Intracellular signaling in M-CSF-induced microglia activation: Role of Iba1

GLIA

Volumn 40, Issue 2, 2002, Pages 164-174

  Imai, Yoshinori ^a   Kohsaka, Shinichi ^a  

^a NATIONAL INSTITUTE OF NEUROSCIENCE   (Japan)

Author keywords

Actin; Fms; Iba1; M CSF; PI3K; PLC ; Rac

Indexed keywords

AIF1 PROTEIN, HUMAN; CALCIUM BINDING PROTEIN; COLONY STIMULATING FACTOR 1; COLONY STIMULATING FACTOR RECEPTOR; DNA BINDING PROTEIN; ISOENZYME; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHOLIPASE C; PHOSPHOLIPASE C GAMMA; RAC PROTEIN;

ANIMAL; DRUG EFFECT; HUMAN; METABOLISM; MICROGLIA; MOLECULAR GENETICS; PHAGOCYTOSIS; PHYSIOLOGY; REVIEW; SEQUENCE HOMOLOGY; SIGNAL TRANSDUCTION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; CALCIUM-BINDING PROTEINS; DNA-BINDING PROTEINS; HUMANS; ISOENZYMES; MACROPHAGE COLONY-STIMULATING FACTOR; MICROGLIA; MOLECULAR SEQUENCE DATA; PHAGOCYTOSIS; PHOSPHOLIPASE C; PHOSPHOLIPASE C GAMMA; RAC GTP-BINDING PROTEINS; RECEPTOR, MACROPHAGE COLONY-STIMULATING FACTOR; SEQUENCE HOMOLOGY, AMINO ACID; SIGNAL TRANSDUCTION;

EID: 0036849026     PISSN: 08941491     EISSN: None     Source Type: Journal    
DOI: 10.1002/glia.10149     Document Type: Review

References (69)

1. Abo A, Pick E, Hall A, Totty N, Teahan CG, Segal AW. 1991. Activation of the NADPH oxidase involves the small GTP-binding protein p21 rac1. Nature 353:668-670.
2. Allen WE, Jones, GE, Pollard JW, Ridley AJ. 1997. Rho, Rac and Cdc42 regulate actin organization and cell adhesion in macrophages. J Cell Sci 110:707-720.
3. Alterman RL, Stanley ER. 1994. Colony stimulating factor-1 expression in human glioma. Mol Chem Neuropathol 21:177-188.
4. Autieri MV, Prystowsky MB, Ohlstein EH. 1996. Isolation and characterization of BART-1: A novel balloon angioplasty responsive transcript in rat carotid arteries. DNA Cell Biol 15:297-304.
5. Barger SW, Harmon AD. 1997. Microglial activation by Alzheimer amyloid precursor protein and modulation by apolipoprotein E. Nature 388:878-881.
6. Berezovskaya O, Maysinger D, Fedroff S. 1995. The hematopoietic cytokine, colony-stimulating factor 1, is also a growth factor in the CNS: Congenital absence of CSF-1 in mice results in abnormal microglial response and increased neuron vulnerability to injury. Int J Neurosci 13:285-299.
7. Bourette RP, Rohrschneider LR. 2000. Early events in M-CSF receptor signaling. Growth Factors 17:155-166.
8. Brown DR, Schmidt B, Kretzschmer HA. 1996. Role of microglia and host prion protein in neurotoxicity of a prion protein fragment. Nature 380:345-347.
9. Bruccoleri A, Harry GJ. 2000. Chemical-induced hippocampal neurodegeneration and elevations in TNFα, TNFβ, IL-1α, IP-10, and MCP-1 mRNA in osteopetrotic (op/op) mice. J Neurosci Res 62:146-155.
10. Carenini S, Mäurer M, Werner A, Blazyca H, Toyka KV, Schmid CD, Raivich G, Martin R. 2001. The role of macrophages in demyelinating peripheral nervous system of mice heterozygously deficient in p0. J Cell Biol 152:301-308.
11. Caron E, Hall A. 1998. Identification of two distinct mechanisms of phagocytosis controlled by different Rho GTPases. Science 282:1717-1721.
12. Chen Z-W, Ahren B, Östenson C-G, Cintra A, Bergman T, Möller C, Fuxe K, Mutt V, Jörnvall H, Efendic S. 1997. Identification, isolation, and characterization of daintain (allograft inflammatory factor 1), a macrophage polypeptide with effects on insulin secretion and abundantly present in the pancreas of prediabetic BB rats. Proc Natl Acad Sci U S A 94:13879-13884.
13. Elliott JL. 2001. Cytokine upregulation in a murine model of familial amyotrophic lateral sclerosis. Brain Res Mol Brain Res 95:172-178.
14. Fujiki K, Shin DH, Nakao M, Yano T. 1999. Molecular cloning of carp (Cyprinus carpio) CC chemokine, CXC chemokine receptors, allograft inflammatory factor-1, and natural killer cell enhancing factor by use of suppression subtractive hybridization. Immunogenetics 49:909-914.
15. Galiano M, Liu ZQ, Kalla R, Bohatschek M, Koppius A, Gschwendtner A, Xu S-L, Werner A, Kloss CUA, Jones LL, Bluethmann H, Raivich G. 2001. Interleukln-6 (IL-6) and cellular response to facial nerve injury: Effects on lymphocyte recruitment, early microglial activation and axonal outgrowth in IL-6 deficient mice. Eur J Neurosci 14:327-341.
16. Gallo P, De Rossi A, Sivieri S, Chieco-Bianchi L, Tavolato B. 1994. M-CSF production by HIV-1-infected monocytes and its intrathecal synthesis. Implications for neurological HIV-1-related disease. J Neuroimmunol 51:193-198.
17. Graeber MG, López-Redondo F, Ikoma E, Ishikawa M, Imai Y, Nakajima K, Kreutzberg GW, Kohsaka S. 1998. The microglia/macrophage response in the neonatal rat facial nucleus following axotomy. Brain Res 813:241-253.
18. Hall A. 1998. Rho GTPases and the actin cytoskeleton. Science 279:509-514.
19. Hao AJ, Dheen ST, Ling EA. 2001. Response of amoeboid microglia/brain macrophages in fetal rat brain exposed to a teratogen. J Neurosci Res 64:79-93.
20. Hawkins PT, Eguinoa A, Qiu R-G, Stokoe D, Cooke FT, Walters R, Wennström S, Claesson-Welsh L, Evans T, Symons M, Stephens L. 1995. PDGF stimulate an increase in GTP-Rac via activation of phosphoinositide 3-kinase. Curr Biol 5:393-403.
21. Herbomel P, Thisse B, Thisse C. 2001. Zebrafish early macrophages colonize cephalic mesenchyme and developing brain, retina, and epidermis through a M-CSF receptor-dependent invasive process. Dev Biol 238:274-288.
22. Imai Y, Ibata I, Ito D, Ohsawa K, Kohsaka S. 1996. A novel gene iba1 in the major histocompatibility complex class III region encoding an EF hand protein expressed in a monocytic lineage. Biophys Biochem Res Commun 224:855-862.
23. Ito D, Imai Y, Ohsawa K, Nakajima K, Fukuuchi Y, Kohsaka S. 1998. Microglia-specific localisation of a novel calcium binding protein Iba1. Brain Res Mol Brain Res 57:1-9.
24. Ito D, Tanaka K, Suzuki S, Dembo T, Fukuuchi Y. 2001. Enhanced expression of Iba1, ionized calcium-binding adapter molecule 1, after transient focal cerebral ischemia in rat brain. Stroke 32:1208-1215.
25. Kalla R, Liu Z, Xu S, Koppius A, Imai Y, Kloss CUA, Kohsaka S, Gschwendtner A, Möller JC, Werner A, Raivich G. 2001. Microglia and the early phase of immune surveillance in the axotomized facial motor nucleus: Impaired microglial activation and lymphocyte recruitment but no effect on neuronal survival or axonal regeneration in macrophage-colony stimulating factor-deficient mice. J Comp Neurol 436:182-201.
26. Kanazawa H, Ohsawa K, Sakaki Y, Kohsaka S., Imai Y. 2002. Microglia specific protein Iba1 enhances Rac activation via phospholipase C-γ-dependent pathway. J Biol Chem 277:20026-20032.
27. Kazlauskas A. 1994. Receptor tyrosine kinases and their target. Curr Biol 4:5-14.
28. Kozma R, Ahmed S, Best A, Lim L. 1995. The Ras-related protein Cdc42Hs and bradykinin promote formation of peripheral actin microspikes and filopodia in Swiss 3T3 fibroblasts. Mol Cell Biol 15:1942-1952.
29. Kraus UG, Heyworth PG, Evans T, Curnutte JT, Bokoch GM. 1991. Regulation of phagocyte oxygen radical production by the GTP-binding protein Rac 2. Science 254:1512-1515.
30. Kreutzberg GW. 1996. Microglia: A sensor for pathological evens in the CNS. Trends Neurosci 19:312-318.
31. Kreutzberg GW, Graeber MB, Streit WJ. 1989. Neuron-glial relationship during regeneration of motor neurons. Metab Brain Dis 4:81-85.
32. Kruse M, Steffen R, Batel R, Müller IM, Müller WE. 1999. Differential expression of allograft inflammatory factor i and of glutathione peroxidase during auto- and allograft response in marine sponges. J Cell Sci 112:4305-4313.
33. Lue LF, Rydel R, Brigham EF, Yang LB, Hampel H, Murphy GM Jr, Brachova L, Yan SD, Walker DG, Shen Y, Rogers J. 2001a. Inflammatory repertoire of Alzheimer's disease and nondemented elderly microglia in vitro. Glia 35:72-79.
34. Lue LF, Walker DG, Rogers J. 2001b. Modeling microglial activation in Alzheimer's disease with human postmortem microglial cultures. Neurobiol Aging 22:945-956.
35. McDonald DR, Brunden KR, Landreth GE. 1997. Amyloid fibrils activate tyrosine kinase-dependent signaling and superoxide production in microglia. J Neurosci 17:2284-2294.
36. McGeer PL, Itagaki S, Boyes BE, McGeer EG. 1988. Reactive microglia are positive for HLA-DR in the substantia nigra of Parkinson's and Alzheimer's disease brains. Neurology 38:1285-1291.
37. Meda L, Cassatella MA, Szendrei GI, Otvos L Jr, Baron P, Villalba M, Ferrari D, Rossi F. 1995. Activation of microglial cells by β-amyloid protein and interferon-β. Nature 374:647-650.
38. Mitrasinovic OM, Perez GV, Zhao F, Lee YL, Poon C, Murphy GM Jr. 2001. Overexpression of macrophage colony-stimulating factor receptor on microglial cells induces an inflammatory response. J Biol Chem 276:30142-30149.
39. Mori I, Imai Y, Kohsaka S, Kimura Y. 2000. Upregulated expression of Iba1 molecules in the central nervous system of mice in response to neurovirulent influenza A virus infection. Microbiol Immunol 44:729-735.
40. Murphy GM Jr, Yang L, Cordell B. 1998. Macrophage colony-stimulating factor augments beta-amyloid-induced interleukin-1, interleukin-6, and nitric oxide production by microglial cells. J Biol Chem 273:20967-20971.
41. V717F transgenic mouse model of Alzheimer's disease. Am J Pathol 157:895-904.
42. Nakajima K, Kohsaka S. 2001. Microglia: Activation and their significance in the central nervous system. J Biol 130:169-175.
43. Ng Y-K, Yong V-W, Ling E-A. 1999. Microglial reaction in some CNS nuclei following nerves transection in BALB/c and interferon-γ gene knockout mice. Neurosci Lett 262:207-210.
44. Nobes CD, Hall A. 1995. Rho, Rac, and Cdc42 GTPases regulate the assembly of multimolecular focal complex associated with actin stress fibers, lamellipodia, and filopodia. Cell 81:53-62.
45. Nobes CD, Hawkins P, Stephens L, Hall A. 1995. Activation of the small GTP-binding proteins rho and rac by growth factor receptor. J Cell Sci 108:225-233.
46. Ohsawa K, Imai Y, Nakajima K, Kohsaka S. 1997. Generation and characterization of a microglial cell line, MG5, derived from a p53-deficient mouse. Glia 21:285-298.
47. Ohsawa K, Imai Y, Kanazawa H, Sasaki Y, Kohsaka S. 2000. Involvement of Iba1 in membrane ruffling and phagocytosis of macrophages/microglia. J Cell Sci 113:3073-3084.
48. Olsson T, Kristensson K, Ljungdahl Å, Maehlen J, Holmdahl R, Klareskog L. 1989. Gamma-interferon-like immunoreactivity in axotomized rat motor neurons. J Neurosci 9:3870-3875.
49. Papavasiliou AK, Mehler MF, Mabie PC, Marmur R, Qingbin S, Keating RF, Kessler JA. 1997. Paracrine regulation of colony-stimulating factor-1 in medulloblastoma: Implications for pathogenesis and therapeutic interventions. Neurosurgery 41:916-923.
50. Raivich G, Gehrmann J, Kreutzberg GW. 1991. Increase of macrophage colony-stimulating factor and granulocyte-macrophage colony-stimulating factor receptors in the regenerating rat facial nucleus. J Neuroscl Res 30:682-686.
51. Raivich G, Haas S, Werner A, Klein MA, Kloss C, Kreutzberg GW, 1998a. Regulation of MCSF receptors on microglia in the normal and injured mouse central nervous system: A quantitative immunofluorescence study using confocal laser microscopy. J Comp Neurol 395:342-358.
52. Raivich G, Jones LL, Kloss CUA, Werner A, Neuman H, Kreutzberg GW. 1998b. Immune surveillance in the injured nervous system: T-lymphocytes invade the axotomized mouse facial motor nucleus and aggregate around sites of neuronal degeneration. J Neurosci 18:5804-5816.
53. Ridley AJ, Hall A. 1992. The small GTP-binding protein rho regulates the assembly of focal adhesion and actin stress fibers in response to growth factors. Cell 70:389-399.
54. Ridley AJ, Paterson HF, Johnston CL, Diekmann D, Hall A. 1992. The small GTP-binding protein rac regulates growth factor-induced membrane ruffling. Cell 70:401-410.
55. Rönnstrand L, Mori S, Arridsson A-K, Eriksson A, Wernstedt C, Hellman U, Claesson-Welsh L, Heldin C-H. 1992. Identification of two C-terminal autophosphorylation sites in the PDGF β-receptor: Involvement in the interaction with phospholipase C-γ. EMBO J 11:3911-3919.
56. Sibinga NES, Feinberg MW, Yang H, Werner F, Jain MK. 2002. Macrophage-restricted interferon-γ-inducible expression of the allograft inflammatory factor-1 gene requires Pu.1. J Biol Chem 277:16202-16210.
57. Stossel TP. 1993. On the crawling of animal cells. Science 260:1086-1094.
58. Streit WJ, Kincaid-Colton CA. 1995. The brain's immune system. Sci Am 275:54-61.
59. Takeuchi A, Miyaishi O, Kiuchi K, Isobe K. 2001. Macrophage colony-stimulating factor is expressed in neuron and microglia after focal brain injury. J Neurosci Res 65:38-44.
60. Thery C, Hetier E, Evrard C, Mallat M. 1990. Expression of macrophage colony-stimulating factor gene in the mouse brain during development. J Neurosci Res 26:129-133.
61. Tran CT, Wolz P, Egensperger R, Kösel S, Imai Y, Bise K, Kohsaka S, Mehraein P, Graeber MB. 1998. Differential expression of MHC class II molecules by microglia and neoplastic astroglia: Relevance for the escape of astrocytoma cells from immune surveillance. Neuropathol Appl Neurobiol 24:293-301.
62. Tsukada T, Tomooka Y, Takei S, Ueda Y, Nishikawa S, Yagi T, Tokunaga T, Takeda N, Suda Y, Abe S, Matsuo I, Ikawa Y, Aizawa S. 1993. Enhanced proliferative potential in culture of cells from p53-defiecient mice. Oncogene 8:3313-3322.
63. Utans U, Arceci RJ, Yamashita Y, Russell ME. 1995. Cloning and characterization of allograft inflammatory factor-1: A novel macrophage factor identified in rat cardiac allografts with chronic rejection. J Clin Invest 95:2954-2962.
64. Utans U, Quist WC, McManus BM, Wilson JE, Arceci RJ, Wallace AF, Russell ME. 1996. Allograft inflammatory factory-1. A cytokine-responsive macrophage molecule expressed in transplanted human hearts. Transplantation 61:1387-1392.
65. v Eitzen U, Egensperger R, Kösel S, Grasbon-Frodl EM, Imai Y, Bise K, Kohsaka S, Mehraein P, Graeber MB. 1997. Microglia and the development of spongiform change in Creutzfeldt-Jakob disease. J Neuropathol Exp Neurol 57:246-256.
66. Wang Y, Berezovska O, Fedoroff S. 1999. Expression of colony stimulating factor-1 receptor (CSF-1R) by CNS neurons in mice. J Neurosci Res 57:616-632.
67. Wennström S, Siegbahn A, Yokote K, Arvidsson A-K, Heldin C-H, Mori S, Claesson-Welsh L. 1994. Membrane ruffling and chemotaxis transduced by the PDGF β-receptor require the binding site for phosphatidylinositol 3′ kinase. Oncogene 9:651-660.
68. Yan SD, Zhu H, Fu J, Yan SF, Roher A, Tourtellotte WW, Rajavashisth T, Chen X, Godman GC, Stern D, Schmidt AM. 1997. Amyloid-β peptide-receptor for advanced glycation endproduct interaction elicits neuronal expression of macrophage-colony stimulating factor: A proinflammatory pathway in Alzheimer disease. Proc Natl Acad Sci USA 94:5296-5301.
69. Yoshida H, Hayashi S-I, Kunisasa Z, Ogawa M, Nishikawa S, Okamura H, Sudo T, Shultz LD, Nishikawa S-I. 1990. The murine mutation osteopetrosis is in the coding region of the macrophages colony stimulating factor gene. Nature 345:442-444.