor H Y402H variant and risk of age-related macular degeneration in Asians: a systematic review and meta-analysis
    • PID: 20869121
    • Kondo N, Bessho H, Honda S, Negi A (2011) Complement factor H Y402H variant and risk of age-related macular degeneration in Asians: a systematic review and meta-analysis. Ophthalmology 118:339–344
    • (2011) Ophthalmology , vol.118 , pp. 339-344
    • Kondo, N.1    Bessho, H.2    Honda, S.3    Negi, A.4
  • 93
    • 84884746239 scopus 로고    scopus 로고
    • Alzheimer’s disease and geriatric eye diseases in the aspect of amyloid genesis
    • COI: 1:CAS:528:DC%2BC3sXhslahtLrO, PID: 24006764
    • Ermilov VV, Tiurenkov IN, Nesterova AA, Zagrebin VA (2013) Alzheimer’s disease and geriatric eye diseases in the aspect of amyloid genesis. Arkh Patol 75:37–42
    • (2013) Arkh Patol , vol.75 , pp. 37-42
    • Ermilov, V.V.1    Tiurenkov, I.N.2    Nesterova, A.A.3    Zagrebin, V.A.4
  • 96
    • 84903362065 scopus 로고    scopus 로고
    • Triggering receptor expressed on myeloid cells 2 knockdown exacerbates aging-related neuroinflammation and cognitive deficiency in senescence-accelerated mouse prone 8 mice
    • COI: 1:CAS:528:DC%2BC3sXitVWisrbO, PID: 24368090
    • Jiang T, Yu JT, Zhu XC, Tan MS, Gu LZ, Zhang YD et al (2014) Triggering receptor expressed on myeloid cells 2 knockdown exacerbates aging-related neuroinflammation and cognitive deficiency in senescence-accelerated mouse prone 8 mice. Neurobiol Aging 35:1243–1251
    • (2014) Neurobiol Aging , vol.35 , pp. 1243-1251
    • Jiang, T.1    Yu, J.T.2    Zhu, X.C.3    Tan, M.S.4    Gu, L.Z.5    Zhang, Y.D.6
  • 98
    • 19744380563 scopus 로고    scopus 로고
    • Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo
    • COI: 1:CAS:528:DC%2BD2MXks1Ciuro%3D, PID: 15831717
    • Nimmerjahn A, Kirchhoff F, Helmchen F (2005) Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo. Science 308:1314–1318
    • (2005) Science , vol.308 , pp. 1314-1318
    • Nimmerjahn, A.1    Kirchhoff, F.2    Helmchen, F.3
  • 100
    • 84874743342 scopus 로고    scopus 로고
    • The aging eye: common degenerative mechanisms between the Alzheimer’s brain and retinal disease
    • PID: 23364356
    • Sivak JM (2013) The aging eye: common degenerative mechanisms between the Alzheimer’s brain and retinal disease. Invest Ophthalmol Vis Sci 54:871–880
    • (2013) Invest Ophthalmol Vis Sci , vol.54 , pp. 871-880
    • Sivak, J.M.1
  • 101
    • 65649144141 scopus 로고    scopus 로고
    • Early age-related macular degeneration, cognitive function, and dementia: the Cardiovascular Health Study
    • PID: 19433718
    • Baker ML, Wang JJ, Rogers S, Klein R, Kuller LH, Larsen EK, Wong TY (2009) Early age-related macular degeneration, cognitive function, and dementia: the Cardiovascular Health Study. Arch Ophthalmol 127:667–673
    • (2009) Arch Ophthalmol , vol.127 , pp. 667-673
    • Baker, M.L.1    Wang, J.J.2    Rogers, S.3    Klein, R.4    Kuller, L.H.5    Larsen, E.K.6    Wong, T.Y.7
  • 103
    • 77249114260 scopus 로고    scopus 로고
    • Variability in gene expression underlies incomplete penetrance
    • COI: 1:CAS:528:DC%2BC3cXitFemsrw%3D, PID: 20164922
    • Raj A, Rifkin SA, Andersen E, van Oudenaarden A (2010) Variability in gene expression underlies incomplete penetrance. Nature 463:913–918
    • (2010) Nature , vol.463 , pp. 913-918
    • Raj, A.1    Rifkin, S.A.2    Andersen, E.3    van Oudenaarden, A.4
  • 104
    • 84863717137 scopus 로고    scopus 로고
    • Neurodegeneration of the retina in mouse models of Alzheimer’s disease: what can we learn from the retina?
    • COI: 1:CAS:528:DC%2BC38XmtlOrs7w%3D
    • Chiu K, Chan TF, Wu A, Leung IY, So KF, Chang RC (2012) Neurodegeneration of the retina in mouse models of Alzheimer’s disease: what can we learn from the retina? Age (Dordr) 34:633–649
    • (2012) Age (Dordr) , vol.34 , pp. 633-649
    • Chiu, K.1    Chan, T.F.2    Wu, A.3    Leung, I.Y.4    So, K.F.5    Chang, R.C.6
  • 106
    • 84872450218 scopus 로고    scopus 로고
    • Human genetic individuality
    • COI: 1:CAS:528:DC%2BC38XhsVGitrfL, PID: 22657391
    • Olson MV (2012) Human genetic individuality. Annu Rev Genomics Hum Genet 13:1–27
    • (2012) Annu Rev Genomics Hum Genet , vol.13
    • Olson, M.V.1
  • 107
    • 38749112528 scopus 로고    scopus 로고
    • Targeting age-related macular degeneration with Alzheimer’s disease based immunotherapies: anti-amyloid-beta antibody attenuates pathologies in an age-related macular degeneration mouse model
    • COI: 1:CAS:528:DC%2BD1cXhtlOmt7o%3D, PID: 17888483
    • Ding JD, Lin J, Mace BE, Herrmann R, Sullivan P, Bowes Rickman C (2008) Targeting age-related macular degeneration with Alzheimer’s disease based immunotherapies: anti-amyloid-beta antibody attenuates pathologies in an age-related macular degeneration mouse model. Vis Res 48:339–345
    • (2008) Vis Res , vol.48 , pp. 339-345
    • Ding, J.D.1    Lin, J.2    Mace, B.E.3    Herrmann, R.4    Sullivan, P.5    Bowes Rickman, C.6
  • 109
    • 84894052033 scopus 로고    scopus 로고
    • Decreased expression of CD33 in peripheral mononuclear cells of Alzheimer’s disease patients
    • COI: 1:CAS:528:DC%2BC2cXjvFWjt78%3D, PID: 24412678
    • Hu N, Tan MS, Sun L, Jiang T, Wang YL, Tan L, Zhang W, Yu JT, Tan L (2014) Decreased expression of CD33 in peripheral mononuclear cells of Alzheimer’s disease patients. Neurosci Lett 563:51–54
    • (2014) Neurosci Lett , vol.563 , pp. 51-54
    • Hu, N.1    Tan, M.S.2    Sun, L.3    Jiang, T.4    Wang, Y.L.5    Tan, L.6    Zhang, W.7    Yu, J.T.8    Tan, L.9
  • 110
    • 68549111222 scopus 로고    scopus 로고
    • Amyloid precursor protein processing and retinal pathology in mouse models of Alzheimer’s disease
    • COI: 1:CAS:528:DC%2BD1MXptlOlu78%3D, PID: 19271231
    • Dutescu RM, Li QX, Crowston J, Masters CL, Baird PN, Culvenor JG (2009) Amyloid precursor protein processing and retinal pathology in mouse models of Alzheimer’s disease. Graefes Arch Clin Exp Ophthalmol 247:1213–1221
    • (2009) Graefes Arch Clin Exp Ophthalmol , vol.247 , pp. 1213-1221
    • Dutescu, R.M.1    Li, Q.X.2    Crowston, J.3    Masters, C.L.4    Baird, P.N.5    Culvenor, J.G.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.