Synthesis and evaluation of isatin-β-thiosemicarbazones as novel agents against antibiotic-resistant Gram-positive bacterial species

European Journal of Medicinal Chemistry

Volumn 101, Issue , 2015, Pages 419-430

  Zhang, Xu Meng ^a   Guo, Hui ^b   Li, Zai Shun ^a   Song, Fu Hang ^b   Wang, Wei Min ^a   Dai, Huan Qin ^b   Zhang, Li Xin ^b   Wang, Jian Guo ^a  

^a NANKAI UNIVERSITY   (China)

^b INSTITUTE OF MICROBIOLOGY   (China)

Author keywords

In vitro activity; Isatin b thiosemicarbazone; Methicillin resistant Staphylococcus aureus; Structureeactivity relationships; Vancomycin resistant Enterococcus

Indexed keywords

2 (2 OXOINDOLIN 3 YLIDENE) N PHENYLHYDRAZINECARBOTHIOAMIDE; 2 (5 BROMO 2 OXOINDOLIN 3 YLIDENE) N PHENYLHYDRAZINECARBOTHIOAMIDE; 2 (5 CHLORO 2 OXOINDOLIN 3 YLIDENE) N (4 FLUOROPHENYL)HYDRAZINECARBOTHIOAMIDE; 2 (5 FLUORO 2 OXOINDOLIN 3 YLIDENE) N (4 FLUOROPHENYL)HYDRAZINECARBOTHIOAMIDE; 2 (5,7 DIBROMO 2 OXOINDOLIN 3 YLIDENE) N (4 FLUOROPHENYL)HYDRAZINECARBOTHIOAMIDE; 2 (7 BROMO 2 OXOINDOLIN 3 YLIDENE) N (4 CHLOROPHENYL)HYDRAZINECARBOTHIOAMIDE; 2 (7 BROMO 2 OXOINDOLIN 3 YLIDENE) N (4 FLUOROPHENYL)HYDRAZINECARBOTHIOAMIDE; 2 (7 BROMO 2 OXOINDOLIN 3 YLIDENE) N (PARA TOLYL)HYDRAZINECARBOTHIOAMIDE; 2 (7 BROMO 5 NITRO 2 OXOINDOLIN 3 YLIDENE) N (4 FLUOROPHENYL)HYDRAZINECARBOTHIOAMIDE; 2 (7 CHLORO 2 OXOINDOLIN 3 YLIDENE) N (4 CHLOROPHENYL)HYDRAZINECARBOTHIOAMIDE; 2 (7 CHLORO 2 OXOINDOLIN 3 YLIDENE) N (META TOLYL)HYDRAZINECARBOTHIOAMIDE; 2 (7 CHLORO 2 OXOINDOLIN 3 YLIDENE) N (ORTHO TOLYL)HYDRAZINECARBOTHIOAMIDE; 2 (7 CHLORO 2 OXOINDOLIN 3 YLIDENE) N (PARA TOLYL)HYDRAZINECARBOTHIOAMIDE; 2 (7 CHLORO 2 OXOINDOLIN 3 YLIDENE) N PHENYLHYDRAZINECARBOTHIOAMIDE; 2 (7 FLUORO 2 OXOINDOLIN 3 YLIDENE) N (3 METHOXYPHENYL)HYDRAZINECARBOTHIOAMIDE; 2 (7 FLUORO 2 OXOINDOLIN 3 YLIDENE) N (4 FLUOROPHENYL)HYDRAZINECARBOTHIOAMIDE; 2 (7 FLUORO 2 OXOINDOLIN 3 YLIDENE) N (META TOLYL)HYDRAZINECARBOTHIOAMIDE; 2 (7 FLUORO 2 OXOINDOLIN 3 YLIDENE) N (ORTHO TOLYL)HYDRAZINECARBOTHIOAMIDE; 2 (7 FLUORO 2 OXOINDOLIN 3 YLIDENE) N PHENYLHYDRAZINECARBOTHIOAMIDE; 2 (7 METHYL 2 OXOINDOLIN 3 YLIDENE) N (PARA TOLYL)HYDRAZINECARBOTHIOAMIDE; ANTIBIOTIC AGENT; ISATIN BETA THIOSEMICARBAZONE DERIVATIVE; ISATIN DERIVATIVE; N (4 CHLOROPHENYL) 2 (7 METHYL 2 OXOINDOLIN 3 YLIDENE)HYDRAZINECARBOTHIOAMIDE; N (4 FLUOROPHENYL) 2 (2 OXOINDOLIN 3 YLIDENE)HYDRAZINECARBOTHIOAMIDE; N (4 FLUOROPHENYL) 2 (5 NITRO 2 OXOINDOLIN 3 YLIDENE)HYDRAZINECARBOTHIOAMIDE; N (4 FLUOROPHENYL) 2 (7 METHYL 2 OXOINDOLIN 3 YLIDENE)HYDRAZINECARBOTHIOAMIDE; THIOSEMICARBAZONE DERIVATIVE; UNCLASSIFIED DRUG; UNINDEXED DRUG; VANCOMYCIN; ANTIINFECTIVE AGENT; ISATIN;

ANTIBIOTIC RESISTANCE; ANTIBIOTIC SENSITIVITY; ANTIMICROBIAL ACTIVITY; ARTICLE; BACILLUS SUBTILIS; BACTERIAL GROWTH; BACTERIAL STRAIN; BACTERIUM ISOLATE; COMPARATIVE FIELD ANALYSIS; COMPARATIVE STUDY; CRYSTAL STRUCTURE; DRUG DESIGN; DRUG SCREENING; DRUG SYNTHESIS; ENTEROCOCCUS FAECALIS; KLEBSIELLA PNEUMONIAE; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; MINIMUM INHIBITORY CONCENTRATION; MOLECULAR WEIGHT; NONHUMAN; PSEUDOMONAS AERUGINOSA; STAPHYLOCOCCUS AUREUS; STRUCTURE ACTIVITY RELATION; VANCOMYCIN RESISTANT ENTEROCOCCUS; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; DRUG EFFECTS; MICROBIAL SENSITIVITY TEST; SYNTHESIS;

ANTI-BACTERIAL AGENTS; DOSE-RESPONSE RELATIONSHIP, DRUG; ISATIN; METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS; MICROBIAL SENSITIVITY TESTS; MOLECULAR STRUCTURE; STRUCTURE-ACTIVITY RELATIONSHIP; THIOSEMICARBAZONES; VANCOMYCIN-RESISTANT ENTEROCOCCI;

EID: 84937003282     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2015.06.047     Document Type: Article

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