The nucleotide-binding domain, leucine-rich repeat protein 3 inflammasome/IL-1 receptor I axis mediates innate, but not adaptive, immune responses after exposure to particulate matter under 10 μm

American Journal of Respiratory Cell and Molecular Biology

Volumn 52, Issue 1, 2015, Pages 96-105

  Hirota, Jeremy A ^a,b   Gold, Matthew J ^a   Hiebert, Paul R ^a   Parkinson, Leigh G ^a   Wee, Tracee ^a   Smith, Dirk ^c   Hansbro, Phil M ^d   Carlsten, Chris ^a,b   VanEeden, Stephan ^a   Sin, Don D ^a   McNagny, Kelly M ^a   Knight, Darryl A ^d,e  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b VANCOUVER GENERAL HOSPITAL   (Canada)

^c AMGEN INC   (United States)

^d HUNTER MEDICAL RESEARCH INSTITUTE   (Australia)

^e UNIVERSITY OF NEWCASTLE   (Australia)

Author keywords

Air pollution; Airway epithelium; Allergic sensitization; Asthma; Human

Indexed keywords

CYCLIN DEPENDENT KINASE 4; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INFLAMMASOME; INTERLEUKIN 1 RECEPTOR TYPE I; INTERLEUKIN 1BETA; MACROPHAGE INFLAMMATORY PROTEIN 3ALPHA; NUCLEOTIDE BINDING DOMAIN LEUCINE RICH REPEAT PROTEIN 3 INFLAMMASOME; TELOMERASE REVERSE TRANSCRIPTASE; UNCLASSIFIED DRUG; CARRIER PROTEIN; CIAS1 PROTEIN, MOUSE; CYTOKINE; IL1R1 PROTEIN, HUMAN; IL1R1 PROTEIN, MOUSE; NLRP3 PROTEIN, HUMAN; PARTICULATE MATTER;

ADAPTIVE IMMUNITY; AIR POLLUTION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN PRESENTATION; ARTICLE; CELL ACTIVATION; CELL MIGRATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; DENDRITIC CELL; DOSE RESPONSE; ENVIRONMENTAL EXPOSURE; EPITHELIUM CELL; FEMALE; GRANULOCYTE; HUMAN; HUMAN CELL; IN VITRO STUDY; INNATE IMMUNITY; MACROPHAGE; MOUSE; NEUTROPHILIA; NONHUMAN; PARTICULATE MATTER; PROTEIN DOMAIN; RESPIRATORY EPITHELIUM; SENSITIZATION; WILD TYPE; ANIMAL; ASTHMA; BAGG ALBINO MOUSE; CHEMICALLY INDUCED; DRUG EFFECTS; IMMUNOLOGY; PATHOLOGY; RESPIRATORY TRACT MUCOSA; SIGNAL TRANSDUCTION; TRANSFORMED CELL LINE;

MUS;

ADAPTIVE IMMUNITY; ANIMALS; ASTHMA; CARRIER PROTEINS; CELL LINE, TRANSFORMED; CYTOKINES; DENDRITIC CELLS; HUMANS; IMMUNITY, INNATE; INFLAMMASOMES; MICE; MICE, INBRED BALB C; PARTICULATE MATTER; RECEPTORS, INTERLEUKIN-1 TYPE I; RESPIRATORY MUCOSA; SIGNAL TRANSDUCTION;

EID: 84920283137     PISSN: 10441549     EISSN: 15354989     Source Type: Journal    
DOI: 10.1165/rcmb.2014-0158OC     Document Type: Article

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