STAT3 regulation of glioblastoma pathogenesis

Current Molecular Medicine

Volumn 9, Issue 5, 2009, Pages 580-590

  De La Iglesia, Núria ^a   Puram, Sidharth V ^a   Bonni, Azad ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; EPIDERMAL GROWTH FACTOR RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR 8; INTERLEUKIN 8 INHIBITOR; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; STAT3 PROTEIN; STAT3 PROTEIN INHIBITOR; UNCLASSIFIED DRUG;

CANCER GENETICS; CARCINOGENESIS; CELL DIFFERENTIATION; CELL LINEAGE; DRUG EFFICACY; GENETIC VARIABILITY; GLIA CELL; GLIOBLASTOMA; HUMAN; MALIGNANT TRANSFORMATION; MOLECULAR BIOLOGY; NEURAL STEM CELL; NEUROBIOLOGY; NEUROPATHOLOGY; NEUROSURGERY; NONHUMAN; PROTEIN ANALYSIS; PROTEIN FUNCTION; REVIEW; SIGNAL TRANSDUCTION; TUMOR VASCULARIZATION;

ANIMALS; BRAIN NEOPLASMS; GENE EXPRESSION REGULATION, NEOPLASTIC; GLIOBLASTOMA; HUMANS; INTERLEUKIN-8; MEMBRANE PROTEINS; MODELS, BIOLOGICAL; MUTATION; PTEN PHOSPHOHYDROLASE; STAT3 TRANSCRIPTION FACTOR;

EID: 70350525582     PISSN: 15665240     EISSN: None     Source Type: Journal    
DOI: 10.2174/156652409788488739     Document Type: Review

References (116)

1. Central Brain Tumor Registry of the United States (CBTRUS) report (2002-2003) http://www.cbtrus.org.
2. Ries, LAG, E.M., Kosary, C.L., Hankey, B.F., Miller, B.A., Clegg, L., Mariotto, A., Fay, M.P., Feuer, E.J., Edwards, B.K. (eds) (2004) SEER Cancer Statistics Rev., 1975-2001.
3. Jemal, A., Siegel, R., Ward, E., Hao, Y., Xu, J., Murray, T. and Thun, M.J. (2008) CA Cancer J. Clin., 58, 71-96.
4. Louis, D.N., Ohgaki, H., Wiestler, O.D. and Cavenee, W.K.E. (2007) World Health Organization Histological Classification of Tumours of the Central Nervous System, IARC Press. International Agency for Research on Cancer (IARC).
5. Jaeckle, K.A., Cohen, M.E. and Duffner, P.K. (1996) Clinical Presentation and Therapy of Nervous System Tumors, Butterworth-Heinemann, 1131-1149
6. Bernstein, J.J. and Woodard, C.A. (1995) Neurosurgery, 36, 124-32; discussion 32.
7. Stupp, R., Mason, W.P., van den Bent, M.J., Weller, M., Fisher, B., Taphoorn, M.J., Belanger, K., Brandes, A.A., Marosi, C., Bogdahn, U., Curschmann, J., Janzer, R.C., Ludwin, S.K., Gorlia, T., Allgeier, A., Lacombe, D., Cairncross, J.G., Eisenhauer, E. and Mirimanoff, R.O. (2005) N. Engl. J. Med., 352, 987-996
8. Athanassiou, H., Synodinou, M., Maragoudakis, E., Paraskevaidis, M., Verigos, C., Misailidou, D., Antonadou, D., Saris, G., Beroukas, K. and Karageorgis, P. (2005) J. Clin. Oncol., 23, 2372-2377
9. Lamborn, K.R., Chang, S.M. and Prados, M.D. (2004) Neuro. Oncol., 6, 227-235
10. Furnari, F.B., Fenton, T., Bachoo, R.M., Mukasa, A., Stommel, J.M., Stegh, A., Hahn, W.C., Ligon, K.L., Louis, D.N., Brennan, C., Chin, L., DePinho, R.A. and Cavenee, W.K. (2007) Genes Dev., 21, 2683-2710
11. Konopka, G. and Bonni, A. (2003) Curr. Mol. Med., 3, 73-84.
12. Holland, E.C. (2001) Nat. Rev. Genet., 2, 120-129
13. Hanahan, D. and Weinberg, R.A. (2000) Cell, 100, 57-70.
14. Steck, P.A., Pershouse, M.A., Jasser, S.A., Yung, W.K., Lin, H., Ligon, A.H., Langford, L.A., Baumgard, M.L., Hattier, T., Davis, T., Frye, C., Hu, R., Swedlund, B., Teng, D.H. and Tavtigian, S.V. (1997) Nat. Genet., 15, 356-362
15. Li, J., Yen, C., Liaw, D., Podsypanina, K., Bose, S., Wang, S.I., Puc, J., Miliaresis, C., Rodgers, L., McCombie, R., Bigner, S.H., Giovanella, B.C., Ittmann, M., Tycko, B., Hibshoosh, H., Wigler, M.H. and Parsons, R. (1997) Science, 275, 1943-1947
16. Nagane, M., Lin, H., Cavenee, W.K. and Huang, H.J. (2001) Cancer Lett., 162 Suppl, S17-S21.
17. Friedman, H.S. and Bigner, D.D. (2005) N. Engl. J. Med., 353, 1997-1999
18. Louis, D.N. (2006) Annu. Rev. Pathol., 1, 97-117.
19. Bachoo, R.M., Maher, E.A., Ligon, K.L., Sharpless, N.E., Chan, S.S., You, M.J., Tang, Y., DeFrances, J., Stover, E., Weissleder, R., Rowitch, D.H., Louis, D.N. and DePinho, R.A. (2002) Cancer Cell, 1, 269-277
20. Uhrbom, L., Dai, C., Celestino, J.C., Rosenblum, M.K., Fuller, G.N. and Holland, E.C. (2002) Cancer Res., 62, 5551-5558
21. Bajenaru, M.L., Hernandez, M.R., Perry, A., Zhu, Y., Parada, L.F., Garbow, J.R. and Gutmann, D.H. (2003) Cancer Res., 63, 8573-8577
22. Kwon, C.H., Zhao, D., Chen, J., Alcantara, S., Li, Y., Burns, D.K., Mason, R.P., Lee, E.Y., Wu, H. and Parada, L.F. (2008) Cancer Res., 68, 3286-3294
23. Bonni, A. (2003) STATs in the central nervous system, Kluwer Academic Publishers, Dordrecht, 42, 663-685
24. Guillemot, F. (2007) Prog. Neurobiol., 83, 37-52.
25. Shi, Y., Sun, G., Zhao, C. and Stewart, R. (2008) Crit. Rev. Oncol. Hematol., 65, 43-53.
26. Bonni, A., Sun, Y., Nadal-Vicens, M., Bhatt, A., Frank, D.A., Rozovsky, I., Stahl, N., Yancopoulos, G.D. and Greenberg, M.E. (1997) Science, 278, 477-483
27. Rajan, P. and McKay, R.D. (1998) J. Neurosci., 18, 3620-3629
28. Yoshimatsu, T., Kawaguchi, D., Oishi, K., Takeda, K., Akira, S., Masuyama, N. and Gotoh, Y. (2006) Development, 133, 2553-2563
29. de la Iglesia, N., Konopka, G., Puram, S.V., Chan, J.A., Bachoo, R.M., You, M.J., Levy, D.E., Depinho, R.A. and Bonni, A. (2008) Genes Dev., 22, 449-462
30. Bromberg, J. (2002) J. Clin. Invest., 109, 1139-1142
31. Chan, K.S., Sano, S., Kiguchi, K., Anders, J., Komazawa, N., Takeda, J. and DiGiovanni, J. (2004) J. Clin. Invest., 114, 720-728
32. Chiarle, R., Simmons, W.J., Cai, H., Dhall, G., Zamo, A., Raz, R., Karras, J.G., Levy, D.E. and Inghirami, G. (2005) Nat. Med., 11, 623-629
33. Ling, X. and Arlinghaus, R.B. (2005) Cancer Res., 65, 2532-2536
34. Schlessinger, K. and Levy, D.E. (2005) Cancer Res., 65, 5828-5834
35. Darnell, J.E., Jr. (1997) Science, 277, 1630-1635
36. Darnell, J.E., Jr., Kerr, I.M. and Stark, G.R. (1994) Science, 264, 1415-1421
37. Frank, D.A. and Greenberg, M.E. (1996) Perspect. Dev. Neurobiol., 4, 3-18.
38. Horvath, C.M. and Darnell, J.E. (1997) Curr. Opin. Cell Biol., 9, 233-239
39. Saharinen, P. and Silvennoinen, O. (2003) JAK Kinases, Kluwer Academic Publishers, Dordrecht, 27-39.
40. Wegenka, U.M., Buschmann, J., Lutticken, C., Heinrich, P.C. and Horn, F. (1993) Mol. Cell Biol., 13, 276-288
41. Wegenka, U.M., Lutticken, C., Buschmann, J., Yuan, J., Lottspeich, F., Muller-Esterl, W., Schindler, C., Roeb, E., Heinrich, P.C. and Horn, F. (1994) Mol. Cell Biol., 14, 3186-3196
42. Shuai, K., Stark, G.R., Kerr, I.M. and Darnell, J.E., Jr. (1993) Science, 261, 1744-1746
43. Kaptein, A., Paillard, V. and Saunders, M. (1996) J. Biol. Chem., 271, 5961-5964
44. Shao, H., Cheng, H.Y., Cook, R.G. and Tweardy, D.J. (2003) Cancer research, 63, 3923-3930
45. Bhattacharya, S., Eckner, R., Grossman, S., Oldread, E., Arany, Z., D'Andrea, A. and Livingston, D.M. (1996) Nature, 383, 344-347
46. Zhang, J.J., Vinkemeier, U., Gu, W., Chakravarti, D., Horvath, C.M. and Darnell, J.E., Jr. (1996) Proc. Natl. Acad. Sci. USA, 93, 15092-15096
47. Gingras, S., Simard, J., Groner, B. and Pfitzner, E. (1999) Nucleic Acids Res., 27, 2722-2729
48. McDonald, C. and Reich, N.C. (1999) J. Interferon Cytokine Res., 19, 711-722
49. Paulson, M., Press, C., Smith, E., Tanese, N. and Levy, D.E. (2002) Nat. Cell Biol., 4, 140-147
50. Lau, J.F., Nusinzon, I., Burakov, D., Freedman, L.P. and Horvath, C.M. (2003) Mol. Cell Biol., 23, 620-628
51. Poli, V. and Alonzi, T. (2003) STAT3 functions in vivo, Kluwer Academic Publishers, Dordrecht, 493-512.
52. Takeda, K. and Akira, S. (2003) Tissue-specific function of STAT3, Kluwer Academic Publishers, Dordrecht, 513-523
53. Aberg, M.A., Ryttsen, F., Hellgren, G., Lindell, K., Rosengren, L.E., MacLennan, A.J., Carlsson, B., Orwar, O. and Eriksson, P.S. (2001) Mol. Cell Neurosci., 17, 426-443
54. Ge, W., Martinowich, K., Wu, X., He, F., Miyamoto, A., Fan, G., Weinmaster, G. and Sun, Y.E. (2002) J. Neurosci. Res., 69, 848-860
55. Ware, C.B., Horowitz, M.C. Renshaw, B.R., Hunt, J.S., Liggitt, D., Koblar, S.A., Gliniak, B.C., McKenna, H.J., Papayannopoulou, T., Thoma, B., Cheng, L., Donovan, P.J., Peschon, J.J., Bartlett, P.F., Willis, C.R., Wright, B.D., Carpenter, M.K., Davison, B.L. and Gearing D.P. (1995) Development, 121, 1283-1299
56. Rajan, P., Panchision, D.M., Newell, L.F. and McKay, R.D. (2003) J. Cell Biol., 161, 911-921
57. Bromberg, J. and Chen, X. (2001) Methods Enzymol., 333, 138-151
58. Levy, D.E. and Lee, C.K. (2002) J. Clin. Invest., 109, 1143-1148
59. Bromberg, J.F., Wrzeszczynska, M.H., Devgan, G., Zhao, Y., Pestell, R.G., Albanese, C. and Darnell, J.E., Jr. (1999) Cell, 98, 295-303.
60. Turkson, J. and Jove, R. (2000) Oncogene, 19, 6613-6626
61. Turkson, J., Ryan, D., Kim, J.S., Zhang, Y., Chen, Z., Haura, E., Laudano, A., Sebti, S., Hamilton, A.D. and Jove, R. (2001) J. Biol. Chem., 276, 45443-45455
62. Leong, P.L., Andrews, G.A., Johnson, D.E., Dyer, K.F., Xi, S., Mai, J.C., Robbins, P.D., Gadiparthi, S., Burke, N.A., Watkins, S.F. and Grandis, J.R. (2003) Proc. Natl. Acad. Sci. USA, 100, 4138-4143
63. Song, H., Wang, R., Wang, S. and Lin, J. (2005) Proc. Natl. Acad. Sci. USA, 102, 4700-4705
64. Kortylewski, M., Heinrich, P.C., Mackiewicz, A., Schniertshauer, U., Klingmuller, U., Nakajima, K., Hirano, T., Horn, F. and Behrmann, I. (1999) Oncogene, 18, 3742-3753
65. Smithgall, T.E., Briggs, S.D., Schreiner, S., Lerner, E.C., Cheng, H. and Wilson, M.B. (2000) Oncogene, 19, 2612-2618
66. Spiotto, M.T. and Chung, T.D. (2000) Prostate, 42, 186-195
67. McLemore, M.L., Grewal, S., Liu, F., Archambault, A., Poursine-Laurent, J., Haug, J. and Link, D.C. (2001) Immunity, 14, 193-204.
68. Wu, R., Sun, S. and Steinberg, B.M. (2003) Mol. Med., 9, 77-84.
69. Nakajima, K., Yamanaka, Y., Nakae, K., Kojima, H., Ichiba, M., Kiuchi, N., Kitaoka, T., Fukada, T., Hibi, M. and Hirano, T. (1996) EMBO J., 15, 3651-3658
70. Minami, M., Inoue, M., Wei, S., Takeda, K., Matsumoto, M., Kishimoto, T. and Akira, S. (1996) Proc. Natl. Acad. Sci. USA, 93, 3963-3966
71. Spiotto, M.T. and Chung, T.D. (2000) Prostate, 42, 88-98.
72. Ward, A.C., Touw, I. and Yoshimura, A. (2000) Blood, 95, 19-29.
73. Tian, S.S., Lamb, P., Seidel, H.M., Stein, R.B. and Rosen, J. (1994) Blood, 84, 1760-1764
74. Tian, S.S., Tapley, P., Sincich, C., Stein, R.B., Rosen, J. and Lamb, P. (1996) Blood, 88, 4435-4444
75. de Koning, J.P., Soede-Bobok, A.A., Ward, A.C., Schelen, A.M., Antonissen, C., van Leeuwen, D., Lowenberg, B. and Touw, I.P. (2000) Oncogene, 19, 3290-3298
76. Lee, C.K., Raz, R., Gimeno, R., Gertner, R., Wistinghausen, B., Takeshita, K., DePinho, R.A. and Levy, D.E. (2002) Immunity, 17, 63-72.
77. Hauser, P.J., Agrawal, D., Hackney, J. and Pledger, W.J. (1998) Cell Growth Differ., 9, 847-855
78. Boccaccio, C., Ando, M., Tamagnone, L., Bardelli, A., Michieli, P., Battistini, C. and Comoglio, P.M. (1998) Nature, 391, 285-288
79. Philp, J.C., Burdon, T.G. and Watson, C.J. (1996) FEBS Lett., 396, 77-80.
80. Liu, X.W., Robinson, G.W. and Hennighausen, L. (1996) Mol. Endocrinol., 1496-1506
81. Chapman, R.S., Lourenco, P.C., Tonner, E., Flint, D.J., Selbert, S., Takeda, K., Akira, S., Clarke, A.R. and Watson, C.J. (1999) Genes Dev., 13, 2604-2616
82. de la Iglesia, N., Konopka, G., Lim, K.L., Nutt, C.L., Bromberg, J.F., Frank, D.A., Mischel, P.S., Louis, D.N. and Bonni, A. (2008) J. Neurosci., 28, 5870-5878
83. Yamanaka, R., Tanaka, R., Saitoh, T. and Okoshi, S. (1994) J. Neurooncol., 21, 243-247
84. Garkavtsev, I., Kozin, S.V., Chernova, O., Xu, L., Winkler, F., Brown, E., Barnett, G.H. and Jain, R.K. (2004) Nature, 428, 328-332
85. Yu, Z., Zhang, W. and Kone, B.C. (2002) Biochem. J., 367, 97-105.
86. Yu, Z. and Kone, B.C. (2004) J. Am. Soc. Nephrol., 15, 585-591
87. Rahaman, S.O., Harbor, P.C., Chernova, O., Barnett, G.H., Vogelbaum, M.A. and Haque, S.J. (2002) Oncogene, 21, 8404-8413
88. Konnikova, L., Kotecki, M., Kruger, M.M. and Cochran, B.H. (2003) BMC Cancer, 3, 23.
89. Weissenberger, J., Loeffler, S., Kappeler, A., Kopf, M., Lukes, A., Afanasieva, T.A., Aguzzi, A. and Weis, J. (2004) Oncogene, 23, 3308-3316
90. Schaefer, L.K., Ren, Z., Fuller, G.N. and Schaefer, T.S. (2002) Oncogene, 21, 2058-2065
91. Wang, H., Zhang, W., Huang, H.J., Liao, W.S. and Fuller, G.N. (2004) Lab Invest.
92. Lin, S.Y., Makino, K., Xia, W., Matin, A., Wen, Y., Kwong, K.Y., Bourguignon, L. and Hung, M.C. (2001) Nat. Cell Biol., 3, 802-808
93. Lo, H.W., Hsu, S.C., Ali-Seyed, M., Gunduz, M., Xia, W., Wei, Y., Bartholomeusz, G., Shih, J.Y. and Hung, M.C. (2005) Cancer Cell, 7, 575-589
94. Choe, G., Horvath, S., Cloughesy, T.F., Crosby, K., Seligson, D., Palotie, A., Inge, L., Smith, B.L., Sawyers, C.L. and Mischel, P.S. (2003) Cancer Res., 63, 2742-2746
95. Mellinghoff, I.K., Wang, M.Y., Vivanco, I., Haas-Kogan, D.A., Zhu, S., Dia, E.Q., Lu, K.V., Yoshimoto, K., Huang, J.H., Chute, D.J., Riggs, B.L., Horvath, S., Liau, L.M., Cavenee, W.K., Rao, P.N., Beroukhim, R., Peck, T.C., Lee, J.C., Sellers, W.R., Stokoe, D., Prados, M., Cloughesy, T.F., Sawyers, C.L. and Mischel, P.S. (2005) N. Engl. J. Med., 353, 2012-2024
96. Weerasinghe, P., Li, Y., Guan, Y., Zhang, R., Tweardy, D.J. and Jing, N. (2008) Prostate, 68(13), 1430-1442
97. van Kester, M.S., Out-Luiting, J.J., von dem Borne, P.A., Willemze, R., Tensen, C.P. and Vermeer, M.H. (2008) J. Invest. Dermatol., 128, 1691-1695
98. Xiong, H., Zhang, Z.G., Tian, X.Q., Sun, D.F., Liang, Q.C., Zhang, Y.J., Lu, R., Chen, Y.X. and Fang, J.Y. (2008) Neoplasia, 10, 287-297
99. Dowlati, A., Kluge, A., Nethery, D., Halmos, B. and Kern, J.A. (2008) Anticancer Drugs, 19, 9-16.
100. Deng, J., Grande, F. and Neamati, N. (2007) Curr. Cancer Drug Targets, 7, 91-107.
101. Bhasin, D., Cisek, K., Pandharkar, T., Regan, N., Li, C., Pandit, B., Lin, J. and Li, P.K. (2008) Bioorg. Med. Chem. Lett., 18, 391-395
102. Zhang, X., Zhang, J., Wang, L., Wei, H. and Tian, Z. (2007) BMC Cancer, 7, 149.
103. Gariboldi, M.B., Ravizza, R., Molteni, R., Osella, D., Gabano, E. and Monti, E. (2007) Cancer Lett., 258, 181-188
104. Hellmuth, K., Grosskopf, S., Lum, C.T., Wurtele, M., Roder, N., von Kries, J.P., Rosario, M., Rademann, J. and Birchmeier, W. (2008) Proc. Natl. Acad. Sci. USA, 105, 7275-7280
105. Chen, L., Sung, S.S., Yip, M.L., Lawrence, H.R., Ren, Y., Guida, W.C., Sebti, S.M., Lawrence, N.J. and Wu, J. (2006) Mol. Pharmacol., 70, 562-570
106. Auernhammer, C.J., Isele, N.B., Kopp, F.B., Spoettl, G., Cengic, N., Weber, M.M., Senaldi, G. and Engelhardt, D. (2003) Endocrinology, 144, 1202-1210
107. Yadav, A., Kalita, A., Dhillon, S. and Banerjee, K. (2005) J. Biol. Chem., 280, 31830-31840
108. Merkle, F.T., Mirzadeh, Z. and Alvarez-Buylla, A. (2007) Science, 317, 381-384
109. Singh, S.K., Hawkins, C., Clarke, I.D., Squire, J.A., Bayani, J., Hide, T., Henkelman, R.M., Cusimano, M.D. and Dirks, P.B. (2004) Nature, 432, 396-401.
110. Bao, S., Wu, Q., McLendon, R.E., Hao, Y., Shi, Q., Hjelmeland, A.B., Dewhirst, M.W., Bigner, D.D. and Rich, J.N. (2006) Nature, 444, 756-760
111. Piccirillo, S.G., Reynolds, B.A., Zanetti, N., Lamorte, G., Binda, E., Broggi, G., Brem, H., Olivi, A., Dimeco, F. and Vescovi, A.L. (2006) Nature, 444, 761-765
112. Singh, S.K., Clarke, I.D., Terasaki, M., Bonn, V.E., Hawkins, C., Squire, J. and Dirks, P.B. (2003) Cancer Res., 63, 5821-5828
113. Wikstrand, C.J., Hale, L.P., Batra, S.K., Hill, M.L., Humphrey, P.A., Kurpad, S.N., McLendon, R.E., Moscatello, D., Pegram, C.N., Reist, C.J., Traweek, S.T., Wong, A.J., Zalutsky, M.R. and Bigner, D.D. (1995) Cancer Res., 55, 3140-3148
114. de la Iglesia, N., Puram, S.V. and Bonni, A. (2009) Curr. Mol. Med., 9(5), (un published).
115. Ligon, K.L., Huillard, E., Mehta, S., Kesari, S., Liu, H., Alberta, J.A., Bachoo, R.M., Kane, M., Louis, D.N., Depinho, R.A., Anderson, D.J., Stiles, C.D. and Rowitch, D.H. (2007) Neuron, 53, 503-517
116. Lee, J., Son, M.J., Woolard, K., Donin, N.M., Li, A., Cheng, C.H., Kotliarova, S., Kotliarov, Y., Walling, J., Ahn, S., Kim, M., Totonchy, M., Cusack, T., Ene, C., Ma, H., Su, Q., Zenklusen, J.C., Zhang, W., Maric, D. and Fine, H.A. (2008) Cancer Cell, 13, 69-80.