Evolution of broad spectrum β-lactam resistance in an engineered metallo-β-lactamase

Journal of Biological Chemistry

Volumn 288, Issue 4, 2013, Pages 2314-2324

  Sun, Song ^a   Zhang, Wei ^a   Mannervik, Bengt ^a,b   Andersson, Dan I ^a  

^a UPPSALA UNIVERSITY   (Sweden)

^b STOCKHOLM UNIVERSITY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE SITE; ACTIVITY PROFILE; AMINO ACID RESIDUES; BACTERIAL RESISTANCE; BROAD SPECTRUM; CEFOPERAZONE; CEFOTAXIME; CEPHALOTHIN; LACTAMASES; LOW LEVEL; MULTI VARIATE ANALYSIS; MUTANT ENZYMES; MUTANT LIBRARIES; PENICILLIN G; PROTEIN LEVEL; RESISTANCE MECHANISMS; SALMONELLA TYPHIMURIUM;

AMIDES; AMINO ACIDS; ENZYMES; SALMONELLA;

ANTIBIOTICS;

AMINO ACID; AMPICILLIN; BACTERIAL PROTEIN; BETA LACTAM; CEFACLOR; CEFALOTIN; CEFOPERAZONE; CEFOTAXIME; CEFUROXIME; MESSENGER RNA; METALLO BETA LACTAMASE; METALLO BETA LACTAMASE 9; PENICILLIN G; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIAL GENE; BACTERIAL IMMUNITY; BACTERIAL STRAIN; CONCENTRATION RESPONSE; CONTROLLED STUDY; CROSS RESISTANCE; DNA LIBRARY; DNA SEQUENCE; DRUG EFFECT; ENZYME BINDING; ENZYME INHIBITION; ENZYME SPECIFICITY; GENE EXPRESSION REGULATION; GENE OVEREXPRESSION; GENETIC ENGINEERING; METALLO BETA LACTAMASE 9 GENE; MINIMUM INHIBITORY CONCENTRATION; MOLECULAR EVOLUTION; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SALMONELLA TYPHIMURIUM;

AMINO ACID SEQUENCE; ANTI-BACTERIAL AGENTS; BETA-LACTAM RESISTANCE; BETA-LACTAMASES; GENE LIBRARY; GENETIC ENGINEERING; HUMANS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MULTIVARIATE ANALYSIS; MUTAGENESIS, SITE-DIRECTED; MUTATION; PLASMIDS; RNA, MESSENGER; SALMONELLA TYPHIMURIUM; THIOLESTER HYDROLASES;

EID: 84873823168     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.430199     Document Type: Article

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