Pyrazole and Isoxazole Derivatives as New, Potent, and Selective 20-Hydroxy-5,8,11,14-eicosatetraenoic Acid Synthase Inhibitors

Journal of Medicinal Chemistry

Volumn 46, Issue 25, 2003, Pages 5416-5427

  Nakamura, Toshio ^a   Sato, Masakazu ^a   Kakinuma, Hiroyuki ^a   Miyata, Noriyuki ^a   Taniguchi, Kazuo ^a   Bando, Kagumi ^a   Koda, Ayumi ^a   Kameo, Kazuya ^a  

^a TAISHO PHARMACEUTICAL CO LTD   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

20 HYDROXY 5,8,11,14 EICOSATETRAENOIC ACID SYNTHASE INHIBITOR; CYTOCHROME P450; ENZYME INHIBITOR; HET0016; IMIDAZOLE; ISOXAZOLE DERIVATIVE; N HYDROXYFORMAMIDINE DERIVATIVE; PYRAZOLE DERIVATIVE; PYRROLE DERIVATIVE; UNCLASSIFIED DRUG;

ACIDITY; ARTICLE; BRAIN DISEASE; DRUG ACTIVITY; DRUG POTENCY; DRUG SELECTIVITY; DRUG SOLUBILITY; DRUG STRUCTURE; IC 50;

ARACHIDONIC ACID; CYTOCHROME P-450 ENZYME SYSTEM; HUMANS; ISOXAZOLES; LYASES; MICROSOMES; PYRAZOLES; SOLUBILITY; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0344550360     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm020557k     Document Type: Article

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