Structure-activity relationship study and optimisation of 2-aminopyrrole-1-benzyl-4,5-diphenyl-1H-pyrrole-3-carbonitrile as a broad spectrum metallo-β-lactamase inhibitor

European Journal of Medicinal Chemistry

Volumn 137, Issue , 2017, Pages 351-364

  McGeary, Ross P ^a   Tan, Daniel T C ^a   Selleck, Christopher ^a   Monteiro Pedroso, Marcelo ^a   Sidjabat, Hanna E ^b   Schenk, Gerhard ^a  

^a UNIVERSITY OF QUEENSLAND   (Australia)

^b UNIVERSITY OF QUEENSLAND   (Australia)

Author keywords

Antibiotics resistance; Enzyme inhibition; Metallo lactamase

Indexed keywords

2 AMINOPYRROLE 1 BENZYL 4,5 DIPHENYL 1H PYRROLE 3 CARBONITRILE; ANTIBIOTIC AGENT; BETA LACTAMASE INHIBITOR; MEROPENEM; METALLO BETA LACTAMASE INHIBITOR; PYRROLE DERIVATIVE; UNCLASSIFIED DRUG; BETA LACTAMASE; ENZYME INHIBITOR; NITRILE;

ANTIBIOTIC RESISTANCE; ARTICLE; CONTROLLED STUDY; DRUG POTENCY; ENZYME INHIBITION; INHIBITION CONSTANT; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; STRUCTURE ACTIVITY RELATION; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; HUMAN; METABOLISM; SYNTHESIS;

BETA-LACTAMASES; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; HUMANS; MOLECULAR STRUCTURE; NITRILES; PYRROLES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 85020462323     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2017.05.061     Document Type: Article

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