메뉴 건너뛰기




Volumn 139, Issue 3, 2016, Pages 653-661

Immunosenescence of microglia and macrophages: Impact on the ageing central nervous system

Author keywords

Ageing; Macrophage; Microglia; Rejuvenation; White matter injury

Indexed keywords

CYTOKINE;

EID: 84964659735     PISSN: 00068950     EISSN: 14602156     Source Type: Journal    
DOI: 10.1093/brain/awv395     Document Type: Article
Times cited : (206)

References (86)
  • 1
    • 80052246111 scopus 로고    scopus 로고
    • Infiltrating monocytes trigger EAE progression, but do not contribute to the resident microglia pool
    • Ajami B, Bennett JL, Krieger C, McNagny KM, Rossi FM. Infiltrating monocytes trigger EAE progression, but do not contribute to the resident microglia pool. Nat Neurosci 2011;14:1142-9.
    • (2011) Nat Neurosci , vol.14 , pp. 1142-1149
    • Ajami, B.1    Bennett, J.L.2    Krieger, C.3    McNagny, K.M.4    Rossi, F.M.5
  • 2
    • 36448994709 scopus 로고    scopus 로고
    • Local selfrenewal can sustain CNS microglia maintenance and function throughout adult life
    • Ajami B, Bennett JL, Krieger C, Tetzlaff W, Rossi FM. Local selfrenewal can sustain CNS microglia maintenance and function throughout adult life. Nat Neurosci 2007;10:1538-43.
    • (2007) Nat Neurosci , vol.10 , pp. 1538-1543
    • Ajami, B.1    Bennett, J.L.2    Krieger, C.3    Tetzlaff, W.4    Rossi, F.M.5
  • 3
    • 84907659600 scopus 로고    scopus 로고
    • Aging-induced type I interferon response at the choroid plexus negatively affects brain function
    • Baruch K, Deczkowska A, David E, Castellano JM, Miller O, Kertser A, et al. Aging-induced type I interferon response at the choroid plexus negatively affects brain function. Science 2014;346:89-93.
    • (2014) Science , vol.346 , pp. 89-93
    • Baruch, K.1    Deczkowska, A.2    David, E.3    Castellano, J.M.4    Miller, O.5    Kertser, A.6
  • 4
    • 84873475219 scopus 로고    scopus 로고
    • CNS-specific immunity at the choroid plexus shifts toward destructive Th2 inflammation in brain aging
    • Baruch K, Ron-Harel N, Gal H, Deczkowska A, Shifrut E, Ndifon W, et al. CNS-specific immunity at the choroid plexus shifts toward destructive Th2 inflammation in brain aging. Proc Natl Acad Sci USA 2013;110:2264-9.
    • (2013) Proc Natl Acad Sci USA , vol.110 , pp. 2264-2269
    • Baruch, K.1    Ron-Harel, N.2    Gal, H.3    Deczkowska, A.4    Shifrut, E.5    Ndifon, W.6
  • 5
    • 84885063645 scopus 로고    scopus 로고
    • CNS-specific T cells shape brain function via the choroid plexus
    • Baruch K, Schwartz M. CNS-specific T cells shape brain function via the choroid plexus. Brain Behav Immun 2013;34:11-16.
    • (2013) Brain Behav Immun , vol.34 , pp. 11-16
    • Baruch, K.1    Schwartz, M.2
  • 6
    • 84875965163 scopus 로고    scopus 로고
    • Proliferation-dependent alterations of the DNA methylation landscape underlie hematopoietic stem cell aging
    • Beerman I, Bock C, Garrison BS, Smith ZD, Gu H, Meissner A, et al. Proliferation-dependent alterations of the DNA methylation landscape underlie hematopoietic stem cell aging. Cell Stem Cell 2013;12:413-25.
    • (2013) Cell Stem Cell , vol.12 , pp. 413-425
    • Beerman, I.1    Bock, C.2    Garrison, B.S.3    Smith, Z.D.4    Gu, H.5    Meissner, A.6
  • 7
    • 13844281550 scopus 로고    scopus 로고
    • How chronic inflammation can affect the brain and support the development of Alzheimer's disease in old age: The role of microglia and astrocytes
    • Blasko I, Stampfer-Kountchev M, Robatscher P, Veerhuis R, Eikelenboom P, Grubeck-Loebenstein B. How chronic inflammation can affect the brain and support the development of Alzheimer's disease in old age: the role of microglia and astrocytes. Aging Cell 2004;3:169-76.
    • (2004) Aging Cell , vol.3 , pp. 169-176
    • Blasko, I.1    Stampfer-Kountchev, M.2    Robatscher, P.3    Veerhuis, R.4    Eikelenboom, P.5    Grubeck-Loebenstein, B.6
  • 8
    • 0842309938 scopus 로고    scopus 로고
    • Age-dependent decrease in Toll-like receptor 4-mediated proinflammatory cytokine production and mitogen-activated protein kinase expression
    • Boehmer ED, Goral J, Faunce DE, Kovacs EJ. Age-dependent decrease in Toll-like receptor 4-mediated proinflammatory cytokine production and mitogen-activated protein kinase expression. J Leukoc Biol 2004;75:342-9.
    • (2004) J Leukoc Biol , vol.75 , pp. 342-349
    • Boehmer, E.D.1    Goral, J.2    Faunce, D.E.3    Kovacs, E.J.4
  • 9
    • 27644480499 scopus 로고    scopus 로고
    • Aging negatively skews macrophage TLR2- and TLR4-mediated pro-inflammatory responses without affecting the IL-2-stimulated pathway
    • Boehmer ED, Meehan MJ, Cutro BT, Kovacs EJ. Aging negatively skews macrophage TLR2- and TLR4-mediated pro-inflammatory responses without affecting the IL-2-stimulated pathway. Mech Ageing Dev 2005;126:1305-13.
    • (2005) Mech Ageing Dev , vol.126 , pp. 1305-1313
    • Boehmer, E.D.1    Meehan, M.J.2    Cutro, B.T.3    Kovacs, E.J.4
  • 10
    • 65249119363 scopus 로고    scopus 로고
    • Powerful beneficial effects of macrophage colony-stimulating factor on beta-amyloid deposition and cognitive impairment in Alzheimer's disease
    • Boissonneault V, Filali M, Lessard M, Relton J, Wong G, Rivest S. Powerful beneficial effects of macrophage colony-stimulating factor on beta-amyloid deposition and cognitive impairment in Alzheimer's disease. Brain 2009;132(Pt 4):1078-92.
    • (2009) Brain , vol.132 , pp. 1078-1092
    • Boissonneault, V.1    Filali, M.2    Lessard, M.3    Relton, J.4    Wong, G.5    Rivest, S.6
  • 11
    • 84937738858 scopus 로고    scopus 로고
    • Genetic cell ablation reveals clusters of local self-renewing microglia in the mammalian central nervous system
    • Bruttger J, Karram K, Wortge S, Regen T, Marini F, Hoppmann N, et al. Genetic cell ablation reveals clusters of local self-renewing microglia in the mammalian central nervous system. Immunity 2015;43:92-106.
    • (2015) Immunity , vol.43 , pp. 92-106
    • Bruttger, J.1    Karram, K.2    Wortge, S.3    Regen, T.4    Marini, F.5    Hoppmann, N.6
  • 15
    • 16844363815 scopus 로고    scopus 로고
    • The unresponsiveness of aged mice to polysaccharide antigens is a result of a defect in macrophage function
    • Chelvarajan RL, Collins SM, Van Willigen JM, Bondada S. The unresponsiveness of aged mice to polysaccharide antigens is a result of a defect in macrophage function. J Leukoc Biol 2005;77:503-12.
    • (2005) J Leukoc Biol , vol.77 , pp. 503-512
    • Chelvarajan, R.L.1    Collins, S.M.2    Van Willigen, J.M.3    Bondada, S.4
  • 16
    • 75549090275 scopus 로고    scopus 로고
    • mTOR regulation and therapeutic rejuvenation of aging hematopoietic stem cells
    • Chen C, Liu Y, Liu Y, Zheng P. mTOR regulation and therapeutic rejuvenation of aging hematopoietic stem cells. Sci Signal 2009;2:ra75.
    • (2009) Sci Signal , vol.2 , pp. ra75
    • Chen, C.1    Liu, Y.2    Liu, Y.3    Zheng, P.4
  • 17
    • 84918825145 scopus 로고    scopus 로고
    • Chronic exposure to TGFbeta1 regulates myeloid cell inflammatory response in an IRF7-dependent manner
    • Cohen M, Matcovitch O, David E, Barnett-Itzhaki Z, Keren-Shaul H, Blecher-Gonen R, et al. Chronic exposure to TGFbeta1 regulates myeloid cell inflammatory response in an IRF7-dependent manner. EMBO J 2014;33:2906-21.
    • (2014) EMBO J , vol.33 , pp. 2906-2921
    • Cohen, M.1    Matcovitch, O.2    David, E.3    Barnett-Itzhaki, Z.4    Keren-Shaul, H.5    Blecher-Gonen, R.6
  • 20
    • 0035116752 scopus 로고    scopus 로고
    • Acute central cervical cord injury: The effect of age upon prognosis
    • Dai LY. Acute central cervical cord injury: the effect of age upon prognosis. Injury 2001;32:195-9.
    • (2001) Injury , vol.32 , pp. 195-199
    • Dai, L.Y.1
  • 22
    • 84921519046 scopus 로고    scopus 로고
    • Stimulation of monocytes, macrophages, and microglia by amphotericin B and macrophage colony-stimulating factor promotes remyelination
    • Doring A, Sloka S, Lau L, Mishra M, van Minnen J, Zhang X, et al. Stimulation of monocytes, macrophages, and microglia by amphotericin B and macrophage colony-stimulating factor promotes remyelination. J Neurosci 2015;35:1136-48.
    • (2015) J Neurosci , vol.35 , pp. 1136-1148
    • Doring, A.1    Sloka, S.2    Lau, L.3    Mishra, M.4    Van Minnen, J.5    Zhang, X.6
  • 23
    • 77957689347 scopus 로고    scopus 로고
    • TGFbeta signaling in the brain increases with aging and signals to astrocytes and innate immune cells in the weeks after stroke
    • Doyle KP, Cekanaviciute E, Mamer LE, Buckwalter MS. TGFbeta signaling in the brain increases with aging and signals to astrocytes and innate immune cells in the weeks after stroke. J Neuroinflammation 2010;7:62.
    • (2010) J Neuroinflammation , vol.7 , pp. 62
    • Doyle, K.P.1    Cekanaviciute, E.2    Mamer, L.E.3    Buckwalter, M.S.4
  • 24
    • 84858649330 scopus 로고    scopus 로고
    • Rantes/Ccl5 influences hematopoietic stem cell subtypes and causes myeloid skewing
    • Ergen AV, Boles NC, Goodell MA. Rantes/Ccl5 influences hematopoietic stem cell subtypes and causes myeloid skewing. Blood 2012;119:2500-9.
    • (2012) Blood , vol.119 , pp. 2500-2509
    • Ergen, A.V.1    Boles, N.C.2    Goodell, M.A.3
  • 26
    • 33947545098 scopus 로고    scopus 로고
    • Minocycline reduces microglial activation and improves behavioral deficits in a transgenic model of cerebral microvascular amyloid
    • Fan R, Xu F, Previti ML, Davis J, Grande AM, Robinson JK, et al. Minocycline reduces microglial activation and improves behavioral deficits in a transgenic model of cerebral microvascular amyloid. J Neurosci 2007;27:3057-63.
    • (2007) J Neurosci , vol.27 , pp. 3057-3063
    • Fan, R.1    Xu, F.2    Previti, M.L.3    Davis, J.4    Grande, A.M.5    Robinson, J.K.6
  • 27
    • 84903160194 scopus 로고    scopus 로고
    • IL-4 signaling drives a unique arginase +/IL-1beta + microglia phenotype and recruits macrophages to the inflammatory CNS: Consequences of age-related deficits in IL-4Ralpha after traumatic spinal cord injury
    • Fenn AM, Hall JC, Gensel JC, Popovich PG, Godbout JP. IL-4 signaling drives a unique arginase +/IL-1beta + microglia phenotype and recruits macrophages to the inflammatory CNS: consequences of age-related deficits in IL-4Ralpha after traumatic spinal cord injury. J Neurosci 2014;34:8904-17.
    • (2014) J Neurosci , vol.34 , pp. 8904-8917
    • Fenn, A.M.1    Hall, J.C.2    Gensel, J.C.3    Popovich, P.G.4    Godbout, J.P.5
  • 29
    • 79960744467 scopus 로고    scopus 로고
    • Microglia demonstrate age-dependent interaction with amyloid-beta fibrils
    • Floden AM, Combs CK. Microglia demonstrate age-dependent interaction with amyloid-beta fibrils. J Alzheimers Dis 2011;25:279-93.
    • (2011) J Alzheimers Dis , vol.25 , pp. 279-293
    • Floden, A.M.1    Combs, C.K.2
  • 31
    • 84883361779 scopus 로고    scopus 로고
    • Scara1 deficiency impairs clearance of soluble amyloid-beta by mononuclear phagocytes and accelerates Alzheimer's-like disease progression
    • Frenkel D, Wilkinson K, Zhao L, Hickman SE, Means TK, Puckett L, et al. Scara1 deficiency impairs clearance of soluble amyloid-beta by mononuclear phagocytes and accelerates Alzheimer's-like disease progression. Nat Commun 2013;4:2030.
    • (2013) Nat Commun , vol.4 , pp. 2030
    • Frenkel, D.1    Wilkinson, K.2    Zhao, L.3    Hickman, S.E.4    Means, T.K.5    Puckett, L.6
  • 32
    • 84876909069 scopus 로고    scopus 로고
    • The ageing haematopoietic stem cell compartment
    • Geiger H, de Haan G, Florian MC. The ageing haematopoietic stem cell compartment. Nat Rev Immunol 2013;13:376-89.
    • (2013) Nat Rev Immunol , vol.13 , pp. 376-389
    • Geiger, H.1    De Haan, G.2    Florian, M.C.3
  • 33
    • 78149360132 scopus 로고    scopus 로고
    • Fate mapping analysis reveals that adult microglia derive from primitive macrophages
    • Ginhoux F, Greter M, Leboeuf M, Nandi S, See P, Gokhan S, et al. Fate mapping analysis reveals that adult microglia derive from primitive macrophages. Science 2010;330:841-5.
    • (2010) Science , vol.330 , pp. 841-845
    • Ginhoux, F.1    Greter, M.2    Leboeuf, M.3    Nandi, S.4    See, P.5    Gokhan, S.6
  • 34
    • 23444443814 scopus 로고    scopus 로고
    • Exaggerated neuroinflammation and sickness behavior in aged mice following activation of the peripheral innate immune system
    • Godbout JP, Chen J, Abraham J, Richwine AF, Berg BM, Kelley KW, et al. Exaggerated neuroinflammation and sickness behavior in aged mice following activation of the peripheral innate immune system. FASEB J 2005;19:1329-31.
    • (2005) FASEB J , vol.19 , pp. 1329-1331
    • Godbout, J.P.1    Chen, J.2    Abraham, J.3    Richwine, A.F.4    Berg, B.M.5    Kelley, K.W.6
  • 35
    • 67650079567 scopus 로고    scopus 로고
    • Remyelination capacity of the MS brain decreases with disease chronicity
    • Goldschmidt T, Antel J, Konig FB, Bruck W, Kuhlmann T. Remyelination capacity of the MS brain decreases with disease chronicity. Neurology 2009;72:1914-21.
    • (2009) Neurology , vol.72 , pp. 1914-1921
    • Goldschmidt, T.1    Antel, J.2    Konig, F.B.3    Bruck, W.4    Kuhlmann, T.5
  • 36
    • 0029737506 scopus 로고    scopus 로고
    • Lower serum concentrations of cytokines in elderly patients with pneumonia and the impaired production of cytokines by peripheral blood monocytes in the elderly
    • Gon Y, Hashimoto S, Hayashi S, Koura T, Matsumoto K, Horie T. Lower serum concentrations of cytokines in elderly patients with pneumonia and the impaired production of cytokines by peripheral blood monocytes in the elderly. Clin Exp Immunol 1996;106:120-6.
    • (1996) Clin Exp Immunol , vol.106 , pp. 120-126
    • Gon, Y.1    Hashimoto, S.2    Hayashi, S.3    Koura, T.4    Matsumoto, K.5    Horie, T.6
  • 37
    • 84920724792 scopus 로고    scopus 로고
    • Environment drives selection and function of enhancers controlling tissue-specific macrophage identities
    • Gosselin D, Link VM, Romanoski CE, Fonseca GJ, Eichenfield DZ, Spann NJ, et al. Environment drives selection and function of enhancers controlling tissue-specific macrophage identities. Cell 2014;159:1327-40.
    • (2014) Cell , vol.159 , pp. 1327-1340
    • Gosselin, D.1    Link, V.M.2    Romanoski, C.E.3    Fonseca, G.J.4    Eichenfield, D.Z.5    Spann, N.J.6
  • 38
    • 84899636196 scopus 로고    scopus 로고
    • Differences in the phagocytic response of microglia and peripheral macrophages after spinal cord injury and its effects on cell death
    • Greenhalgh AD, David S. Differences in the phagocytic response of microglia and peripheral macrophages after spinal cord injury and its effects on cell death. J Neurosci 2014;34:6316-22.
    • (2014) J Neurosci , vol.34 , pp. 6316-6322
    • Greenhalgh, A.D.1    David, S.2
  • 40
    • 84875892857 scopus 로고    scopus 로고
    • Microglia emerge from erythromyeloid precursors via Pu.1- and Irf8-dependent pathways
    • Kierdorf K, Erny D, Goldmann T, Sander V, Schulz C, Perdiguero EG, et al. Microglia emerge from erythromyeloid precursors via Pu.1- and Irf8-dependent pathways. Nat Neurosci 2013;16:273-80.
    • (2013) Nat Neurosci , vol.16 , pp. 273-280
    • Kierdorf, K.1    Erny, D.2    Goldmann, T.3    Sander, V.4    Schulz, C.5    Perdiguero, E.G.6
  • 42
    • 30644476095 scopus 로고    scopus 로고
    • Myelin impairs CNS remyelination by inhibiting oligodendrocyte precursor cell differentiation
    • Kotter MR, Li WW, Zhao C, Franklin RJ. Myelin impairs CNS remyelination by inhibiting oligodendrocyte precursor cell differentiation. J Neurosci 2006;26:328-32.
    • (2006) J Neurosci , vol.26 , pp. 328-332
    • Kotter, M.R.1    Li, W.W.2    Zhao, C.3    Franklin, R.J.4
  • 43
    • 84873452455 scopus 로고    scopus 로고
    • Traumatic brain injury in aged animals increases lesion size and chronically alters microglial/macrophage classical and alternative activation states
    • Kumar A, Stoica BA, Sabirzhanov B, Burns MP, Faden AI, Loane DJ. Traumatic brain injury in aged animals increases lesion size and chronically alters microglial/macrophage classical and alternative activation states. Neurobiol Aging 2013;34:1397-411.
    • (2013) Neurobiol Aging , vol.34 , pp. 1397-1411
    • Kumar, A.1    Stoica, B.A.2    Sabirzhanov, B.3    Burns, M.P.4    Faden, A.I.5    Loane, D.J.6
  • 44
    • 84885345875 scopus 로고    scopus 로고
    • Migration of bone marrow-derived cells into the central nervous system in models of neurodegeneration
    • Lampron A, Pimentel-Coelho PM, Rivest S. Migration of bone marrow-derived cells into the central nervous system in models of neurodegeneration. J Comp Neurol 2013;521:3863-76.
    • (2013) J Comp Neurol , vol.521 , pp. 3863-3876
    • Lampron, A.1    Pimentel-Coelho, P.M.2    Rivest, S.3
  • 45
    • 84920724791 scopus 로고    scopus 로고
    • Tissue-resident macrophage enhancer landscapes are shaped by the local microenvironment
    • Lavin Y, Winter D, Blecher-Gonen R, David E, Keren-Shaul H, Merad M, et al. Tissue-resident macrophage enhancer landscapes are shaped by the local microenvironment. Cell 2014;159:1312-26.
    • (2014) Cell , vol.159 , pp. 1312-1326
    • Lavin, Y.1    Winter, D.2    Blecher-Gonen, R.3    David, E.4    Keren-Shaul, H.5    Merad, M.6
  • 46
    • 80355146399 scopus 로고    scopus 로고
    • Transcriptional regulation of macrophage polarization: Enabling diversity with identity
    • Lawrence T, Natoli G. Transcriptional regulation of macrophage polarization: enabling diversity with identity. Nat Rev Immunol 2011;11:750-61.
    • (2011) Nat Rev Immunol , vol.11 , pp. 750-761
    • Lawrence, T.1    Natoli, G.2
  • 48
    • 84897556094 scopus 로고    scopus 로고
    • The M1 and M2 paradigm of macrophage activation: Time for reassessment
    • Martinez FO, Gordon S. The M1 and M2 paradigm of macrophage activation: time for reassessment. F1000Prime Rep 2014;6:13.
    • (2014) F1000Prime Rep , vol.6 , pp. 13
    • Martinez, F.O.1    Gordon, S.2
  • 51
    • 75749090492 scopus 로고    scopus 로고
    • Systemic signals regulate ageing and rejuvenation of blood stem cell niches
    • Mayack SR, Shadrach JL, Kim FS, Wagers AJ. Systemic signals regulate ageing and rejuvenation of blood stem cell niches. Nature 2010;463:495-500.
    • (2010) Nature , vol.463 , pp. 495-500
    • Mayack, S.R.1    Shadrach, J.L.2    Kim, F.S.3    Wagers, A.J.4
  • 52
    • 84873111294 scopus 로고    scopus 로고
    • Toll-like receptor 4 stimulation with the detoxified ligand monophosphoryl lipid A improves Alzheimer's disease-related pathology
    • Michaud JP, Halle M, Lampron A, Theriault P, Prefontaine P, Filali M, et al. Toll-like receptor 4 stimulation with the detoxified ligand monophosphoryl lipid A improves Alzheimer's disease-related pathology. Proc Natl Acad Sci USA 2013;110:1941-6.
    • (2013) Proc Natl Acad Sci USA , vol.110 , pp. 1941-1946
    • Michaud, J.P.1    Halle, M.2    Lampron, A.3    Theriault, P.4    Prefontaine, P.5    Filali, M.6
  • 54
    • 84883454794 scopus 로고    scopus 로고
    • M2 microglia and macrophages drive oligodendrocyte differentiation during CNS remyelination
    • Miron VE, Boyd A, Zhao JW, Yuen TJ, Ruckh JM, Shadrach JL, et al. M2 microglia and macrophages drive oligodendrocyte differentiation during CNS remyelination. Nat Neurosci 2013;16:1211-18.
    • (2013) Nat Neurosci , vol.16 , pp. 1211-1218
    • Miron, V.E.1    Boyd, A.2    Zhao, J.W.3    Yuen, T.J.4    Ruckh, J.M.5    Shadrach, J.L.6
  • 56
    • 84951172662 scopus 로고    scopus 로고
    • Retinoid X receptor activation reverses agerelated deficiencies in myelin debris phagocytosis and remyelination
    • Natrajan MS, de la Fuente AG, Crawford AH, Linehan E, Nunez V, Johnson KR, et al. Retinoid X receptor activation reverses agerelated deficiencies in myelin debris phagocytosis and remyelination. Brain 2015;138:3581-97.
    • (2015) Brain , vol.138 , pp. 3581-3597
    • Natrajan, M.S.1    De La Fuente, A.G.2    Crawford, A.H.3    Linehan, E.4    Nunez, V.5    Johnson, K.R.6
  • 57
    • 19744380563 scopus 로고    scopus 로고
    • Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo
    • Nimmerjahn A, Kirchhoff F, Helmchen F. Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo. Science 2005;308:1314-18.
    • (2005) Science , vol.308 , pp. 1314-1318
    • Nimmerjahn, A.1    Kirchhoff, F.2    Helmchen, F.3
  • 58
    • 81355132325 scopus 로고    scopus 로고
    • Ex vivo cultures of microglia from young and aged rodent brain reveal age-related changes in microglial function
    • Njie EG, Boelen E, Stassen FR, Steinbusch HW, Borchelt DR, Streit WJ. Ex vivo cultures of microglia from young and aged rodent brain reveal age-related changes in microglial function. Neurobiol Aging 2012;33:195.e112-.
    • (2012) Neurobiol Aging , vol.33 , pp. 195e112
    • Njie, E.G.1    Boelen, E.2    Stassen, F.R.3    Steinbusch, H.W.4    Borchelt, D.R.5    Streit, W.J.6
  • 59
    • 84905741423 scopus 로고    scopus 로고
    • Stem cell aging: Mechanisms, regulators and therapeutic opportunities
    • Oh J, Lee YD, Wagers AJ. Stem cell aging: mechanisms, regulators and therapeutic opportunities. Nat Med 2014;20:870-80.
    • (2014) Nat Med , vol.20 , pp. 870-880
    • Oh, J.1    Lee, Y.D.2    Wagers, A.J.3
  • 60
    • 84925465211 scopus 로고    scopus 로고
    • Tissue-resident macrophages originate from yolk-sac-derived erythro-myeloid progenitors
    • Perdiguero EG, Klapproth K, Schulz C, Busch K, Azzoni E, Crozet L, et al. Tissue-resident macrophages originate from yolk-sac-derived erythro-myeloid progenitors. Nature 2015;518:547-51.
    • (2015) Nature , vol.518 , pp. 547-551
    • Perdiguero, E.G.1    Klapproth, K.2    Schulz, C.3    Busch, K.4    Azzoni, E.5    Crozet, L.6
  • 61
    • 84897976299 scopus 로고    scopus 로고
    • Microglial priming in neurodegenerative disease
    • Perry VH, Holmes C. Microglial priming in neurodegenerative disease. Nat Rev Neurol 2014;10:217-24.
    • (2014) Nat Rev Neurol , vol.10 , pp. 217-224
    • Perry, V.H.1    Holmes, C.2
  • 62
    • 0034842126 scopus 로고    scopus 로고
    • Transected neurites, apoptotic neurons, and reduced inflammation in cortical multiple sclerosis lesions
    • Peterson JW, Bo L, Mork S, Chang A, Trapp BD. Transected neurites, apoptotic neurons, and reduced inflammation in cortical multiple sclerosis lesions. Ann Neurol 2001;50:389-400.
    • (2001) Ann Neurol , vol.50 , pp. 389-400
    • Peterson, J.W.1    Bo, L.2    Mork, S.3    Chang, A.4    Trapp, B.D.5
  • 63
    • 84899418705 scopus 로고    scopus 로고
    • Microglia and brain macrophages in the molecular age: From origin to neuropsychiatric disease
    • Prinz M, Priller J. Microglia and brain macrophages in the molecular age: from origin to neuropsychiatric disease. Nat Rev Neurosci 2014;15:300-12.
    • (2014) Nat Rev Neurosci , vol.15 , pp. 300-312
    • Prinz, M.1    Priller, J.2
  • 64
    • 84880162763 scopus 로고    scopus 로고
    • The benefits and detriments of macrophages/microglia in models of multiple sclerosis
    • Rawji KS, Yong VW. The benefits and detriments of macrophages/microglia in models of multiple sclerosis. Clin Dev Immunol 2013;2013:948976.
    • (2013) Clin Dev Immunol , vol.2013 , pp. 948976
    • Rawji, K.S.1    Yong, V.W.2
  • 65
    • 79952338609 scopus 로고    scopus 로고
    • Accumulation of DNA damage in hematopoietic stem and progenitor cells during human aging
    • Rube CE, Fricke A, Widmann TA, Furst T, Madry H, Pfreundschuh M, et al. Accumulation of DNA damage in hematopoietic stem and progenitor cells during human aging. PLoS One 2011;6:e17487.
    • (2011) PLoS One , vol.6 , pp. e17487
    • Rube, C.E.1    Fricke, A.2    Widmann, T.A.3    Furst, T.4    Madry, H.5    Pfreundschuh, M.6
  • 67
    • 0030707780 scopus 로고    scopus 로고
    • Risk factors, outcomes, and stroke subtypes for ischemic stroke
    • Sacco RL. Risk factors, outcomes, and stroke subtypes for ischemic stroke. Neurology 1997;49(Suppl 4):S39-44.
    • (1997) Neurology , vol.49 , pp. S39-S44
    • Sacco, R.L.1
  • 69
    • 51549101179 scopus 로고    scopus 로고
    • Exacerbated glial response in the aged mouse hippocampus following controlled cortical impact injury
    • Sandhir R, Onyszchuk G, Berman NE. Exacerbated glial response in the aged mouse hippocampus following controlled cortical impact injury. Exp Neurol 2008;213:372-80.
    • (2008) Exp Neurol , vol.213 , pp. 372-380
    • Sandhir, R.1    Onyszchuk, G.2    Berman, N.E.3
  • 70
    • 84893770485 scopus 로고    scopus 로고
    • Therapeutic activation of macrophages and microglia to suppress brain tumor-initiating cells
    • Sarkar S, Doring A, Zemp FJ, Silva C, Lun X, Wang X, et al. Therapeutic activation of macrophages and microglia to suppress brain tumor-initiating cells. Nat Neurosci 2014;17:46-55.
    • (2014) Nat Neurosci , vol.17 , pp. 46-55
    • Sarkar, S.1    Doring, A.2    Zemp, F.J.3    Silva, C.4    Lun, X.5    Wang, X.6
  • 72
    • 84887093048 scopus 로고    scopus 로고
    • How do immune cells support and shape the brain in health, disease, and aging?
    • Schwartz M, Kipnis J, Rivest S, Prat A. How do immune cells support and shape the brain in health, disease, and aging?. J Neurosci 2013;33:17587-96.
    • (2013) J Neurosci , vol.33 , pp. 17587-17596
    • Schwartz, M.1    Kipnis, J.2    Rivest, S.3    Prat, A.4
  • 74
    • 84875553508 scopus 로고    scopus 로고
    • Recruitment of beneficial M2 macrophages to injured spinal cord is orchestrated by remote brain choroid plexus
    • Shechter R, Miller O, Yovel G, Rosenzweig N, London A, Ruckh J, et al. Recruitment of beneficial M2 macrophages to injured spinal cord is orchestrated by remote brain choroid plexus. Immunity 2013;38:555-69.
    • (2013) Immunity , vol.38 , pp. 555-569
    • Shechter, R.1    Miller, O.2    Yovel, G.3    Rosenzweig, N.4    London, A.5    Ruckh, J.6
  • 75
    • 84942526430 scopus 로고    scopus 로고
    • Microglia plasticity during health and disease: An immunological perspective
    • Shemer A, Erny D, Jung S, Prinz M. Microglia plasticity during health and disease: an immunological perspective. Trends Immunol 2015;36:614-24.
    • (2015) Trends Immunol , vol.36 , pp. 614-624
    • Shemer, A.1    Erny, D.2    Jung, S.3    Prinz, M.4
  • 76
    • 0031909973 scopus 로고    scopus 로고
    • Enlarged and phagocytic, but not primed, interleukin-1 alpha-immunoreactive microglia increase with age in normal human brain
    • Sheng JG, Mrak RE, Griffin WS. Enlarged and phagocytic, but not primed, interleukin-1 alpha-immunoreactive microglia increase with age in normal human brain. Acta Neuropathol 1998;95:229-34.
    • (1998) Acta Neuropathol , vol.95 , pp. 229-234
    • Sheng, J.G.1    Mrak, R.E.2    Griffin, W.S.3
  • 77
    • 33846980461 scopus 로고    scopus 로고
    • Microglia derived from aging mice exhibit an altered inflammatory profile
    • Sierra A, Gottfried-Blackmore AC, McEwen BS, Bulloch K. Microglia derived from aging mice exhibit an altered inflammatory profile. Glia 2007;55:412-24.
    • (2007) Glia , vol.55 , pp. 412-424
    • Sierra, A.1    Gottfried-Blackmore, A.C.2    McEwen, B.S.3    Bulloch, K.4
  • 78
    • 84856756074 scopus 로고    scopus 로고
    • Effects of aging and sensory loss on glial cells in mouse visual and auditory cortices
    • Tremblay ME, Zettel ML, Ison JR, Allen PD, Majewska AK. Effects of aging and sensory loss on glial cells in mouse visual and auditory cortices. Glia 2012;60:541-58.
    • (2012) Glia , vol.60 , pp. 541-558
    • Tremblay, M.E.1    Zettel, M.L.2    Ison, J.R.3    Allen, P.D.4    Majewska, A.K.5
  • 80
    • 80052410357 scopus 로고    scopus 로고
    • The ageing systemic milieu negatively regulates neurogenesis and cognitive function
    • Villeda SA, Luo J, Mosher KI, Zou B, Britschgi M, Bieri G, et al. The ageing systemic milieu negatively regulates neurogenesis and cognitive function. Nature 2011;477:90-4.
    • (2011) Nature , vol.477 , pp. 90-94
    • Villeda, S.A.1    Luo, J.2    Mosher, K.I.3    Zou, B.4    Britschgi, M.5    Bieri, G.6
  • 81
    • 84924207006 scopus 로고    scopus 로고
    • HDAC inhibition prevents white matter injury by modulating microglia/macrophage polarization through the GSK3beta/PTEN/Akt axis
    • Wang G, Shi Y, Jiang X, Leak RK, Hu X, Wu Y, et al. HDAC inhibition prevents white matter injury by modulating microglia/macrophage polarization through the GSK3beta/PTEN/Akt axis. Proc Natl Acad Sci USA 2015;112:2853-8.
    • (2015) Proc Natl Acad Sci USA , vol.112 , pp. 2853-2858
    • Wang, G.1    Shi, Y.2    Jiang, X.3    Leak, R.K.4    Hu, X.5    Wu, Y.6
  • 82
    • 84989448031 scopus 로고
    • Observations on human monocyte kinetics after pulse labeling
    • Whitelaw DM. Observations on human monocyte kinetics after pulse labeling. Cell Tissue Kinet 1972;5:311-17.
    • (1972) Cell Tissue Kinet , vol.5 , pp. 311-317
    • Whitelaw, D.M.1
  • 83
    • 84894102230 scopus 로고    scopus 로고
    • Transcriptome-based network analysis reveals a spectrum model of human macrophage activation
    • Xue J, Schmidt SV, Sander J, Draffehn A, Krebs W, Quester I, et al. Transcriptome-based network analysis reveals a spectrum model of human macrophage activation. Immunity 2014;40:274-88.
    • (2014) Immunity , vol.40 , pp. 274-288
    • Xue, J.1    Schmidt, S.V.2    Sander, J.3    Draffehn, A.4    Krebs, W.5    Quester, I.6
  • 84
    • 84870226700 scopus 로고    scopus 로고
    • PPARgamma/RXRalpha-induced and CD36-mediated microglial amyloid-beta phagocytosis results in cognitive improvement in amyloid precursor protein/presenilin 1 mice
    • Yamanaka M, Ishikawa T, Griep A, Axt D, Kummer MP, Heneka MT. PPARgamma/RXRalpha-induced and CD36-mediated microglial amyloid-beta phagocytosis results in cognitive improvement in amyloid precursor protein/presenilin 1 mice. J Neurosci 2012;32:17321-31.
    • (2012) J Neurosci , vol.32 , pp. 17321-17331
    • Yamanaka, M.1    Ishikawa, T.2    Griep, A.3    Axt, D.4    Kummer, M.P.5    Heneka, M.T.6
  • 85
    • 84905116959 scopus 로고    scopus 로고
    • Differential roles of microglia and monocytes in the inflamed central nervous system
    • Yamasaki R, Lu H, Butovsky O, Ohno N, Rietsch AM, Cialic R, et al. Differential roles of microglia and monocytes in the inflamed central nervous system. J Exp Med 2014;211:1533-49.
    • (2014) J Exp Med , vol.211 , pp. 1533-1549
    • Yamasaki, R.1    Lu, H.2    Butovsky, O.3    Ohno, N.4    Rietsch, A.M.5    Cialic, R.6
  • 86
    • 33644910475 scopus 로고    scopus 로고
    • Differences in the early inflammatory responses to toxin-induced demyelination are associated with the age-related decline in CNS remyelination
    • Zhao C, Li WW, Franklin RJ. Differences in the early inflammatory responses to toxin-induced demyelination are associated with the age-related decline in CNS remyelination. Neurobiol Aging 2006;27:1298-307.
    • (2006) Neurobiol Aging , vol.27 , pp. 1298-1307
    • Zhao, C.1    Li, W.W.2    Franklin, R.J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.