Targeting CXCR4 by a selective peptide antagonist modulates tumor microenvironment and microglia reactivity in a human glioblastoma model

Journal of Experimental and Clinical Cancer Research

Volumn 35, Issue 1, 2016, Pages

  Mercurio, Laura ^a   Ajmone Cat, Maria Antonietta ^a   Cecchetti, Serena ^a   Ricci, Alessandro ^a   Bozzuto, Giuseppina ^a   Molinari, Agnese ^a   Manni, Isabella ^b   Pollo, Bianca ^c   Scala, Stefania ^d   Carpinelli, Giulia ^a   Minghetti, Luisa ^a  

^a ISTITUTO SUPERIORE DI SANITÀ   (Italy)

^b REGINA ELENA NATIONAL CANCER INSTITUTE   (Italy)

^c DEPARTMENT OF NEUROSURGERY   (Italy)

^d NATIONAL CANCER INSTITUTE   (Italy)

Author keywords

CXCL12; CXCR4; GAM; Glioma; Macrophage polarization; Microglia; Plerixafor; Tumor microenvironment

Indexed keywords

CD31 ANTIGEN; CHEMOKINE RECEPTOR CXCR4; CHEMOKINE RECEPTOR CXCR4 ANTAGONIST; PEPTIDE R; PLERIXAFOR; STROMAL CELL DERIVED FACTOR 1; UNCLASSIFIED DRUG; VASCULOTROPIN; CXCL12 PROTEIN, HUMAN; CXCR4 PROTEIN, HUMAN; PEPTIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTROCYTOSIS; CELL ACTIVITY; CELL METABOLISM; CELL MIGRATION; CELL POLARITY; CELL PROLIFERATION; CELL SURVIVAL; CONTROLLED STUDY; GLIOBLASTOMA; GLIOBLASTOMA CELL LINE; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MACROPHAGE; MICROGLIA; MOUSE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN TARGETING; TUMOR MICROENVIRONMENT; TUMOR VASCULARIZATION; TUMOR VOLUME; ANIMAL; ANTAGONISTS AND INHIBITORS; BRAIN NEOPLASMS; CELL MOTION; DRUG EFFECTS; DRUG SCREENING; FEMALE; GENE EXPRESSION REGULATION; METABOLISM; NUDE MOUSE; PATHOLOGY; TUMOR CELL LINE;

ANIMALS; BRAIN NEOPLASMS; CELL LINE, TUMOR; CELL MOVEMENT; CELL PROLIFERATION; CHEMOKINE CXCL12; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; GLIOBLASTOMA; HUMANS; MICE; MICE, NUDE; MICROGLIA; PEPTIDES; RECEPTORS, CXCR4; TUMOR BURDEN; TUMOR MICROENVIRONMENT; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84962268586     PISSN: None     EISSN: 17569966     Source Type: Journal    
DOI: 10.1186/s13046-016-0326-y     Document Type: Article

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