Chiral pyrrolo[2,3-d]pyrimidine and pyrimido[4,5-b]indole derivatives: Structure-activity relationships of potent, highly stereoselective A1-adenosine receptor antagonists

Journal of Medicinal Chemistry

Volumn 39, Issue 13, 1996, Pages 2482-2491

  Müller, Christa E ^a   Geis, Uli ^a   Grahner, Bettina ^a   Lanzner, Wolfgang ^b   Eger, Kurt ^b  

^a UNIVERSITY OF WÜRZBURG   (Germany)

^b UNIVERSITY OF LEIPZIG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINO 5,6 DIMETHYL 2 (3 CHLOROPHENYL) 7H PYRROLO[2,3 D]PYRIMIDINE; ADENINE DERIVATIVE; ADENOSINE A1 RECEPTOR ANTAGONIST; HYPOXANTHINE DERIVATIVE; INDOLE DERIVATIVE; N (1 PHENYLETHYL) 4 AMINO 5,6 DIMETHYL 2 PHENYL 7H PYRROLO[2,3 D]PYRIMIDINE; PYRIMIDINE DERIVATIVE; PYRIMIDO[4,5 B]INDOLE DERIVATIVE; PYRROLO[2,3 D]PYRIMIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CHIRALITY; DRUG RECEPTOR BINDING; DRUG SOLUBILITY; LIGAND BINDING; LIPOPHILICITY; NONHUMAN; RAT; STEREOCHEMISTRY; STRUCTURE ACTIVITY RELATION;

ADENINE; ANIMALS; CEREBRAL CORTEX; COMPUTER GRAPHICS; CORPUS STRIATUM; HYPOXANTHINES; INDOLES; MAGNETIC RESONANCE SPECTROSCOPY; MOLECULAR CONFORMATION; MOLECULAR STRUCTURE; PROTEIN BINDING; PYRIMIDINES; RADIOLIGAND ASSAY; RATS; RECEPTORS, PURINERGIC P1; SOLUBILITY; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0029896075     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm960011w     Document Type: Article

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