Combined Haemophilus influenzae respiratory infection and allergic airways disease drives chronic infection and features of neutrophilic asthma

Thorax

Volumn 67, Issue 7, 2012, Pages 588-599

  Essilfie, Ama Tawiah ^a   Simpson, Jodie L ^a,b   Dunkley, Margaret L ^c   Morgan, Lucy C ^d   Oliver, Brian G ^e   Gibson, Peter G ^a,b   Foster, Paul S ^a   Hansbro, Philip M ^a  

^a UNIVERSITY OF NEWCASTLE   (Australia)

^b JOHN HUNTER HOSPITAL   (Australia)

^c Hunter Immunology Ltd   (Australia)

^d Department of Microbiology and Infectious Diseases   (Australia)

^e UNIVERSITY OF SYDNEY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

DEXAMETHASONE; GAMMA INTERFERON; INTERLEUKIN 13; INTERLEUKIN 17; INTERLEUKIN 5; L SELECTIN; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTHMA; BACTERIAL COLONIZATION; CELL ACTIVATION; CELL COUNT; CELL MATURATION; CELL TRANSPORT; CLINICAL FEATURE; CONTROLLED STUDY; CYTOKINE RELEASE; CYTOKINE RESPONSE; DISEASE ASSOCIATION; DRUG RESPONSE; DRUG SENSITIVITY; FEMALE; HAEMOPHILUS INFLUENZAE; IMMUNOMODULATION; INFLUENZA; INNATE IMMUNITY; LUNG INFECTION; MACROPHAGE; MOUSE; NEUTROPHIL; NEUTROPHILIC ASTHMA; NONHUMAN; PHAGOCYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECEPTOR DOWN REGULATION; RESPIRATORY TRACT ALLERGY; TH17 CELL;

EID: 84862754513     PISSN: 00406376     EISSN: 14683296     Source Type: Journal    
DOI: 10.1136/thoraxjnl-2011-200160     Document Type: Article

References (35)

1. Umetsu DT, McIntire JJ, Akbari O, et al. Asthma: an epidemic of dysregulated immunity. Nat Immunol 2002;3:715-20.
2. Simpson JL, Scott R, Boyle MJ, et al. Inflammatory subtypes in asthma: assessment and identification using induced sputum. Respirology 2006;11:54-61.
3. Wang W, Li JJ, Foster PS, et al. Potential therapeutic targets for steroid-resistant asthma. Curr Drug Targets 2010;11:957-70.
4. Simpson JL, Phipps S, Gibson PG. Inflammatory mechanisms and treatment of obstructive airway diseases with neutrophilic bronchitis. Pharmacol Ther 2009;124:86-95.
5. Stockley RA. Neutrophils and the pathogenesis of COPD. Chest 2002;121:151Se5S.
6. Zaas AK, Schwartz DA. Innate immunity and the lung: defense at the interface between host and environment. Trends Cardiovasc Med 2005;15:195-202.
7. Simpson JL, Grissell TV, Douwes J, et al. Innate immune activation in neutrophilic asthma and bronchiectasis. Thorax 2007;62:211-18.
8. Baines KJ, Simpson JL, Scott RJ, et al. Immune responses of airway neutrophils are impaired in asthma. Exp Lung Res 2009;35:554-69.
9. Droemann D, Goldmann T, Tiedje T, et al. Toll-like receptor 2 expression is decreased on alveolar macrophages in cigarette smokers and COPD patients. Respir Res 2005;6:68.
10. Yoshikawa T, Dent G, Ward J, et al. Impaired neutrophil chemotaxis in chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2007;175:473-9.
11. Hansbro NG, Horvat JC, Wark PA, et al. Understanding the mechanisms of viral induced asthma: new therapeutic directions. Pharmacol Ther 2008;117:313-53.
12. Hansbro PM, Beagley KW, Horvat JC, et al. Role of atypical bacterial infection of the lung in predisposition/protection of asthma. Pharmacol Ther 2004;101:193-210.
13. Jackson DJ, Johnston SL. The role of viruses in acute exacerbations of asthma. J Allergy Clin Immunol 2010;125:1178-87.
14. Bisgaard H, Hermansen MN, Buchvald F, et al. Childhood asthma after bacterial colonization of the airway in neonates. N Engl J Med 2007;357:1487-95.
15. Wood LG, Simpson JL, Hansbro PM, et al. Potentially pathogenic bacteria cultured from the sputum of stable asthmatics are associated with increased 8-isoprostane and airway neutrophilia. Free Radic Res 2010;44:146-54.
16. Murphy TF, Brauer AL, Schiffmacher AT, et al. Persistent colonization by Haemophilus influenzae in chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2004;170:266-72.
17. Essilfie AT, Simpson JL, Horvat JC, et al. Haemophilus influenzae infection drives IL- 17-mediated neutrophilic allergic airways disease. PLoS Pathog 2011;7:e1002244.
18. Preston JA, Essilfie A-T, Horvat JC, et al. Inhibition of allergic airways disease by immunomodulatory therapy with whole killed Streptococcus pneumoniae. Vaccine 2007;25:8154-62.
19. Horvat JC, Starkey MR, Kim RY, et al. Early-life chlamydial lung infection enhances allergic airways disease through age-dependent differences in immunopathology. J Allergy Clin Immunol 2010;125:617-25, 625.e1-625.e6.
20. Horvat JC, Starkey MR, Kim RY, et al. Chlamydial respiratory infection during allergen sensitization drives neutrophilic allergic airways disease. J Immunol 2010;184:4159-69.
21. Thorburn AN, O'Sullivan BJ, Ranjeny T, et al. Pneumococcal conjugate vaccine-induced regulatory T cells suppress the development of allergic airways disease. Thorax 2010;65:1053-60.
22. Rayner CF, Rutman A, Dewar A, et al. Ciliary disorientation in patients with chronic upper respiratory tract inflammation. Am J Respir Crit Care Med 1995;151:800-4.
23. Preston JA, Beagley KW, Gibson PG, et al. Genetic background affects susceptibility in nonfatal pneumococcal bronchopneumonia Eur Respir J 2004;23:224-31.
24. Angrill J, Agusti C, de Celis R, et al. Bacterial colonisation in patients with bronchiectasis: microbiological pattern and risk factors. Thorax 2002;57:15-19.
25. Cox G. Glucocorticoid treatment inhibits apoptosis in human neutrophils. Separation of survival and activation outcomes. J Immunol 1995;154:4719-25.
26. Vazquez-Tello A, Semlali A, Chakir J, et al. Induction of glucocorticoid receptor-β expression in epithelial cells of asthmatic airways by T-helper type 17 cytokines. Clin Exp Allergy 2010;40:1312-22.
27. Parker LC, Whyte MK, Dower SK, et al. The expression and roles of toll-like receptors in the biology of the human neutrophil. J Leukoc Biol 2005;77:886-92.
28. Wieland CW, Florquin S, Maris NA, et al. The MyD88-dependent, but not the MyD88-independent, pathway of TLR4 signaling is important in clearing nontypeable Haemophilus influenzae from the mouse lung. J Immunol 2005;175:6042-9.
29. van Eeden SF, Klut ME, Walker BA, et al. The use of flow cytometry to measure neutrophil function. J Immunol Methods 1999;232:23-43.
30. Springer TA. Traffic signals for lymphocyte recirculation and leukocyte emigration: the multistep paradigm. Cell 1994;76:301-14.
31. Spertini O, Luscinskas FW, Gimbrone MA, et al. Monocyte attachment to activated human vascular endothelium in vitro is mediated by leukocyte adhesion molecule-1 (L-selectin) under nonstatic conditions. J Exp Med 1992;175:1789-92.
32. von Andrian UH, Chambers JD, McEvoy LM, et al. Two-step model of leukocyte-endothelial cell interaction in inflammation: distinct roles for LECAM-1 and the leukocyte beta 2 integrins in vivo. Proc Natl Acad Sci United States America 1991;88:7538-42.
33. Neufert C, Pai RK, Noss EH, et al. Mycobacterium tuberculosis 19-kDa lipoprotein promotes neutrophil activation. J Immunol 2001;167:1542-9.
34. Luscinskas FW, Kansas GS, Ding H, et al. Monocyte rolling, arrest and spreading on IL-4-activated vascular endothelium under flow is mediated via sequential action of -Lselectin, beta 1-integrins, and beta 2-integrins. J Cell Biol 1994;125:1417-27.
35. Wood LG, Gibson PG, Garg ML. Biomarkers of lipid peroxidation, airway inflammation and asthma. Eur Respir J 2003;21:177-86.