메뉴 건너뛰기




Volumn 140, Issue 6, 2017, Pages 1548-1560

Glioblastoma-associated microglia and macrophages: Targets for therapies to improve prognosis

Author keywords

Glioblastoma; Glioma; Immunotherapy; Macrophages; Microglia

Indexed keywords

ANGIOGENESIS; CANCER IMMUNOLOGY; CANCER IMMUNOTHERAPY; CANCER MODEL; CANCER PROGNOSIS; CELL MANIPULATION; DEPLETION; GLIOBLASTOMA; HUMAN; IN VITRO STUDY; IN VIVO STUDY; MACROPHAGE; MACROPHAGE FUNCTION; MICROGLIA; MOLECULAR BIOLOGY; MURINE MODEL; NEUROMODULATION; NONHUMAN; PHASE 1 CLINICAL TRIAL (TOPIC); PHASE 2 CLINICAL TRIAL (TOPIC); PRIORITY JOURNAL; REVIEW; TARGET CELL; TUMOR INVASION; TUMOR PROMOTION; BRAIN NEOPLASMS; IMMUNOLOGY; IMMUNOTHERAPY; PROCEDURES;

EID: 85022061790     PISSN: 00068950     EISSN: 14602156     Source Type: Journal    
DOI: 10.1093/brain/aww355     Document Type: Review
Times cited : (162)

References (168)
  • 1
    • 0029397770 scopus 로고
    • Transgenic and gene disruption techniques in the study of neurocarcinogenesis
    • Aguzzi A, Brandner S, Isenmann S, Steinbach JP, Sure U. Transgenic and gene disruption techniques in the study of neurocarcinogenesis. Glia 1995; 15: 348-64.
    • (1995) Glia , vol.15 , pp. 348-364
    • Aguzzi, A.1    Brandner, S.2    Isenmann, S.3    Steinbach, J.P.4    Sure, U.5
  • 2
    • 0028225493 scopus 로고
    • Colony stimulating factor-1 expression in human glioma
    • Alterman RL, Stanley ER. Colony stimulating factor-1 expression in human glioma. Mol Chem Neuropathol 1994; 21: 177-88.
    • (1994) Mol Chem Neuropathol , vol.21 , pp. 177-188
    • Alterman, R.L.1    Stanley, E.R.2
  • 3
    • 0014851851 scopus 로고
    • Studies on the chemotherapy of experimental brain tumors: Development of an experimental model
    • Ausman JI, Shapiro WR, Rall DP. Studies on the chemotherapy of experimental brain tumors: development of an experimental model. Cancer Res 1970; 30: 2394-400.
    • (1970) Cancer Res , vol.30 , pp. 2394-2400
    • Ausman, J.I.1    Shapiro, W.R.2    Rall, D.P.3
  • 4
    • 80052642756 scopus 로고    scopus 로고
    • Photothermal treatment of glioma; An in vitro study of macrophage-mediated delivery of gold nanoshells
    • Baek SK, Makkouk AR, Krasieva T, Sun CH, Madsen SJ, Hirschberg H. Photothermal treatment of glioma; an in vitro study of macrophage-mediated delivery of gold nanoshells. J Neurooncol 2011; 104: 439-48.
    • (2011) J Neurooncol , vol.104 , pp. 439-448
    • Baek, S.K.1    Makkouk, A.R.2    Krasieva, T.3    Sun, C.H.4    Madsen, S.J.5    Hirschberg, H.6
  • 5
    • 84964754235 scopus 로고    scopus 로고
    • Time lapse in vivo microscopy reveals distinct dynamics of microglia-tumor environment interactions-A new role for the tumor perivascular space as highway for trafficking microglia
    • Bayerl SH, Niesner R, Cseresnyes Z, Radbruch H, Pohlan J, Brandenburg S, et al. Time lapse in vivo microscopy reveals distinct dynamics of microglia-tumor environment interactions-a new role for the tumor perivascular space as highway for trafficking microglia. Glia 2016; 64: 1210-26.
    • (2016) Glia , vol.64 , pp. 1210-1226
    • Bayerl, S.H.1    Niesner, R.2    Cseresnyes, Z.3    Radbruch, H.4    Pohlan, J.5    Brandenburg, S.6
  • 7
    • 84959378533 scopus 로고    scopus 로고
    • Immunotherapy for cancer in the central nervous system: Current and future directions
    • Binder DC, Davis AA, Wainwright DA. Immunotherapy for cancer in the central nervous system: current and future directions. Oncoimmunology 2016; 5: e1082027.
    • (2016) Oncoimmunology , vol.5 , pp. e1082027
    • Binder, D.C.1    Davis, A.A.2    Wainwright, D.A.3
  • 8
    • 79951602633 scopus 로고    scopus 로고
    • Targeted therapy for high-grade glioma with the TGF-beta2 inhibitor trabedersen: Results of a randomized and controlled phase IIb study
    • Bogdahn U, Hau P, Stockhammer G, Venkataramana NK, Mahapatra AK, Suri A, et al. Targeted therapy for high-grade glioma with the TGF-beta2 inhibitor trabedersen: results of a randomized and controlled phase IIb study. Neuro Oncol 2011; 13: 132-42.
    • (2011) Neuro Oncol , vol.13 , pp. 132-142
    • Bogdahn, U.1    Hau, P.2    Stockhammer, G.3    Venkataramana, N.K.4    Mahapatra, A.K.5    Suri, A.6
  • 9
    • 84958125517 scopus 로고    scopus 로고
    • Resident microglia rather than peripheral macrophages promote vascularization in brain tumors and are source of alternative pro-angiogenic factors
    • Brandenburg S, Muller A, Turkowski K, Radev YT, Rot S, Schmidt C, et al. Resident microglia rather than peripheral macrophages promote vascularization in brain tumors and are source of alternative pro-angiogenic factors. Acta Neuropathol 2016; 131: 365-78.
    • (2016) Acta Neuropathol , vol.131 , pp. 365-378
    • Brandenburg, S.1    Muller, A.2    Turkowski, K.3    Radev, Y.T.4    Rot, S.5    Schmidt, C.6
  • 11
    • 57349153494 scopus 로고    scopus 로고
    • A phase II clinical trial of poly-ICLC with radiation for adult patients with newly diagnosed supratentorial glioblastoma: A North American Brain Tumor Consortium (NABTC01-05)
    • Butowski N, Chang SM, Junck L, DeAngelis LM, Abrey L, Fink K, et al. A phase II clinical trial of poly-ICLC with radiation for adult patients with newly diagnosed supratentorial glioblastoma: a North American Brain Tumor Consortium (NABTC01-05). J Neurooncol 2009; 91: 175-82.
    • (2009) J Neurooncol , vol.91 , pp. 175-182
    • Butowski, N.1    Chang, S.M.2    Junck, L.3    DeAngelis, L.M.4    Abrey, L.5    Fink, K.6
  • 12
    • 84966552295 scopus 로고    scopus 로고
    • Orally administered colony stimulating factor 1 receptor inhibitor PLX3397 in recurrent glioblastoma: An Ivy Foundation Early Phase Clinical Trials Consortium phase II study
    • Butowski N, Colman H, De Groot JF, Omuro AM, Nayak L, Wen PY, et al. Orally administered colony stimulating factor 1 receptor inhibitor PLX3397 in recurrent glioblastoma: an Ivy Foundation Early Phase Clinical Trials Consortium phase II study. Neuro Oncol 2016; 18: 557-64.
    • (2016) Neuro Oncol , vol.18 , pp. 557-564
    • Butowski, N.1    Colman, H.2    De Groot, J.F.3    Omuro, A.M.4    Nayak, L.5    Wen, P.Y.6
  • 14
    • 57249088999 scopus 로고    scopus 로고
    • Modeling CNS microglia: The quest to identify predictive models
    • Carson MJ, Crane J, Xie AX. Modeling CNS microglia: the quest to identify predictive models. Drug Discov Today Dis Models 2008; 5: 19-25.
    • (2008) Drug Discov Today Dis Models , vol.5 , pp. 19-25
    • Carson, M.J.1    Crane, J.2    Xie, A.X.3
  • 15
    • 0035137409 scopus 로고    scopus 로고
    • Phagocytosis of apoptotic inflammatory cells by microglia and modulation by different cytokines: Mechanism for removal of apoptotic cells in the inflamed nervous system
    • Chan A, Magnus T, Gold R. Phagocytosis of apoptotic inflammatory cells by microglia and modulation by different cytokines: mechanism for removal of apoptotic cells in the inflamed nervous system. Glia 2001; 33: 87-95.
    • (2001) Glia , vol.33 , pp. 87-95
    • Chan, A.1    Magnus, T.2    Gold, R.3
  • 17
    • 84917706979 scopus 로고    scopus 로고
    • RAGE expression in tumor-associated macrophages promotes angiogenesis in glioma
    • Chen X, Zhang L, Zhang IY, Liang J, Wang H, Ouyang M, et al. RAGE expression in tumor-associated macrophages promotes angiogenesis in glioma. Cancer Res 2014; 74: 7285-97.
    • (2014) Cancer Res , vol.74 , pp. 7285-7297
    • Chen, X.1    Zhang, L.2    Zhang, I.Y.3    Liang, J.4    Wang, H.5    Ouyang, M.6
  • 18
    • 33846993355 scopus 로고    scopus 로고
    • The in vivo antitumoral effects of lipopolysaccharide against glioblastoma multiforme are mediated in part by Toll-like receptor 4
    • discussion 81
    • Chicoine MR, Zahner M, Won EK, Kalra RR, Kitamura T, Perry A, et al. The in vivo antitumoral effects of lipopolysaccharide against glioblastoma multiforme are mediated in part by Toll-like receptor 4. Neurosurgery 2007; 60: 372-80; discussion 81.
    • (2007) Neurosurgery , vol.60 , pp. 372-380
    • Chicoine, M.R.1    Zahner, M.2    Won, E.K.3    Kalra, R.R.4    Kitamura, T.5    Perry, A.6
  • 19
    • 84865614917 scopus 로고    scopus 로고
    • Microglial stimulation of glioblastoma invasion involves epidermal growth factor receptor (EGFR) and colony stimulating factor 1 receptor (CSF-1R) signaling
    • Coniglio SJ, Eugenin E, Dobrenis K, Stanley ER, West BL, Symons MH, et al. Microglial stimulation of glioblastoma invasion involves epidermal growth factor receptor (EGFR) and colony stimulating factor 1 receptor (CSF-1R) signaling. Mol Med 2012; 18: 519-27.
    • (2012) Mol Med , vol.18 , pp. 519-527
    • Coniglio, S.J.1    Eugenin, E.2    Dobrenis, K.3    Stanley, E.R.4    West, B.L.5    Symons, M.H.6
  • 20
    • 84889095438 scopus 로고    scopus 로고
    • Review: Molecular mechanism of microglia stimulated glioblastoma invasion
    • Coniglio SJ, Segall JE. Review: molecular mechanism of microglia stimulated glioblastoma invasion. Matrix Biol 2013; 32: 372-80.
    • (2013) Matrix Biol , vol.32 , pp. 372-380
    • Coniglio, S.J.1    Segall, J.E.2
  • 21
    • 84891441830 scopus 로고    scopus 로고
    • Microglia and macrophages in malignant gliomas: Recent discoveries and implications for promising therapies
    • da Fonseca AC, Badie B. Microglia and macrophages in malignant gliomas: recent discoveries and implications for promising therapies. Clin Dev Immunol 2013; 2013: 264124.
    • (2013) Clin Dev Immunol , vol.2013 , pp. 264124
    • Da Fonseca, A.C.1    Badie, B.2
  • 22
    • 84960079590 scopus 로고    scopus 로고
    • Comparative genomic and genetic analysis of glioblastomaderived brain tumor-initiating cells and their parent tumors
    • Davis B, Shen Y, Poon CC, Luchman HA, Stechishin OD, Pontifex CS, et al. Comparative genomic and genetic analysis of glioblastomaderived brain tumor-initiating cells and their parent tumors. Neuro Oncol 2016; 18: 350-60.
    • (2016) Neuro Oncol , vol.18 , pp. 350-360
    • Davis, B.1    Shen, Y.2    Poon, C.C.3    Luchman, H.A.4    Stechishin, O.D.5    Pontifex, C.S.6
  • 23
    • 84969651875 scopus 로고    scopus 로고
    • CSF1 overexpression promotes high-grade glioma formation without impacting the polarization status of glioma-associated microglia and macrophages
    • De I, Steffen MD, Clark PA, Patros CJ, Sokn E, Bishop SM, et al. CSF1 overexpression promotes high-grade glioma formation without impacting the polarization status of glioma-associated microglia and macrophages. Cancer Res 2016; 76: 2552-60.
    • (2016) Cancer Res , vol.76 , pp. 2552-2560
    • De, I.1    Steffen, M.D.2    Clark, P.A.3    Patros, C.J.4    Sokn, E.5    Bishop, S.M.6
  • 24
    • 70350525582 scopus 로고    scopus 로고
    • STAT3 regulation of glioblastoma pathogenesis
    • de la Iglesia N, Puram SV, Bonni A. STAT3 regulation of glioblastoma pathogenesis. Curr Mol Med 2009; 9: 580-90.
    • (2009) Curr Mol Med , vol.9 , pp. 580-590
    • De La Iglesia, N.1    Puram, S.V.2    Bonni, A.3
  • 25
    • 49649113879 scopus 로고    scopus 로고
    • Postoperative adjuvant dendritic cell-based immunotherapy in patients with relapsed glioblastoma multiforme
    • De Vleeschouwer S, Fieuws S, Rutkowski S, Van Calenbergh F, Van Loon J, Goffin J, et al. Postoperative adjuvant dendritic cell-based immunotherapy in patients with relapsed glioblastoma multiforme. Clin Cancer Res 2008; 14: 3098-104.
    • (2008) Clin Cancer Res , vol.14 , pp. 3098-3104
    • De Vleeschouwer, S.1    Fieuws, S.2    Rutkowski, S.3    Van Calenbergh, F.4    Van Loon, J.5    Goffin, J.6
  • 26
    • 84943381229 scopus 로고    scopus 로고
    • Glioblastoma-derived extracellular vesicles modify the phenotype of monocytic cells
    • de Vrij J, Maas SL, Kwappenberg KM, Schnoor R, Kleijn A, Dekker L, et al. Glioblastoma-derived extracellular vesicles modify the phenotype of monocytic cells. Int J Cancer 2015; 137: 1630-42.
    • (2015) Int J Cancer , vol.137 , pp. 1630-1642
    • De Vrij, J.1    Maas, S.L.2    Kwappenberg, K.M.3    Schnoor, R.4    Kleijn, A.5    Dekker, L.6
  • 27
    • 0347302952 scopus 로고    scopus 로고
    • Cytokines in cancer pathogenesis and cancer therapy
    • Dranoff G. Cytokines in cancer pathogenesis and cancer therapy. Nat Rev Cancer 2004; 4: 11-22.
    • (2004) Nat Rev Cancer , vol.4 , pp. 11-22
    • Dranoff, G.1
  • 28
    • 84898676953 scopus 로고    scopus 로고
    • Colony-stimulating factor 1 receptor signaling is necessary for microglia viability, unmasking a microglia progenitor cell in the adult brain
    • Elmore MR, Najafi AR, Koike MA, Dagher NN, Spangenberg EE, Rice RA, et al. Colony-stimulating factor 1 receptor signaling is necessary for microglia viability, unmasking a microglia progenitor cell in the adult brain. Neuron 2014; 82: 380-97.
    • (2014) Neuron , vol.82 , pp. 380-397
    • Elmore, M.R.1    Najafi, A.R.2    Koike, M.A.3    Dagher, N.N.4    Spangenberg, E.E.5    Rice, R.A.6
  • 29
    • 80055051144 scopus 로고    scopus 로고
    • Absence of colony stimulation factor-1 receptor results in loss of microglia, disrupted brain development and olfactory deficits
    • Erblich B, Zhu L, Etgen AM, Dobrenis K, Pollard JW. Absence of colony stimulation factor-1 receptor results in loss of microglia, disrupted brain development and olfactory deficits. PloS One 2011; 6: e26317.
    • (2011) PloS One , vol.6 , pp. e26317
    • Erblich, B.1    Zhu, L.2    Etgen, A.M.3    Dobrenis, K.4    Pollard, J.W.5
  • 30
    • 0033178679 scopus 로고    scopus 로고
    • Loss of CCR2 expression and functional response to monocyte chemotactic protein (MCP-1) during the differentiation of human monocytes: Role of secreted MCP-1 in the regulation of the chemotactic response
    • Fantuzzi L, Borghi P, Ciolli V, Pavlakis G, Belardelli F, Gessani S. Loss of CCR2 expression and functional response to monocyte chemotactic protein (MCP-1) during the differentiation of human monocytes: role of secreted MCP-1 in the regulation of the chemotactic response. Blood 1999; 94: 875-83.
    • (1999) Blood , vol.94 , pp. 875-883
    • Fantuzzi, L.1    Borghi, P.2    Ciolli, V.3    Pavlakis, G.4    Belardelli, F.5    Gessani, S.6
  • 31
    • 0036849437 scopus 로고    scopus 로고
    • Vascular endothelial growth factor induces chemotaxis and proliferation of microglial cells
    • Forstreuter F, Lucius R, Mentlein R. Vascular endothelial growth factor induces chemotaxis and proliferation of microglial cells. J Neuroimmunol 2002; 132: 93-8.
    • (2002) J Neuroimmunol , vol.132 , pp. 93-98
    • Forstreuter, F.1    Lucius, R.2    Mentlein, R.3
  • 32
    • 84955178929 scopus 로고    scopus 로고
    • Limited advances in therapy of glioblastoma trigger re-consideration of research policy
    • Frosina G. Limited advances in therapy of glioblastoma trigger re-consideration of research policy. Crit Rev Oncol Hematol 2015; 96: 257-61.
    • (2015) Crit Rev Oncol Hematol , vol.96 , pp. 257-261
    • Frosina, G.1
  • 33
    • 80053516019 scopus 로고    scopus 로고
    • Oleanolic acid inhibits macrophage differentiation into the M2 phenotype and glioblastoma cell proliferation by suppressing the activation of STAT3
    • Fujiwara Y, Komohara Y, Kudo R, Tsurushima K, Ohnishi K, Ikeda T, et al. Oleanolic acid inhibits macrophage differentiation into the M2 phenotype and glioblastoma cell proliferation by suppressing the activation of STAT3. Oncol Rep 2011; 26: 1533-7.
    • (2011) Oncol Rep , vol.26 , pp. 1533-1537
    • Fujiwara, Y.1    Komohara, Y.2    Kudo, R.3    Tsurushima, K.4    Ohnishi, K.5    Ikeda, T.6
  • 36
    • 84966642499 scopus 로고    scopus 로고
    • MIF-CD74 signaling impedes microglial M1 polarization and facilitates brain tumorigenesis
    • Ghoochani A, Schwarz MA, Yakubov E, Engelhorn T, Doerfler A, Buchfelder M, et al. MIF-CD74 signaling impedes microglial M1 polarization and facilitates brain tumorigenesis. Oncogene 2016; 35: 6246-61.
    • (2016) Oncogene , vol.35 , pp. 6246-6261
    • Ghoochani, A.1    Schwarz, M.A.2    Yakubov, E.3    Engelhorn, T.4    Doerfler, A.5    Buchfelder, M.6
  • 37
    • 78149360132 scopus 로고    scopus 로고
    • Fate mapping analysis reveals that adult microglia derive from primitive macrophages
    • Ginhoux F, Greter M, Leboeuf M, Nandi S, See P, Gokhan S, et al. Fate mapping analysis reveals that adult microglia derive from primitive macrophages. Science 2010; 330: 841-5.
    • (2010) Science , vol.330 , pp. 841-845
    • Ginhoux, F.1    Greter, M.2    Leboeuf, M.3    Nandi, S.4    See, P.5    Gokhan, S.6
  • 39
    • 84925465211 scopus 로고    scopus 로고
    • Tissue-resident macrophages originate from yolksac-derived erythro-myeloid progenitors
    • Gomez Perdiguero E, Klapproth K, Schulz C, Busch K, Azzoni E, Crozet L, et al. Tissue-resident macrophages originate from yolksac-derived erythro-myeloid progenitors. Nature 2015; 518: 547-51.
    • (2015) Nature , vol.518 , pp. 547-551
    • Gomez Perdiguero, E.1    Klapproth, K.2    Schulz, C.3    Busch, K.4    Azzoni, E.5    Crozet, L.6
  • 40
    • 0037265240 scopus 로고    scopus 로고
    • Alternative activation of macrophages
    • Gordon S. Alternative activation of macrophages. Nat Rev Immunol 2003; 3: 23-35.
    • (2003) Nat Rev Immunol , vol.3 , pp. 23-35
    • Gordon, S.1
  • 41
    • 33749189084 scopus 로고    scopus 로고
    • Phase II trial of temozolomide plus marimastat for recurrent anaplastic gliomas: A relationship among efficacy, joint toxicity and anticonvulsant status
    • Groves MD, Puduvalli VK, Conrad CA, Gilbert MR, Yung WK, Jaeckle K, et al. Phase II trial of temozolomide plus marimastat for recurrent anaplastic gliomas: a relationship among efficacy, joint toxicity and anticonvulsant status. J Neurooncol 2006; 80: 83-90.
    • (2006) J Neurooncol , vol.80 , pp. 83-90
    • Groves, M.D.1    Puduvalli, V.K.2    Conrad, C.A.3    Gilbert, M.R.4    Yung, W.K.5    Jaeckle, K.6
  • 42
    • 14644399862 scopus 로고    scopus 로고
    • Up-regulation of angiopoietin-2, matrix metalloprotease-2, membrane type 1 metalloprotease, and laminin 5 gamma 2 correlates with the invasiveness of human glioma
    • Guo P, Imanishi Y, Cackowski FC, Jarzynka MJ, Tao HQ, Nishikawa R, et al. Up-regulation of angiopoietin-2, matrix metalloprotease-2, membrane type 1 metalloprotease, and laminin 5 gamma 2 correlates with the invasiveness of human glioma. Am J Pathol 2005; 166: 877-90.
    • (2005) Am J Pathol , vol.166 , pp. 877-890
    • Guo, P.1    Imanishi, Y.2    Cackowski, F.C.3    Jarzynka, M.J.4    Tao, H.Q.5    Nishikawa, R.6
  • 43
    • 84957810905 scopus 로고    scopus 로고
    • Glioblastoma: Defining tumor niches
    • Hambardzumyan D, Bergers G. Glioblastoma: defining tumor niches. Trends Cancer 2015; 1: 252-65.
    • (2015) Trends Cancer , vol.1 , pp. 252-265
    • Hambardzumyan, D.1    Bergers, G.2
  • 44
    • 84953747412 scopus 로고    scopus 로고
    • The role of microglia and macrophages in glioma maintenance and progression
    • Hambardzumyan D, Gutmann DH, Kettenmann H. The role of microglia and macrophages in glioma maintenance and progression. Nat Neurosci 2016; 19: 20-7.
    • (2016) Nat Neurosci , vol.19 , pp. 20-27
    • Hambardzumyan, D.1    Gutmann, D.H.2    Kettenmann, H.3
  • 45
    • 0036849018 scopus 로고    scopus 로고
    • Microglia as a source and target of cytokines
    • Hanisch UK. Microglia as a source and target of cytokines. Glia 2002; 40: 140-55.
    • (2002) Glia , vol.40 , pp. 140-155
    • Hanisch, U.K.1
  • 46
    • 0036935383 scopus 로고    scopus 로고
    • Cytokine and cytokine receptor mRNA expression in human glioblastomas: Evidence of Th1, Th2 and Th3 cytokine dysregulation
    • Hao C, Parney IF, Roa WH, Turner J, Petruk KC, Ramsay DA. Cytokine and cytokine receptor mRNA expression in human glioblastomas: evidence of Th1, Th2 and Th3 cytokine dysregulation. Acta Neuropathol 2002; 103: 171-8.
    • (2002) Acta Neuropathol , vol.103 , pp. 171-178
    • Hao, C.1    Parney, I.F.2    Roa, W.H.3    Turner, J.4    Petruk, K.C.5    Ramsay, D.A.6
  • 48
    • 20044376483 scopus 로고    scopus 로고
    • Experimental autoimmune encephalomyelitis repressed by microglial paralysis
    • Heppner FL, Greter M, Marino D, Falsig J, Raivich G, Hovelmeyer N, et al. Experimental autoimmune encephalomyelitis repressed by microglial paralysis. Nat Med 2005; 11: 146-52.
    • (2005) Nat Med , vol.11 , pp. 146-152
    • Heppner, F.L.1    Greter, M.2    Marino, D.3    Falsig, J.4    Raivich, G.5    Hovelmeyer, N.6
  • 51
    • 0032418416 scopus 로고    scopus 로고
    • A constitutively active epidermal growth factor receptor cooperates with disruption of G1 cell-cycle arrest pathways to induce glioma-like lesions in mice
    • Holland EC, Hively WP, DePinho RA, Varmus HE. A constitutively active epidermal growth factor receptor cooperates with disruption of G1 cell-cycle arrest pathways to induce glioma-like lesions in mice. Genes Dev 1998; 12: 3675-85.
    • (1998) Genes Dev , vol.12 , pp. 3675-3685
    • Holland, E.C.1    Hively, W.P.2    DePinho, R.A.3    Varmus, H.E.4
  • 52
    • 53149124406 scopus 로고    scopus 로고
    • Differential migration, LPS-induced cytokine, chemokine, and NO expression in immortalized BV-2 and HAPI cell lines and primary microglial cultures
    • Horvath RJ, Nutile-McMenemy N, Alkaitis MS, Deleo JA. Differential migration, LPS-induced cytokine, chemokine, and NO expression in immortalized BV-2 and HAPI cell lines and primary microglial cultures. J Neurochem 2008; 107: 557-69.
    • (2008) J Neurochem , vol.107 , pp. 557-569
    • Horvath, R.J.1    Nutile-McMenemy, N.2    Alkaitis, M.S.3    Deleo, J.A.4
  • 54
    • 35448979864 scopus 로고    scopus 로고
    • A novel small molecule inhibitor of signal transducers and activators of transcription 3 reverses immune tolerance in malignant glioma patients
    • Hussain SF, Kong LY, Jordan J, Conrad C, Madden T, Fokt I, et al. A novel small molecule inhibitor of signal transducers and activators of transcription 3 reverses immune tolerance in malignant glioma patients. Cancer Res 2007; 67: 9630-6.
    • (2007) Cancer Res , vol.67 , pp. 9630-9636
    • Hussain, S.F.1    Kong, L.Y.2    Jordan, J.3    Conrad, C.4    Madden, T.5    Fokt, I.6
  • 55
    • 33748532939 scopus 로고    scopus 로고
    • The role of human glioma-infiltrating microglia/macrophages in mediating antitumor immune responses
    • Hussain SF, Yang D, Suki D, Aldape K, Grimm E, Heimberger AB. The role of human glioma-infiltrating microglia/macrophages in mediating antitumor immune responses. Neuro Oncol 2006; 8: 261-79.
    • (2006) Neuro Oncol , vol.8 , pp. 261-279
    • Hussain, S.F.1    Yang, D.2    Suki, D.3    Aldape, K.4    Grimm, E.5    Heimberger, A.B.6
  • 56
    • 71749096751 scopus 로고    scopus 로고
    • Induction of glioma apoptosis by microglia-secreted molecules: The role of nitric oxide and cathepsin B
    • Hwang SY, Yoo BC, Jung JW, Oh ES, Hwang JS, Shin JA, et al. Induction of glioma apoptosis by microglia-secreted molecules: the role of nitric oxide and cathepsin B. Biochim Biophys Acta 2009; 1793: 1656-68.
    • (2009) Biochim Biophys Acta , vol.1793 , pp. 1656-1668
    • Hwang, S.Y.1    Yoo, B.C.2    Jung, J.W.3    Oh, E.S.4    Hwang, J.S.5    Shin, J.A.6
  • 57
    • 0036849026 scopus 로고    scopus 로고
    • Intracellular signaling in M-CSF-induced microglia activation: Role of Iba1
    • Imai Y, Kohsaka S. Intracellular signaling in M-CSF-induced microglia activation: role of Iba1. Glia 2002; 40: 164-74.
    • (2002) Glia , vol.40 , pp. 164-174
    • Imai, Y.1    Kohsaka, S.2
  • 58
    • 84859518369 scopus 로고    scopus 로고
    • Propentofylline decreases tumor growth in a rodent model of glioblastoma multiforme by a direct mechanism on microglia
    • Jacobs VL, Landry RP, Liu Y, Romero-Sandoval EA, De Leo JA. Propentofylline decreases tumor growth in a rodent model of glioblastoma multiforme by a direct mechanism on microglia. Neuro Oncol 2012a; 14: 119-31.
    • (2012) Neuro Oncol , vol.14 , pp. 119-131
    • Jacobs, V.L.1    Landry, R.P.2    Liu, Y.3    Romero-Sandoval, E.A.4    De Leo, J.A.5
  • 59
    • 84861395022 scopus 로고    scopus 로고
    • Propentofylline targets TROY, a novel microglial signaling pathway
    • Jacobs VL, Liu Y, De Leo JA. Propentofylline targets TROY, a novel microglial signaling pathway. PLoS One 2012b; 7: e37955.
    • (2012) PLoS One , vol.7 , pp. e37955
    • Jacobs, V.L.1    Liu, Y.2    De Leo, J.A.3
  • 60
    • 80052979540 scopus 로고    scopus 로고
    • Current review of in vivo GBM rodent models: Emphasis on the CNS-1 tumour model
    • Jacobs VL, Valdes PA, Hickey WF, De Leo JA. Current review of in vivo GBM rodent models: emphasis on the CNS-1 tumour model. ASN Neuro 2011; 3: e00063.
    • (2011) ASN Neuro , vol.3 , pp. e00063
    • Jacobs, V.L.1    Valdes, P.A.2    Hickey, W.F.3    De Leo, J.A.4
  • 63
    • 84856292648 scopus 로고    scopus 로고
    • Microglia isolated from patients with glioma gain antitumor activities on poly (I:C) stimulation
    • Kees T, Lohr J, Noack J, Mora R, Gdynia G, Todt G, et al. Microglia isolated from patients with glioma gain antitumor activities on poly (I:C) stimulation. Neuro Oncol 2012; 14: 64-78.
    • (2012) Neuro Oncol , vol.14 , pp. 64-78
    • Kees, T.1    Lohr, J.2    Noack, J.3    Mora, R.4    Gdynia, G.5    Todt, G.6
  • 66
    • 84964402874 scopus 로고    scopus 로고
    • Ang-2/VEGF bispecific antibody reprograms macrophages and resident microglia to anti-tumor phenotype and prolongs glioblastoma survival
    • Kloepper J, Riedemann L, Amoozgar Z, Seano G, Susek K, Yu V, et al. Ang-2/VEGF bispecific antibody reprograms macrophages and resident microglia to anti-tumor phenotype and prolongs glioblastoma survival. Proc Natl Acad Sci USA 2016; 113: 4476-81.
    • (2016) Proc Natl Acad Sci USA , vol.113 , pp. 4476-4481
    • Kloepper, J.1    Riedemann, L.2    Amoozgar, Z.3    Seano, G.4    Susek, K.5    Yu, V.6
  • 67
    • 84870657385 scopus 로고    scopus 로고
    • Importance of direct macrophage-tumor cell interaction on progression of human glioma
    • Komohara Y, Horlad H, Ohnishi K, Fujiwara Y, Bai B, Nakagawa T, et al. Importance of direct macrophage-tumor cell interaction on progression of human glioma. Cancer Sci 2012; 103: 2165-72.
    • (2012) Cancer Sci , vol.103 , pp. 2165-2172
    • Komohara, Y.1    Horlad, H.2    Ohnishi, K.3    Fujiwara, Y.4    Bai, B.5    Nakagawa, T.6
  • 68
    • 50249144131 scopus 로고    scopus 로고
    • Possible involvement of the M2 anti-inflammatory macrophage phenotype in growth of human gliomas
    • Komohara Y, Ohnishi K, Kuratsu J, Takeya M. Possible involvement of the M2 anti-inflammatory macrophage phenotype in growth of human gliomas. J Pathol 2008; 216: 15-24.
    • (2008) J Pathol , vol.216 , pp. 15-24
    • Komohara, Y.1    Ohnishi, K.2    Kuratsu, J.3    Takeya, M.4
  • 69
    • 28644445445 scopus 로고    scopus 로고
    • Inhibiting Stat3 signaling in the hematopoietic system elicits multicomponent antitumor immunity
    • Kortylewski M, Kujawski M, Wang T, Wei S, Zhang S, Pilon-Thomas S, et al. Inhibiting Stat3 signaling in the hematopoietic system elicits multicomponent antitumor immunity. Nat Med 2005; 11: 1314-21.
    • (2005) Nat Med , vol.11 , pp. 1314-1321
    • Kortylewski, M.1    Kujawski, M.2    Wang, T.3    Wei, S.4    Zhang, S.5    Pilon-Thomas, S.6
  • 71
    • 44849089702 scopus 로고    scopus 로고
    • Pten haploinsufficiency accelerates formation of high-grade astrocytomas
    • Kwon CH, Zhao D, Chen J, Alcantara S, Li Y, Burns DK, et al. Pten haploinsufficiency accelerates formation of high-grade astrocytomas. Cancer Res 2008; 68: 3286-94.
    • (2008) Cancer Res , vol.68 , pp. 3286-3294
    • Kwon, C.H.1    Zhao, D.2    Chen, J.3    Alcantara, S.4    Li, Y.5    Burns, D.K.6
  • 72
    • 84928891810 scopus 로고    scopus 로고
    • Thrombinprocessed Ecrg4 recruits myeloid cells and induces antitumorigenic inflammation
    • Lee J, Dang X, Borboa A, Coimbra R, Baird A, Eliceiri BP. Thrombinprocessed Ecrg4 recruits myeloid cells and induces antitumorigenic inflammation. Neuro Oncol 2015; 17: 685-96.
    • (2015) Neuro Oncol , vol.17 , pp. 685-696
    • Lee, J.1    Dang, X.2    Borboa, A.3    Coimbra, R.4    Baird, A.5    Eliceiri, B.P.6
  • 73
    • 0031944290 scopus 로고    scopus 로고
    • Regulation of immune responses by TGF-beta
    • Letterio JJ, Roberts AB. Regulation of immune responses by TGF-beta. Ann Rev Immunol 1998; 16: 137-61.
    • (1998) Ann Rev Immunol , vol.16 , pp. 137-161
    • Letterio, J.J.1    Roberts, A.B.2
  • 74
    • 0030951515 scopus 로고    scopus 로고
    • Monocyte chemoattractant protein-1 expression and macrophage infiltration in gliomas
    • Leung SY, Wong MP, Chung LP, Chan AS, Yuen ST. Monocyte chemoattractant protein-1 expression and macrophage infiltration in gliomas. Acta Neuropathol 1997; 93: 518-27.
    • (1997) Acta Neuropathol , vol.93 , pp. 518-527
    • Leung, S.Y.1    Wong, M.P.2    Chung, L.P.3    Chan, A.S.4    Yuen, S.T.5
  • 75
    • 84864709456 scopus 로고    scopus 로고
    • The molecular profile of microglia under the influence of glioma
    • Li W, Graeber MB. The molecular profile of microglia under the influence of glioma. Neuro Oncol 2012; 14: 958-78.
    • (2012) Neuro Oncol , vol.14 , pp. 958-978
    • Li, W.1    Graeber, M.B.2
  • 77
    • 33845684545 scopus 로고    scopus 로고
    • TGF-beta2 inhibition augments the effect of tumor vaccine and improves the survival of animals with pre-established brain tumors
    • Liu Y, Wang Q, Kleinschmidt-DeMasters BK, Franzusoff A, Ng KY, Lillehei KO. TGF-beta2 inhibition augments the effect of tumor vaccine and improves the survival of animals with pre-established brain tumors. J Neuro Oncol 2007; 81: 149-62.
    • (2007) J Neuro Oncol , vol.81 , pp. 149-162
    • Liu, Y.1    Wang, Q.2    Kleinschmidt-DeMasters, B.K.3    Franzusoff, A.4    Ng, K.Y.5    Lillehei, K.O.6
  • 78
    • 84875928941 scopus 로고    scopus 로고
    • Microglia and monocyte-derived macrophages: Functionally distinct populations that act in concert in CNS plasticity and repair
    • London A, Cohen M, Schwartz M. Microglia and monocyte-derived macrophages: functionally distinct populations that act in concert in CNS plasticity and repair. Front Cell Neurosci 2013; 7: 34.
    • (2013) Front Cell Neurosci , vol.7 , pp. 34
    • London, A.1    Cohen, M.2    Schwartz, M.3
  • 79
    • 84880667542 scopus 로고    scopus 로고
    • Increase in tumor-associated macrophages after antiangiogenic therapy is associated with poor survival among patients with recurrent glioblastoma
    • Lu-Emerson C, Snuderl M, Kirkpatrick ND, Goveia J, Davidson C, Huang Y, et al. Increase in tumor-associated macrophages after antiangiogenic therapy is associated with poor survival among patients with recurrent glioblastoma. Neuro Oncol 2013; 15: 1079-87.
    • (2013) Neuro Oncol , vol.15 , pp. 1079-1087
    • Lu-Emerson, C.1    Snuderl, M.2    Kirkpatrick, N.D.3    Goveia, J.4    Davidson, C.5    Huang, Y.6
  • 80
    • 84879005716 scopus 로고    scopus 로고
    • The role of Stat3 in glioblastoma multiforme
    • Luwor RB, Stylli SS, Kaye AH. The role of Stat3 in glioblastoma multiforme. J Clin Neurosci 2013; 20: 907-11.
    • (2013) J Clin Neurosci , vol.20 , pp. 907-911
    • Luwor, R.B.1    Stylli, S.S.2    Kaye, A.H.3
  • 81
    • 73849167296 scopus 로고
    • Cellular resistance to infection
    • Mackaness GB. Cellular resistance to infection. J Exp Med 1962; 116: 381-406.
    • (1962) J Exp Med , vol.116 , pp. 381-406
    • Mackaness, G.B.1
  • 82
    • 79151475507 scopus 로고    scopus 로고
    • Experimental immunotherapy for malignant glioma: Lessons from two decades of research in the GL261 model
    • Maes W, Van Gool SW. Experimental immunotherapy for malignant glioma: lessons from two decades of research in the GL261 model. Cancer Immunol Immunother 2011; 60: 153-60.
    • (2011) Cancer Immunol Immunother , vol.60 , pp. 153-160
    • Maes, W.1    Van Gool, S.W.2
  • 84
    • 24644490056 scopus 로고    scopus 로고
    • Microglia stimulate the invasiveness of glioma cells by increasing the activity of metalloprotease-2
    • Markovic DS, Glass R, Synowitz M, Rooijen N, Kettenmann H. Microglia stimulate the invasiveness of glioma cells by increasing the activity of metalloprotease-2. J Neuropathol Exp Neurol 2005; 64: 754-62.
    • (2005) J Neuropathol Exp Neurol , vol.64 , pp. 754-762
    • Markovic, D.S.1    Glass, R.2    Synowitz, M.3    Rooijen, N.4    Kettenmann, H.5
  • 86
    • 84897556094 scopus 로고    scopus 로고
    • The M1 and M2 paradigm of macrophage activation: Time for reassessment
    • Martinez FO, Gordon S. The M1 and M2 paradigm of macrophage activation: time for reassessment. F1000Prime Rep 2014; 6: 13.
    • (2014) F1000Prime Rep , vol.6 , pp. 13
    • Martinez, F.O.1    Gordon, S.2
  • 87
    • 67650485985 scopus 로고    scopus 로고
    • Alternative activation of macrophages: An immunologic functional perspective
    • Martinez FO, Helming L, Gordon S. Alternative activation of macrophages: an immunologic functional perspective. Annu Rev Immunol 2009; 27: 451-83.
    • (2009) Annu Rev Immunol , vol.27 , pp. 451-483
    • Martinez, F.O.1    Helming, L.2    Gordon, S.3
  • 89
    • 0026708995 scopus 로고
    • CD11b (Mac-1): A marker for CD8+ cytotoxic T cell activation and memory in virus infection
    • McFarland HI, Nahill SR, Maciaszek JW, Welsh RM. CD11b (Mac-1): a marker for CD8+ cytotoxic T cell activation and memory in virus infection. J Immunol 1992; 149: 1326-33.
    • (1992) J Immunol , vol.149 , pp. 1326-1333
    • McFarland, H.I.1    Nahill, S.R.2    Maciaszek, J.W.3    Welsh, R.M.4
  • 90
    • 84962268586 scopus 로고    scopus 로고
    • Targeting CXCR4 by a selective peptide antagonist modulates tumor microenvironment and microglia reactivity in a human glioblastoma model
    • Mercurio L, Ajmone-Cat MA, Cecchetti S, Ricci A, Bozzuto G, Molinari A, et al. Targeting CXCR4 by a selective peptide antagonist modulates tumor microenvironment and microglia reactivity in a human glioblastoma model. J Exp Clin Cancer Res 2016; 35: 55.
    • (2016) J Exp Clin Cancer Res , vol.35 , pp. 55
    • Mercurio, L.1    Ajmone-Cat, M.A.2    Cecchetti, S.3    Ricci, A.4    Bozzuto, G.5    Molinari, A.6
  • 92
    • 67349251479 scopus 로고    scopus 로고
    • Characterization of the microglial phenotype under specific pro-inflammatory and anti-inflammatory conditions: Effects of oligomeric and fibrillar amyloid-beta
    • Michelucci A, Heurtaux T, Grandbarbe L, Morga E, Heuschling P. Characterization of the microglial phenotype under specific pro-inflammatory and anti-inflammatory conditions: effects of oligomeric and fibrillar amyloid-beta. J Neuroimmunol 2009; 210: 3-12.
    • (2009) J Neuroimmunol , vol.210 , pp. 3-12
    • Michelucci, A.1    Heurtaux, T.2    Grandbarbe, L.3    Morga, E.4    Heuschling, P.5
  • 93
    • 84946025187 scopus 로고    scopus 로고
    • Down-regulation of IKKbeta expression in glioma-infiltrating microglia/macrophages is associated with defective inflammatory/immune gene responses in glioblastoma
    • Mieczkowski J, Kocyk M, Nauman P, Gabrusiewicz K, Sielska M, Przanowski P, et al. Down-regulation of IKKbeta expression in glioma-infiltrating microglia/macrophages is associated with defective inflammatory/immune gene responses in glioblastoma. Oncotarget 2015; 6: 33077-90.
    • (2015) Oncotarget , vol.6 , pp. 33077-33090
    • Mieczkowski, J.1    Kocyk, M.2    Nauman, P.3    Gabrusiewicz, K.4    Sielska, M.5    Przanowski, P.6
  • 94
    • 84963614964 scopus 로고    scopus 로고
    • A reappraisal of macrophage polarization in glioblastoma: Histopathological and immunohistochemical findings and review of the literature
    • Mignogna C, Signorelli F, Vismara MF, Zeppa P, Camastra C, Barni T, et al. A reappraisal of macrophage polarization in glioblastoma: histopathological and immunohistochemical findings and review of the literature. Pathol Res Pract 2016; 212: 491-9.
    • (2016) Pathol Res Pract , vol.212 , pp. 491-499
    • Mignogna, C.1    Signorelli, F.2    Vismara, M.F.3    Zeppa, P.4    Camastra, C.5    Barni, T.6
  • 96
    • 65249134734 scopus 로고    scopus 로고
    • TNF-alpha-and TRAIL-resistant glioma cells undergo autophagydependent cell death induced by activated microglia
    • Mora R, Abschuetz A, Kees T, Dokic I, Joschko N, Kleber S, et al. TNF-alpha-and TRAIL-resistant glioma cells undergo autophagydependent cell death induced by activated microglia. Glia 2009; 57: 561-81.
    • (2009) Glia , vol.57 , pp. 561-581
    • Mora, R.1    Abschuetz, A.2    Kees, T.3    Dokic, I.4    Joschko, N.5    Kleber, S.6
  • 97
    • 0018355350 scopus 로고
    • Macrophages in experimental and human brain tumors Part 2: Studies of the macrophage content of human brain tumors
    • Morantz RA, Wood GW, Foster M, Clark M, Gollahon K. Macrophages in experimental and human brain tumors. Part 2: studies of the macrophage content of human brain tumors. J Neurosurg 1979; 50: 305-11.
    • (1979) J Neurosurg , vol.50 , pp. 305-311
    • Morantz, R.A.1    Wood, G.W.2    Foster, M.3    Clark, M.4    Gollahon, K.5
  • 98
    • 84929258477 scopus 로고    scopus 로고
    • Resident microglia, and not peripheral macrophages, are the main source of brain tumor mononuclear cells
    • Muller A, Brandenburg S, Turkowski K, Muller S, Vajkoczy P. Resident microglia, and not peripheral macrophages, are the main source of brain tumor mononuclear cells. Int J Cancer 2015; 137: 278-88.
    • (2015) Int J Cancer , vol.137 , pp. 278-288
    • Muller, A.1    Brandenburg, S.2    Turkowski, K.3    Muller, S.4    Vajkoczy, P.5
  • 99
    • 0042839756 scopus 로고    scopus 로고
    • Vascular endothelial growth factor expression correlates with matrix metalloproteinases MT1-MMP, MMP-2 and MMP-9 in human glioblastomas
    • Munaut C, Noel A, Hougrand O, Foidart JM, Boniver J, Deprez M. Vascular endothelial growth factor expression correlates with matrix metalloproteinases MT1-MMP, MMP-2 and MMP-9 in human glioblastomas. Int J Cancer 2003; 106: 848-55.
    • (2003) Int J Cancer , vol.106 , pp. 848-855
    • Munaut, C.1    Noel, A.2    Hougrand, O.3    Foidart, J.M.4    Boniver, J.5    Deprez, M.6
  • 100
    • 34247890112 scopus 로고    scopus 로고
    • TNF expressed by tumor-associated macrophages, but not microglia, can eliminate glioma
    • Nakagawa J, Saio M, Tamakawa N, Suwa T, Frey AB, Nonaka K, et al. TNF expressed by tumor-associated macrophages, but not microglia, can eliminate glioma. Intl J Oncol 2007; 30: 803-11.
    • (2007) Intl J Oncol , vol.30 , pp. 803-811
    • Nakagawa, J.1    Saio, M.2    Tamakawa, N.3    Suwa, T.4    Frey, A.B.5    Nonaka, K.6
  • 101
    • 0020502358 scopus 로고
    • Identification of interferon-gamma as the lymphokine that activates human macrophage oxidative metabolism and antimicrobial activity
    • Nathan CF, Murray HW, Wiebe ME, Rubin BY. Identification of interferon-gamma as the lymphokine that activates human macrophage oxidative metabolism and antimicrobial activity. J Exp Med 1983; 158: 670-89.
    • (1983) J Exp Med , vol.158 , pp. 670-689
    • Nathan, C.F.1    Murray, H.W.2    Wiebe, M.E.3    Rubin, B.Y.4
  • 102
    • 84942906491 scopus 로고    scopus 로고
    • Glioblastoma-derived Macrophage Colony-stimulating Factor (MCSF) Induces Microglial Release of Insulin-like Growth Factorbinding Protein 1 (IGFBP1) to promote angiogenesis
    • Nijaguna MB, Patil V, Urbach S, Shwetha SD, Sravani K, Hegde AS, et al. Glioblastoma-derived Macrophage Colony-stimulating Factor (MCSF) Induces Microglial Release of Insulin-like Growth Factorbinding Protein 1 (IGFBP1) to promote angiogenesis. J Biol Chem 2015; 290: 23401-15.
    • (2015) J Biol Chem , vol.290 , pp. 23401-23415
    • Nijaguna, M.B.1    Patil, V.2    Urbach, S.3    Shwetha, S.D.4    Sravani, K.5    Hegde, A.S.6
  • 104
    • 67649448823 scopus 로고    scopus 로고
    • Tumor-associated macrophage/microglia infiltration in human gliomas is correlated with MCP-3, but not MCP-1
    • Okada M, Saio M, Kito Y, Ohe N, Yano H, Yoshimura S, et al. Tumor-associated macrophage/microglia infiltration in human gliomas is correlated with MCP-3, but not MCP-1. Int J Oncol 2009; 34: 1621-7.
    • (2009) Int J Oncol , vol.34 , pp. 1621-1627
    • Okada, M.1    Saio, M.2    Kito, Y.3    Ohe, N.4    Yano, H.5    Yoshimura, S.6
  • 106
    • 84864464545 scopus 로고    scopus 로고
    • Immune surveillance in the central nervous system
    • Ousman SS, Kubes P. Immune surveillance in the central nervous system. Nat Neurosci 2012; 15: 1096-101.
    • (2012) Nat Neurosci , vol.15 , pp. 1096-1101
    • Ousman, S.S.1    Kubes, P.2
  • 107
    • 63849335831 scopus 로고    scopus 로고
    • Flow cytometry and in vitro analysis of human glioma-associated macrophages Laboratory investigation
    • Parney IF, Waldron JS, Parsa AT. Flow cytometry and in vitro analysis of human glioma-associated macrophages. Laboratory investigation. J Neurosurg 2009; 110: 572-82.
    • (2009) J Neurosurg , vol.110 , pp. 572-582
    • Parney, I.F.1    Waldron, J.S.2    Parsa, A.T.3
  • 108
    • 0028903703 scopus 로고
    • Effects of transforming growth factorbeta 1 on collagen synthesis, integrin expression, adhesion and invasion of glioma cells
    • Paulus W, Baur I, Huettner C, Schmausser B, Roggendorf W, Schlingensiepen KH, et al. Effects of transforming growth factorbeta 1 on collagen synthesis, integrin expression, adhesion and invasion of glioma cells. J Neuropathol Exp Neurol 1995; 54: 236-44.
    • (1995) J Neuropathol Exp Neurol , vol.54 , pp. 236-244
    • Paulus, W.1    Baur, I.2    Huettner, C.3    Schmausser, B.4    Roggendorf, W.5    Schlingensiepen, K.H.6
  • 109
    • 84957661931 scopus 로고    scopus 로고
    • HDAC7 inhibition resets STAT3 tumorigenic activity in human glioblastoma independently of EGFR and PTEN: New opportunities for selected targeted therapies
    • Peixoto P, Blomme A, Costanza B, Ronca R, Rezzola S, Palacios AP, et al. HDAC7 inhibition resets STAT3 tumorigenic activity in human glioblastoma independently of EGFR and PTEN: new opportunities for selected targeted therapies. Oncogene 2016; 35: 4481-94.
    • (2016) Oncogene , vol.35 , pp. 4481-4494
    • Peixoto, P.1    Blomme, A.2    Costanza, B.3    Ronca, R.4    Rezzola, S.5    Palacios, A.P.6
  • 110
    • 63249123273 scopus 로고    scopus 로고
    • TGF-beta increases glioma-initiating cell self-renewal through the induction of LIF in human glioblastoma
    • Penuelas S, Anido J, Prieto-Sanchez RM, Folch G, Barba I, Cuartas I, et al. TGF-beta increases glioma-initiating cell self-renewal through the induction of LIF in human glioblastoma. Cancer Cell 2009; 15: 315-27.
    • (2009) Cancer Cell , vol.15 , pp. 315-327
    • Penuelas, S.1    Anido, J.2    Prieto-Sanchez, R.M.3    Folch, G.4    Barba, I.5    Cuartas, I.6
  • 111
    • 84935143364 scopus 로고    scopus 로고
    • Immunosuppressive mechanisms of malignant gliomas: Parallels at non-CNS sites
    • Perng P, Lim M. Immunosuppressive mechanisms of malignant gliomas: parallels at non-CNS sites. Front Oncol 2015; 5: 153.
    • (2015) Front Oncol , vol.5 , pp. 153
    • Perng, P.1    Lim, M.2
  • 112
    • 0041835842 scopus 로고    scopus 로고
    • Monocyte chemoattractant protein-1 increases microglial infiltration and aggressiveness of gliomas
    • Platten M, Kretz A, Naumann U, Aulwurm S, Egashira K, Isenmann S, et al. Monocyte chemoattractant protein-1 increases microglial infiltration and aggressiveness of gliomas. Ann Neurol 2003; 54: 388-92.
    • (2003) Ann Neurol , vol.54 , pp. 388-392
    • Platten, M.1    Kretz, A.2    Naumann, U.3    Aulwurm, S.4    Egashira, K.5    Isenmann, S.6
  • 113
    • 84884683149 scopus 로고    scopus 로고
    • Targeting glioblastoma with NK cells and mAb against NG2/CSPG4 prolongs animal survival
    • Poli A, Wang J, Domingues O, Planaguma J, Yan T, Rygh CB, et al. Targeting glioblastoma with NK cells and mAb against NG2/CSPG4 prolongs animal survival. Oncotarget 2013; 4: 1527-46.
    • (2013) Oncotarget , vol.4 , pp. 1527-1546
    • Poli, A.1    Wang, J.2    Domingues, O.3    Planaguma, J.4    Yan, T.5    Rygh, C.B.6
  • 114
  • 118
    • 84971538906 scopus 로고    scopus 로고
    • The tumor microenvironment underlies acquired resistance to CSF-1R inhibition in gliomas
    • Quail DF, Bowman RL, Akkari L, Quick ML, Schuhmacher AJ, Huse JT, et al. The tumor microenvironment underlies acquired resistance to CSF-1R inhibition in gliomas. Science 2016; 352: aad3018.
    • (2016) Science , vol.352 , pp. aad3018
    • Quail, D.F.1    Bowman, R.L.2    Akkari, L.3    Quick, M.L.4    Schuhmacher, A.J.5    Huse, J.T.6
  • 119
    • 84964659735 scopus 로고    scopus 로고
    • Immunosenescence of microglia and macrophages: Impact on the ageing central nervous system
    • Rawji KS, Mishra MK, Michaels NJ, Rivest S, Stys PK, Yong VW. Immunosenescence of microglia and macrophages: impact on the ageing central nervous system. Brain 2016; 139 (Pt 3): 653-61.
    • (2016) Brain , vol.139 , pp. 653-661
    • Rawji, K.S.1    Mishra, M.K.2    Michaels, N.J.3    Rivest, S.4    Stys, P.K.5    Yong, V.W.6
  • 120
    • 0033959917 scopus 로고    scopus 로고
    • Identification and localization of the cytokine SDF1 and its receptor, CXC chemokine receptor 4, to regions of necrosis and angiogenesis in human glioblastoma
    • Rempel SA, Dudas S, Ge S, Gutierrez JA. Identification and localization of the cytokine SDF1 and its receptor, CXC chemokine receptor 4, to regions of necrosis and angiogenesis in human glioblastoma. Clin Cancer Res 2000; 6: 102-11.
    • (2000) Clin Cancer Res , vol.6 , pp. 102-111
    • Rempel, S.A.1    Dudas, S.2    Ge, S.3    Gutierrez, J.A.4
  • 121
    • 84958176970 scopus 로고    scopus 로고
    • Evaluation of TgH(CX3CR1-EGFP) mice implanted with mCherry-GL261 cells as an in vivo model for morphometrical analysis of glioma-microglia interaction
    • Resende FF, Bai X, Del Bel EA, Kirchhoff F, Scheller A, Titze-de-Almeida R. Evaluation of TgH(CX3CR1-EGFP) mice implanted with mCherry-GL261 cells as an in vivo model for morphometrical analysis of glioma-microglia interaction. BMC Cancer 2015; 16: 72.
    • (2015) BMC Cancer , vol.16 , pp. 72
    • Resende, F.F.1    Bai, X.2    Del Bel, E.A.3    Kirchhoff, F.4    Scheller, A.5    Titze-De-Almeida, R.6
  • 122
    • 84934873928 scopus 로고    scopus 로고
    • Glioma-associated microglia and macrophages/monocytes display distinct electrophysiological properties and do not communicate via gap junctions
    • Richter N, Wendt S, Georgieva PB, Hambardzumyan D, Nolte C, Kettenmann H. Glioma-associated microglia and macrophages/monocytes display distinct electrophysiological properties and do not communicate via gap junctions. Neurosci Lett 2014; 583: 130-5.
    • (2014) Neurosci Lett , vol.583 , pp. 130-135
    • Richter, N.1    Wendt, S.2    Georgieva, P.B.3    Hambardzumyan, D.4    Nolte, C.5    Kettenmann, H.6
  • 124
    • 70450196586 scopus 로고    scopus 로고
    • Challenges in clinical design of immunotherapy trials for malignant glioma
    • Rolle CE, Sengupta S, Lesniak MS. Challenges in clinical design of immunotherapy trials for malignant glioma. Neurosurg Clin N Am 2010; 21: 201-14.
    • (2010) Neurosurg Clin N Am , vol.21 , pp. 201-214
    • Rolle, C.E.1    Sengupta, S.2    Lesniak, M.S.3
  • 127
    • 0031045382 scopus 로고    scopus 로고
    • Microglia-derived cytotoxic factors Part I: Inhibition of tumor cell growth in vitro
    • Rosales AA, Roque RS. Microglia-derived cytotoxic factors. Part I: inhibition of tumor cell growth in vitro. Brain Res 1997; 748: 195-204.
    • (1997) Brain Res , vol.748 , pp. 195-204
    • Rosales, A.A.1    Roque, R.S.2
  • 128
    • 78650138274 scopus 로고    scopus 로고
    • A multi-institution phase II study of poly-ICLC and radiotherapy with concurrent and adjuvant temozolomide in adults with newly diagnosed glioblastoma
    • Rosenfeld MR, Chamberlain MC, Grossman SA, Peereboom DM, Lesser GJ, Batchelor TT, et al. A multi-institution phase II study of poly-ICLC and radiotherapy with concurrent and adjuvant temozolomide in adults with newly diagnosed glioblastoma. Neuro Oncol 2010; 12: 1071-7.
    • (2010) Neuro Oncol , vol.12 , pp. 1071-1077
    • Rosenfeld, M.R.1    Chamberlain, M.C.2    Grossman, S.A.3    Peereboom, D.M.4    Lesser, G.J.5    Batchelor, T.T.6
  • 130
    • 78149438403 scopus 로고    scopus 로고
    • Selective chemokine receptor usage by central nervous system myeloid cells in CCR2-red fluorescent protein knock-in mice
    • Saederup N, Cardona AE, Croft K, Mizutani M, Cotleur AC, Tsou CL, et al. Selective chemokine receptor usage by central nervous system myeloid cells in CCR2-red fluorescent protein knock-in mice. PLoS One 2010; 5: e13693.
    • (2010) PLoS One , vol.5 , pp. e13693
    • Saederup, N.1    Cardona, A.E.2    Croft, K.3    Mizutani, M.4    Cotleur, A.C.5    Tsou, C.L.6
  • 132
    • 51349083585 scopus 로고    scopus 로고
    • Tumor-specific immunotherapy targeting the EGFRvIII mutation in patients with malignant glioma
    • Sampson JH, Archer GE, Mitchell DA, Heimberger AB, Bigner DD. Tumor-specific immunotherapy targeting the EGFRvIII mutation in patients with malignant glioma. Semin Immunol 2008; 20: 267-75.
    • (2008) Semin Immunol , vol.20 , pp. 267-275
    • Sampson, J.H.1    Archer, G.E.2    Mitchell, D.A.3    Heimberger, A.B.4    Bigner, D.D.5
  • 133
    • 70350236627 scopus 로고    scopus 로고
    • An epidermal growth factor receptor variant III-targeted vaccine is safe and immunogenic in patients with glioblastoma multiforme
    • Sampson JH, Archer GE, Mitchell DA, Heimberger AB, Herndon JE II, Lally-Goss D, et al. An epidermal growth factor receptor variant III-targeted vaccine is safe and immunogenic in patients with glioblastoma multiforme. Mol Cancer Ther 2009; 8: 2773-9.
    • (2009) Mol Cancer Ther , vol.8 , pp. 2773-2779
    • Sampson, J.H.1    Archer, G.E.2    Mitchell, D.A.3    Heimberger, A.B.4    Herndon, J.E.5    Lally-Goss, D.6
  • 134
    • 84893770485 scopus 로고    scopus 로고
    • Therapeutic activation of macrophages and microglia to suppress brain tumor-initiating cells
    • Sarkar S, Doring A, Zemp FJ, Silva C, Lun X, Wang X, et al. Therapeutic activation of macrophages and microglia to suppress brain tumor-initiating cells. Nat Neurosci 2014; 17: 46-55.
    • (2014) Nat Neurosci , vol.17 , pp. 46-55
    • Sarkar, S.1    Doring, A.2    Zemp, F.J.3    Silva, C.4    Lun, X.5    Wang, X.6
  • 135
    • 0032853465 scopus 로고    scopus 로고
    • Which glioblastoma multiforme patient will become a long-term survivor? A population-based study
    • Scott JN, Rewcastle NB, Brasher PM, Fulton D, MacKinnon JA, Hamilton M, et al. Which glioblastoma multiforme patient will become a long-term survivor? A population-based study. Ann Neurol 1999; 46: 183-8.
    • (1999) Ann Neurol , vol.46 , pp. 183-188
    • Scott, J.N.1    Rewcastle, N.B.2    Brasher, P.M.3    Fulton, D.4    MacKinnon, J.A.5    Hamilton, M.6
  • 136
    • 70350212976 scopus 로고    scopus 로고
    • STAT3 is required for proliferation and maintenance of multipotency in glioblastoma stem cells
    • Sherry MM, Reeves A, Wu JK, Cochran BH. STAT3 is required for proliferation and maintenance of multipotency in glioblastoma stem cells. Stem Cells 2009; 27: 2383-92.
    • (2009) Stem Cells , vol.27 , pp. 2383-2392
    • Sherry, M.M.1    Reeves, A.2    Wu, J.K.3    Cochran, B.H.4
  • 137
    • 70350712285 scopus 로고    scopus 로고
    • Elevated levels of MIC-1/GDF15 in the cerebrospinal fluid of patients are associated with glioblastoma and worse outcome
    • Shnaper S, Desbaillets I, Brown DA, Murat A, Migliavacca E, Schluep M, et al. Elevated levels of MIC-1/GDF15 in the cerebrospinal fluid of patients are associated with glioblastoma and worse outcome. Int J Cancer 2009; 125: 2624-30.
    • (2009) Int J Cancer , vol.125 , pp. 2624-2630
    • Shnaper, S.1    Desbaillets, I.2    Brown, D.A.3    Murat, A.4    Migliavacca, E.5    Schluep, M.6
  • 138
    • 84878811407 scopus 로고    scopus 로고
    • Distinct roles of CSF family cytokines in macrophage infiltration and activation in glioma progression and injury response
    • Sielska M, Przanowski P, Wylot B, Gabrusiewicz K, Maleszewska M, Kijewska M, et al. Distinct roles of CSF family cytokines in macrophage infiltration and activation in glioma progression and injury response. J Pathol 2013; 230: 310-21.
    • (2013) J Pathol , vol.230 , pp. 310-321
    • Sielska, M.1    Przanowski, P.2    Wylot, B.3    Gabrusiewicz, K.4    Maleszewska, M.5    Kijewska, M.6
  • 139
    • 84872893030 scopus 로고    scopus 로고
    • Janus-faced microglia: Beneficial and detrimental consequences of microglial phagocytosis
    • Sierra A, Abiega O, Shahraz A, Neumann H. Janus-faced microglia: beneficial and detrimental consequences of microglial phagocytosis. Front Cell Neurosci 2013; 7: 6.
    • (2013) Front Cell Neurosci , vol.7 , pp. 6
    • Sierra, A.1    Abiega, O.2    Shahraz, A.3    Neumann, H.4
  • 140
    • 84978371387 scopus 로고    scopus 로고
    • Origin and role of a subset of tumor-associated neutrophils with antigen-presenting cell features in early-stage human lung cancer
    • Singhal S, Bhojnagarwala PS, O'Brien S, Moon EK, Garfall AL, Rao AS, et al. Origin and role of a subset of tumor-associated neutrophils with antigen-presenting cell features in early-stage human lung cancer. Cancer Cell 2016; 30: 120-35.
    • (2016) Cancer Cell , vol.30 , pp. 120-135
    • Singhal, S.1    Bhojnagarwala, P.S.2    O'Brien, S.3    Moon, E.K.4    Garfall, A.L.5    Rao, A.S.6
  • 141
    • 84861602597 scopus 로고    scopus 로고
    • A comparative review of cell culture systems for the study of microglial biology in Alzheimer's disease
    • Stansley B, Post J, Hensley K. A comparative review of cell culture systems for the study of microglial biology in Alzheimer's disease. J Neuroinflammation 2012; 9: 115.
    • (2012) J Neuroinflammation , vol.9 , pp. 115
    • Stansley, B.1    Post, J.2    Hensley, K.3
  • 142
    • 0026762988 scopus 로고
    • Interleukin 4 potently enhances murine macrophage mannose receptor activity: A marker of alternative immunologic macrophage activation
    • Stein M, Keshav S, Harris N, Gordon S. Interleukin 4 potently enhances murine macrophage mannose receptor activity: a marker of alternative immunologic macrophage activation. J Exp Med 1992; 176: 287-92.
    • (1992) J Exp Med , vol.176 , pp. 287-292
    • Stein, M.1    Keshav, S.2    Harris, N.3    Gordon, S.4
  • 143
    • 70449699924 scopus 로고    scopus 로고
    • Immunological considerations of modern animal models of malignant primary brain tumors
    • Sughrue ME, Yang I, Kane AJ, Rutkowski MJ, Fang S, James CD, et al. Immunological considerations of modern animal models of malignant primary brain tumors. J Transl Med 2009; 7: 84.
    • (2009) J Transl Med , vol.7 , pp. 84
    • Sughrue, M.E.1    Yang, I.2    Kane, A.J.3    Rutkowski, M.J.4    Fang, S.5    James, C.D.6
  • 144
    • 0027200944 scopus 로고
    • Transforming growth factor-beta suppresses activation and proliferation of microglia in vitro
    • Suzumura A, Sawada M, Yamamoto H, Marunouchi T. Transforming growth factor-beta suppresses activation and proliferation of microglia in vitro. J Immunol 1993; 151: 2150-8.
    • (1993) J Immunol , vol.151 , pp. 2150-2158
    • Suzumura, A.1    Sawada, M.2    Yamamoto, H.3    Marunouchi, T.4
  • 145
    • 33744548728 scopus 로고    scopus 로고
    • Detailed characterization of the mouse glioma 261 tumor model for experimental glioblastoma therapy
    • Szatmari T, Lumniczky K, Desaknai S, Trajcevski S, Hidvegi EJ, Hamada H, et al. Detailed characterization of the mouse glioma 261 tumor model for experimental glioblastoma therapy. Cancer Sci 2006; 97: 546-53.
    • (2006) Cancer Sci , vol.97 , pp. 546-553
    • Szatmari, T.1    Lumniczky, K.2    Desaknai, S.3    Trajcevski, S.4    Hidvegi, E.J.5    Hamada, H.6
  • 146
    • 84975241222 scopus 로고    scopus 로고
    • Human glioblastoma-associated microglia/monocytes express a distinct RNA profile compared to human control and murine samples
    • Szulzewsky F, Arora S, de Witte L, Ulas T, Markovic D, Schultze JL, et al. Human glioblastoma-associated microglia/monocytes express a distinct RNA profile compared to human control and murine samples. Glia 2016; 64: 1416-36.
    • (2016) Glia , vol.64 , pp. 1416-1436
    • Szulzewsky, F.1    Arora, S.2    De Witte, L.3    Ulas, T.4    Markovic, D.5    Schultze, J.L.6
  • 147
    • 84922658111 scopus 로고    scopus 로고
    • Glioma-associated microglia/macrophages display an expression profile different from M1 and M2 polarization and highly express Gpnmb and Spp1
    • Szulzewsky F, Pelz A, Feng X, Synowitz M, Markovic D, Langmann T, et al. Glioma-associated microglia/macrophages display an expression profile different from M1 and M2 polarization and highly express Gpnmb and Spp1. PLoS One 2015; 10: e0116644.
    • (2015) PLoS One , vol.10 , pp. e0116644
    • Szulzewsky, F.1    Pelz, A.2    Feng, X.3    Synowitz, M.4    Markovic, D.5    Langmann, T.6
  • 148
    • 70350708139 scopus 로고    scopus 로고
    • Systemic inhibition of transforming growth factor-beta in glioma-bearing mice improves the therapeutic efficacy of gliomaassociated antigen peptide vaccines
    • Ueda R, Fujita M, Zhu X, Sasaki K, Kastenhuber ER, Kohanbash G, et al. Systemic inhibition of transforming growth factor-beta in glioma-bearing mice improves the therapeutic efficacy of gliomaassociated antigen peptide vaccines. Clin Cancer Res 2009; 15: 6551-9.
    • (2009) Clin Cancer Res , vol.15 , pp. 6551-6559
    • Ueda, R.1    Fujita, M.2    Zhu, X.3    Sasaki, K.4    Kastenhuber, E.R.5    Kohanbash, G.6
  • 149
    • 7444226411 scopus 로고    scopus 로고
    • SD-208, a novel transforming growth factor beta receptor i kinase inhibitor, inhibits growth and invasiveness and enhances immunogenicity of murine and human glioma cells in vitro and in vivo
    • Uhl M, Aulwurm S, Wischhusen J, Weiler M, Ma JY, Almirez R, et al. SD-208, a novel transforming growth factor beta receptor I kinase inhibitor, inhibits growth and invasiveness and enhances immunogenicity of murine and human glioma cells in vitro and in vivo. Cancer Res 2004; 64: 7954-61.
    • (2004) Cancer Res , vol.64 , pp. 7954-7961
    • Uhl, M.1    Aulwurm, S.2    Wischhusen, J.3    Weiler, M.4    Ma, J.Y.5    Almirez, R.6
  • 150
    • 84855251694 scopus 로고    scopus 로고
    • Tumor-secreted SDF-1 promotes glioma invasiveness and TAM tropism toward hypoxia in a murine astrocytoma model
    • Wang SC, Hong JH, Hsueh C, Chiang CS. Tumor-secreted SDF-1 promotes glioma invasiveness and TAM tropism toward hypoxia in a murine astrocytoma model. Lab Invest 2012; 92: 151-62.
    • (2012) Lab Invest , vol.92 , pp. 151-162
    • Wang, S.C.1    Hong, J.H.2    Hsueh, C.3    Chiang, C.S.4
  • 152
    • 70450213189 scopus 로고    scopus 로고
    • Glioblastoma-derived mechanisms of systemic immunosuppression
    • Waziri A. Glioblastoma-derived mechanisms of systemic immunosuppression. Neurosurg Clin N Am 2010; 21: 31-42.
    • (2010) Neurosurg Clin N Am , vol.21 , pp. 31-42
    • Waziri, A.1
  • 153
    • 84881504052 scopus 로고    scopus 로고
    • The controversial role of microglia in malignant gliomas
    • Wei J, Gabrusiewicz K, Heimberger A. The controversial role of microglia in malignant gliomas. Clin Dev Immunol 2013; 2013: 285246.
    • (2013) Clin Dev Immunol , vol.2013 , pp. 285246
    • Wei, J.1    Gabrusiewicz, K.2    Heimberger, A.3
  • 154
    • 38949165993 scopus 로고    scopus 로고
    • Microglia-derived TGF-beta as an important regulator of glioblastoma invasion-an inhibition of TGF-beta-dependent effects by shRNA against human TGF-beta type II receptor
    • Wesolowska A, Kwiatkowska A, Slomnicki L, Dembinski M, Master A, Sliwa M, et al. Microglia-derived TGF-beta as an important regulator of glioblastoma invasion-an inhibition of TGF-beta-dependent effects by shRNA against human TGF-beta type II receptor. Oncogene 2008; 27: 918-30.
    • (2008) Oncogene , vol.27 , pp. 918-930
    • Wesolowska, A.1    Kwiatkowska, A.2    Slomnicki, L.3    Dembinski, M.4    Master, A.5    Sliwa, M.6
  • 155
    • 78049270536 scopus 로고    scopus 로고
    • Glioma cancer stem cells induce immunosuppressive macrophages/microglia
    • Wu A, Wei J, Kong LY, Wang Y, Priebe W, Qiao W, et al. Glioma cancer stem cells induce immunosuppressive macrophages/microglia. Neuro Oncol 2010; 12: 1113-25.
    • (2010) Neuro Oncol , vol.12 , pp. 1113-1125
    • Wu, A.1    Wei, J.2    Kong, L.Y.3    Wang, Y.4    Priebe, W.5    Qiao, W.6
  • 156
    • 84861134237 scopus 로고    scopus 로고
    • In silico experimentation of glioma microenvironment development and anti-tumor therapy
    • Wu Y, Lu Y, Chen W, Fu J, Fan R. In silico experimentation of glioma microenvironment development and anti-tumor therapy. PLoS Comput Biol 2012; 8: e1002355.
    • (2012) PLoS Comput Biol , vol.8 , pp. e1002355
    • Wu, Y.1    Lu, Y.2    Chen, W.3    Fu, J.4    Fan, R.5
  • 157
    • 84904856334 scopus 로고    scopus 로고
    • Effect of miR-142-3p on the M2 macrophage and therapeutic efficacy against murine glioblastoma
    • Xu S, Wei J, Wang F, Kong LY, Ling XY, Nduom E, et al. Effect of miR-142-3p on the M2 macrophage and therapeutic efficacy against murine glioblastoma. J Natl Cancer Inst 2014; 106: 1-11.
    • (2014) J Natl Cancer Inst , vol.106 , pp. 1-11
    • Xu, S.1    Wei, J.2    Wang, F.3    Kong, L.Y.4    Ling, X.Y.5    Nduom, E.6
  • 158
  • 159
    • 72449154567 scopus 로고    scopus 로고
    • The role of microglia in central nervous system immunity and glioma immunology
    • Yang I, Han SJ, Kaur G, Crane C, Parsa AT. The role of microglia in central nervous system immunity and glioma immunology. J Clin Neurosci 2010; 17: 6-10.
    • (2010) J Clin Neurosci , vol.17 , pp. 6-10
    • Yang, I.1    Han, S.J.2    Kaur, G.3    Crane, C.4    Parsa, A.T.5
  • 160
    • 84862879740 scopus 로고    scopus 로고
    • Tumorassociated microglia/macrophages enhance the invasion of glioma stem-like cells via TGF-beta1 signaling pathway
    • Ye XZ, Xu SL, Xin YH, Yu SC, Ping YF, Chen L, et al. Tumorassociated microglia/macrophages enhance the invasion of glioma stem-like cells via TGF-beta1 signaling pathway. J Immunol 2012; 189: 444-53.
    • (2012) J Immunol , vol.189 , pp. 444-453
    • Ye, X.Z.1    Xu, S.L.2    Xin, Y.H.3    Yu, S.C.4    Ping, Y.F.5    Chen, L.6
  • 161
    • 84863049147 scopus 로고    scopus 로고
    • A dialog between glioma and microglia that promotes tumor invasiveness through the CCL2/CCR2/interleukin-6 axis
    • Zhang J, Sarkar S, Cua R, Zhou Y, Hader W, Yong VW. A dialog between glioma and microglia that promotes tumor invasiveness through the CCL2/CCR2/interleukin-6 axis. Carcinogenesis 2012; 33: 312-19.
    • (2012) Carcinogenesis , vol.33 , pp. 312-319
    • Zhang, J.1    Sarkar, S.2    Cua, R.3    Zhou, Y.4    Hader, W.5    Yong, V.W.6
  • 162
    • 70349097179 scopus 로고    scopus 로고
    • Stat3 inhibition activates tumor macrophages and abrogates glioma growth in mice
    • Zhang L, Alizadeh D, Van Handel M, Kortylewski M, Yu H, Badie B. Stat3 inhibition activates tumor macrophages and abrogates glioma growth in mice. Glia 2009; 57: 1458-67.
    • (2009) Glia , vol.57 , pp. 1458-1467
    • Zhang, L.1    Alizadeh, D.2    Van Handel, M.3    Kortylewski, M.4    Yu, H.5    Badie, B.6
  • 163
    • 84988549301 scopus 로고    scopus 로고
    • Liverinfiltrating CD11b-CD27-NK subsets account for NK-cell dysfunction in patients with hepatocellular carcinoma and are associated with tumor progression
    • Zhang QF, Yin WW, Xia Y, Yi YY, He QF, Wang X, et al. Liverinfiltrating CD11b-CD27-NK subsets account for NK-cell dysfunction in patients with hepatocellular carcinoma and are associated with tumor progression. Cell Mol Immunol 2016; 13: 1-11.
    • (2016) Cell Mol Immunol , vol.13 , pp. 1-11
    • Zhang, Q.F.1    Yin, W.W.2    Xia, Y.3    Yi, Y.Y.4    He, Q.F.5    Wang, X.6
  • 164
    • 58849167699 scopus 로고    scopus 로고
    • The isolation and characterization of murine macrophages
    • Unit 14 1 Chapter 14
    • Zhang X, Goncalves R, Mosser DM. The isolation and characterization of murine macrophages. Curr Protoc Immunol 2008; Chapter 14: Unit 14 1.
    • (2008) Curr Protoc Immunol
    • Zhang, X.1    Goncalves, R.2    Mosser, D.M.3
  • 166
    • 84897097203 scopus 로고    scopus 로고
    • Reciprocal supportive interplay between glioblastoma and tumor-associated macrophages
    • Zhou W, Bao S. Reciprocal supportive interplay between glioblastoma and tumor-associated macrophages. Cancers 2014; 6: 723-40.
    • (2014) Cancers , vol.6 , pp. 723-740
    • Zhou, W.1    Bao, S.2
  • 167
    • 84923068676 scopus 로고    scopus 로고
    • Periostin secreted by glioblastoma stem cells recruits M2 tumourassociated macrophages and promotes malignant growth
    • Zhou W, Ke SQ, Huang Z, Flavahan W, Fang X, Paul J, et al. Periostin secreted by glioblastoma stem cells recruits M2 tumourassociated macrophages and promotes malignant growth. Nat Cell Biol 2015; 17: 170-82.
    • (2015) Nat Cell Biol , vol.17 , pp. 170-182
    • Zhou, W.1    Ke, S.Q.2    Huang, Z.3    Flavahan, W.4    Fang, X.5    Paul, J.6
  • 168
    • 23644443053 scopus 로고    scopus 로고
    • Early inactivation of p53 tumor suppressor gene cooperating with NF1 loss induces malignant astrocytoma
    • Zhu Y, Guignard F, Zhao D, Liu L, Burns DK, Mason RP, et al. Early inactivation of p53 tumor suppressor gene cooperating with NF1 loss induces malignant astrocytoma. Cancer Cell 2005; 8: 119-30.
    • (2005) Cancer Cell , vol.8 , pp. 119-130
    • Zhu, Y.1    Guignard, F.2    Zhao, D.3    Liu, L.4    Burns, D.K.5    Mason, R.P.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.