Identification, SAR studies, and X-ray Co-crystallographic analysis of a novel furanopyrimidine aurora kinase a inhibitor

ChemMedChem

Volumn 5, Issue 2, 2010, Pages 255-267

  Coumar, Mohane Selvaraj ^a   Tsai, Ming Tsung ^a,b   Chu, Chang Ying ^a   Uang, Biing Jiun ^b   Lin, Wen Hsing ^a   Chang, Chun Yu ^a   Chang, Teng Yuan ^a   Leou, Jiun Shyang ^a   Teng, Chi Huang ^a   Wu, Jian Sung ^a   Fang, Ming Yu ^a   Chen, Chun Hwa ^a   Hsu, John T A ^a,c   Wu, Su Ying ^a   Chao, Yu Sheng ^a   Hsieh, Hsing Pang ^a  

^a NATIONAL HEALTH RESEARCH INSTITUTES   (Taiwan)

^b NATIONAL TSING HUA UNIVERSITY   (Taiwan)

^c NATIONAL CHIAO TUNG UNIVERSITY   (Taiwan)

Author keywords

Aurora kinase inhibitors; Hit identification; Structural biology; Structure activity relationships; Substructure searches

Indexed keywords

2 (5 BROMO 6 PHENYLFURO[2,3 D]PYRIMIDIN 4 YLAMINO)ETHANOL; 2 (5 ETHYL 6 PHENYLFURO[2,3 D]PYRIMIDIN 4 YLAMINO)ETHANOL; 2 (5 ETHYNYL 6 PHENYLFURO[2,3 D]PYRIMIDIN 4 YLAMINO)ETHANOL; 2 (5 FURAN 2 YL 6 PHENYLFURO[2,3 D]PYRIMIDIN 4 YLAMINO)ETHANOL; 2 (5 METHYL 6 PHENYLFURO[2,3 D]PYRIMIDIN 4 YLAMINO)ETHANOL; 2 (5 PHENYLFURO[2,3 D]PYRIMIDIN 4 YLAMINO)ETHANOL; 2 (5,6 DIFURAN 2 YLFURO[2,3 D]PYRIMIDIN 4 YLAMINO)ETHANOL; 2 (5,6 DIPHENYL 7H PYRROLO[2,3 D]PYRIMIDIN 4 YLAMINO)ETHANOL; 2 (5,6 DIPHENYLFURO[2,3 D]PYRIMIDIN 4 YLAMINO)ETHANOL; 2 (5,6 DIPHENYLTHIENO[2,3 D]PYRIMIDIN 4 YLAMINO)ETHANOL; 2 (6 BROMO 5 PHENYLFURO[2,3 D]PYRIMIDIN 4 YLAMINO)ETHANOL; 2 (6 PHENYL 5 PYRIDIN 3 YLFURO[2,3 D]PYRIMIDIN 4 YLAMINO)ETHANOL; 2 (6 PHENYLFURO[2,3 D]PYRIMIDIN 4 YLAMINO)ETHANOL; 2 (7 BENZYL 5,6 DIPHENYL 7H PYRROLO[2,3 D]PYRIMIDIN 4 YLAMINO)ETHANOL; 2 [5 (4 ACETAMIDOPHENYL) 6 PHENYLFURO[2,3 D]PYRIMIDIN 4 YLAMINO]ETHANOL; 2 [5 (4 HYDROXYPHENYL) 6 PHENYLFURO[2,3 D]PYRIMIDIN 4 YLAMINO]ETHANOL; 2 [5 (4 METHOXYPHENYL) 6 PHENYLFURO[2,3 D]PYRIMIDIN 4 YLAMINO]ETHANOL; 2 [5 (4 NITROPHENYL) 6 PHENYLFURO[2,3 D]PYRIMIDIN 4 YLAMINO]ETHANOL; 2 [5,6 BIS(4 HYDROXYPHENYL)FURO[2,3 D]PYRIMIDIN 4 YLAMINO]ETHAOL; AURORA A KINASE INHIBITOR; PROTEIN SERINE THREONINE KINASE INHIBITOR; PYRIMIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CRYSTAL STRUCTURE; DRUG DESIGN; DRUG IDENTIFICATION; DRUG STRUCTURE; IC 50; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION; X RAY CRYSTALLOGRAPHY;

BINDING SITES; CRYSTALLOGRAPHY, X-RAY; FURANS; HIGH-THROUGHPUT SCREENING ASSAYS; PROTEIN BINDING; PROTEIN KINASE INHIBITORS; PROTEIN-SERINE-THREONINE KINASES; PYRIMIDINES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 75749152578     PISSN: 18607179     EISSN: 18607187     Source Type: Journal    
DOI: 10.1002/cmdc.200900339     Document Type: Article

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