Infectious chlamydia pneumoniae is associated with elevated interleukin-8 and airway neutrophilia in children with refractory asthma

Pediatric Infectious Disease Journal

Volumn 29, Issue 12, 2010, Pages 1093-1098

  Patel, Katir K ^a   Vicencio, Alfin G ^b   Du, Zhongfang ^b   Tsirilakis, Kalliope ^b   Salva, Paul S ^c   Webley, Wilmore C ^a  

^a UNIVERSITY OF MASSACHUSETTS   (United States)

^b ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^c BAYSTATE MEDICAL CENTER   (United States)

Author keywords

children; Chlamydia pneumoniae; IL 8; refractory asthma

Indexed keywords

BETA ADRENERGIC RECEPTOR STIMULATING AGENT; CORTICOSTEROID; DNA 16S; GENOMIC DNA; INTERLEUKIN 8; LEUKOTRIENE RECEPTOR BLOCKING AGENT; LONG ACTING DRUG; OMALIZUMAB;

AIRWAY NEUTROPHILIA; ARTICLE; ASTHMA; BRONCHOSCOPY; CELL COUNT; CHILD; CHLAMYDIA TRACHOMATIS; CHLAMYDIAL PNEUMONIA; CLINICAL ARTICLE; CLINICAL EVALUATION; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DISEASE ASSOCIATION; DNA ISOLATION; ENZYME LINKED IMMUNOSORBENT ASSAY; ETHNICITY; FEMALE; HUMAN; LUNG LAVAGE; MALE; MYCOPLASMA; NEUTROPHILIA; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; REFRACTORY ASTHMA; REFRACTORYASTHMA; SCHOOL CHILD;

ASTHMA; BRONCHOALVEOLAR LAVAGE FLUID; CHILD; CHLAMYDIA TRACHOMATIS; CHLAMYDOPHILA INFECTIONS; CHLAMYDOPHILA PNEUMONIAE; DNA, BACTERIAL; DNA, RIBOSOMAL; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMANS; INTERLEUKIN-8; MALE; MASSACHUSETTS; MYCOPLASMA; NEUTROPHILS; NEW YORK CITY; POLYMERASE CHAIN REACTION; RESPIRATORY SYSTEM; RNA, RIBOSOMAL, 16S;

EID: 78650325777     PISSN: 08913668     EISSN: 15320987     Source Type: Journal    
DOI: 10.1097/INF.0b013e3181eaebdc     Document Type: Article

References (36)

1. Wenzel SE, Schwartz LB, Langmack EL, et al. Evidence that severe asthma can be divided pathologically into two inflammatory subtypes with distinct physiologic and clinical characteristics. Am J Respir Crit Care Med. 1999;160:1001-1008.
2. Louis R, Lau LC, Bron AO, et al. The relationship between airways inflammation and asthma severity. Am J Respir Crit Care Med. 2000;161:9-16.
3. Kikuchi S, Nagata M, Kikuchi I, et al. Association between neutrophilic and eosinophilic inflammation in patients with severe persistent asthma. Int Arch Allergy Immunol. 2005;137(suppl 1):7-11. (Pubitemid 40868767)
4. Jatakanon A, Uasuf C, Maziak W, et al. Neutrophilic inflammation in severe persistent asthma. Am J Respir Crit Care Med. 1999;160:1532-1539.
5. Hauk PJ, Krawiec M, Murphy J, et al. Neutrophilic airway inflammation and association with bacterial lipopolysaccharide in children with asthma and wheezing. Pediatr Pulmonol. 2008;43:916-923.
6. Simpson JL, Scott RJ, Boyle MJ, et al. Differential proteolytic enzyme activity in eosinophilic and neutrophilic asthma. Am J Respir Crit Care Med. 2005;172:559-565.
7. Yoshimura T, Matsushima K, Oppenheim JJ, et al. Neutrophil chemotactic factor produced by lipopolysaccharide (LPS)-stimulated human blood mononuclear leukocytes: partial characterization and separation from inter-leukin 1 (IL 1). 1987. J Immunol. 2005;175:5569-5574.
8. Rolfe MW, Kunkel SL, Standiford TJ, et al. Pulmonary fibroblast expression of interleukin-8: a model for alveolar macrophage-derived cytokine networking. Am J Respir Cell Mol Biol. 1991;5:493-501.
9. Nakamura H, Yoshimura K, Jaffe HA, et al. Interleukin-8 gene expression in human bronchial epithelial cells. J Biol Chem. 1991;266:19611-19617.
10. Ordonez CL, Shaughnessy TE, Matthay MA, et al. Increased neutrophil numbers and IL-8 levels in airway secretions in acute severe asthma: clinical and biologic significance. Am J Respir Crit Care Med. 2000;161: 1185-1190.
11. Malerba M, Ricciardolo F, Radaeli A, et al. Neutrophilic inflammation and IL-8 levels in induced sputum of alpha-1-antitrypsin PiMZ subjects. Thorax. 2006;61:129-133.
12. Lapperre TS, Willems LN, Timens W, et al. Small airways dysfunction and neutrophilic inflammation in bronchial biopsies and BAL in COPD. Chest. 2007;131:53-59.
13. Oishi K, Sonoda F, Kobayashi S, et al. Role of interleukin-8 (IL-8) and an inhibitory effect of erythromycin on IL-8 release in the airways of patients with chronic airway diseases. Infect Immun. 1994;62:4145-4152.
14. Webley WC, Tilahun Y, Lay K, et al. Occurrence of Chlamydia tracho-matis and Chlamydia pneumoniae in paediatric respiratory infections. Eur Respir J. 2009;33:360-367.
15. Webley WC, Salva PS, Andrzejewski C, et al. The bronchial lavage of pediatric patients with asthma contains infectious Chlamydia. Am J Respir Crit Care Med. 2005;171:1083-1088.
16. Jahn HU, Krull M, Wuppermann FN, et al. Infection and activation of airway epithelial cells by Chlamydia pneumoniae. J Infect Dis. 2000;182: 1678-1687.
17. Yang J, Hooper WC, Phillips DJ, et al. Induction of proinflammatory cytokines in human lung epithelial cells during Chlamydia pneumoniae infection. Infect Immun. 2003;71:614-620.
18. Hahn DL, Peeling RW. Airflow limitation, asthma, and Chlamydia pneu-moniae-specific heat shock protein 60. Ann Allergy Asthma Immunol. 2008;101:614-618.
19. Vicencio AG, Patel K, Du Z, et al. Increased IL-8 in bronchoalveolar lavage (BAL) fluid from C. pneumoniae DNA-positive asthmatic children. Am J Respir Crit Care Med. 2009;179:A5986.
20. NHLBI 2007 Expert Panel Report 3 (EPR-3). Guidelines for the Diagnosis and Management of Asthma-Summary Report 2007. Bethesda, MD: US Department of Health and Human Services; 2007:74.
21. Salva PS, Theroux C, Schwartz D. Safety of endobronchial biopsy in 170 children with chronic respiratory symptoms. Thorax. 2003;58:1058-1060.
22. GIfA. Global Strategy for Asthma Management and Prevention. Bethesda, MD: Global Initiative for Asthma (GINA); 2009.
23. Bateman ED, Hurd SS, Barnes PJ, et al. Global strategy for asthma management and prevention: GINA executive summary. Eur Respir J. 2008;31:143-178.
24. Krull M, Kramp J, Petrov T, et al. Differences in cell activation by Chlamydophila pneumoniae and Chlamydia trachomatis infection in human endothelial cells. Infect Immun. 2004;72:6615-6621.
25. van Zandbergen G, Gieffers J, Kothe H, et al. Chlamydia pneumoniae multiply in neutrophil granulocytes and delay their spontaneous apoptosis. J Immunol. 2004;172:1768-1776.
26. Reinhardt N, Chen CI, Loppow D, et al. Cellular profiles of induced sputum in children with stable cystic fibrosis: comparison with BAL. Eur Respir J. 2003;22:497-502.
27. Cloutier MM. Neutrophils or eosinophils in young children with wheezing: which comes first? Chest. 2002;122:761-763.
28. Tessier V, Chadelat K, Baculard A, et al. BAL in children: a controlled study of differential cytology and cytokine expression profiles by alveolar cells in pediatric sarcoidosis. Chest. 1996;109:1430-1438.
29. Sharma S, Jaffe A, Dixon G. Immunomodulatory effects of macrolide antibiotics in respiratory disease: therapeutic implications for asthma and cystic fibrosis. Paediatr Drugs. 2007;9:107-118.
30. Saiman L. The use of macrolide antibiotics in patients with cystic fibrosis. Curr Opin Pulm Med. 2004;10:515-523.
31. Simpson JL, Powell H, Boyle MJ, et al. Clarithromycin targets neutrophilic airway inflammation in refractory asthma. Am J Respir Crit Care Med. 2008;177:148-155.
32. Strunk RC, Bacharier LB, Phillips BR, et al. Azithromycin or montelukast as inhaled corticosteroid-sparing agents in moderate-to-severe childhood asthma study. J Allergy Clin Immunol. 2008;122:1138-1144.e4.
33. Toews GB. Impact of bacterial infections on airway disease. Eur Respir Rev. 2005;14:62-68.
34. Principi N, Esposito S. Mycoplasma pneumoniae and Chlamydia pneu-moniae cause lower respiratory tract disease in paediatric patients. Curr Opin Infect Dis. 2002;15:295-300. (Pubitemid 34548193)
35. Chandran L, Boykan R. Chlamydial infections in children and adolescents. Pediatr Rev. 2009;30:243-250.
36. Hammerschlag MR. Chlamydial infections in children and adolescents. N Y State J Med. 1988;88:502-503.