IL-1 receptor antagonist reduces endotoxin-induced airway inflammation in healthy volunteers

Journal of Allergy and Clinical Immunology

Volumn 135, Issue 2, 2015, Pages 379-385

  Hernandez, Michelle L ^a   Mills, Katherine ^a   Almond, Martha ^a   Todoric, Krista ^a   Aleman, Maria M ^a   Zhang, Hongtao ^b   Zhou, Haibo ^b   Peden, David B ^a  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^b IL   (United States)

Author keywords

anakinra; asthma; Endotoxin; IL 1 receptor antagonist; IL 1 ; induced sputum; innate immunity; LPS; neutrophil

Indexed keywords

ENDOTOXIN; INTERLEUKIN 1BETA; INTERLEUKIN 6; INTERLEUKIN 8; PLACEBO; RECOMBINANT INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; ANTIINFLAMMATORY AGENT; AUTACOID; CYTOKINE; INTERLEUKIN 1 RECEPTOR; INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; LIPOPOLYSACCHARIDE;

ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; CROSSOVER PROCEDURE; DOUBLE BLIND PROCEDURE; DRUG SAFETY; ENDOTOXIN INDUCED AIRWAY INFLAMMATION; FEMALE; HUMAN; INNATE IMMUNITY; MALE; NEUTROPHIL; NEUTROPHIL COUNT; NEUTROPHILIA; PHASE 1 CLINICAL TRIAL; PRIORITY JOURNAL; RESPIRATORY TRACT INFLAMMATION; SPUTUM; ANTAGONISTS AND INHIBITORS; CHEMICALLY INDUCED; CLINICAL TRIAL; CYTOLOGY; DRUG EFFECTS; IMMUNOLOGY; INFLAMMATION; INHALATIONAL DRUG ADMINISTRATION; LEUKOCYTE COUNT; METABOLISM; NEUTROPHIL CHEMOTAXIS; NORMAL HUMAN; PREMEDICATION; RANDOMIZED CONTROLLED TRIAL; RESPIRATORY TRACT DISEASES; TREATMENT OUTCOME; YOUNG ADULT;

ADMINISTRATION, INHALATION; ADULT; ANTI-INFLAMMATORY AGENTS; CROSS-OVER STUDIES; CYTOKINES; ENDOTOXINS; FEMALE; HEALTHY VOLUNTEERS; HUMANS; INFLAMMATION; INFLAMMATION MEDIATORS; INTERLEUKIN 1 RECEPTOR ANTAGONIST PROTEIN; LEUKOCYTE COUNT; LIPOPOLYSACCHARIDES; MALE; NEUTROPHIL INFILTRATION; PREMEDICATION; RECEPTORS, INTERLEUKIN-1; RESPIRATORY TRACT DISEASES; SPUTUM; TREATMENT OUTCOME; YOUNG ADULT;

EID: 84922370441     PISSN: 00916749     EISSN: 10976825     Source Type: Journal    
DOI: 10.1016/j.jaci.2014.07.039     Document Type: Article

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