Understanding the determinants of substrate specificity in IMP family metallo-β-lactamases: The importance of residue 262

Protein Science

Volumn 23, Issue 10, 2014, Pages 1451-1460

  Pegg, Kevin M ^a   Liu, Eleanor M ^b   George, Alex C ^a   LaCuran, Alecander E ^b   Bethel, Christopher R ^c   Bonomo, Robert A ^c,d   Oelschlaeger, Peter ^b  

^a CALIFORNIA STATE POLYTECHNIC UNIVERSITY   (United States)

^b WESTERN UNIVERSITY OF HEALTH SCIENCES   (United States)

^c LOUIS STOKES CLEVELAND VA MEDICAL CENTER   (United States)

^d CASE WESTERN RESERVE UNIVERSITY   (United States)

Author keywords

antibiotic resistance; enzyme evolution; IMP 1 antibody; metallo lactamase; point mutation

Indexed keywords

AMPICILLIN; AZTREONAM; CEFALOTIN; CEFOTAXIME; CEFTAZIDIME; IMIPENEM; MEROPENEM; METALLO BETA LACTAMASE; NITROCEFIN; PENICILLIN G; THREONINE; BACTERIAL PROTEIN; BETA LACTAMASE; SERINE; VALINE;

ANTIBIOTIC RESISTANCE; ANTIBIOTIC SENSITIVITY; ARTICLE; BACTERIAL CELL; CATALYTIC EFFICIENCY; CIRCULAR DICHROISM; CONTROLLED STUDY; CYTOLYSIS; ELECTROSPRAY MASS SPECTROMETRY; ENZYME SPECIFICITY; ESCHERICHIA COLI; GENE EXPRESSION; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; POLYACRYLAMIDE GEL ELECTROPHORESIS; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN SECONDARY STRUCTURE; SITE DIRECTED MUTAGENESIS; STRUCTURE ACTIVITY RELATION; WESTERN BLOTTING; AMINO ACID SUBSTITUTION; CHEMICAL STRUCTURE; CHEMISTRY; ENZYME ACTIVE SITE; ENZYMOLOGY; GENETIC VARIABILITY; GENETICS; GRAM NEGATIVE BACTERIUM; METABOLISM;

BACTERIA (MICROORGANISMS); NEGIBACTERIA;

AMINO ACID SUBSTITUTION; BACTERIAL PROTEINS; BETA-LACTAMASES; CATALYTIC DOMAIN; CEPHALOTHIN; GENETIC VARIATION; GRAM-NEGATIVE BACTERIA; MODELS, MOLECULAR; PROTEIN STRUCTURE, SECONDARY; SERINE; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY; THREONINE; VALINE;

EID: 84923223411     PISSN: 09618368     EISSN: 1469896X     Source Type: Journal    
DOI: 10.1002/pro.2530     Document Type: Article

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