IgE regulation and roles in asthma pathogenesis

Journal of Allergy and Clinical Immunology

Volumn 107, Issue 3, 2001, Pages 429-441

  Oettgen, Hans C ^a   Geha, Raif S ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Allergy; Asthma; CD40; CD40 ligand; IgE; IL 13; IL 4; IL 4 receptor

Indexed keywords

CD23 ANTIGEN; CD40 ANTIGEN; GLYCOPROTEIN GP 39; IMMUNOGLOBULIN E; IMMUNOGLOBULIN FC FRAGMENT; INTERLEUKIN 13; INTERLEUKIN 4; INTERLEUKIN 4 RECEPTOR;

ASTHMA; B LYMPHOCYTE; BRONCHUS HYPERREACTIVITY; DISEASE SEVERITY; GENETIC LINKAGE; IMMEDIATE TYPE HYPERSENSITIVITY; IMMUNOGLOBULIN PRODUCTION; INFLAMMATION; MOLECULAR GENETICS; PATHOGENESIS; PRIORITY JOURNAL; REVIEW; SIGNAL TRANSDUCTION;

EID: 0035092548     PISSN: 00916749     EISSN: None     Source Type: Journal    
DOI: 10.1067/mai.2001.113759     Document Type: Article

References (147)

1. Genetic susceptibility to asthma - Bronchial hyperresponsiveness coinherited with a major gene for atopy
2. Relation between airway responsiveness and serum IgE in children with asthma and in apparently normal children
3. Elevation of total serum immunoglobulin E is associated with asthma in nonallergic individuals
4. The relevance of allergen exposure to the development of asthma in childhood
5. The association of atopic dermatitis in infancy with immunoglobulin E food sensitization
6. The relationship between mast cell-mediator release and bronchial reactivity in allergic asthma
7. An animal model of late pulmonary responses to Alternaria challenge
8. Comparative effects of inhaled salbutamol, sodium cromoglycate and beclomethasone dipropionate on allergen-induced early asthmatic responses, late asthmatic responses and increased bronchial responsiveness to histamine
9. Allergen-induced increase in bronchial responsiveness to histamine: Relationship to the late asthmatic response and change in airway caliber
10. Asthma
11. Low-affinity IgE receptor (CD23) function on mouse B cells: Role in IgE-dependent antigen focusing
12. IgE-dependent antigen focusing by human B lymphocytes is mediated by the low-affinity receptor for IgE
13. Serum-IgE-facilitated allergen presentation in atopic disease
14. In vivo enhancement of the specific antibody response via the low-affinity receptor for IgE
15. CD23/IgE-mediated regulation of the specific antibody response in vivo
16. The absence of IgE antibody-mediated augmentation of immune responses in CD23-deficient mice
17. Restoration of the antibody response to IgE/antigen complexes in CD23-deficient mice by CD23+ spleen or bone marrow cells
18. Passive transfer of immediate hypersensitivity and airway hyperresponsiveness by allergen-specific immunoglobulin (Ig) E and IgGl in mice
19. Allergen-specific IgE and IL-5 are essential for the development of airway hyperresponsiveness
20. Role of IgE in the development of allergic airway inflammation and airway hyperresponsiveness - A murine model
21. Central role of immunoglobulin (Ig) E in the induction of lung eosinophil infiltration and T helper 2 cell cytokine production: Inhibition by a nonanaphylactogenic anti-IgE antibody
22. Characterization of a murine model of allergic pulmonary inflammation
23. Attenuation of allergic airway inflammation in IL-4 deficient mice
24. Development of eosinophilic airway inflammation and airway hyperresponsiveness in mast cell-deficient mice
25. An essential role of mast cells in the development of airway hyperresponsiveness in a murine asthma model
26. Mast cells can amplify airway reactivity and features of chronic inflammation in an asthma model in mice
27. Murine B cell hybridomas beating ligand-inducible Fc receptors for IgE
28. The murine lymphocyte receptor for IgE. IV: The mechanism of ligand-specific receptor upregulation on B cells
29. IgE enhances mouse mast cell FcεRI expression in vitro and in vivo. Evidence for a novel amplification mechanism for IgE-dependent reactions
30. Down-regulation of human basophil IgE and FC epsilon RI alpha surface densities and mediator release by anti-IgE-infusions is reversible in vitro and in vivo
31. The expression of murine B cell CD23, in vivo, is regulated by its ligand, IgE
32. IgE regulates mouse basophil FceRI expression in vivo
33. Mononuclear cell-bound CD23 is elevated in both atopic dermatitis and psoriasis
34. A reduction in allergen-induced Fc epsilon R2/CD23 expression on peripheral B cells correlates with successful hyposensitization in grass pollinosis
35. Binding the low affinity Fc epsilon R on B cells suppresses ongoing human IgE synthesis
36. Negative feedback regulation of IgE synthesis by murine CD23
37. CD23 deficient mice develop allergic airway hyperresponsiveness following sensitization with ovalbumin
38. CD23 and allergic pulmonary inflammation: Potential role as an inhibitor
39. CD23 exhibits negative regulatory effects on allergic sensitization and airway hyperresponsiveness
40. The role of CD23 on allergen-induced IgE levels, pulmonary eosinophilia and bronchial hyperresponsiveness in mice
41. Cleavage of the low-affinity receptor for human IgE (CD23) by a mite cysteine protease: Nature of the cleaved fragment in relation to the structure and function of CD23
42. The cysteine protease activity of the major dust mite allergen Der p 1 selectively enhances the immunoglobulin E antibody response
43. Inhibition of CD23 processing correlates with inhibition of IL-4- stimulated IgE production in human PBL and hu-PBL-reconstituted SCID mice
44. IgE secretion is attenuated by an inhibitor of proteolytic processing of CD23 (Fc epsilonRII)
45. Soluble CD23 containing B cell supematants induce IgE from peripheral blood B-lymphocytes and costimulate with interleukin-4 in induction of IgE
46. Recombinant soluble Fc epsilon receptor II (Fc epsilon RII/CD23) has IgE binding activity but no B cell growth promoting activity
47. Active anaphylaxis in IgE-deficient mice
48. Allergen-induced bronchial hyperreactivity and eosinophilic inflammation occur in the absence of IgE in a mouse model of asthma
49. The immune responses in CD40-deficient mice: Impaired immunoglobulin class switching and germinal center formation
50. CD40-deficient mice generated by recombination-activating gene-2-deficient blastocyst complementation
51. CD40L, but not CD40, is required for allergen-induced bronchial hyperresponsiveness in mice
52. Allergic eosinophil-rich inflammation develops in lungs and airways of B cell-deficient mice
53. Antigen-induced airway hyperresponsiveness, pulmonary eosinophilia, and chemokine expression in B cell-deficient mice
54. Development of eosinophilic airway inflammation and airway hyperresponsiveness requires interleukin-5 but not immunoglobulin E or B lymphocytes
55. A murine model of allergic rhinitis: Studies on the role of IgE in pathogenesis and analysis of the eosinophil influx elicited by allergen and eotaxin
56. Identification of activated T lymphocytes and eosinophils in bronchial biopsies in stable atopic asthma
57. Evidence for a predominant "Th2 type" bronchoalveolar lavage T-lymphocyte population in atopic asthma
58. Identification of T lymphocytes, macrophages, and activated eosinophils in the bronchial mucosa in intrinsic asthma. Relationship to symptoms and bronchial responsiveness
59. Induction of airway mucus production by T helper 2 (Th2) cells: A critical role for interleukin 4 in cell recruitment but not mucus production
60. IL-4-independent induction of airway hyperresponsiveness by Th2, but not Th1, cells
61. Requirements for allergen-induced airway hyperreactivity in T and B cell-deficient mice
62. T cell-dependent regulation of eotaxin in antigen-induced pulmonary eosinophilia
63. Systemic anaphylaxis in the mouse can be mediated largely through IgGl and Fc gammaRIII. Assessment of the cardiopulmonary changes, mast cell degranulation, and death associated with active or IgE- or IgGl-dependent passive anaphylaxis
64. Inhibitory effects of an anti-IgE antibody E25 on allergen-induced early asthmatic response
65. The effect of an anti-IgE monoclonal antibody on the early- and late-phase responses to allergen inhalation in asthmatic subjects
66. Treatment of allergic asthma with monoclonal anti-IgE antibody, rhuMAb-E25 Study Group
67. Use of an anti-IgE humanized monoclonal antibody in ragweed-induced allergic rhinitis
68. Recombinant humanized mAb-E25, an anti-IgE mAb, in birch pollen-induced seasonal allergic rhinitis
69. Regulation of the IgE isotype switch: New insights on cytokine signals and the functions of varepsilon germline transcripts
70. Induction of human IgE synthesis requires interleukin 4 and T/B interactions involving the T cell receptor/CD3 complex and MHC class II antigens
71. IL-4 is an essential factor for the IgE synthesis induced in vitro by human T cells clones and their supematants
72. Structure and expression of germline e transcripts in human B cells induced by interleukin 4 to switch to IgE production
73. Shutdown of class switch recombination by deletion of a switch region control element
74. A selective defect in IgG2b switching as a result of targeted mutation of the I gamma 2b promoter and exon
75. S region transcription per se promotes basal IgE class switch recombination but additional factors regulate the efficiency of the process
76. Switch transcripts in immunoglobulin class switching
77. Interleukin 13 induces interleukin 4-independent IgG4 and IgE synthesis and CD23 expression by human B cells
78. Interleukin 13 is a B cell stimulating factor
79. Involvement of the Jak-3 Janus kinase in signalling by interleukins 2 and 4 in lymphoid and myeloid cells
80. JAK3 associates with the human interleukin 4 receptor and is tyrosine phosphorylated following receptor triggering
81. IL-4 and IL-13 activate the JAK2 tyrosine kinase and STAT6 in cultured human vascular endothelial cells through a common pathway that does not involve the γc chain
82. Interleukin-13 signal transduction in lymphohemopoietic cells
83. STF-IL-4: A novel IL-4-induced signal transducing factor
84. Cytokines and STATs: How can signals achieve specificity?
85. Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted Stat6 gene
86. Identification of a conserved lipopolysaccharide-plus-interleukin-4-responsive element located at the promoter of germ line epsilon transcripts
87. The transcription factor B cell-specific activator protein (BSAP) enhances both IL-4-and CD40-mediated activation of the human epsilon germline promoter
88. Characterization of an interleukin 4 (IL-4) responsive region in the immunoglobulin heavy chain germline epsilon promoter: Regulation by NF-IL-4, a C/EBP family member and NF-kappa B/p50
89. Interaction of stat6 and NF-kappaB: Direct association and synergistic activation of interleukin-4-induced transcription
90. Targeted disruption of the p50 subunit of NF-kappa B leads to multifocal defects in immune responses
91. Lymphocytes lacking IkappaB-alpha develop normally, but have selective defects in proliferation and function
92. Functional synergism of STAT6 with either NF-kappa B or PU.1 to mediate IL-4-induced activation of IgE germline gene transcription
93. Transcriptional repression of Stat6-dependent interleukin-4-induced genes by BCL-6: Specific regulation of epsilon transcription and immunoglobulin E switching
94. Variants of B cell lymphoma 6 (BCL6) and marked atopy
95. Induction of RNA-stabilized DNA conformers by transcription of an immunoglobulin switch region
96. Triple helix stabilization?
97. RNA:DNA complex formation upon transcription of immunoglobulin switch regions: Implications for the mechanism and regulation of class switch recombination
98. Transcription induced cleavage of immunoglobulin switch regions by nucleotide excision repair nucleases in vitro
99. A central role of CD40 ligand in the regulation of CD4+ T-cell responses
100. Involvement of CRAF1, a relative of TRAF, in CD40 signaling
101. TRAF5, a novel tumor necrosis factor receptor-associated factor family protein, mediates CD40 signaling
102. Identification of TRAF6, a novel tumor necrosis factor receptor-associated protein that mediates signaling from an amino-terminal domain of the CD40 cytoplasmic region
103. The Epstein-Barr virus transforming protein LMP-1 engages signaling proteins for the tumor necrosis factor receptor family
104. TRAF5, an activator of NF-κB and putative signal transducer for the lymphotoxin-b receptor
105. TRAF2-mediated activation of NF-kappa B by TNF receptor 2 and CD40
106. Cooperation of binding sites for STAT6 and NFkB/rel in the IL-4-induced up-regulation of the human IgE germline promoter
107. CD40 cross-linking induces IgE germline transcripts in B cells via activation of NF-κB
108. Signal transduction via CD40 involves activation of lyn kinase and phosphatidylinositol-3-kinase, and phosphorylation of phospholipase C gamma 2
109. Tyrosine phosphorylation defines a unique transduction pathway in human B cells mediated via CD40
110. CD40 ligand gene defects responsible for X-linked hyper-IgM syndrome
111. The CD40 ligand, gp39, is defective in activated T cells from patients with X-linked hyper-IgM syndrome
112. Defective expression of the CD40 ligand in X chromosome-linked immunoglobulin deficiency with normal or elevated IgM
113. CD40 ligand mutations in X-linked immunodeficiency with hyper-IgM
114. Defective expression of CD40 ligand causes X-linked immunodeficiency with hyper-IgM
115. Mice deficient for CD40 ligand
116. CD40-deficient mice generated by recombination-activating gene-2-deficient blastocyst complementation
117. The immune responses in CD40-deficient mice: Impaired immunoglobulin class switching and germinal center formation
118. Specific expression of activation-induced cytidine deaminase (AID), a novel member of the RNA-editing deaminase family in germinal center B cells
119. Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme
120. Activation-induced cytidine deaminase (AID) deficiency causes the autosomal recessive form of the Hyper-IgM syndrome (HIGM2)
121. Two types of murine helper T cell clone. I: Definition according to profiles of lymphokine activities and secreted proteins
122. Selective expression of the eotaxin receptor CCR3 by human T helper 2 cells
123. Molecules associated with human Th1 or Th2 cells
124. Crucial role of the interleukin 1 receptor family member T1/ST2 in T helper cell type 2-mediated lung mucosa immune responses
125. The role of chemokine receptors in primary, effector, and memory immune responses
126. T cell differentiation: A mechanistic view
127. Differentiation of the T helper phenotypes by analysis of the methylation state of the 1FN-gamma gene
128. Hypomethylation of the interferon-gamma gene correlates with its expression by primary T-lineage cells
129. Distinct methylation of the interferon gamma (IFN-gamma) and interleukin 3 (IL-3) genes in newly activated primary CD8+ T lymphocytes: Regional IFN-gamma promoter demethylation and mRNA expression are heritable in CD44(high)CD8+ T cells
130. Molecular regulation of cytokine gene expression during the immune response
131. Murine cutaneous leishmaniasis: Resistance correlates with the capacity to generate interferon-gamma in response to Leishmania antigens in vitro
132. Cellular and humoral immunity to Leishmania major in genetically susceptible mice after in vivo depletion of L3T4+ T cells
133. The relationship between immunological responsiveness controlled by T-helper 2 lymphocytes and infections with parasitic helminths
134. T helper differentiation proceeds through Stat4-dependent. Stat4-dependent and Stat4-independent phases
135. Origin and steady-state turnover of class II MHC-bearing dendritic cells in the epithelium of the conducting airways
136. Dendritic cells are recruited into the airway epithelium during the inflammatory response to a broad spectrum of stimuli
137. The antigen-presenting activities of Ia+ dendritic cells shift dynamically from lung to lymph node after an airway challenge with soluble antigen
138. Dendritic cells are required for the development of chronic eosinophilic airway inflammation in response to inhaled antigen in sensitized mice
139. Mast cells as a source of multifunctional cytokines
140. IgE-dependent expression of mRNA for IL-4 and IL-5 in human lung mast cells
141. Defective IgE production by SJL mice is linked to the absence of CD4+, NK1.1+ T cells that promptly produce interleukin 4
142. Beta 2-microglobulin-dependent NK1.1+T cells are not essential for T helper cell 2 immune responses
143. Increased interleukin 4 and immunoglobulin E production in transgenic mice overexpressing NK1 T cells
144. Natural killer cells determine development of allergen-induced eosinophilic airway inflammation in mice
145. Differentiation of human NK cells into NK1 and NK2 subsets
146. IL-13 production by NK cells: IL-13-producing NK and T cells are present in vivo in the absence of IFN-gamma
147. Reciprocal regulation of polarized cytokine production by effector B and T cells