-
1
-
-
80052246111
-
Infiltrating monocytes trigger EAE progression, but do not contribute to the resident microglia pool
-
Ajami B, Bennett JL, Krieger C, McNagny KM, Rossi FM. Infiltrating monocytes trigger EAE progression, but do not contribute to the resident microglia pool. Nat Neurosci 2011;14:1142-9.
-
(2011)
Nat Neurosci
, vol.14
, pp. 1142-1149
-
-
Ajami, B.1
Bennett, J.L.2
Krieger, C.3
McNagny, K.M.4
Rossi, F.M.5
-
2
-
-
36448994709
-
Local selfrenewal can sustain CNS microglia maintenance and function throughout adult life
-
Ajami B, Bennett JL, Krieger C, Tetzlaff W, Rossi FM. Local selfrenewal can sustain CNS microglia maintenance and function throughout adult life. Nat Neurosci 2007;10:1538-43.
-
(2007)
Nat Neurosci
, vol.10
, pp. 1538-1543
-
-
Ajami, B.1
Bennett, J.L.2
Krieger, C.3
Tetzlaff, W.4
Rossi, F.M.5
-
3
-
-
84907659600
-
Aging-induced type I interferon response at the choroid plexus negatively affects brain function
-
Baruch K, Deczkowska A, David E, Castellano JM, Miller O, Kertser A, et al. Aging-induced type I interferon response at the choroid plexus negatively affects brain function. Science 2014;346:89-93.
-
(2014)
Science
, vol.346
, pp. 89-93
-
-
Baruch, K.1
Deczkowska, A.2
David, E.3
Castellano, J.M.4
Miller, O.5
Kertser, A.6
-
4
-
-
84873475219
-
CNS-specific immunity at the choroid plexus shifts toward destructive Th2 inflammation in brain aging
-
Baruch K, Ron-Harel N, Gal H, Deczkowska A, Shifrut E, Ndifon W, et al. CNS-specific immunity at the choroid plexus shifts toward destructive Th2 inflammation in brain aging. Proc Natl Acad Sci USA 2013;110:2264-9.
-
(2013)
Proc Natl Acad Sci USA
, vol.110
, pp. 2264-2269
-
-
Baruch, K.1
Ron-Harel, N.2
Gal, H.3
Deczkowska, A.4
Shifrut, E.5
Ndifon, W.6
-
5
-
-
84885063645
-
CNS-specific T cells shape brain function via the choroid plexus
-
Baruch K, Schwartz M. CNS-specific T cells shape brain function via the choroid plexus. Brain Behav Immun 2013;34:11-16.
-
(2013)
Brain Behav Immun
, vol.34
, pp. 11-16
-
-
Baruch, K.1
Schwartz, M.2
-
6
-
-
84875965163
-
Proliferation-dependent alterations of the DNA methylation landscape underlie hematopoietic stem cell aging
-
Beerman I, Bock C, Garrison BS, Smith ZD, Gu H, Meissner A, et al. Proliferation-dependent alterations of the DNA methylation landscape underlie hematopoietic stem cell aging. Cell Stem Cell 2013;12:413-25.
-
(2013)
Cell Stem Cell
, vol.12
, pp. 413-425
-
-
Beerman, I.1
Bock, C.2
Garrison, B.S.3
Smith, Z.D.4
Gu, H.5
Meissner, A.6
-
7
-
-
13844281550
-
How chronic inflammation can affect the brain and support the development of Alzheimer's disease in old age: The role of microglia and astrocytes
-
Blasko I, Stampfer-Kountchev M, Robatscher P, Veerhuis R, Eikelenboom P, Grubeck-Loebenstein B. How chronic inflammation can affect the brain and support the development of Alzheimer's disease in old age: the role of microglia and astrocytes. Aging Cell 2004;3:169-76.
-
(2004)
Aging Cell
, vol.3
, pp. 169-176
-
-
Blasko, I.1
Stampfer-Kountchev, M.2
Robatscher, P.3
Veerhuis, R.4
Eikelenboom, P.5
Grubeck-Loebenstein, B.6
-
8
-
-
0842309938
-
Age-dependent decrease in Toll-like receptor 4-mediated proinflammatory cytokine production and mitogen-activated protein kinase expression
-
Boehmer ED, Goral J, Faunce DE, Kovacs EJ. Age-dependent decrease in Toll-like receptor 4-mediated proinflammatory cytokine production and mitogen-activated protein kinase expression. J Leukoc Biol 2004;75:342-9.
-
(2004)
J Leukoc Biol
, vol.75
, pp. 342-349
-
-
Boehmer, E.D.1
Goral, J.2
Faunce, D.E.3
Kovacs, E.J.4
-
9
-
-
27644480499
-
Aging negatively skews macrophage TLR2- and TLR4-mediated pro-inflammatory responses without affecting the IL-2-stimulated pathway
-
Boehmer ED, Meehan MJ, Cutro BT, Kovacs EJ. Aging negatively skews macrophage TLR2- and TLR4-mediated pro-inflammatory responses without affecting the IL-2-stimulated pathway. Mech Ageing Dev 2005;126:1305-13.
-
(2005)
Mech Ageing Dev
, vol.126
, pp. 1305-1313
-
-
Boehmer, E.D.1
Meehan, M.J.2
Cutro, B.T.3
Kovacs, E.J.4
-
10
-
-
65249119363
-
Powerful beneficial effects of macrophage colony-stimulating factor on beta-amyloid deposition and cognitive impairment in Alzheimer's disease
-
Boissonneault V, Filali M, Lessard M, Relton J, Wong G, Rivest S. Powerful beneficial effects of macrophage colony-stimulating factor on beta-amyloid deposition and cognitive impairment in Alzheimer's disease. Brain 2009;132(Pt 4):1078-92.
-
(2009)
Brain
, vol.132
, pp. 1078-1092
-
-
Boissonneault, V.1
Filali, M.2
Lessard, M.3
Relton, J.4
Wong, G.5
Rivest, S.6
-
11
-
-
84937738858
-
Genetic cell ablation reveals clusters of local self-renewing microglia in the mammalian central nervous system
-
Bruttger J, Karram K, Wortge S, Regen T, Marini F, Hoppmann N, et al. Genetic cell ablation reveals clusters of local self-renewing microglia in the mammalian central nervous system. Immunity 2015;43:92-106.
-
(2015)
Immunity
, vol.43
, pp. 92-106
-
-
Bruttger, J.1
Karram, K.2
Wortge, S.3
Regen, T.4
Marini, F.5
Hoppmann, N.6
-
12
-
-
84893745524
-
Identification of a unique TGF-beta-dependent molecular and functional signature in microglia
-
Butovsky O, Jedrychowski MP, Moore CS, Cialic R, Lanser AJ, Gabriely G, et al. Identification of a unique TGF-beta-dependent molecular and functional signature in microglia. Nat Neurosci 2014;17:131-43.
-
(2014)
Nat Neurosci
, vol.17
, pp. 131-143
-
-
Butovsky, O.1
Jedrychowski, M.P.2
Moore, C.S.3
Cialic, R.4
Lanser, A.J.5
Gabriely, G.6
-
13
-
-
34548208677
-
Aging hematopoietic stem cells decline in function and exhibit epigenetic dysregulation
-
Chambers SM, Shaw CA, Gatza C, Fisk CJ, Donehower LA, Goodell MA. Aging hematopoietic stem cells decline in function and exhibit epigenetic dysregulation. PLoS Biol 2007;5:e201.
-
(2007)
PLoS Biol
, vol.5
, pp. e201
-
-
Chambers, S.M.1
Shaw, C.A.2
Gatza, C.3
Fisk, C.J.4
Donehower, L.A.5
Goodell, M.A.6
-
14
-
-
84871980802
-
Cortical remyelination: A new target for repair therapies in multiple sclerosis
-
Chang A, Staugaitis SM, Dutta R, Batt CE, Easley KE, Chomyk AM, et al. Cortical remyelination: a new target for repair therapies in multiple sclerosis. Ann Neurol 2012;72:918-26.
-
(2012)
Ann Neurol
, vol.72
, pp. 918-926
-
-
Chang, A.1
Staugaitis, S.M.2
Dutta, R.3
Batt, C.E.4
Easley, K.E.5
Chomyk, A.M.6
-
15
-
-
16844363815
-
The unresponsiveness of aged mice to polysaccharide antigens is a result of a defect in macrophage function
-
Chelvarajan RL, Collins SM, Van Willigen JM, Bondada S. The unresponsiveness of aged mice to polysaccharide antigens is a result of a defect in macrophage function. J Leukoc Biol 2005;77:503-12.
-
(2005)
J Leukoc Biol
, vol.77
, pp. 503-512
-
-
Chelvarajan, R.L.1
Collins, S.M.2
Van Willigen, J.M.3
Bondada, S.4
-
16
-
-
75549090275
-
mTOR regulation and therapeutic rejuvenation of aging hematopoietic stem cells
-
Chen C, Liu Y, Liu Y, Zheng P. mTOR regulation and therapeutic rejuvenation of aging hematopoietic stem cells. Sci Signal 2009;2:ra75.
-
(2009)
Sci Signal
, vol.2
, pp. ra75
-
-
Chen, C.1
Liu, Y.2
Liu, Y.3
Zheng, P.4
-
17
-
-
84918825145
-
Chronic exposure to TGFbeta1 regulates myeloid cell inflammatory response in an IRF7-dependent manner
-
Cohen M, Matcovitch O, David E, Barnett-Itzhaki Z, Keren-Shaul H, Blecher-Gonen R, et al. Chronic exposure to TGFbeta1 regulates myeloid cell inflammatory response in an IRF7-dependent manner. EMBO J 2014;33:2906-21.
-
(2014)
EMBO J
, vol.33
, pp. 2906-2921
-
-
Cohen, M.1
Matcovitch, O.2
David, E.3
Barnett-Itzhaki, Z.4
Keren-Shaul, H.5
Blecher-Gonen, R.6
-
18
-
-
13944261231
-
Rejuvenation of aged progenitor cells by exposure to a young systemic environment
-
Conboy IM, Conboy MJ, Wagers AJ, Girma ER, Weissman IL, Rando TA. Rejuvenation of aged progenitor cells by exposure to a young systemic environment. Nature 2005;433:760-4.
-
(2005)
Nature
, vol.433
, pp. 760-764
-
-
Conboy, I.M.1
Conboy, M.J.2
Wagers, A.J.3
Girma, E.R.4
Weissman, I.L.5
Rando, T.A.6
-
20
-
-
0035116752
-
Acute central cervical cord injury: The effect of age upon prognosis
-
Dai LY. Acute central cervical cord injury: the effect of age upon prognosis. Injury 2001;32:195-9.
-
(2001)
Injury
, vol.32
, pp. 195-199
-
-
Dai, L.Y.1
-
21
-
-
79952610280
-
Age-related alterations in the dynamic behavior of microglia
-
Damani MR, Zhao L, Fontainhas AM, Amaral J, Fariss RN, Wong WT. Age-related alterations in the dynamic behavior of microglia. Aging Cell 2011;10:263-76.
-
(2011)
Aging Cell
, vol.10
, pp. 263-276
-
-
Damani, M.R.1
Zhao, L.2
Fontainhas, A.M.3
Amaral, J.4
Fariss, R.N.5
Wong, W.T.6
-
22
-
-
84921519046
-
Stimulation of monocytes, macrophages, and microglia by amphotericin B and macrophage colony-stimulating factor promotes remyelination
-
Doring A, Sloka S, Lau L, Mishra M, van Minnen J, Zhang X, et al. Stimulation of monocytes, macrophages, and microglia by amphotericin B and macrophage colony-stimulating factor promotes remyelination. J Neurosci 2015;35:1136-48.
-
(2015)
J Neurosci
, vol.35
, pp. 1136-1148
-
-
Doring, A.1
Sloka, S.2
Lau, L.3
Mishra, M.4
Van Minnen, J.5
Zhang, X.6
-
23
-
-
77957689347
-
TGFbeta signaling in the brain increases with aging and signals to astrocytes and innate immune cells in the weeks after stroke
-
Doyle KP, Cekanaviciute E, Mamer LE, Buckwalter MS. TGFbeta signaling in the brain increases with aging and signals to astrocytes and innate immune cells in the weeks after stroke. J Neuroinflammation 2010;7:62.
-
(2010)
J Neuroinflammation
, vol.7
, pp. 62
-
-
Doyle, K.P.1
Cekanaviciute, E.2
Mamer, L.E.3
Buckwalter, M.S.4
-
24
-
-
84858649330
-
Rantes/Ccl5 influences hematopoietic stem cell subtypes and causes myeloid skewing
-
Ergen AV, Boles NC, Goodell MA. Rantes/Ccl5 influences hematopoietic stem cell subtypes and causes myeloid skewing. Blood 2012;119:2500-9.
-
(2012)
Blood
, vol.119
, pp. 2500-2509
-
-
Ergen, A.V.1
Boles, N.C.2
Goodell, M.A.3
-
25
-
-
84933043202
-
Host microbiota constantly control maturation and function of microglia in the CNS
-
Erny D, Hrabe de Angelis AL, Jaitin D, Wieghofer P, Staszewski O, David E, et al. Host microbiota constantly control maturation and function of microglia in the CNS. Nat Neurosci 2015;18:965-77.
-
(2015)
Nat Neurosci
, vol.18
, pp. 965-977
-
-
Erny, D.1
Hrabe De Angelis, A.L.2
Jaitin, D.3
Wieghofer, P.4
Staszewski, O.5
David, E.6
-
26
-
-
33947545098
-
Minocycline reduces microglial activation and improves behavioral deficits in a transgenic model of cerebral microvascular amyloid
-
Fan R, Xu F, Previti ML, Davis J, Grande AM, Robinson JK, et al. Minocycline reduces microglial activation and improves behavioral deficits in a transgenic model of cerebral microvascular amyloid. J Neurosci 2007;27:3057-63.
-
(2007)
J Neurosci
, vol.27
, pp. 3057-3063
-
-
Fan, R.1
Xu, F.2
Previti, M.L.3
Davis, J.4
Grande, A.M.5
Robinson, J.K.6
-
27
-
-
84903160194
-
IL-4 signaling drives a unique arginase +/IL-1beta + microglia phenotype and recruits macrophages to the inflammatory CNS: Consequences of age-related deficits in IL-4Ralpha after traumatic spinal cord injury
-
Fenn AM, Hall JC, Gensel JC, Popovich PG, Godbout JP. IL-4 signaling drives a unique arginase +/IL-1beta + microglia phenotype and recruits macrophages to the inflammatory CNS: consequences of age-related deficits in IL-4Ralpha after traumatic spinal cord injury. J Neurosci 2014;34:8904-17.
-
(2014)
J Neurosci
, vol.34
, pp. 8904-8917
-
-
Fenn, A.M.1
Hall, J.C.2
Gensel, J.C.3
Popovich, P.G.4
Godbout, J.P.5
-
28
-
-
33947397925
-
Evidence that aging and amyloid promote microglial cell senescence
-
Flanary BE, Sammons NW, Nguyen C, Walker D, Streit WJ. Evidence that aging and amyloid promote microglial cell senescence. Rejuvenation Res 2007;10:61-74.
-
(2007)
Rejuvenation Res
, vol.10
, pp. 61-74
-
-
Flanary, B.E.1
Sammons, N.W.2
Nguyen, C.3
Walker, D.4
Streit, W.J.5
-
29
-
-
79960744467
-
Microglia demonstrate age-dependent interaction with amyloid-beta fibrils
-
Floden AM, Combs CK. Microglia demonstrate age-dependent interaction with amyloid-beta fibrils. J Alzheimers Dis 2011;25:279-93.
-
(2011)
J Alzheimers Dis
, vol.25
, pp. 279-293
-
-
Floden, A.M.1
Combs, C.K.2
-
30
-
-
84860634046
-
Cdc42 activity regulates hematopoietic stem cell aging and rejuvenation
-
Florian MC, Dorr K, Niebel A, Daria D, Schrezenmeier H, Rojewski M, et al. Cdc42 activity regulates hematopoietic stem cell aging and rejuvenation. Cell Stem Cell 2012;10:520-30.
-
(2012)
Cell Stem Cell
, vol.10
, pp. 520-530
-
-
Florian, M.C.1
Dorr, K.2
Niebel, A.3
Daria, D.4
Schrezenmeier, H.5
Rojewski, M.6
-
31
-
-
84883361779
-
Scara1 deficiency impairs clearance of soluble amyloid-beta by mononuclear phagocytes and accelerates Alzheimer's-like disease progression
-
Frenkel D, Wilkinson K, Zhao L, Hickman SE, Means TK, Puckett L, et al. Scara1 deficiency impairs clearance of soluble amyloid-beta by mononuclear phagocytes and accelerates Alzheimer's-like disease progression. Nat Commun 2013;4:2030.
-
(2013)
Nat Commun
, vol.4
, pp. 2030
-
-
Frenkel, D.1
Wilkinson, K.2
Zhao, L.3
Hickman, S.E.4
Means, T.K.5
Puckett, L.6
-
33
-
-
78149360132
-
Fate mapping analysis reveals that adult microglia derive from primitive macrophages
-
Ginhoux F, Greter M, Leboeuf M, Nandi S, See P, Gokhan S, et al. Fate mapping analysis reveals that adult microglia derive from primitive macrophages. Science 2010;330:841-5.
-
(2010)
Science
, vol.330
, pp. 841-845
-
-
Ginhoux, F.1
Greter, M.2
Leboeuf, M.3
Nandi, S.4
See, P.5
Gokhan, S.6
-
34
-
-
23444443814
-
Exaggerated neuroinflammation and sickness behavior in aged mice following activation of the peripheral innate immune system
-
Godbout JP, Chen J, Abraham J, Richwine AF, Berg BM, Kelley KW, et al. Exaggerated neuroinflammation and sickness behavior in aged mice following activation of the peripheral innate immune system. FASEB J 2005;19:1329-31.
-
(2005)
FASEB J
, vol.19
, pp. 1329-1331
-
-
Godbout, J.P.1
Chen, J.2
Abraham, J.3
Richwine, A.F.4
Berg, B.M.5
Kelley, K.W.6
-
35
-
-
67650079567
-
Remyelination capacity of the MS brain decreases with disease chronicity
-
Goldschmidt T, Antel J, Konig FB, Bruck W, Kuhlmann T. Remyelination capacity of the MS brain decreases with disease chronicity. Neurology 2009;72:1914-21.
-
(2009)
Neurology
, vol.72
, pp. 1914-1921
-
-
Goldschmidt, T.1
Antel, J.2
Konig, F.B.3
Bruck, W.4
Kuhlmann, T.5
-
36
-
-
0029737506
-
Lower serum concentrations of cytokines in elderly patients with pneumonia and the impaired production of cytokines by peripheral blood monocytes in the elderly
-
Gon Y, Hashimoto S, Hayashi S, Koura T, Matsumoto K, Horie T. Lower serum concentrations of cytokines in elderly patients with pneumonia and the impaired production of cytokines by peripheral blood monocytes in the elderly. Clin Exp Immunol 1996;106:120-6.
-
(1996)
Clin Exp Immunol
, vol.106
, pp. 120-126
-
-
Gon, Y.1
Hashimoto, S.2
Hayashi, S.3
Koura, T.4
Matsumoto, K.5
Horie, T.6
-
37
-
-
84920724792
-
Environment drives selection and function of enhancers controlling tissue-specific macrophage identities
-
Gosselin D, Link VM, Romanoski CE, Fonseca GJ, Eichenfield DZ, Spann NJ, et al. Environment drives selection and function of enhancers controlling tissue-specific macrophage identities. Cell 2014;159:1327-40.
-
(2014)
Cell
, vol.159
, pp. 1327-1340
-
-
Gosselin, D.1
Link, V.M.2
Romanoski, C.E.3
Fonseca, G.J.4
Eichenfield, D.Z.5
Spann, N.J.6
-
38
-
-
84899636196
-
Differences in the phagocytic response of microglia and peripheral macrophages after spinal cord injury and its effects on cell death
-
Greenhalgh AD, David S. Differences in the phagocytic response of microglia and peripheral macrophages after spinal cord injury and its effects on cell death. J Neurosci 2014;34:6316-22.
-
(2014)
J Neurosci
, vol.34
, pp. 6316-6322
-
-
Greenhalgh, A.D.1
David, S.2
-
39
-
-
33749172559
-
Stem-cell ageing modified by the cyclin-dependent kinase inhibitor p16INK4a
-
Janzen V, Forkert R, Fleming HE, Saito Y, Waring MT, Dombkowski DM, et al. Stem-cell ageing modified by the cyclin-dependent kinase inhibitor p16INK4a. Nature 2006;443:421-6.
-
(2006)
Nature
, vol.443
, pp. 421-426
-
-
Janzen, V.1
Forkert, R.2
Fleming, H.E.3
Saito, Y.4
Waring, M.T.5
Dombkowski, D.M.6
-
40
-
-
84875892857
-
Microglia emerge from erythromyeloid precursors via Pu.1- and Irf8-dependent pathways
-
Kierdorf K, Erny D, Goldmann T, Sander V, Schulz C, Perdiguero EG, et al. Microglia emerge from erythromyeloid precursors via Pu.1- and Irf8-dependent pathways. Nat Neurosci 2013;16:273-80.
-
(2013)
Nat Neurosci
, vol.16
, pp. 273-280
-
-
Kierdorf, K.1
Erny, D.2
Goldmann, T.3
Sander, V.4
Schulz, C.5
Perdiguero, E.G.6
-
41
-
-
84875880772
-
Minocycline selectively inhibits M1 polarization of microglia
-
Kobayashi K, Imagama S, Ohgomori T, Hirano K, Uchimura K, Sakamoto K, et al. Minocycline selectively inhibits M1 polarization of microglia. Cell Death Dis 2013;4:e525.
-
(2013)
Cell Death Dis
, vol.4
, pp. e525
-
-
Kobayashi, K.1
Imagama, S.2
Ohgomori, T.3
Hirano, K.4
Uchimura, K.5
Sakamoto, K.6
-
42
-
-
30644476095
-
Myelin impairs CNS remyelination by inhibiting oligodendrocyte precursor cell differentiation
-
Kotter MR, Li WW, Zhao C, Franklin RJ. Myelin impairs CNS remyelination by inhibiting oligodendrocyte precursor cell differentiation. J Neurosci 2006;26:328-32.
-
(2006)
J Neurosci
, vol.26
, pp. 328-332
-
-
Kotter, M.R.1
Li, W.W.2
Zhao, C.3
Franklin, R.J.4
-
43
-
-
84873452455
-
Traumatic brain injury in aged animals increases lesion size and chronically alters microglial/macrophage classical and alternative activation states
-
Kumar A, Stoica BA, Sabirzhanov B, Burns MP, Faden AI, Loane DJ. Traumatic brain injury in aged animals increases lesion size and chronically alters microglial/macrophage classical and alternative activation states. Neurobiol Aging 2013;34:1397-411.
-
(2013)
Neurobiol Aging
, vol.34
, pp. 1397-1411
-
-
Kumar, A.1
Stoica, B.A.2
Sabirzhanov, B.3
Burns, M.P.4
Faden, A.I.5
Loane, D.J.6
-
44
-
-
84885345875
-
Migration of bone marrow-derived cells into the central nervous system in models of neurodegeneration
-
Lampron A, Pimentel-Coelho PM, Rivest S. Migration of bone marrow-derived cells into the central nervous system in models of neurodegeneration. J Comp Neurol 2013;521:3863-76.
-
(2013)
J Comp Neurol
, vol.521
, pp. 3863-3876
-
-
Lampron, A.1
Pimentel-Coelho, P.M.2
Rivest, S.3
-
45
-
-
84920724791
-
Tissue-resident macrophage enhancer landscapes are shaped by the local microenvironment
-
Lavin Y, Winter D, Blecher-Gonen R, David E, Keren-Shaul H, Merad M, et al. Tissue-resident macrophage enhancer landscapes are shaped by the local microenvironment. Cell 2014;159:1312-26.
-
(2014)
Cell
, vol.159
, pp. 1312-1326
-
-
Lavin, Y.1
Winter, D.2
Blecher-Gonen, R.3
David, E.4
Keren-Shaul, H.5
Merad, M.6
-
46
-
-
80355146399
-
Transcriptional regulation of macrophage polarization: Enabling diversity with identity
-
Lawrence T, Natoli G. Transcriptional regulation of macrophage polarization: enabling diversity with identity. Nat Rev Immunol 2011;11:750-61.
-
(2011)
Nat Rev Immunol
, vol.11
, pp. 750-761
-
-
Lawrence, T.1
Natoli, G.2
-
47
-
-
42649093477
-
Impact of age on long-term recovery from traumatic brain injury
-
Marquez de la Plata CD, Hart T, Hammond FM, Frol AB, Hudak A, Harper CR, et al. Impact of age on long-term recovery from traumatic brain injury. Arch Phys Med Rehabil 2008;89:896-903.
-
(2008)
Arch Phys Med Rehabil
, vol.89
, pp. 896-903
-
-
Marquez De La Plata, C.D.1
Hart, T.2
Hammond, F.M.3
Frol, A.B.4
Hudak, A.5
Harper, C.R.6
-
48
-
-
84897556094
-
The M1 and M2 paradigm of macrophage activation: Time for reassessment
-
Martinez FO, Gordon S. The M1 and M2 paradigm of macrophage activation: time for reassessment. F1000Prime Rep 2014;6:13.
-
(2014)
F1000Prime Rep
, vol.6
, pp. 13
-
-
Martinez, F.O.1
Gordon, S.2
-
50
-
-
34250854079
-
The vaccine adjuvant monophosphoryl lipid A as a TRIF-biased agonist of TLR4
-
Mata-Haro V, Cekic C, Martin M, Chilton PM, Casella CR, Mitchell TC. The vaccine adjuvant monophosphoryl lipid A as a TRIF-biased agonist of TLR4. Science 2007;316:1628-32.
-
(2007)
Science
, vol.316
, pp. 1628-1632
-
-
Mata-Haro, V.1
Cekic, C.2
Martin, M.3
Chilton, P.M.4
Casella, C.R.5
Mitchell, T.C.6
-
51
-
-
75749090492
-
Systemic signals regulate ageing and rejuvenation of blood stem cell niches
-
Mayack SR, Shadrach JL, Kim FS, Wagers AJ. Systemic signals regulate ageing and rejuvenation of blood stem cell niches. Nature 2010;463:495-500.
-
(2010)
Nature
, vol.463
, pp. 495-500
-
-
Mayack, S.R.1
Shadrach, J.L.2
Kim, F.S.3
Wagers, A.J.4
-
52
-
-
84873111294
-
Toll-like receptor 4 stimulation with the detoxified ligand monophosphoryl lipid A improves Alzheimer's disease-related pathology
-
Michaud JP, Halle M, Lampron A, Theriault P, Prefontaine P, Filali M, et al. Toll-like receptor 4 stimulation with the detoxified ligand monophosphoryl lipid A improves Alzheimer's disease-related pathology. Proc Natl Acad Sci USA 2013;110:1941-6.
-
(2013)
Proc Natl Acad Sci USA
, vol.110
, pp. 1941-1946
-
-
Michaud, J.P.1
Halle, M.2
Lampron, A.3
Theriault, P.4
Prefontaine, P.5
Filali, M.6
-
53
-
-
84929657353
-
Roles of microglia in brain development, tissue maintenance and repair
-
Michell-Robinson MA, Touil H, Healy LM, Owen DR, Durafourt BA, Bar-Or A, et al. Roles of microglia in brain development, tissue maintenance and repair. Brain 2015;138(Pt 5):1138-59.
-
(2015)
Brain
, vol.138
, pp. 1138-1159
-
-
Michell-Robinson, M.A.1
Touil, H.2
Healy, L.M.3
Owen, D.R.4
Durafourt, B.A.5
Bar-Or, A.6
-
54
-
-
84883454794
-
M2 microglia and macrophages drive oligodendrocyte differentiation during CNS remyelination
-
Miron VE, Boyd A, Zhao JW, Yuen TJ, Ruckh JM, Shadrach JL, et al. M2 microglia and macrophages drive oligodendrocyte differentiation during CNS remyelination. Nat Neurosci 2013;16:1211-18.
-
(2013)
Nat Neurosci
, vol.16
, pp. 1211-1218
-
-
Miron, V.E.1
Boyd, A.2
Zhao, J.W.3
Yuen, T.J.4
Ruckh, J.M.5
Shadrach, J.L.6
-
55
-
-
84922986271
-
Laquinimod reduces neuroaxonal injury through inhibiting microglial activation
-
Mishra MK, Wang J, Keough MB, Fan Y, Silva C, Sloka S, et al. Laquinimod reduces neuroaxonal injury through inhibiting microglial activation. Ann Clin Transl Neurol 2014;1:409-22.
-
(2014)
Ann Clin Transl Neurol
, vol.1
, pp. 409-422
-
-
Mishra, M.K.1
Wang, J.2
Keough, M.B.3
Fan, Y.4
Silva, C.5
Sloka, S.6
-
56
-
-
84951172662
-
Retinoid X receptor activation reverses agerelated deficiencies in myelin debris phagocytosis and remyelination
-
Natrajan MS, de la Fuente AG, Crawford AH, Linehan E, Nunez V, Johnson KR, et al. Retinoid X receptor activation reverses agerelated deficiencies in myelin debris phagocytosis and remyelination. Brain 2015;138:3581-97.
-
(2015)
Brain
, vol.138
, pp. 3581-3597
-
-
Natrajan, M.S.1
De La Fuente, A.G.2
Crawford, A.H.3
Linehan, E.4
Nunez, V.5
Johnson, K.R.6
-
57
-
-
19744380563
-
Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo
-
Nimmerjahn A, Kirchhoff F, Helmchen F. Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo. Science 2005;308:1314-18.
-
(2005)
Science
, vol.308
, pp. 1314-1318
-
-
Nimmerjahn, A.1
Kirchhoff, F.2
Helmchen, F.3
-
58
-
-
81355132325
-
Ex vivo cultures of microglia from young and aged rodent brain reveal age-related changes in microglial function
-
Njie EG, Boelen E, Stassen FR, Steinbusch HW, Borchelt DR, Streit WJ. Ex vivo cultures of microglia from young and aged rodent brain reveal age-related changes in microglial function. Neurobiol Aging 2012;33:195.e112-.
-
(2012)
Neurobiol Aging
, vol.33
, pp. 195e112
-
-
Njie, E.G.1
Boelen, E.2
Stassen, F.R.3
Steinbusch, H.W.4
Borchelt, D.R.5
Streit, W.J.6
-
59
-
-
84905741423
-
Stem cell aging: Mechanisms, regulators and therapeutic opportunities
-
Oh J, Lee YD, Wagers AJ. Stem cell aging: mechanisms, regulators and therapeutic opportunities. Nat Med 2014;20:870-80.
-
(2014)
Nat Med
, vol.20
, pp. 870-880
-
-
Oh, J.1
Lee, Y.D.2
Wagers, A.J.3
-
60
-
-
84925465211
-
Tissue-resident macrophages originate from yolk-sac-derived erythro-myeloid progenitors
-
Perdiguero EG, Klapproth K, Schulz C, Busch K, Azzoni E, Crozet L, et al. Tissue-resident macrophages originate from yolk-sac-derived erythro-myeloid progenitors. Nature 2015;518:547-51.
-
(2015)
Nature
, vol.518
, pp. 547-551
-
-
Perdiguero, E.G.1
Klapproth, K.2
Schulz, C.3
Busch, K.4
Azzoni, E.5
Crozet, L.6
-
61
-
-
84897976299
-
Microglial priming in neurodegenerative disease
-
Perry VH, Holmes C. Microglial priming in neurodegenerative disease. Nat Rev Neurol 2014;10:217-24.
-
(2014)
Nat Rev Neurol
, vol.10
, pp. 217-224
-
-
Perry, V.H.1
Holmes, C.2
-
62
-
-
0034842126
-
Transected neurites, apoptotic neurons, and reduced inflammation in cortical multiple sclerosis lesions
-
Peterson JW, Bo L, Mork S, Chang A, Trapp BD. Transected neurites, apoptotic neurons, and reduced inflammation in cortical multiple sclerosis lesions. Ann Neurol 2001;50:389-400.
-
(2001)
Ann Neurol
, vol.50
, pp. 389-400
-
-
Peterson, J.W.1
Bo, L.2
Mork, S.3
Chang, A.4
Trapp, B.D.5
-
63
-
-
84899418705
-
Microglia and brain macrophages in the molecular age: From origin to neuropsychiatric disease
-
Prinz M, Priller J. Microglia and brain macrophages in the molecular age: from origin to neuropsychiatric disease. Nat Rev Neurosci 2014;15:300-12.
-
(2014)
Nat Rev Neurosci
, vol.15
, pp. 300-312
-
-
Prinz, M.1
Priller, J.2
-
64
-
-
84880162763
-
The benefits and detriments of macrophages/microglia in models of multiple sclerosis
-
Rawji KS, Yong VW. The benefits and detriments of macrophages/microglia in models of multiple sclerosis. Clin Dev Immunol 2013;2013:948976.
-
(2013)
Clin Dev Immunol
, vol.2013
, pp. 948976
-
-
Rawji, K.S.1
Yong, V.W.2
-
65
-
-
79952338609
-
Accumulation of DNA damage in hematopoietic stem and progenitor cells during human aging
-
Rube CE, Fricke A, Widmann TA, Furst T, Madry H, Pfreundschuh M, et al. Accumulation of DNA damage in hematopoietic stem and progenitor cells during human aging. PLoS One 2011;6:e17487.
-
(2011)
PLoS One
, vol.6
, pp. e17487
-
-
Rube, C.E.1
Fricke, A.2
Widmann, T.A.3
Furst, T.4
Madry, H.5
Pfreundschuh, M.6
-
66
-
-
84862908705
-
Rejuvenation of regeneration in the aging central nervous system
-
Ruckh JM, Zhao JW, Shadrach JL, van Wijngaarden P, Rao TN, Wagers AJ, et al. Rejuvenation of regeneration in the aging central nervous system. Cell Stem Cell 2012;10:96-103.
-
(2012)
Cell Stem Cell
, vol.10
, pp. 96-103
-
-
Ruckh, J.M.1
Zhao, J.W.2
Shadrach, J.L.3
Van Wijngaarden, P.4
Rao, T.N.5
Wagers, A.J.6
-
67
-
-
0030707780
-
Risk factors, outcomes, and stroke subtypes for ischemic stroke
-
Sacco RL. Risk factors, outcomes, and stroke subtypes for ischemic stroke. Neurology 1997;49(Suppl 4):S39-44.
-
(1997)
Neurology
, vol.49
, pp. S39-S44
-
-
Sacco, R.L.1
-
68
-
-
84888071422
-
Screening for inhibitors of microglia to reduce neuroinflammation
-
Samanani S, Mishra M, Silva C, Verhaeghe B, Wang J, Tong J, et al. Screening for inhibitors of microglia to reduce neuroinflammation. CNS Neurol Disord Drug Targets 2013;12:741-9.
-
(2013)
CNS Neurol Disord Drug Targets
, vol.12
, pp. 741-749
-
-
Samanani, S.1
Mishra, M.2
Silva, C.3
Verhaeghe, B.4
Wang, J.5
Tong, J.6
-
69
-
-
51549101179
-
Exacerbated glial response in the aged mouse hippocampus following controlled cortical impact injury
-
Sandhir R, Onyszchuk G, Berman NE. Exacerbated glial response in the aged mouse hippocampus following controlled cortical impact injury. Exp Neurol 2008;213:372-80.
-
(2008)
Exp Neurol
, vol.213
, pp. 372-380
-
-
Sandhir, R.1
Onyszchuk, G.2
Berman, N.E.3
-
70
-
-
84893770485
-
Therapeutic activation of macrophages and microglia to suppress brain tumor-initiating cells
-
Sarkar S, Doring A, Zemp FJ, Silva C, Lun X, Wang X, et al. Therapeutic activation of macrophages and microglia to suppress brain tumor-initiating cells. Nat Neurosci 2014;17:46-55.
-
(2014)
Nat Neurosci
, vol.17
, pp. 46-55
-
-
Sarkar, S.1
Doring, A.2
Zemp, F.J.3
Silva, C.4
Lun, X.5
Wang, X.6
-
71
-
-
84859508307
-
A lineage of myeloid cells independent of Myb and hematopoietic stem cells
-
Schulz C, Gomez Perdiguero E, Chorro L, Szabo-Rogers H, Cagnard N, Kierdorf K, et al. A lineage of myeloid cells independent of Myb and hematopoietic stem cells. Science 2012;336:86-90.
-
(2012)
Science
, vol.336
, pp. 86-90
-
-
Schulz, C.1
Gomez Perdiguero, E.2
Chorro, L.3
Szabo-Rogers, H.4
Cagnard, N.5
Kierdorf, K.6
-
72
-
-
84887093048
-
How do immune cells support and shape the brain in health, disease, and aging?
-
Schwartz M, Kipnis J, Rivest S, Prat A. How do immune cells support and shape the brain in health, disease, and aging?. J Neurosci 2013;33:17587-96.
-
(2013)
J Neurosci
, vol.33
, pp. 17587-17596
-
-
Schwartz, M.1
Kipnis, J.2
Rivest, S.3
Prat, A.4
-
74
-
-
84875553508
-
Recruitment of beneficial M2 macrophages to injured spinal cord is orchestrated by remote brain choroid plexus
-
Shechter R, Miller O, Yovel G, Rosenzweig N, London A, Ruckh J, et al. Recruitment of beneficial M2 macrophages to injured spinal cord is orchestrated by remote brain choroid plexus. Immunity 2013;38:555-69.
-
(2013)
Immunity
, vol.38
, pp. 555-569
-
-
Shechter, R.1
Miller, O.2
Yovel, G.3
Rosenzweig, N.4
London, A.5
Ruckh, J.6
-
75
-
-
84942526430
-
Microglia plasticity during health and disease: An immunological perspective
-
Shemer A, Erny D, Jung S, Prinz M. Microglia plasticity during health and disease: an immunological perspective. Trends Immunol 2015;36:614-24.
-
(2015)
Trends Immunol
, vol.36
, pp. 614-624
-
-
Shemer, A.1
Erny, D.2
Jung, S.3
Prinz, M.4
-
76
-
-
0031909973
-
Enlarged and phagocytic, but not primed, interleukin-1 alpha-immunoreactive microglia increase with age in normal human brain
-
Sheng JG, Mrak RE, Griffin WS. Enlarged and phagocytic, but not primed, interleukin-1 alpha-immunoreactive microglia increase with age in normal human brain. Acta Neuropathol 1998;95:229-34.
-
(1998)
Acta Neuropathol
, vol.95
, pp. 229-234
-
-
Sheng, J.G.1
Mrak, R.E.2
Griffin, W.S.3
-
77
-
-
33846980461
-
Microglia derived from aging mice exhibit an altered inflammatory profile
-
Sierra A, Gottfried-Blackmore AC, McEwen BS, Bulloch K. Microglia derived from aging mice exhibit an altered inflammatory profile. Glia 2007;55:412-24.
-
(2007)
Glia
, vol.55
, pp. 412-424
-
-
Sierra, A.1
Gottfried-Blackmore, A.C.2
McEwen, B.S.3
Bulloch, K.4
-
78
-
-
84856756074
-
Effects of aging and sensory loss on glial cells in mouse visual and auditory cortices
-
Tremblay ME, Zettel ML, Ison JR, Allen PD, Majewska AK. Effects of aging and sensory loss on glial cells in mouse visual and auditory cortices. Glia 2012;60:541-58.
-
(2012)
Glia
, vol.60
, pp. 541-558
-
-
Tremblay, M.E.1
Zettel, M.L.2
Ison, J.R.3
Allen, P.D.4
Majewska, A.K.5
-
79
-
-
33846208784
-
Age-associated defect in human TLR-1/2 function
-
van Duin D, Mohanty S, Thomas V, Ginter S, Montgomery RR, Fikrig E, et al. Age-associated defect in human TLR-1/2 function. J Immunol 2007;178:970-5.
-
(2007)
J Immunol
, vol.178
, pp. 970-975
-
-
Van Duin, D.1
Mohanty, S.2
Thomas, V.3
Ginter, S.4
Montgomery, R.R.5
Fikrig, E.6
-
80
-
-
80052410357
-
The ageing systemic milieu negatively regulates neurogenesis and cognitive function
-
Villeda SA, Luo J, Mosher KI, Zou B, Britschgi M, Bieri G, et al. The ageing systemic milieu negatively regulates neurogenesis and cognitive function. Nature 2011;477:90-4.
-
(2011)
Nature
, vol.477
, pp. 90-94
-
-
Villeda, S.A.1
Luo, J.2
Mosher, K.I.3
Zou, B.4
Britschgi, M.5
Bieri, G.6
-
81
-
-
84924207006
-
HDAC inhibition prevents white matter injury by modulating microglia/macrophage polarization through the GSK3beta/PTEN/Akt axis
-
Wang G, Shi Y, Jiang X, Leak RK, Hu X, Wu Y, et al. HDAC inhibition prevents white matter injury by modulating microglia/macrophage polarization through the GSK3beta/PTEN/Akt axis. Proc Natl Acad Sci USA 2015;112:2853-8.
-
(2015)
Proc Natl Acad Sci USA
, vol.112
, pp. 2853-2858
-
-
Wang, G.1
Shi, Y.2
Jiang, X.3
Leak, R.K.4
Hu, X.5
Wu, Y.6
-
82
-
-
84989448031
-
Observations on human monocyte kinetics after pulse labeling
-
Whitelaw DM. Observations on human monocyte kinetics after pulse labeling. Cell Tissue Kinet 1972;5:311-17.
-
(1972)
Cell Tissue Kinet
, vol.5
, pp. 311-317
-
-
Whitelaw, D.M.1
-
83
-
-
84894102230
-
Transcriptome-based network analysis reveals a spectrum model of human macrophage activation
-
Xue J, Schmidt SV, Sander J, Draffehn A, Krebs W, Quester I, et al. Transcriptome-based network analysis reveals a spectrum model of human macrophage activation. Immunity 2014;40:274-88.
-
(2014)
Immunity
, vol.40
, pp. 274-288
-
-
Xue, J.1
Schmidt, S.V.2
Sander, J.3
Draffehn, A.4
Krebs, W.5
Quester, I.6
-
84
-
-
84870226700
-
PPARgamma/RXRalpha-induced and CD36-mediated microglial amyloid-beta phagocytosis results in cognitive improvement in amyloid precursor protein/presenilin 1 mice
-
Yamanaka M, Ishikawa T, Griep A, Axt D, Kummer MP, Heneka MT. PPARgamma/RXRalpha-induced and CD36-mediated microglial amyloid-beta phagocytosis results in cognitive improvement in amyloid precursor protein/presenilin 1 mice. J Neurosci 2012;32:17321-31.
-
(2012)
J Neurosci
, vol.32
, pp. 17321-17331
-
-
Yamanaka, M.1
Ishikawa, T.2
Griep, A.3
Axt, D.4
Kummer, M.P.5
Heneka, M.T.6
-
85
-
-
84905116959
-
Differential roles of microglia and monocytes in the inflamed central nervous system
-
Yamasaki R, Lu H, Butovsky O, Ohno N, Rietsch AM, Cialic R, et al. Differential roles of microglia and monocytes in the inflamed central nervous system. J Exp Med 2014;211:1533-49.
-
(2014)
J Exp Med
, vol.211
, pp. 1533-1549
-
-
Yamasaki, R.1
Lu, H.2
Butovsky, O.3
Ohno, N.4
Rietsch, A.M.5
Cialic, R.6
-
86
-
-
33644910475
-
Differences in the early inflammatory responses to toxin-induced demyelination are associated with the age-related decline in CNS remyelination
-
Zhao C, Li WW, Franklin RJ. Differences in the early inflammatory responses to toxin-induced demyelination are associated with the age-related decline in CNS remyelination. Neurobiol Aging 2006;27:1298-307.
-
(2006)
Neurobiol Aging
, vol.27
, pp. 1298-1307
-
-
Zhao, C.1
Li, W.W.2
Franklin, R.J.3
|