Design, synthesis, and in vitro and biological evaluation of potent amino acid-derived thiol inhibitors of the metallo-β-lactamase IMP-1

European Journal of Medicinal Chemistry

Volumn 114, Issue , 2016, Pages 318-327

  Arjomandi, Omid Khalili ^a   Hussein, Waleed M ^a,b   Vella, Peter ^a   Yusof, Yusralina ^a   Sidjabat, Hanna E ^c   Schenk, Gerhard ^a   McGeary, Ross P ^a  

^a UNIVERSITY OF QUEENSLAND   (Australia)

^b Helwan   (Egypt)

^c UNIVERSITY OF QUEENSLAND   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

2 (2 MERCAPTOACETAMIDO) 3 PHENYLPROPANOIC ACID; 2 (3 MERCAPTOPROPANAMIDO) 3 PHENYLPROPANOIC; 2 (4 MERCAPTOBUTANAMIDO) 3 PHENYLPROPANOIC ACID; 3 (1H INDOL 3 YL) 2 (2 MERCAPTOACETAMIDO)PROPANOIC ACID; 3 (1H INDOL 3 YL) 2 (3 MERCAPTOPROPANAMIDO)PROPANOIC ACID; 3 (1H INDOL 3 YL) 2 (4 MERCAPTOBUTANAMIDO)PROPANOIC ACID; 3 (4 HYDROXYPHENYL) 2 (2 MERCAPTOACETAMIDO)PROPANOIC ACID; 3 (4 HYDROXYPHENYL) 2 (3 MERCAPTOPROPANAMIDO)PROPANOIC ACID; 3 (4 HYDROXYPHENYL) 2 (4 MERCAPTOBUTANAMIDO)PROPANOIC ACID; 3 [4 (BENZYLOXY)PHENYL] 2 (2 MERCAPTOACETAMIDO)PROPANOIC ACID; 3 [4 (BENZYLOXY)PHENYL] 2 (3 MERCAPTOPROPANAMIDO)PROPANOIC ACID; 3 [4 (BENZYLOXY)PHENYL] 2 (4 MERCAPTOBUTANAMIDO)PROPANOIC ACID; AMINO ACID DERIVATIVE; ANTIBIOTIC AGENT; HYDROLASE INHIBITOR; IMIPENEM; METALLO BETA LACTAMASE; METALLO BETA LACTAMASE IMP 1; PENICILLIN G; THIOL REAGENT; UNCLASSIFIED DRUG; AMINO ACID; BETA LACTAMASE; BETA LACTAMASE INHIBITOR; THIOL DERIVATIVE;

ANTIBIOTIC RESISTANCE; ARTICLE; COMPETITIVE INHIBITION; CONTROLLED STUDY; DRUG DESIGN; DRUG SCREENING; DRUG SYNTHESIS; ESCHERICHIA COLI; GROWTH INHIBITION; IN VITRO STUDY; INHIBITION CONSTANT; MINIMUM INHIBITORY CONCENTRATION; MOLECULAR DOCKING; NONHUMAN; PROTEIN EXPRESSION; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; ENZYMOLOGY; KINETICS; KLEBSIELLA PNEUMONIAE; METABOLISM; PSEUDOMONAS AERUGINOSA; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

AMINO ACIDS; BETA-LACTAMASE INHIBITORS; BETA-LACTAMASES; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; KINETICS; KLEBSIELLA PNEUMONIAE; MOLECULAR STRUCTURE; PSEUDOMONAS AERUGINOSA; STRUCTURE-ACTIVITY RELATIONSHIP; SULFHYDRYL COMPOUNDS;

EID: 84962239845     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2016.03.017     Document Type: Article

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