-
1
-
-
46149087663
-
-
Available from
-
From the Global Strategy for Asthma Management and Prevention. Global Initiative for Asthma (GINA) 2015. Available from http://www.ginasthma.org/.
-
(2015)
Global Initiative for Asthma (GINA)
-
-
-
2
-
-
84942818901
-
-
Updated Results, 2011–12. Available from
-
Australian Bureau of Statistics. Australian Health Survey. Updated Results, 2011–12. Available from http://www.abs.gov.au/AUSSTATS/subscriber.nsf/log?openagent &43640do007_20112012.xls&4364.0.55.001&DataCubes&18DEF104A278854D CA257B820017A5DB&0&2011-12&07.06.2013&Latest.
-
Australian Health Survey
-
-
-
3
-
-
85137322645
-
World Health Organisation
-
Available from
-
World Health Organisation. Bronchial Asthma 2016. Available from http://www.who. int/mediacentre/factsheets/fs206/en/.
-
(2016)
Bronchial Asthma
-
-
-
4
-
-
79953718767
-
Cytokine/anti‐cytokine therapy–novel treatments for asthma?
-
Hansbro PM, Kaiko GE, Foster PS. Cytokine/anti‐cytokine therapy–novel treatments for asthma? Br J Pharmacol 2011; 163: 81–95.
-
(2011)
Br J Pharmacol
, vol.163
, pp. 81-95
-
-
Hansbro, P.M.1
Kaiko, G.E.2
Foster, P.S.3
-
5
-
-
84871013520
-
Th2 cytokine antagonists: Potential treatments for severe asthma
-
Hansbro PM, Scott GV, Essilfie A-T, Kim RY, Starkey MR, Nguyen DH et al. Th2 cytokine antagonists: potential treatments for severe asthma. Expert Opin Investig Drugs 2013; 22: 49–69.
-
(2013)
Expert Opin Investig Drugs
, vol.22
, pp. 49-69
-
-
Hansbro, P.M.1
Scott, G.V.2
Essilfie, A.-T.3
Kim, R.Y.4
Starkey, M.R.5
Nguyen, D.H.6
-
6
-
-
84893513577
-
International ERS/ATS guidelines on definition, evaluation and treatment of severe asthma
-
Chung KF, Wenzel SE, Brozek JL, Bush A, Castro M, Sterk PJ et al. International ERS/ATS guidelines on definition, evaluation and treatment of severe asthma. Eur Respir J 2013; 43: 343–373.
-
(2013)
Eur Respir J
, vol.43
, pp. 343-373
-
-
Chung, K.F.1
Wenzel, S.E.2
Brozek, J.L.3
Bush, A.4
Castro, M.5
Sterk, P.J.6
-
7
-
-
84929440358
-
Asthma control in Australia: A cross-sectional web-based survey in a nationally representative population
-
Reddel H, Sawyer S, Everett P, Flood P, Peters M. Asthma control in Australia: a cross-sectional web-based survey in a nationally representative population. Med J Aust 2015; 202: 492–496.
-
(2015)
Med J Aust
, vol.202
, pp. 492-496
-
-
Reddel, H.1
Sawyer, S.2
Everett, P.3
Flood, P.4
Peters, M.5
-
8
-
-
84875225940
-
Corticosteroid resistance in patients with asthma and chronic obstructive pulmonary disease
-
Barnes PJ. Corticosteroid resistance in patients with asthma and chronic obstructive pulmonary disease. J Allergy Clin Immunol 2013; 131: 636–645.
-
(2013)
J Allergy Clin Immunol
, vol.131
, pp. 636-645
-
-
Barnes, P.J.1
-
9
-
-
84893401365
-
Airway epithelial regulation of pulmonary immune homeostasis and inflammation
-
Hallstrand TS, Hackett TL, Altemeier WA, Matute-Bello G, Hansbro PM, Knight DA. Airway epithelial regulation of pulmonary immune homeostasis and inflammation. Clin Immunol 2014; 151: 1–15.
-
(2014)
Clin Immunol
, vol.151
, pp. 1-15
-
-
Hallstrand, T.S.1
Hackett, T.L.2
Altemeier, W.A.3
Matute-Bello, G.4
Hansbro, P.M.5
Knight, D.A.6
-
10
-
-
0029893414
-
Airway structure and inflammatory cells in fatal attacks of asthma
-
Carroll N, Carello S, Cooke C, James A. Airway structure and inflammatory cells in fatal attacks of asthma. Eur Respir J 1996; 9: 709–715.
-
(1996)
Eur Respir J
, vol.9
, pp. 709-715
-
-
Carroll, N.1
Carello, S.2
Cooke, C.3
James, A.4
-
11
-
-
0042921284
-
Understanding asthma pathophysiology
-
Fireman P. Understanding asthma pathophysiology. Allergy Asthma Proc 2003; 24: 79–83.
-
(2003)
Allergy Asthma Proc
, vol.24
, pp. 79-83
-
-
-
12
-
-
0024505353
-
Subepithelial fibrosis in the bronchi of asthmatics
-
Roche W, Williams J, Beasley R, Holgate S. Subepithelial fibrosis in the bronchi of asthmatics. Lancet 1989; 333: 520–524.
-
(1989)
Lancet
, vol.333
, pp. 520-524
-
-
Roche, W.1
Williams, J.2
Beasley, R.3
Holgate, S.4
-
13
-
-
0030895523
-
The measurement of reticular basement membrane and submucosal collagen in the asthmatic airway
-
Wilson J, Li X. The measurement of reticular basement membrane and submucosal collagen in the asthmatic airway. Clin Exp Allergy 1997; 27: 363–371.
-
(1997)
Clin Exp Allergy
, vol.27
, pp. 363-371
-
-
Wilson, J.1
Li, X.2
-
14
-
-
70349852569
-
T-helper type 2–driven inflammation defines major subphenotypes of asthma
-
Woodruff PG, Modrek B, Choy DF, Jia G, Abbas AR, Ellwanger A et al. T-helper type 2–driven inflammation defines major subphenotypes of asthma. Am J Resp Crit Care Med 2009; 180: 388–395.
-
(2009)
Am J Resp Crit Care Med
, vol.180
, pp. 388-395
-
-
Woodruff, P.G.1
Modrek, B.2
Choy, D.F.3
Jia, G.4
Abbas, A.R.5
Ellwanger, A.6
-
15
-
-
84879401471
-
Dupilumab in persistent asthma with elevated eosinophil levels
-
Wenzel S, Ford L, Pearlman D, Spector S, Sher L, Skobieranda F et al. Dupilumab in persistent asthma with elevated eosinophil levels. N Engl J Med 2013; 368: 2455–2466.
-
(2013)
N Engl J Med
, vol.368
, pp. 2455-2466
-
-
Wenzel, S.1
Ford, L.2
Pearlman, D.3
Spector, S.4
Sher, L.5
Skobieranda, F.6
-
16
-
-
0034942124
-
Heterogeneity of airway inflammation in persistent asthma: Evidence of neutrophilic inflammation and increased sputum interleukin-8
-
Gibson PG, Simpson JL, Saltos N. Heterogeneity of airway inflammation in persistent asthma: evidence of neutrophilic inflammation and increased sputum interleukin-8. Chest 2001; 119: 1329–1336.
-
(2001)
Chest
, vol.119
, pp. 1329-1336
-
-
Gibson, P.G.1
Simpson, J.L.2
Saltos, N.3
-
17
-
-
38649090061
-
Immunological decision‐making: How does the immune system decide to mount a helper T‐cell response?
-
Kaiko GE, Horvat JC, Beagley KW, Hansbro PM. Immunological decision‐making: how does the immune system decide to mount a helper T‐cell response? Immunol 2008; 123: 326–338.
-
(2008)
Immunol
, vol.123
, pp. 326-338
-
-
Kaiko, G.E.1
Horvat, J.C.2
Beagley, K.W.3
Hansbro, P.M.4
-
18
-
-
0033763038
-
Antigen presentation in the lung
-
Holt PG. Antigen presentation in the lung. Am J Resp Crit Care Med 2000; 162: S151–S156.
-
(2000)
Am J Resp Crit Care Med
, vol.162
, pp. S151-S156
-
-
Holt, P.G.1
-
19
-
-
0022568935
-
B cell stimulatory factor-1 enhances the IgE response of lipopolysaccharide-activated B cells
-
Coffman RL, Ohara J, Bond MW, Carty J, Zlotnik A, Paul W. B cell stimulatory factor-1 enhances the IgE response of lipopolysaccharide-activated B cells. J Immunol 1986; 136: 4538–4541.
-
(1986)
J Immunol
, vol.136
, pp. 4538-4541
-
-
Coffman, R.L.1
Ohara, J.2
Bond, M.W.3
Carty, J.4
Zlotnik, A.5
Paul, W.6
-
21
-
-
0035092548
-
IgE regulation and roles in asthma pathogenesis
-
Oettgen HC, Geha RS. IgE regulation and roles in asthma pathogenesis. J Allergy Clin Immunol 2001; 107: 429–441.
-
(2001)
J Allergy Clin Immunol
, vol.107
, pp. 429-441
-
-
Oettgen, H.C.1
Geha, R.S.2
-
22
-
-
0038152342
-
The biology of IgE and the basis of allergic disease
-
Gould HJ, Sutton BJ, Beavil AJ, Beavil RL, McCloskey N, Coker HA et al. The biology of IgE and the basis of allergic disease. Annu Rev Immunol 2003; 21: 579–628.
-
(2003)
Annu Rev Immunol
, vol.21
, pp. 579-628
-
-
Gould, H.J.1
Sutton, B.J.2
Beavil, A.J.3
Beavil, R.L.4
McCloskey, N.5
Coker, H.A.6
-
23
-
-
40049092917
-
Treatment strategies for allergy and asthma
-
Holgate ST, Polosa R. Treatment strategies for allergy and asthma. Nat Rev Immunol 2008; 8: 218–230.
-
(2008)
Nat Rev Immunol
, vol.8
, pp. 218-230
-
-
Holgate, S.T.1
Polosa, R.2
-
24
-
-
0027413678
-
Interleukin 13, a T-cell-derived cytokine that regulates human monocyte and B-cell function
-
McKenzie A, Culpepper J, de Waal Malefyt R, Briere F, Punnonen J, Aversa G et al. Interleukin 13, a T-cell-derived cytokine that regulates human monocyte and B-cell function. Proc Natl Acad Sci USA 1993; 90: 3735–3739.
-
(1993)
Proc Natl Acad Sci USA
, vol.90
, pp. 3735-3739
-
-
McKenzie, A.1
Culpepper, J.2
de Waal Malefyt, R.3
Briere, F.4
Punnonen, J.5
Aversa, G.6
-
25
-
-
0032545433
-
Requirement for IL-13 independently of IL-4 in experimental asthma
-
Grünig G, Warnock M, Wakil AE, Venkayya R, Brombacher F, Rennick DM et al. Requirement for IL-13 independently of IL-4 in experimental asthma. Science 1998; 282: 2261–2263.
-
(1998)
Science
, vol.282
, pp. 2261-2263
-
-
Grünig, G.1
Warnock, M.2
Wakil, A.E.3
Venkayya, R.4
Brombacher, F.5
Rennick, D.M.6
-
26
-
-
84883256475
-
Dose-ranging study of lebrikizumab in asthmatic patients not receiving inhaled steroids
-
e512
-
Noonan M, Korenblat P, Mosesova S, Scheerens H, Arron JR, Zheng Y et al. Dose-ranging study of lebrikizumab in asthmatic patients not receiving inhaled steroids. J Allergy Clin Immunol 2013; 132: 567–574, e512.
-
(2013)
J Allergy Clin Immunol
, vol.132
, pp. 567-574
-
-
Noonan, M.1
Korenblat, P.2
Mosesova, S.3
Scheerens, H.4
Arron, J.R.5
Zheng, Y.6
-
27
-
-
33947588653
-
Innate immune activation in neutrophilic asthma and bronchiectasis
-
Simpson JL, Grissell TV, Douwes J, Scott RJ, Boyle MJ, Gibson PG. Innate immune activation in neutrophilic asthma and bronchiectasis. Thorax 2007; 62: 211–218.
-
(2007)
Thorax
, vol.62
, pp. 211-218
-
-
Simpson, J.L.1
Grissell, T.V.2
Douwes, J.3
Scott, R.J.4
Boyle, M.J.5
Gibson, P.G.6
-
30
-
-
84897434287
-
Elevated expression of the NLRP3 inflammasome in neutrophilic asthma
-
Simpson JL, Phipps S, Baines KJ, Oreo KM, Gunawardhana L, Gibson PG. Elevated expression of the NLRP3 inflammasome in neutrophilic asthma. Eur Respir J 2014; 43: 1067–1076.
-
(2014)
Eur Respir J
, vol.43
, pp. 1067-1076
-
-
Simpson, J.L.1
Phipps, S.2
Baines, K.J.3
Oreo, K.M.4
Gunawardhana, L.5
Gibson, P.G.6
-
31
-
-
78650864775
-
Transcriptional phenotypes of asthma defined by gene expression profiling of induced sputum samples
-
Baines KJ, Simpson JL, Wood LG, Scott RJ, Gibson PG. Transcriptional phenotypes of asthma defined by gene expression profiling of induced sputum samples. J Allergy Clin Immunol 2011; 127: 153–160.
-
(2011)
J Allergy Clin Immunol
, vol.127
, pp. 153-160
-
-
Baines, K.J.1
Simpson, J.L.2
Wood, L.G.3
Scott, R.J.4
Gibson, P.G.5
-
32
-
-
84857215266
-
Interleukin (IL)-4, IL-13, and IL-17A differentially affect the profibrotic and proinflammatory functions of fibrocytes from asthmatic patients
-
Bellini A, Marini M, Bianchetti L, Barczyk M, Schmidt M, Mattoli S. Interleukin (IL)-4, IL-13, and IL-17A differentially affect the profibrotic and proinflammatory functions of fibrocytes from asthmatic patients. Mucosal Immunol 2012; 5: 140–149.
-
(2012)
Mucosal Immunol
, vol.5
, pp. 140-149
-
-
Bellini, A.1
Marini, M.2
Bianchetti, L.3
Barczyk, M.4
Schmidt, M.5
Mattoli, S.6
-
33
-
-
84874088635
-
Th17 responses in chronic allergic airway inflammation abrogate regulatory T-cell-mediated tolerance and contribute to airway remodeling
-
Zhao J, Lloyd CM, Noble A. Th17 responses in chronic allergic airway inflammation abrogate regulatory T-cell-mediated tolerance and contribute to airway remodeling. Mucosal Immunol 2013; 6: 335–346.
-
(2013)
Mucosal Immunol
, vol.6
, pp. 335-346
-
-
Zhao, J.1
Lloyd, C.M.2
Noble, A.3
-
34
-
-
84890026323
-
Randomized, double-blind, placebo-controlled study of brodalumab, a human anti–IL-17 receptor monoclonal antibody, in moderate to severe asthma
-
Busse WW, Holgate S, Kerwin E, Chon Y, Feng J, Lin J et al. Randomized, double-blind, placebo-controlled study of brodalumab, a human anti–IL-17 receptor monoclonal antibody, in moderate to severe asthma. Am J Resp Crit Care Med 2013; 188: 1294–1302.
-
(2013)
Am J Resp Crit Care Med
, vol.188
, pp. 1294-1302
-
-
Busse, W.W.1
Holgate, S.2
Kerwin, E.3
Chon, Y.4
Feng, J.5
Lin, J.6
-
35
-
-
84939795095
-
TH2 and TH17 inflammatory pathways are reciprocally regulated in asthma
-
Choy DF, Hart KM, Borthwick LA, Shikotra A, Nagarkar DR, Siddiqui S et al. TH2 and TH17 inflammatory pathways are reciprocally regulated in asthma. Sci Transl Med 2015; 7: 301ra129.
-
(2015)
Sci Transl Med
, vol.7
, pp. 301ra129
-
-
Choy, D.F.1
Hart, K.M.2
Borthwick, L.A.3
Shikotra, A.4
Nagarkar, D.R.5
Siddiqui, S.6
-
36
-
-
34249779227
-
Specificity of basement membrane thickening in severe asthma
-
Bourdin A, Neveu D, Vachier I, Paganin F, Godard P, Chanez P. Specificity of basement membrane thickening in severe asthma. J Allergy Clin Immunol 2007; 119: 1367–1374.
-
(2007)
J Allergy Clin Immunol
, vol.119
, pp. 1367-1374
-
-
Bourdin, A.1
Neveu, D.2
Vachier, I.3
Paganin, F.4
Godard, P.5
Chanez, P.6
-
37
-
-
33751180809
-
IL-17 mRNA in sputum of asthmatic patients: Linking T cell driven inflammation and granulocytic influx
-
Bullens D, Truyen E, Coteur L, Dilissen E, Hellings PW, Dupont LJ et al. IL-17 mRNA in sputum of asthmatic patients: linking T cell driven inflammation and granulocytic influx. Respir Res 2006; 7: 135.
-
(2006)
Respir Res
, vol.7
-
-
Bullens, D.1
Truyen, E.2
Coteur, L.3
Dilissen, E.4
Hellings, P.W.5
Dupont, L.J.6
-
38
-
-
0019412311
-
Corticosteroid resistance in chronic asthma
-
Carmichael J, Paterson IC, Diaz P, Crompton G, Kay A, Grant I. Corticosteroid resistance in chronic asthma. BMJ 1981; 282: 1419–1422.
-
(1981)
BMJ
, vol.282
, pp. 1419-1422
-
-
Carmichael, J.1
Paterson, I.C.2
Diaz, P.3
Crompton, G.4
Kay, A.5
Grant, I.6
-
39
-
-
84957865023
-
Inflammasomes in COPD and neutrophilic asthma
-
Kim RY, Pinkerton JW, Gibson PG, Cooper MA, Horvat JC, Hansbro PM. Inflammasomes in COPD and neutrophilic asthma. Thorax 2015; 70: 1199–1201.
-
(2015)
Thorax
, vol.70
, pp. 1199-1201
-
-
Kim, R.Y.1
Pinkerton, J.W.2
Gibson, P.G.3
Cooper, M.A.4
Horvat, J.C.5
Hansbro, P.M.6
-
40
-
-
84874063346
-
Obesity-associated severe asthma represents a distinct clinical phenotype: Analysis of the British Thoracic Society Difficult Asthma Registry Patient cohort according to BMI
-
Gibeon D, Batuwita K, Osmond M, Heaney LG, Brightling CE, Niven R et al. Obesity-associated severe asthma represents a distinct clinical phenotype: analysis of the British Thoracic Society Difficult Asthma Registry Patient cohort according to BMI. Chest 2013; 143: 406–414.
-
(2013)
Chest
, vol.143
, pp. 406-414
-
-
Gibeon, D.1
Batuwita, K.2
Osmond, M.3
Heaney, L.G.4
Brightling, C.E.5
Niven, R.6
-
41
-
-
77953351470
-
Use of long-acting β-agonists and inhaled steroids in asthma: Meta-analysis of observational studies
-
Hirst C, Calingaert B, Stanford R, Castellsague J. Use of long-acting β-agonists and inhaled steroids in asthma: meta-analysis of observational studies. J Asthma 2010; 47: 439–446.
-
(2010)
J Asthma
, vol.47
, pp. 439-446
-
-
Hirst, C.1
Calingaert, B.2
Stanford, R.3
Castellsague, J.4
-
42
-
-
77956929721
-
Potential therapeutic targets for steroid-resistant asthma
-
Wang W, Li JJ, Foster PS, Hansbro PM, Yang M. Potential therapeutic targets for steroid-resistant asthma. Curr drug targets 2010; 11: 957–970.
-
(2010)
Curr Drug Targets
, vol.11
, pp. 957-970
-
-
Wang, W.1
Li, J.J.2
Foster, P.S.3
Hansbro, P.M.4
Yang, M.5
-
43
-
-
0141497509
-
How do corticosteroids work in asthma?
-
Barnes PJ, Adcock IM. How do corticosteroids work in asthma? Ann Intern Med 2003; 139: 359–370.
-
(2003)
Ann Intern Med
, vol.139
, pp. 359-370
-
-
Barnes, P.J.1
Adcock, I.M.2
-
44
-
-
84865497596
-
Glucocorticoid-resistant asthma and novel anti-inflammatory drugs
-
Keenan CR, Salem S, Fietz ER, Gualano RC, Stewart AG. Glucocorticoid-resistant asthma and novel anti-inflammatory drugs. Drug Discov Today 2012; 17: 1031–1038.
-
(2012)
Drug Discov Today
, vol.17
, pp. 1031-1038
-
-
Keenan, C.R.1
Salem, S.2
Fietz, E.R.3
Gualano, R.C.4
Stewart, A.G.5
-
45
-
-
0032914288
-
Increased glucocorticoid receptor β in airway cells of glucocorticoid-insensitive asthma
-
Hamid QA, Wenzel SE, Hauk PJ, Tsicopoulos A, Wallaert B, Lafitte J-J et al. Increased glucocorticoid receptor β in airway cells of glucocorticoid-insensitive asthma. Am J Resp Crit Care Med 1999; 159: 1600–1604.
-
(1999)
Am J Resp Crit Care Med
, vol.159
, pp. 1600-1604
-
-
Hamid, Q.A.1
Wenzel, S.E.2
Hauk, P.J.3
Tsicopoulos, A.4
Wallaert, B.5
Lafitte, J.-J.6
-
46
-
-
79251540548
-
Streptococcus pneumoniae infection suppresses allergic airways disease by inducing regulatory T-cells
-
Preston J, Thorburn A, Starkey M, Beckett E, Horvat J, Wade M et al. Streptococcus pneumoniae infection suppresses allergic airways disease by inducing regulatory T-cells. Eur Respir J 2011; 37: 53–64.
-
(2011)
Eur Respir J
, vol.37
, pp. 53-64
-
-
Preston, J.1
Thorburn, A.2
Starkey, M.3
Beckett, E.4
Horvat, J.5
Wade, M.6
-
47
-
-
35848933938
-
Inhibition of allergic airways disease by immunomodulatory therapy with whole killed Streptococcus pneumoniae
-
Preston JA, Essilfie A-T, Horvat JC, Wade MA, Beagley KW, Gibson PG et al. Inhibition of allergic airways disease by immunomodulatory therapy with whole killed Streptococcus pneumoniae. Vaccine 2007; 25: 8154–8162.
-
(2007)
Vaccine
, vol.25
, pp. 8154-8162
-
-
Preston, J.A.1
Essilfie, A.-T.2
Horvat, J.C.3
Wade, M.A.4
Beagley, K.W.5
Gibson, P.G.6
-
48
-
-
84860331287
-
Components of Streptococcus pneumoniae suppress allergic airways disease and NKT cells by inducing regulatory T cells
-
Thorburn AN, Foster PS, Gibson PG, Hansbro PM. Components of Streptococcus pneumoniae suppress allergic airways disease and NKT cells by inducing regulatory T cells. J Immunol 2012; 188: 4611–4620.
-
(2012)
J Immunol
, vol.188
, pp. 4611-4620
-
-
Thorburn, A.N.1
Foster, P.S.2
Gibson, P.G.3
Hansbro, P.M.4
-
49
-
-
78149274601
-
Harnessing regulatory T cells to suppress asthma: From potential to therapy
-
Thorburn AN, Hansbro PM. Harnessing regulatory T cells to suppress asthma: from potential to therapy. Am J Resp Cell Mol Biol 2010; 43: 511–519.
-
(2010)
Am J Resp Cell Mol Biol
, vol.43
, pp. 511-519
-
-
Thorburn, A.N.1
Hansbro, P.M.2
-
50
-
-
78649631700
-
Pneumococcal conjugate vaccine-induced regulatory T cells suppress the development of allergic airways disease
-
Thorburn AN, O’Sullivan BJ, Thomas R, Kumar RK, Foster PS, Gibson PG et al. Pneumococcal conjugate vaccine-induced regulatory T cells suppress the development of allergic airways disease. Thorax 2010; 65: 1053–1060.
-
(2010)
Thorax
, vol.65
, pp. 1053-1060
-
-
Thorburn, A.N.1
O’Sullivan, B.J.2
Thomas, R.3
Kumar, R.K.4
Foster, P.S.5
Gibson, P.G.6
-
51
-
-
84929457101
-
Macrolide therapy suppresses key features of experimental steroid-sensitive and steroid-insensitive asthma
-
Essilfie A-T, Horvat JC, Kim RY, Mayall JR, Pinkerton JW, Beckett EL et al. Macrolide therapy suppresses key features of experimental steroid-sensitive and steroid-insensitive asthma. Thorax 2015; 70: 458–467.
-
(2015)
Thorax
, vol.70
, pp. 458-467
-
-
Essilfie, A.-T.1
Horvat, J.C.2
Kim, R.Y.3
Mayall, J.R.4
Pinkerton, J.W.5
Beckett, E.L.6
-
52
-
-
84921001401
-
The effect of azithromycin in adults with stable neutrophilic COPD: A double blind randomised, placebo controlled trial
-
Simpson JL, Powell H, Baines KJ, Milne D, Coxson HO, Hansbro PM et al. The effect of azithromycin in adults with stable neutrophilic COPD: a double blind randomised, placebo controlled trial. PLoS ONE 2014; 9: e105609.
-
(2014)
Plos ONE
, vol.9
-
-
Simpson, J.L.1
Powell, H.2
Baines, K.J.3
Milne, D.4
Coxson, H.O.5
Hansbro, P.M.6
-
53
-
-
0026604612
-
Enhanced superoxide production by alveolar macrophages and air-space cells, airway inflammation, and alveolar macrophage density changes after segmental antigen bronchoprovocation in allergic subjects
-
Calhoun WJ, Reed HE, Moest DR, Stevens CA. Enhanced superoxide production by alveolar macrophages and air-space cells, airway inflammation, and alveolar macrophage density changes after segmental antigen bronchoprovocation in allergic subjects. Am Rev Respir Dis 1992; 145: 317–325.
-
(1992)
Am Rev Respir Dis
, vol.145
, pp. 317-325
-
-
Calhoun, W.J.1
Reed, H.E.2
Moest, D.R.3
Stevens, C.A.4
-
54
-
-
0025939165
-
The role of free radicals in airway obstruction in asthmatic patients
-
Kanazawa H, Kurihara N, Hirata K, Takeda T. The role of free radicals in airway obstruction in asthmatic patients. Chest 1991; 100: 1319–1322.
-
(1991)
Chest
, vol.100
, pp. 1319-1322
-
-
Kanazawa, H.1
Kurihara, N.2
Hirata, K.3
Takeda, T.4
-
55
-
-
51549106954
-
Mitochondrial structural changes and dysfunction are associated with experimental allergic asthma
-
Mabalirajan U, Dinda AK, Kumar S, Roshan R, Gupta P, Sharma SK et al. Mitochondrial structural changes and dysfunction are associated with experimental allergic asthma. J Immunol 2008; 181: 3540–3548.
-
(2008)
J Immunol
, vol.181
, pp. 3540-3548
-
-
Mabalirajan, U.1
Dinda, A.K.2
Kumar, S.3
Roshan, R.4
Gupta, P.5
Sharma, S.K.6
-
56
-
-
84874626721
-
Alteration of nitric oxide synthesis related to abnormal cellular bioenergetics in asthmatic airway epithelium
-
Comhair S, Janocha A, Mavrakis L, Erzurum S, Xu W. Alteration of nitric oxide synthesis related to abnormal cellular bioenergetics in asthmatic airway epithelium. Am J Respir Crit Care Med 2010; 181: A1436.
-
(2010)
Am J Respir Crit Care Med
, vol.181
-
-
Comhair, S.1
Janocha, A.2
Mavrakis, L.3
Erzurum, S.4
Xu, W.5
-
57
-
-
67650409701
-
Ragweed pollen-mediated IgE-independent release of biogenic amines from mast cells via induction of mitochondrial dysfunction
-
Chodaczek G, Bacsi A, Dharajiya N, Sur S, Hazra TK, Boldogh I. Ragweed pollen-mediated IgE-independent release of biogenic amines from mast cells via induction of mitochondrial dysfunction. Mol Immunol 2009; 46: 2505–2514.
-
(2009)
Mol Immunol
, vol.46
, pp. 2505-2514
-
-
Chodaczek, G.1
Bacsi, A.2
Dharajiya, N.3
Sur, S.4
Hazra, T.K.5
Boldogh, I.6
-
58
-
-
84920263527
-
Mitochondrial-targeted antioxidant therapy decreases transforming growth factor-β–mediated collagen production in a murine asthma model
-
Jaffer OA, Carter AB, Sanders PN, Dibbern ME, Winters CJ, Murthy S et al. Mitochondrial-targeted antioxidant therapy decreases transforming growth factor-β–mediated collagen production in a murine asthma model. Am J Resp Cell Mol Biol 2015; 52: 106–115.
-
(2015)
Am J Resp Cell Mol Biol
, vol.52
, pp. 106-115
-
-
Jaffer, O.A.1
Carter, A.B.2
Sanders, P.N.3
Dibbern, M.E.4
Winters, C.J.5
Murthy, S.6
-
59
-
-
34250218888
-
Oxidative stress and steroid resistance in asthma and COPD: Pharmacological manipulation of HDAC-2 as a therapeutic strategy
-
Marwick JA, Ito K, Adcock IM, Kirkham PA. Oxidative stress and steroid resistance in asthma and COPD: pharmacological manipulation of HDAC-2 as a therapeutic strategy. Expert Opin Ther Targets 2007; 11: 745–755.
-
(2007)
Expert Opin Ther Targets
, vol.11
, pp. 745-755
-
-
Marwick, J.A.1
Ito, K.2
Adcock, I.M.3
Kirkham, P.A.4
-
60
-
-
79251570253
-
IL-1β is overexpressed and aberrantly regulated in corticosteroid nonresponders with autoimmune inner ear disease
-
Pathak S, Goldofsky E, Vivas EX, Bonagura VR, Vambutas A. IL-1β is overexpressed and aberrantly regulated in corticosteroid nonresponders with autoimmune inner ear disease. J Immunol 2011; 186: 1870–1879.
-
(2011)
J Immunol
, vol.186
, pp. 1870-1879
-
-
Pathak, S.1
Goldofsky, E.2
Vivas, E.X.3
Bonagura, V.R.4
Vambutas, A.5
-
61
-
-
77953680635
-
A monoclonal antibody to IL-1β attenuates the late asthmatic response to antigen challenge in patients with mild asthma
-
Accessed 8 June 2016
-
Pascoe S, Kanniess F, Bonner J, Lloyd P, Lowe P, Beier J. A monoclonal antibody to IL-1β attenuates the late asthmatic response to antigen challenge in patients with mild asthma. Annu Congr Eur Resp Soc 2006; A752. http://www.ersnet.org/learnin-g_resources_player/abstract_print_06/files/51.pdf. Accessed 8 June 2016.
-
(2006)
Annu Congr Eur Resp Soc
-
-
Pascoe, S.1
Kanniess, F.2
Bonner, J.3
Lloyd, P.4
Lowe, P.5
Beier, J.6
-
62
-
-
84922370441
-
IL-1 receptor antagonist reduces endotoxin-induced airway inflammation in healthy volunteers
-
Hernandez ML, Mills K, Almond M, Todoric K, Aleman MM, Zhang H et al. IL-1 receptor antagonist reduces endotoxin-induced airway inflammation in healthy volunteers. J Allergy Clin Immunol 2015; 135: 379–385.
-
(2015)
J Allergy Clin Immunol
, vol.135
, pp. 379-385
-
-
Hernandez, M.L.1
Mills, K.2
Almond, M.3
Todoric, K.4
Aleman, M.M.5
Zhang, H.6
-
63
-
-
79953683724
-
Differential expression and function of breast regression protein 39 (BRP-39) in murine models of subacute cigarette smoke exposure and allergic airway inflammation
-
Nikota JK, Botelho FM, Bauer CM, Jordana M, Coyle AJ, Humbles AA et al. Differential expression and function of breast regression protein 39 (BRP-39) in murine models of subacute cigarette smoke exposure and allergic airway inflammation. Resp Res 2011; 12: 39.
-
(2011)
Resp Res
, vol.12
, pp. 39
-
-
Nikota, J.K.1
Botelho, F.M.2
Bauer, C.M.3
Jordana, M.4
Coyle, A.J.5
Humbles, A.A.6
-
64
-
-
84866130874
-
Interleukin-1α controls allergic sensitization to inhaled house dust mite via the epithelial release of GM-CSF and IL-33
-
Willart MA, Deswarte K, Pouliot P, Braun H, Beyaert R, Lambrecht BN et al. Interleukin-1α controls allergic sensitization to inhaled house dust mite via the epithelial release of GM-CSF and IL-33. J Exp Med 2012; 209: 1505–1517.
-
(2012)
J Exp Med
, vol.209
, pp. 1505-1517
-
-
Willart, M.A.1
Deswarte, K.2
Pouliot, P.3
Braun, H.4
Beyaert, R.5
Lambrecht, B.N.6
-
65
-
-
0029056558
-
Glucocorticoid receptor beta, a potential endogenous inhibitor of glucocorticoid action in humans
-
Bamberger CM, Bamberger A-M, De Castro M, Chrousos GP. Glucocorticoid receptor beta, a potential endogenous inhibitor of glucocorticoid action in humans. J Clin Invest 1995; 95: 2435.
-
(1995)
J Clin Invest
, vol.95
, pp. 2435
-
-
Bamberger, C.M.1
Bamberger, A.-M.2
de Castro, M.3
Chrousos, G.P.4
-
66
-
-
0035810930
-
Proinflammatory cytokines regulate human glucocorticoid receptor gene expression and lead to the accumulation of the dominant negative β isoform: A mechanism for the generation of glucocorticoid resistance
-
Webster JC, Oakley RH, Jewell CM, Cidlowski JA. Proinflammatory cytokines regulate human glucocorticoid receptor gene expression and lead to the accumulation of the dominant negative β isoform: a mechanism for the generation of glucocorticoid resistance. Proc Natl Acad Sci USA 2001; 98: 6865–6870.
-
(2001)
Proc Natl Acad Sci USA
, vol.98
, pp. 6865-6870
-
-
Webster, J.C.1
Oakley, R.H.2
Jewell, C.M.3
Cidlowski, J.A.4
-
67
-
-
77958117957
-
IL-27/IFN-γ induce MyD88-dependent steroid-resistant airway hyperresponsiveness by inhibiting glucocorticoid signaling in macrophages
-
Li JJ, Wang W, Baines KJ, Bowden NA, Hansbro PM, Gibson PG et al. IL-27/IFN-γ induce MyD88-dependent steroid-resistant airway hyperresponsiveness by inhibiting glucocorticoid signaling in macrophages. J Immunol 2010; 185: 4401–4409.
-
(2010)
J Immunol
, vol.185
, pp. 4401-4409
-
-
Li, J.J.1
Wang, W.2
Baines, K.J.3
Bowden, N.A.4
Hansbro, P.M.5
Gibson, P.G.6
-
68
-
-
84949032151
-
Lack of autophagy induces steroid-resistant airway inflammation
-
e9
-
Suzuki Y, Maazi H, Sankaranarayanan I, Lam J, Khoo B, Soroosh P et al. Lack of autophagy induces steroid-resistant airway inflammation. J Allergy Clin Immunol 2015; 137: 1382–1389.e9.
-
(2015)
J Allergy Clin Immunol
, vol.137
, pp. 1382-1389
-
-
Suzuki, Y.1
Maazi, H.2
Sankaranarayanan, I.3
Lam, J.4
Khoo, B.5
Soroosh, P.6
-
69
-
-
74949114437
-
Reduction of tumstatin in asthmatic airways contributes to angiogenesis, inflammation, and hyperresponsiveness
-
Burgess JK, Boustany S, Moir LM, Weckmann M, Lau JY, Grafton K et al. Reduction of tumstatin in asthmatic airways contributes to angiogenesis, inflammation, and hyperresponsiveness. Am J Resp Crit Care Med 2010; 181: 106–115.
-
(2010)
Am J Resp Crit Care Med
, vol.181
, pp. 106-115
-
-
Burgess, J.K.1
Boustany, S.2
Moir, L.M.3
Weckmann, M.4
Lau, J.Y.5
Grafton, K.6
-
70
-
-
84898670742
-
LF-15 & T7, synthetic peptides derived from tumstatin, attenuate aspects of airway remodelling in a murine model of chronic OVA-induced allergic airway disease
-
Grafton KT, Moir LM, Black JL, Hansbro NG, Hansbro PM, Burgess JK et al. LF-15 & T7, synthetic peptides derived from tumstatin, attenuate aspects of airway remodelling in a murine model of chronic OVA-induced allergic airway disease. PLoS ONE 2014; 9: e85655.
-
(2014)
Plos ONE
, vol.9
-
-
Grafton, K.T.1
Moir, L.M.2
Black, J.L.3
Hansbro, N.G.4
Hansbro, P.M.5
Burgess, J.K.6
-
72
-
-
84876575117
-
Inflammation signals airway smooth muscle cell proliferation in asthma pathogenesis
-
Khan MA. Inflammation signals airway smooth muscle cell proliferation in asthma pathogenesis. Multidiscip Respir Med 2013; 8: 11.
-
(2013)
Multidiscip Respir Med
, vol.8
-
-
Khan, M.A.1
-
73
-
-
77951213247
-
Ca(2+) oscillations regulate contraction of intrapulmonary smooth muscle cells
-
Sanderson MJ, Bai Y, Perez-Zoghbi J. Ca(2+) oscillations regulate contraction of intrapulmonary smooth muscle cells. Adv Exp Med Biol 2010; 661: 77–96.
-
(2010)
Adv Exp Med Biol
, vol.661
, pp. 77-96
-
-
Sanderson, M.J.1
Bai, Y.2
Perez-Zoghbi, J.3
-
74
-
-
0034059497
-
The contractile apparatus and mechanical properties of airway smooth muscle
-
Gunst S, Tang D. The contractile apparatus and mechanical properties of airway smooth muscle. Eur Respir J 2000; 15: 600–616.
-
(2000)
Eur Respir J
, vol.15
, pp. 600-616
-
-
Gunst, S.1
Tang, D.2
-
76
-
-
33646174359
-
Chlamydia pneumoniae infection enhances cellular proliferation and reduces steroid responsiveness of human peripheral blood mononuclear cells via a tumor necrosis factor‐α‐dependent pathway
-
Cho Y, Kim TB, Lee TH, Moon KA, Lee J, Kim YK et al. Chlamydia pneumoniae infection enhances cellular proliferation and reduces steroid responsiveness of human peripheral blood mononuclear cells via a tumor necrosis factor‐α‐dependent pathway. Clin Exp Allergy 2005; 35: 1625–1631.
-
(2005)
Clin Exp Allergy
, vol.35
, pp. 1625-1631
-
-
Cho, Y.1
Kim, T.B.2
Lee, T.H.3
Moon, K.A.4
Lee, J.5
Kim, Y.K.6
-
77
-
-
84860152177
-
Chlamydia pneumoniaespecific IgE is prevalent in asthma and is associated with disease severity
-
Hahn DL, Schure A, Patel K, Childs T, Drizik E, Webley W. Chlamydia pneumoniaespecific IgE is prevalent in asthma and is associated with disease severity. PLoS ONE 2012; 7: e35945.
-
(2012)
Plos ONE
, vol.7
-
-
Hahn, D.L.1
Schure, A.2
Patel, K.3
Childs, T.4
Drizik, E.5
Webley, W.6
-
78
-
-
1542404089
-
Role of atypical bacterial infection of the lung in predisposition/protection of asthma
-
Hansbro PM, Beagley KW, Horvat JC, Gibson PG. Role of atypical bacterial infection of the lung in predisposition/protection of asthma. Pharmacol Ther 2004; 101: 193–210.
-
(2004)
Pharmacol Ther
, vol.101
, pp. 193-210
-
-
Hansbro, P.M.1
Beagley, K.W.2
Horvat, J.C.3
Gibson, P.G.4
-
79
-
-
34548641831
-
Neonatal chlamydial infection induces mixed T-cell responses that drive allergic airway disease
-
Horvat JC, Beagley KW, Wade MA, Preston JA, Hansbro NG, Hickey DK et al. Neonatal chlamydial infection induces mixed T-cell responses that drive allergic airway disease. Am J Resp Crit Care Med 2007; 176: 556–564.
-
(2007)
Am J Resp Crit Care Med
, vol.176
, pp. 556-564
-
-
Horvat, J.C.1
Beagley, K.W.2
Wade, M.A.3
Preston, J.A.4
Hansbro, N.G.5
Hickey, D.K.6
-
80
-
-
77952746227
-
Chlamydial respiratory infection during allergen sensitization drives neutrophilic allergic airways disease
-
Horvat JC, Starkey MR, Kim RY, Beagley KW, Preston JA, Gibson PG et al. Chlamydial respiratory infection during allergen sensitization drives neutrophilic allergic airways disease. J Immunol 2010; 184: 4159–4169.
-
(2010)
J Immunol
, vol.184
, pp. 4159-4169
-
-
Horvat, J.C.1
Starkey, M.R.2
Kim, R.Y.3
Beagley, K.W.4
Preston, J.A.5
Gibson, P.G.6
-
81
-
-
77649273626
-
Early-life chlamydial lung infection enhances allergic airways disease through age-dependent differences in immunopathology
-
Horvat JC, Starkey MR, Kim RY, Phipps S, Gibson PG, Beagley KW et al. Early-life chlamydial lung infection enhances allergic airways disease through age-dependent differences in immunopathology. J Allergy Clin Immunol 2010; 125: 617–625.
-
(2010)
J Allergy Clin Immunol
, vol.125
, pp. 617-625
-
-
Horvat, J.C.1
Starkey, M.R.2
Kim, R.Y.3
Phipps, S.4
Gibson, P.G.5
Beagley, K.W.6
-
82
-
-
0036798281
-
Chlamydia pneumoniae immunoglobulin A reactivation and airway inflammation in acute asthma
-
Wark P, Johnston S, Simpson J, Hensley M, Gibson P. Chlamydia pneumoniae immunoglobulin A reactivation and airway inflammation in acute asthma. Eur Respir J 2002; 20: 834–840.
-
(2002)
Eur Respir J
, vol.20
, pp. 834-840
-
-
Wark, P.1
Johnston, S.2
Simpson, J.3
Hensley, M.4
Gibson, P.5
-
83
-
-
78650325777
-
Infectious Chlamydia pneumoniae is associated with elevated interleukin-8 and airway neutrophilia in children with refractory asthma
-
Patel KK, Vicencio AG, Du Z, Tsirilakis K, Salva PS, Webley WC. Infectious Chlamydia pneumoniae is associated with elevated interleukin-8 and airway neutrophilia in children with refractory asthma. Pediatr Infect Dis J 2010; 29: 1093–1098.
-
(2010)
Pediatr Infect Dis J
, vol.29
, pp. 1093-1098
-
-
Patel, K.K.1
Vicencio, A.G.2
Du, Z.3
Tsirilakis, K.4
Salva, P.S.5
Webley, W.C.6
-
84
-
-
0033972782
-
Serological evidence of infection with Chlamydia pneumoniae is related to the severity of asthma
-
Black P, Scicchitano R, Jenkins C, Blasi F, Allegra L, Wlodarczyk J et al. Serological evidence of infection with Chlamydia pneumoniae is related to the severity of asthma. Eur Respir J 2000; 15: 254–259.
-
(2000)
Eur Respir J
, vol.15
, pp. 254-259
-
-
Black, P.1
Scicchitano, R.2
Jenkins, C.3
Blasi, F.4
Allegra, L.5
Wlodarczyk, J.6
-
85
-
-
69149083126
-
Chlamydial infection of immune cells: Altered function and implications for disease
-
Beagley K, Huston WM, Hansbro PM, Timms P. Chlamydial infection of immune cells: altered function and implications for disease. Crit Rev Immunol 2009; 29: 275–305.
-
(2009)
Crit Rev Immunol
, vol.29
, pp. 275-305
-
-
Beagley, K.1
Huston, W.M.2
Hansbro, P.M.3
Timms, P.4
-
86
-
-
42149111673
-
Chlamydia muridarum infection subverts dendritic cell function to promote Th2 immunity and airways hyperreactivity
-
Kaiko GE, Phipps S, Hickey DK, Lam CE, Hansbro PM, Foster PS et al. Chlamydia muridarum infection subverts dendritic cell function to promote Th2 immunity and airways hyperreactivity. J Immunol 2008; 180: 2225–2232.
-
(2008)
J Immunol
, vol.180
, pp. 2225-2232
-
-
Kaiko, G.E.1
Phipps, S.2
Hickey, D.K.3
Lam, C.E.4
Hansbro, P.M.5
Foster, P.S.6
-
87
-
-
74549186515
-
Potentially pathogenic bacteria cultured from the sputum of stable asthmatics are associated with increased 8-isoprostane and airway neutrophilia
-
Wood LG, Simpson JL, Hansbro PM, Gibson PG. Potentially pathogenic bacteria cultured from the sputum of stable asthmatics are associated with increased 8-isoprostane and airway neutrophilia. Free Radic Res 2010; 44: 146–154.
-
(2010)
Free Radic Res
, vol.44
, pp. 146-154
-
-
Wood, L.G.1
Simpson, J.L.2
Hansbro, P.M.3
Gibson, P.G.4
-
88
-
-
84862754513
-
Combined Haemophilus influenzae respiratory infection and allergic airways disease drives chronic infection and features of neutrophilic asthma
-
Essilfie A-T, Simpson JL, Dunkley ML, Morgan LC, Oliver BG, Gibson PG et al. Combined Haemophilus influenzae respiratory infection and allergic airways disease drives chronic infection and features of neutrophilic asthma. Thorax 2012; 67: 588–599.
-
(2012)
Thorax
, vol.67
, pp. 588-599
-
-
Essilfie, A.-T.1
Simpson, J.L.2
Dunkley, M.L.3
Morgan, L.C.4
Oliver, B.G.5
Gibson, P.G.6
-
89
-
-
80055072377
-
Haemophilus influenzae infection drives IL-17-mediated neutrophilic allergic airways disease
-
Essilfie A-T, Simpson JL, Horvat JC, Preston JA, Dunkley ML, Foster PS et al. Haemophilus influenzae infection drives IL-17-mediated neutrophilic allergic airways disease. PLoS Pathog 2011; 7: e1002244.
-
(2011)
Plos Pathog
, vol.7
-
-
Essilfie, A.-T.1
Simpson, J.L.2
Horvat, J.C.3
Preston, J.A.4
Dunkley, M.L.5
Foster, P.S.6
-
90
-
-
39549106885
-
Understanding the mechanisms of viral induced asthma: New therapeutic directions
-
Hansbro NG, Horvat JC, Wark PA, Hansbro PM. Understanding the mechanisms of viral induced asthma: new therapeutic directions. Pharmacol Ther 2008; 117: 313–353.
-
(2008)
Pharmacol Ther
, vol.117
, pp. 313-353
-
-
Hansbro, N.G.1
Horvat, J.C.2
Wark, P.A.3
Hansbro, P.M.4
-
91
-
-
0036153548
-
Neutrophil degranulation and cell lysis is associated with clinical severity in virus-induced asthma
-
Wark P, Johnston S, Moric I, Simpson J, Hensley M, Gibson P. Neutrophil degranulation and cell lysis is associated with clinical severity in virus-induced asthma. Eur Respir J 2001; 19: 68–75.
-
(2001)
Eur Respir J
, vol.19
, pp. 68-75
-
-
Wark, P.1
Johnston, S.2
Moric, I.3
Simpson, J.4
Hensley, M.5
Gibson, P.6
-
92
-
-
33646480059
-
Intermittent inhaled corticosteroids in infants with episodic wheezing
-
Bisgaard H, Hermansen MN, Loland L, Halkjaer LB, Buchvald F. Intermittent inhaled corticosteroids in infants with episodic wheezing. N Engl J Med 2006; 354: 1998–2005.
-
(2006)
N Engl J Med
, vol.354
, pp. 1998-2005
-
-
Bisgaard, H.1
Hermansen, M.N.2
Loland, L.3
Halkjaer, L.B.4
Buchvald, F.5
-
93
-
-
55249088124
-
Steroid-resistant neutrophilic inflammation in a mouse model of an acute exacerbation of asthma
-
Ito K, Herbert C, Siegle JS, Vuppusetty C, Hansbro N, Thomas PS et al. Steroid-resistant neutrophilic inflammation in a mouse model of an acute exacerbation of asthma. Am J Resp Cell Mol Biol 2008; 39: 543–550.
-
(2008)
Am J Resp Cell Mol Biol
, vol.39
, pp. 543-550
-
-
Ito, K.1
Herbert, C.2
Siegle, J.S.3
Vuppusetty, C.4
Hansbro, N.5
Thomas, P.S.6
-
94
-
-
79958050343
-
Interleukin-13 promotes susceptibility to chlamydial infection of the respiratory and genital tracts
-
Asquith KL, Horvat JC, Kaiko GE, Carey AJ, Beagley KW, Hansbro PM et al. Interleukin-13 promotes susceptibility to chlamydial infection of the respiratory and genital tracts. PLoS Pathog 2011; 7: e1001339.
-
(2011)
Plos Pathog
, vol.7
-
-
Asquith, K.L.1
Horvat, J.C.2
Kaiko, G.E.3
Carey, A.J.4
Beagley, K.W.5
Hansbro, P.M.6
-
95
-
-
84875784606
-
The emerging role of microRNAs in regulating immune and inflammatory responses in the lung
-
Foster PS, Plank M, Collison A, Tay HL, Kaiko GE, Li J et al. The emerging role of microRNAs in regulating immune and inflammatory responses in the lung. Immunol Rev 2013; 253: 198–215.
-
(2013)
Immunol Rev
, vol.253
, pp. 198-215
-
-
Foster, P.S.1
Plank, M.2
Collison, A.3
Tay, H.L.4
Kaiko, G.E.5
Li, J.6
-
96
-
-
84929492776
-
Antagonism of miR-328 increases the antimicrobial function of macrophages and neutrophils and rapid clearance of non-typeable Haemophilus influenzae (NTHi) from infected lung
-
Tay HL, Kaiko GE, Plank M, Li J, Maltby S, Essilfie A-T et al. Antagonism of miR-328 increases the antimicrobial function of macrophages and neutrophils and rapid clearance of non-typeable Haemophilus influenzae (NTHi) from infected lung. PLoS Pathog 2015; 11: e1004549.
-
(2015)
Plos Pathog
, vol.11
-
-
Tay, H.L.1
Kaiko, G.E.2
Plank, M.3
Li, J.4
Maltby, S.5
Essilfie, A.-T.6
-
97
-
-
84860877293
-
Emerging roles of pulmonary macrophages in driving the development of severe asthma
-
Yang M, Kumar RK, Hansbro PM, Foster PS. Emerging roles of pulmonary macrophages in driving the development of severe asthma. J Leukoc Biol 2012; 91: 557–569.
-
(2012)
J Leukoc Biol
, vol.91
, pp. 557-569
-
-
Yang, M.1
Kumar, R.K.2
Hansbro, P.M.3
Foster, P.S.4
-
98
-
-
84876372773
-
Constitutive production of IL-13 promotes early-life Chlamydia respiratory infection and allergic airway disease
-
Starkey M, Essilfie A, Horvat J, Kim R, Nguyen D, Beagley K et al. Constitutive production of IL-13 promotes early-life Chlamydia respiratory infection and allergic airway disease. Mucosal Immunol 2013; 6: 569–579.
-
(2013)
Mucosal Immunol
, vol.6
, pp. 569-579
-
-
Starkey, M.1
Essilfie, A.2
Horvat, J.3
Kim, R.4
Nguyen, D.5
Beagley, K.6
-
99
-
-
84899561991
-
Tumor necrosis factor-related apoptosis-inducing ligand translates neonatal respiratory infection into chronic lung disease
-
Starkey M, Nguyen D, Essilfie A, Kim R, Hatchwell L, Collison A et al. Tumor necrosis factor-related apoptosis-inducing ligand translates neonatal respiratory infection into chronic lung disease. Mucosal Immunol 2014; 7: 478–488.
-
(2014)
Mucosal Immunol
, vol.7
, pp. 478-488
-
-
Starkey, M.1
Nguyen, D.2
Essilfie, A.3
Kim, R.4
Hatchwell, L.5
Collison, A.6
-
100
-
-
84864764856
-
Chlamydia muridarum lung infection in infants alters hematopoietic cells to promote allergic airway disease in mice
-
Starkey MR, Kim RY, Beckett EL, Schilter HC, Shim D, Essilfie A-T et al. Chlamydia muridarum lung infection in infants alters hematopoietic cells to promote allergic airway disease in mice. PLoS ONE 2012; 7: e42588.
-
(2012)
Plos ONE
, vol.7
-
-
Starkey, M.R.1
Kim, R.Y.2
Beckett, E.L.3
Schilter, H.C.4
Shim, D.5
Essilfie, A.-T.6
-
101
-
-
84963779025
-
PD-L1 promotes early-life Chlamydia respiratory infection-induced severe allergic airway disease
-
Starkey MR, Nguyen DH, Brown AC, Essilfie A-T, Kim RY, Yagita H et al. PD-L1 promotes early-life Chlamydia respiratory infection-induced severe allergic airway disease. Am J Resp Cell Mol Biol 2015; 54: 493–503.
-
(2015)
Am J Resp Cell Mol Biol
, vol.54
, pp. 493-503
-
-
Starkey, M.R.1
Nguyen, D.H.2
Brown, A.C.3
Essilfie, A.-T.4
Kim, R.Y.5
Yagita, H.6
-
102
-
-
84881156244
-
Genome-wide association study identifies T H 1 pathway genes associated with lung function in asthmatic patients
-
Li X, Hawkins GA, Ampleford EJ, Moore WC, Li H, Hastie AT et al. Genome-wide association study identifies T H 1 pathway genes associated with lung function in asthmatic patients. J Allergy Clin Immunol 2013; 132: 313–320.
-
(2013)
J Allergy Clin Immunol
, vol.132
, pp. 313-320
-
-
Li, X.1
Hawkins, G.A.2
Ampleford, E.J.3
Moore, W.C.4
Li, H.5
Hastie, A.T.6
-
103
-
-
84865291081
-
Genome-wide association study to identify genetic determinants of severe asthma
-
Wan Y, Shrine N, Artigas MS, Wain L, Blakey J, Moffatt M et al. Genome-wide association study to identify genetic determinants of severe asthma. Thorax 2012; 67: 762–768.
-
(2012)
Thorax
, vol.67
, pp. 762-768
-
-
Wan, Y.1
Shrine, N.2
Artigas, M.S.3
Wain, L.4
Blakey, J.5
Moffatt, M.6
-
104
-
-
84943456033
-
The airway microbiome in patients with severe asthma: Associations with disease features and severity
-
Huang YJ, Nariya S, Harris JM, Lynch SV, Choy DF, Arron JR et al. The airway microbiome in patients with severe asthma: associations with disease features and severity. J Allergy Clin Immunol 2015; 136: 874–884.
-
(2015)
J Allergy Clin Immunol
, vol.136
, pp. 874-884
-
-
Huang, Y.J.1
Nariya, S.2
Harris, J.M.3
Lynch, S.V.4
Choy, D.F.5
Arron, J.R.6
-
105
-
-
84964698860
-
Noninvasive analysis of the sputum transcriptome discriminates clinical phenotypes of asthma
-
Yan X, Chu J-H, Gomez J, Koenigs M, Holm C, He X et al. Noninvasive analysis of the sputum transcriptome discriminates clinical phenotypes of asthma. Am J Resp Crit Care Med 2015; 191: 1116–1125.
-
(2015)
Am J Resp Crit Care Med
, vol.191
, pp. 1116-1125
-
-
Yan, X.1
Chu, J.-H.2
Gomez, J.3
Koenigs, M.4
Holm, C.5
He, X.6
-
107
-
-
84904692363
-
The adaptor ASC has extracellular and ‘prionoid’activities that propagate inflammation
-
Franklin BS, Bossaller L, De Nardo D, Ratter JM, Stutz A, Engels G et al. The adaptor ASC has extracellular and ‘prionoid’activities that propagate inflammation. Nat Immunol 2014; 15: 727–737.
-
(2014)
Nat Immunol
, vol.15
, pp. 727-737
-
-
Franklin, B.S.1
Bossaller, L.2
de Nardo, D.3
Ratter, J.M.4
Stutz, A.5
Engels, G.6
-
108
-
-
84857735166
-
Critical role of constitutive type I interferon response in bronchial epithelial cell to influenza infection
-
Hsu AC, Parsons K, Barr I, Lowther S, Middleton D, Hansbro PM et al. Critical role of constitutive type I interferon response in bronchial epithelial cell to influenza infection. PLoS ONE 2012; 7: e32947.
-
(2012)
Plos ONE
, vol.7
-
-
Hsu, A.C.1
Parsons, K.2
Barr, I.3
Lowther, S.4
Middleton, D.5
Hansbro, P.M.6
-
109
-
-
0030028768
-
Interleukin 5 deficiency abolishes eosinophilia, airways hyperreactivity, and lung damage in a mouse asthma model
-
Foster PS, Hogan SP, Ramsay AJ, Matthaei KI, Young IG. Interleukin 5 deficiency abolishes eosinophilia, airways hyperreactivity, and lung damage in a mouse asthma model. J Exp Med 1996; 183: 195–201.
-
(1996)
J Exp Med
, vol.183
, pp. 195-201
-
-
Foster, P.S.1
Hogan, S.P.2
Ramsay, A.J.3
Matthaei, K.I.4
Young, I.G.5
-
110
-
-
84907424177
-
Mepolizumab treatment in patients with severe eosinophilic asthma
-
Ortega HG, Liu MC, Pavord ID, Brusselle GG, FitzGerald JM, Chetta A et al. Mepolizumab treatment in patients with severe eosinophilic asthma. N Engl J Med 2014; 371: 1198–1207.
-
(2014)
N Engl J Med
, vol.371
, pp. 1198-1207
-
-
Ortega, H.G.1
Liu, M.C.2
Pavord, I.D.3
Brusselle, G.G.4
Fitzgerald, J.M.5
Chetta, A.6
-
111
-
-
84929026123
-
Reslizumab for inadequately controlled asthma with elevated blood eosinophil counts: Results from two multicentre, parallel, double-blind, randomised, placebo-controlled, phase 3 trials
-
Castro M, Zangrilli J, Wechsler ME, Bateman ED, Brusselle GG, Bardin P et al. Reslizumab for inadequately controlled asthma with elevated blood eosinophil counts: results from two multicentre, parallel, double-blind, randomised, placebo-controlled, phase 3 trials. Lancet Resp Med 2015; 3: 355–366.
-
(2015)
Lancet Resp Med
, vol.3
, pp. 355-366
-
-
Castro, M.1
Zangrilli, J.2
Wechsler, M.E.3
Bateman, E.D.4
Brusselle, G.G.5
Bardin, P.6
-
112
-
-
84988961792
-
Cryopreserved human precision-cut lung slices as a bioassay for live tissue banking: A viability study of bronchodilation with bitter-taste receptor agonists
-
Bai Y, Krishnamoorthy N, Patel KR, Rosas I, Sanderson MJ, Ai X. Cryopreserved human precision-cut lung slices as a bioassay for live tissue banking: a viability study of bronchodilation with bitter-taste receptor agonists. Am J Resp Cell Mol Biol 2015; 54: 656–663.
-
(2015)
Am J Resp Cell Mol Biol
, vol.54
, pp. 656-663
-
-
Bai, Y.1
Krishnamoorthy, N.2
Patel, K.R.3
Rosas, I.4
Sanderson, M.J.5
Ai, X.6
-
113
-
-
84947228781
-
Rosiglitazone elicits in vitro relaxation in airways and precision cut lung slices from a mouse model of chronic allergic airways disease
-
Donovan C, Bailey SR, Tran J, Haitsma G, Ibrahim ZA, Foster SR et al. Rosiglitazone elicits in vitro relaxation in airways and precision cut lung slices from a mouse model of chronic allergic airways disease. Am J Physiol Lung Cell Mol Physiol 2015; 309: L1219–L1228.
-
(2015)
Am J Physiol Lung Cell Mol Physiol
, vol.309
, pp. L1219-L1228
-
-
Donovan, C.1
Bailey, S.R.2
Tran, J.3
Haitsma, G.4
Ibrahim, Z.A.5
Foster, S.R.6
-
114
-
-
84942879841
-
Alteration of airway reactivity and reduction of ryanodine receptor expression by cigarette smoke in mice
-
Donovan C, Seow HJ, Royce SG, Bourke JE, Vlahos R. Alteration of airway reactivity and reduction of ryanodine receptor expression by cigarette smoke in mice. Am J Respir Cell Mol Biol 2015; 53: 471–478.
-
(2015)
Am J Respir Cell Mol Biol
, vol.53
, pp. 471-478
-
-
Donovan, C.1
Seow, H.J.2
Royce, S.G.3
Bourke, J.E.4
Vlahos, R.5
-
115
-
-
84879096032
-
Murine models of infectious exacerbations of airway inflammation
-
Starkey MR, Jarnicki AG, Essilfie A-T, Gellatly SL, Kim RY, Brown AC et al. Murine models of infectious exacerbations of airway inflammation. Curr Opin Pharmacol 2013; 13: 337–344.
-
(2013)
Curr Opin Pharmacol
, vol.13
, pp. 337-344
-
-
Starkey, M.R.1
Jarnicki, A.G.2
Essilfie, A.-T.3
Gellatly, S.L.4
Kim, R.Y.5
Brown, A.C.6
-
118
-
-
84903516573
-
Importance of mast cell Prss31/transmembrane tryptase/tryptase-γ in lung function and experimental chronic obstructive pulmonary disease and colitis
-
Hansbro PM, Hamilton MJ, Fricker M, Gellatly SL, Jarnicki AG, Zheng D et al. Importance of mast cell Prss31/transmembrane tryptase/tryptase-γ in lung function and experimental chronic obstructive pulmonary disease and colitis. J Biol Chem 2014; 289: 18214–18227.
-
(2014)
J Biol Chem
, vol.289
, pp. 18214-18227
-
-
Hansbro, P.M.1
Hamilton, M.J.2
Fricker, M.3
Gellatly, S.L.4
Jarnicki, A.G.5
Zheng, D.6
-
119
-
-
84920283137
-
The nucleotidebinding domain, leucine-rich repeat protein 3 inflammasome/IL-1 receptor I axis mediates innate, but not adaptive, immune responses after exposure to particulate matter under 10 μm
-
Hirota JA, Gold MJ, Hiebert PR, Parkinson LG, Wee T, Smith D et al. The nucleotidebinding domain, leucine-rich repeat protein 3 inflammasome/IL-1 receptor I axis mediates innate, but not adaptive, immune responses after exposure to particulate matter under 10 μm. Am J Resp Cell Mol Biol 2015; 52: 96–105.
-
(2015)
Am J Resp Cell Mol Biol
, vol.52
, pp. 96-105
-
-
Hirota, J.A.1
Gold, M.J.2
Hiebert, P.R.3
Parkinson, L.G.4
Wee, T.5
Smith, D.6
-
120
-
-
84858049301
-
Mast cell restricted mouse and human tryptase· heparin complexes hinder thrombin-induced coagulation of plasma and the generation of fibrin by proteolytically destroying fibrinogen
-
Prieto-García A, Zheng D, Adachi R, Xing W, Lane WS, Chung K et al. Mast cell restricted mouse and human tryptase· heparin complexes hinder thrombin-induced coagulation of plasma and the generation of fibrin by proteolytically destroying fibrinogen. J Biol Chem 2012; 287: 7834–7844.
-
(2012)
J Biol Chem
, vol.287
, pp. 7834-7844
-
-
Prieto-García, A.1
Zheng, D.2
Adachi, R.3
Xing, W.4
Lane, W.S.5
Chung, K.6
-
121
-
-
84908374585
-
ZAP-70 genotype disrupts the relationship between microbiota and host, leading to spondyloarthritis and Ileitis in SKG mice
-
Rehaume LM, Mondot S, Aguirre de Cárcer D, Velasco J, Benham H, Hasnain SZ et al. ZAP-70 genotype disrupts the relationship between microbiota and host, leading to spondyloarthritis and Ileitis in SKG mice. Arthritis Rheum 2014; 66: 2780–2792.
-
(2014)
Arthritis Rheum
, vol.66
, pp. 2780-2792
-
-
Rehaume, L.M.1
Mondot, S.2
Aguirre de Cárcer, D.3
Velasco, J.4
Benham, H.5
Hasnain, S.Z.6
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