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Volumn 137, Issue 7, 2015, Pages 1630-1642

Glioblastoma-derived extracellular vesicles modify the phenotype of monocytic cells

Author keywords

exosome; extracellular vesicle; glioblastoma; macrophage; microglia; microvesicle; monocyte

Indexed keywords

CELL MARKER; GAMMA INTERFERON; INTERLEUKIN 6; MATRIX METALLOPROTEINASE 14; NESTIN; RNA; VASCULOTROPIN;

EID: 84943381229     PISSN: 00207136     EISSN: 10970215     Source Type: Journal    
DOI: 10.1002/ijc.29521     Document Type: Article
Times cited : (171)

References (50)
  • 1
    • 65349121788 scopus 로고    scopus 로고
    • Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial
    • Stupp R, Hegi ME, Mason WP, et al., Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial. Lancet Oncol 2009; 10: 459-66.
    • (2009) Lancet Oncol , vol.10 , pp. 459-466
    • Stupp, R.1    Hegi, M.E.2    Mason, W.P.3
  • 2
    • 79955640835 scopus 로고    scopus 로고
    • Mechanisms of immunomodulation in human glioblastoma
    • Avril T, Vauleon E, Tanguy-Royer S, et al., Mechanisms of immunomodulation in human glioblastoma. Immunotherapy 2011; 3: 42-4.
    • (2011) Immunotherapy , vol.3 , pp. 42-44
    • Avril, T.1    Vauleon, E.2    Tanguy-Royer, S.3
  • 3
    • 70450213189 scopus 로고    scopus 로고
    • Glioblastoma-derived mechanisms of systemic immunosuppression
    • Waziri A,. Glioblastoma-derived mechanisms of systemic immunosuppression. Neurosurg Clin N Am 2010; 21: 31-42.
    • (2010) Neurosurg Clin N Am , vol.21 , pp. 31-42
    • Waziri, A.1
  • 4
    • 84891441830 scopus 로고    scopus 로고
    • Microglia and macrophages in malignant gliomas: Recent discoveries and implications for promising therapies
    • da Fonseca AC, Badie B,. Microglia and macrophages in malignant gliomas: recent discoveries and implications for promising therapies. Clin Dev Immunol 2013; 2013: 264124
    • (2013) Clin Dev Immunol , vol.2013 , pp. 264124
    • Da Fonseca, A.C.1    Badie, B.2
  • 5
    • 84866941861 scopus 로고    scopus 로고
    • Myeloid-derived suppressor cells (MDSCs) in gliomas and glioma-development
    • Kohanbash G, Okada H,. Myeloid-derived suppressor cells (MDSCs) in gliomas and glioma-development. Immunol Invest 2012; 41: 658-79.
    • (2012) Immunol Invest , vol.41 , pp. 658-679
    • Kohanbash, G.1    Okada, H.2
  • 6
    • 78349293679 scopus 로고    scopus 로고
    • Systemic immune suppression in glioblastoma: The interplay between cd14+HLA-DRlo/neg monocytes, tumor factors, and dexamethasone
    • Gustafson MP, Lin Y, New KC, et al., Systemic immune suppression in glioblastoma: the interplay between cd14+HLA-DRlo/neg monocytes, tumor factors, and dexamethasone. Neuro Oncol 2010; 12: 631-44.
    • (2010) Neuro Oncol , vol.12 , pp. 631-644
    • Gustafson, M.P.1    Lin, Y.2    New, K.C.3
  • 7
    • 80052069274 scopus 로고    scopus 로고
    • Characteristics of the alternative phenotype of microglia/macrophages and its modulation in experimental gliomas
    • Gabrusiewicz K, Ellert-Miklaszewska A, Lipko M, et al., Characteristics of the alternative phenotype of microglia/macrophages and its modulation in experimental gliomas. PLoS One 2011; 6: e23902
    • (2011) PLoS One , vol.6 , pp. e23902
    • Gabrusiewicz, K.1    Ellert-Miklaszewska, A.2    Lipko, M.3
  • 8
    • 84879604170 scopus 로고    scopus 로고
    • Molecular definition of the pro-tumorigenic phenotype of glioma-activated microglia
    • Ellert-Miklaszewska A, Dabrowski M, Lipko M, et al., Molecular definition of the pro-tumorigenic phenotype of glioma-activated microglia. Glia 2013; 61: 1178-90.
    • (2013) Glia , vol.61 , pp. 1178-1190
    • Ellert-Miklaszewska, A.1    Dabrowski, M.2    Lipko, M.3
  • 9
    • 84881151730 scopus 로고    scopus 로고
    • Glioma grade is associated with the accumulation and activity of cells bearing m2 monocyte markers
    • Prosniak M, Harshyne LA, Andrews DW, et al., Glioma grade is associated with the accumulation and activity of cells bearing m2 monocyte markers. Clin Cancer Res 2013; 19: 3776-86.
    • (2013) Clin Cancer Res , vol.19 , pp. 3776-3786
    • Prosniak, M.1    Harshyne, L.A.2    Andrews, D.W.3
  • 10
    • 84863006570 scopus 로고    scopus 로고
    • Immunotherapy for glioma: Promises and challenges
    • Han SJ, Zygourakis C, Lim M, et al., Immunotherapy for glioma: promises and challenges. Neurosurg Clin N Am 2013; 23: 357-70.
    • (2013) Neurosurg Clin N Am , vol.23 , pp. 357-370
    • Han, S.J.1    Zygourakis, C.2    Lim, M.3
  • 11
    • 79960944057 scopus 로고    scopus 로고
    • Membrane vesicles, current state-of-the-art: Emerging role of extracellular vesicles
    • Gyorgy B, Szabo TG, Pasztoi M, et al., Membrane vesicles, current state-of-the-art: emerging role of extracellular vesicles. Cell Mol Life Sci 2011; 68: 2667-88.
    • (2011) Cell Mol Life Sci , vol.68 , pp. 2667-2688
    • Gyorgy, B.1    Szabo, T.G.2    Pasztoi, M.3
  • 12
    • 84877585949 scopus 로고    scopus 로고
    • Extracellular vesicles: Biology and emerging therapeutic opportunities
    • EL Andaloussi S, Mager I, Breakefield XO, et al., Extracellular vesicles: biology and emerging therapeutic opportunities. Nat Rev Drug Discov 2013; 12: 347-57.
    • (2013) Nat Rev Drug Discov , vol.12 , pp. 347-357
    • Andaloussi S, E.L.1    Mager, I.2    Breakefield, X.O.3
  • 13
    • 67650531887 scopus 로고    scopus 로고
    • Microvesicles: Messengers and mediators of tumor progression
    • 8
    • Al-Nedawi K, Meehan B, Rak J,. Microvesicles: messengers and mediators of tumor progression. Cell Cycle 2009; 8: 2014 8:
    • (2009) Cell Cycle , vol.8 , pp. 2014
    • Al-Nedawi, K.1    Meehan, B.2    Rak, J.3
  • 14
    • 84867120348 scopus 로고    scopus 로고
    • Rab27a supports exosome-dependent and -independent mechanisms that modify the tumor microenvironment and can promote tumor progression
    • Bobrie A, Krumeich S, Reyal F, et al., Rab27a supports exosome-dependent and -independent mechanisms that modify the tumor microenvironment and can promote tumor progression. Cancer Res 2012; 72: 4920-30.
    • (2012) Cancer Res , vol.72 , pp. 4920-4930
    • Bobrie, A.1    Krumeich, S.2    Reyal, F.3
  • 15
    • 84862007577 scopus 로고    scopus 로고
    • Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET
    • Peinado H, Aleckovic M, Lavotshkin S, et al., Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET. Nat Med 2012; 18: 883-91.
    • (2012) Nat Med , vol.18 , pp. 883-891
    • Peinado, H.1    Aleckovic, M.2    Lavotshkin, S.3
  • 16
    • 43049139913 scopus 로고    scopus 로고
    • Intercellular transfer of the oncogenic receptor EGFRvIII by microvesicles derived from tumour cells
    • Al-Nedawi K, Meehan B, Micallef J, et al., Intercellular transfer of the oncogenic receptor EGFRvIII by microvesicles derived from tumour cells. Nat Cell Biol 2008; 10: 619-24.
    • (2008) Nat Cell Biol , vol.10 , pp. 619-624
    • Al-Nedawi, K.1    Meehan, B.2    Micallef, J.3
  • 17
    • 62649095692 scopus 로고    scopus 로고
    • Endothelial expression of autocrine VEGF upon the uptake of tumor-derived microvesicles containing oncogenic EGFR
    • Al-Nedawi K, Meehan B, Kerbel RS, et al., Endothelial expression of autocrine VEGF upon the uptake of tumor-derived microvesicles containing oncogenic EGFR. Proc Natl Acad Sci USA 2009; 106: 3794-9.
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 3794-3799
    • Al-Nedawi, K.1    Meehan, B.2    Kerbel, R.S.3
  • 18
    • 57049103401 scopus 로고    scopus 로고
    • Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers
    • Skog J, Wurdinger T, van Rijn S, et al., Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers. Nat Cell Biol 2008; 10: 1470-6.
    • (2008) Nat Cell Biol , vol.10 , pp. 1470-1476
    • Skog, J.1    Wurdinger, T.2    Van Rijn, S.3
  • 19
    • 84883111834 scopus 로고    scopus 로고
    • Glioma microvesicles carry selectively packaged coding and noncoding RNAs which alter gene expression in recipient cells. RNA
    • Li CC, Eaton SA, Young PE, et al., Glioma microvesicles carry selectively packaged coding and noncoding RNAs which alter gene expression in recipient cells. RNA Biol 2013; 10.
    • (2013) Biol , vol.10
    • Li, C.C.1    Eaton, S.A.2    Young, P.E.3
  • 20
    • 84893851347 scopus 로고    scopus 로고
    • Extracellular vesicles modulate the glioblastoma microenvironment via a tumor suppression signaling network directed by miR-1
    • Bronisz A, Wang Y, Nowicki MO, et al., Extracellular vesicles modulate the glioblastoma microenvironment via a tumor suppression signaling network directed by miR-1. Cancer Res 2014; 74: 738-50.
    • (2014) Cancer Res , vol.74 , pp. 738-750
    • Bronisz, A.1    Wang, Y.2    Nowicki, M.O.3
  • 21
    • 0026688088 scopus 로고
    • Characterization of a cell line derived from a human oligodendroglioma
    • Post GR, Dawson G,. Characterization of a cell line derived from a human oligodendroglioma. Mol Chem Neuropathol 1992; 16: 303-17.
    • (1992) Mol Chem Neuropathol , vol.16 , pp. 303-317
    • Post, G.R.1    Dawson, G.2
  • 22
    • 28444445575 scopus 로고    scopus 로고
    • Endowing human adenovirus serotype 5 vectors with fiber domains of species B greatly enhances gene transfer into human mesenchymal stem cells
    • Knaan-Shanzer S, van de Watering MJ, van der Velde I, et al., Endowing human adenovirus serotype 5 vectors with fiber domains of species B greatly enhances gene transfer into human mesenchymal stem cells. Stem Cells 2005; 23: 1598-607.
    • (2005) Stem Cells , vol.23 , pp. 1598-1607
    • Knaan-Shanzer, S.1    Van De Watering, M.J.2    Van Der Velde, I.3
  • 23
    • 84884590443 scopus 로고    scopus 로고
    • Serum-free culture success of glial tumors is related to specific molecular profiles and expression of extracellular matrix-associated gene modules
    • Balvers RK, Kleijn A, Kloezeman JJ, et al., Serum-free culture success of glial tumors is related to specific molecular profiles and expression of extracellular matrix-associated gene modules. Neuro Oncol 2013; 15: 1684-95.
    • (2013) Neuro Oncol , vol.15 , pp. 1684-1695
    • Balvers, R.K.1    Kleijn, A.2    Kloezeman, J.J.3
  • 24
    • 57649220776 scopus 로고    scopus 로고
    • An efficient method for derivation and propagation of glioblastoma cell lines that conserves the molecular profile of their original tumours
    • Fael Al-Mayhani TM, Ball SL, Zhao JW, et al., An efficient method for derivation and propagation of glioblastoma cell lines that conserves the molecular profile of their original tumours. J Neurosci Methods 2009; 176: 192-9.
    • (2009) J Neurosci Methods , vol.176 , pp. 192-199
    • Fael Al-Mayhani, T.M.1    Ball, S.L.2    Zhao, J.W.3
  • 25
    • 71549126830 scopus 로고    scopus 로고
    • Intrinsic gene expression profiles of gliomas are a better predictor of survival than histology
    • Gravendeel LA, Kouwenhoven MC, Gevaert O, et al., Intrinsic gene expression profiles of gliomas are a better predictor of survival than histology. Cancer Res 2009; 69: 9065-72.
    • (2009) Cancer Res , vol.69 , pp. 9065-9072
    • Gravendeel, L.A.1    Kouwenhoven, M.C.2    Gevaert, O.3
  • 26
    • 43249109372 scopus 로고    scopus 로고
    • Isolation and characterization of exosomes from cell culture supernatants and biological fluids
    • Chapter 3:Unit 3 22.
    • Thery C, Amigorena S, Raposo G, et al., Isolation and characterization of exosomes from cell culture supernatants and biological fluids. Curr Protoc Cell Biol 2006;Chapter 3:Unit 3 22.
    • (2006) Curr Protoc Cell Biol
    • Thery, C.1    Amigorena, S.2    Raposo, G.3
  • 27
    • 84891471981 scopus 로고    scopus 로고
    • Quantification of nanosized extracellular membrane vesicles with scanning ion occlusion sensing
    • de
    • de, Vrij J, Maas SL, van Nispen M, et al., Quantification of nanosized extracellular membrane vesicles with scanning ion occlusion sensing. Nanomedicine (Lond) 2013; 8: 1443-58.
    • (2013) Nanomedicine (Lond) , vol.8 , pp. 1443-1458
    • Vrij, J.1    Maas, S.L.2    Van Nispen, M.3
  • 28
    • 84908352293 scopus 로고    scopus 로고
    • Quantification and size-profiling of extracellular vesicles using tunable resistive pulse sensing
    • Maas SL, De Vrij J, Broekman ML,. Quantification and size-profiling of extracellular vesicles using tunable resistive pulse sensing. J Vis Exp 2014; e51623.
    • (2014) J Vis Exp , pp. e51623
    • Maas, S.L.1    De Vrij, J.2    Broekman, M.L.3
  • 29
    • 79251637745 scopus 로고    scopus 로고
    • An antibody-based biomarker discovery method by mass spectrometry sequencing of complementarity determining regions
    • Dekker LJ, Zeneyedpour L, Brouwer E, et al., An antibody-based biomarker discovery method by mass spectrometry sequencing of complementarity determining regions. Anal Bioanal Chem 2011; 399: 1081-91.
    • (2011) Anal Bioanal Chem , vol.399 , pp. 1081-1091
    • Dekker, L.J.1    Zeneyedpour, L.2    Brouwer, E.3
  • 30
    • 84876515907 scopus 로고    scopus 로고
    • STRING v9.1: Protein-protein interaction networks, with increased coverage and integration
    • Franceschini A, Szklarczyk D, Frankild S, et al., STRING v9.1: protein-protein interaction networks, with increased coverage and integration. Nucleic Acids Res 2013; 41: d808-15.
    • (2013) Nucleic Acids Res , vol.41 , pp. d808-d815
    • Franceschini, A.1    Szklarczyk, D.2    Frankild, S.3
  • 31
    • 0032522113 scopus 로고    scopus 로고
    • Diminished monocytic HLA-DR expression and ex vivo cytokine secretion capacity in patients with glioblastoma: Effect of tumor extirpation
    • Woiciechowsky C, Asadullah K, Nestler D, et al., Diminished monocytic HLA-DR expression and ex vivo cytokine secretion capacity in patients with glioblastoma: effect of tumor extirpation. J Neuroimmunol 1998; 84: 164-71.
    • (1998) J Neuroimmunol , vol.84 , pp. 164-171
    • Woiciechowsky, C.1    Asadullah, K.2    Nestler, D.3
  • 32
    • 33750088421 scopus 로고    scopus 로고
    • Defective receptor expression and dendritic cell differentiation of monocytes in glioblastomas
    • discussion 9-10.
    • Ogden AT, Horgan D, Waziri A, et al., Defective receptor expression and dendritic cell differentiation of monocytes in glioblastomas. Neurosurgery 2006; 59: 902-9; discussion 9-10.
    • (2006) Neurosurgery , vol.59 , pp. 902-909
    • Ogden, A.T.1    Horgan, D.2    Waziri, A.3
  • 33
    • 68149169092 scopus 로고    scopus 로고
    • Gliomas induce and exploit microglial MT1-MMP expression for tumor expansion
    • Markovic DS, Vinnakota K, Chirasani S, et al., Gliomas induce and exploit microglial MT1-MMP expression for tumor expansion. Proc Natl Acad Sci U S A 2009; 106: 12530-5.
    • (2009) Proc Natl Acad Sci U S A , vol.106 , pp. 12530-12535
    • Markovic, D.S.1    Vinnakota, K.2    Chirasani, S.3
  • 34
    • 84891873517 scopus 로고    scopus 로고
    • Toll-like receptor 2 mediates microglia/brain macrophage MT1-MMP expression and glioma expansion
    • Vinnakota K, Hu F, Ku MC, et al., Toll-like receptor 2 mediates microglia/brain macrophage MT1-MMP expression and glioma expansion. Neuro Oncol 2013; 15: 1457-68.
    • (2013) Neuro Oncol , vol.15 , pp. 1457-1468
    • Vinnakota, K.1    Hu, F.2    Ku, M.C.3
  • 35
    • 73649123907 scopus 로고    scopus 로고
    • Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, idh1, EGFR, and nf1
    • Verhaak RG, Hoadley KA, Purdom E, et al., Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, idh1, EGFR, and nf1. Cancer Cell 2010; 17: 98-110.
    • (2010) Cancer Cell , vol.17 , pp. 98-110
    • Verhaak, R.G.1    Hoadley, K.A.2    Purdom, E.3
  • 36
    • 84862677632 scopus 로고    scopus 로고
    • Quantitative and qualitative flow cytometric analysis of nanosized cell-derived membrane vesicles
    • Nolte-'t Hoen EN, van der Vlist EJ, Aalberts M, et al., Quantitative and qualitative flow cytometric analysis of nanosized cell-derived membrane vesicles. Nanomedicine 2011; 8: 712-20.
    • (2011) Nanomedicine , vol.8 , pp. 712-720
    • Nolte-'T Hoen, E.N.1    Van Der Vlist, E.J.2    Aalberts, M.3
  • 37
    • 84870931536 scopus 로고    scopus 로고
    • Protein typing of circulating microvesicles allows real-time monitoring of glioblastoma therapy
    • Shao H, Chung J, Balaj L, et al., Protein typing of circulating microvesicles allows real-time monitoring of glioblastoma therapy. Nat Med 2012; 18: 1835-40.
    • (2012) Nat Med , vol.18 , pp. 1835-1840
    • Shao, H.1    Chung, J.2    Balaj, L.3
  • 38
    • 80055118968 scopus 로고    scopus 로고
    • Sizing and phenotyping of cellular vesicles using nanoparticle tracking analysis
    • Dragovic RA, Gardiner C, Brooks AS, et al., Sizing and phenotyping of cellular vesicles using nanoparticle tracking analysis. Nanomedicine 2011; 7: 780-8.
    • (2011) Nanomedicine , vol.7 , pp. 780-788
    • Dragovic, R.A.1    Gardiner, C.2    Brooks, A.S.3
  • 39
    • 84920736138 scopus 로고    scopus 로고
    • Possibilities and limitations of current technologies for quantification of biological extracellular vesicles and synthetic mimics
    • Maas SL, de Vrij J, van der Vlist EJ, et al., Possibilities and limitations of current technologies for quantification of biological extracellular vesicles and synthetic mimics. J Control Release 2015; 200: 87-96.
    • (2015) J Control Release , vol.200 , pp. 87-96
    • Maas, S.L.1    De Vrij, J.2    Van Der Vlist, E.J.3
  • 40
    • 0242525678 scopus 로고    scopus 로고
    • Tcell apoptosis and suppression of T-cell receptor/CD3-zeta by fas ligand-containing membrane vesicles shed from ovarian tumors
    • 9
    • Taylor DD, Gercel-Taylor C, Lyons KS, et al., Tcell apoptosis and suppression of T-cell receptor/CD3-zeta by fas ligand-containing membrane vesicles shed from ovarian tumors. Clin Cancer Res 2003; 9: 5113 9:
    • (2003) Clin Cancer Res , vol.9 , pp. 5113
    • Taylor, D.D.1    Gercel-Taylor, C.2    Lyons, K.S.3
  • 41
    • 12944329896 scopus 로고    scopus 로고
    • Fas ligand-positive membranous vesicles isolated from sera of patients with oral cancer induce apoptosis of activated T lymphocytes
    • Kim JW, Wieckowski E, Taylor DD, et al., Fas ligand-positive membranous vesicles isolated from sera of patients with oral cancer induce apoptosis of activated T lymphocytes. Clin Cancer Res 2005; 11: 1010-20.
    • (2005) Clin Cancer Res , vol.11 , pp. 1010-1020
    • Kim, J.W.1    Wieckowski, E.2    Taylor, D.D.3
  • 42
    • 24644524011 scopus 로고    scopus 로고
    • Tumor exosomes expressing fas ligand mediate cd8+ T-cell apoptosis
    • Abusamra AJ, Zhong Z, Zheng X, et al., Tumor exosomes expressing fas ligand mediate cd8+ T-cell apoptosis. Blood Cells Mol Dis 2005; 35: 169-73.
    • (2005) Blood Cells Mol Dis , vol.35 , pp. 169-173
    • Abusamra, A.J.1    Zhong, Z.2    Zheng, X.3
  • 43
    • 0035232154 scopus 로고    scopus 로고
    • Analysis of interleukin-6 gene expression in primary human gliomas, glioblastoma xenografts, and glioblastoma cell lines
    • Sasaki A, Ishiuchi S, Kanda T, et al., Analysis of interleukin-6 gene expression in primary human gliomas, glioblastoma xenografts, and glioblastoma cell lines. Brain Tumor Pathol 2001; 18: 13-21.
    • (2001) Brain Tumor Pathol , vol.18 , pp. 13-21
    • Sasaki, A.1    Ishiuchi, S.2    Kanda, T.3
  • 44
    • 84864720266 scopus 로고    scopus 로고
    • In vitro generation of monocyte-derived macrophages under serum-free conditions improves their tumor promoting functions
    • Rey-Giraud F, Hafner M, Ries CH,. In vitro generation of monocyte-derived macrophages under serum-free conditions improves their tumor promoting functions. PLoS One 2012; 7: e42656
    • (2012) PLoS One , vol.7 , pp. e42656
    • Rey-Giraud, F.1    Hafner, M.2    Ries, C.H.3
  • 45
    • 40349098612 scopus 로고    scopus 로고
    • Migratory neighbors and distant invaders: Tumor-associated niche cells
    • Wels J, Kaplan RN, Rafii S, et al., Migratory neighbors and distant invaders: tumor-associated niche cells. Genes Dev 2008; 22: 559-74.
    • (2008) Genes Dev , vol.22 , pp. 559-574
    • Wels, J.1    Kaplan, R.N.2    Rafii, S.3
  • 46
    • 84884543901 scopus 로고    scopus 로고
    • Tumor-infiltrating lymphocytes in glioblastoma are associated with specific genomic alterations and related to transcriptional class
    • Rutledge WC, Kong J, Gao J, et al., Tumor-infiltrating lymphocytes in glioblastoma are associated with specific genomic alterations and related to transcriptional class. Clin Cancer Res 2013; 19: 4951-60.
    • (2013) Clin Cancer Res , vol.19 , pp. 4951-4960
    • Rutledge, W.C.1    Kong, J.2    Gao, J.3
  • 47
    • 84865199671 scopus 로고    scopus 로고
    • Increased microglia/macrophage gene expression in a subset of adult and pediatric astrocytomas
    • Engler JR, Robinson AE, Smirnov I, et al., Increased microglia/macrophage gene expression in a subset of adult and pediatric astrocytomas. PLoS One 2012; 7: e43339
    • (2012) PLoS One , vol.7 , pp. e43339
    • Engler, J.R.1    Robinson, A.E.2    Smirnov, I.3
  • 48
    • 84893745524 scopus 로고    scopus 로고
    • Identification of a unique TGF-beta-dependent molecular and functional signature in microglia
    • Butovsky O, Jedrychowski MP, Moore CS, et al., Identification of a unique TGF-beta-dependent molecular and functional signature in microglia. Nat Neurosci 2014; 17: 131-43.
    • (2014) Nat Neurosci , vol.17 , pp. 131-143
    • Butovsky, O.1    Jedrychowski, M.P.2    Moore, C.S.3
  • 49
    • 84864503916 scopus 로고    scopus 로고
    • MicroRNAs bind to Toll-like receptors to induce prometastatic inflammatory response
    • Fabbri M, Paone A, Calore F, et al., MicroRNAs bind to Toll-like receptors to induce prometastatic inflammatory response. Proc Natl Acad Sci U S A 2012; 109: E2110-6.
    • (2012) Proc Natl Acad Sci U S A , vol.109 , pp. E2110-E2116
    • Fabbri, M.1    Paone, A.2    Calore, F.3
  • 50
    • 84887481716 scopus 로고    scopus 로고
    • CSF-1R inhibition alters macrophage polarization and blocks glioma progression
    • Pyonteck SM, Akkari L, Schuhmacher AJ, et al., CSF-1R inhibition alters macrophage polarization and blocks glioma progression. Nat Med 2013; 19: 1264-72.
    • (2013) Nat Med , vol.19 , pp. 1264-1272
    • Pyonteck, S.M.1    Akkari, L.2    Schuhmacher, A.J.3


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