메뉴 건너뛰기




Volumn 8, Issue 3, 2008, Pages 218-230

Treatment strategies for allergy and asthma

Author keywords

[No Author keywords available]

Indexed keywords

ANTIALLERGIC AGENT; ANTIASTHMATIC AGENT; CYTOKINE; CYTOKINE RECEPTOR; EOTAXIN 2; EOTAXIN 3; GAMMA INTERFERON; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; IMMUNOGLOBULIN E; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 10; INTERLEUKIN 13; INTERLEUKIN 17; INTERLEUKIN 1BETA; INTERLEUKIN 2 RECEPTOR; INTERLEUKIN 3; INTERLEUKIN 4; INTERLEUKIN 5; INTERLEUKIN 8; INTERLEUKIN 9; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MONOCYTE CHEMOTACTIC PROTEIN 1; MONOCYTE CHEMOTACTIC PROTEIN 2; MONOCYTE CHEMOTACTIC PROTEIN 3; MONOCYTE CHEMOTACTIC PROTEIN 4; RANTES; THYMUS AND ACTIVATION REGULATED CHEMOKINE; TRANSCRIPTION FACTOR FOXP3; UNINDEXED DRUG; VASCULAR CELL ADHESION MOLECULE 1;

EID: 40049092917     PISSN: 14741733     EISSN: None     Source Type: Journal    
DOI: 10.1038/nri2262     Document Type: Review
Times cited : (532)

References (174)
  • 1
    • 29244453650 scopus 로고    scopus 로고
    • T-helper cell type-2 regulation in allergic disease
    • Georas, S. N., Guo, J., De, F. U. & Casolaro, V. T-helper cell type-2 regulation in allergic disease. Eur. Respir. J. 26, 1119-1137 (2005).
    • (2005) Eur. Respir. J , vol.26 , pp. 1119-1137
    • Georas, S.N.1    Guo, J.2    De, F.U.3    Casolaro, V.4
  • 2
    • 34548238214 scopus 로고    scopus 로고
    • Peanut allergy: Emerging concepts and approaches for an apparent epidemic
    • Sicherer, S. H. & Sampson, H. A. Peanut allergy: emerging concepts and approaches for an apparent epidemic. J. Allergy Clin. Immunol. 120, 491-503 (2007).
    • (2007) J. Allergy Clin. Immunol , vol.120 , pp. 491-503
    • Sicherer, S.H.1    Sampson, H.A.2
  • 3
    • 33747771435 scopus 로고    scopus 로고
    • Worldwide time trends in the prevalence of symptoms of asthma, allergic rhinoconjunctivitis, and eczema in childhood: ISAAC Phases One and Three repeat multicountry cross-sectional surveys
    • Asher, M. I. et al. Worldwide time trends in the prevalence of symptoms of asthma, allergic rhinoconjunctivitis, and eczema in childhood: ISAAC Phases One and Three repeat multicountry cross-sectional surveys. Lancet 368, 733-743 (2006).
    • (2006) Lancet , vol.368 , pp. 733-743
    • Asher, M.I.1
  • 4
    • 0013992501 scopus 로고
    • Physicochemical properties of reaginic antibody. V. Correlation of reaginic activity wth γ-E-globulin antibody
    • Ishizaka, K., Ishizaka, T. & Hornbrook, M. M. Physicochemical properties of reaginic antibody. V. Correlation of reaginic activity wth γ-E-globulin antibody. J. Immunol. 97, 840-853 (1966).
    • (1966) J. Immunol , vol.97 , pp. 840-853
    • Ishizaka, K.1    Ishizaka, T.2    Hornbrook, M.M.3
  • 6
    • 33746571623 scopus 로고    scopus 로고
    • Recent progress in the biology of airway dendritic cells and implications for understanding the regulation of asthmatic inflammation
    • Hammad, H. & Lambrecht, B. N. Recent progress in the biology of airway dendritic cells and implications for understanding the regulation of asthmatic inflammation. J. Allergy Clin. Immunol. 118, 331-336 (2006).
    • (2006) J. Allergy Clin. Immunol , vol.118 , pp. 331-336
    • Hammad, H.1    Lambrecht, B.N.2
  • 7
    • 34247264407 scopus 로고    scopus 로고
    • Trawling for treasure: Tales of T-bet
    • Glimcher, L. H. Trawling for treasure: tales of T-bet. Nature Immunol. 8, 448-450 (2007).
    • (2007) Nature Immunol , vol.8 , pp. 448-450
    • Glimcher, L.H.1
  • 8
    • 40049088465 scopus 로고    scopus 로고
    • Dendritic cells and epithelial cells: Linking innate and adaptive immunity in asthma
    • Hammad, H. & Lambrecht, B. N. Dendritic cells and epithelial cells: linking innate and adaptive immunity in asthma. Nature Rev. Immunol. 8, 193-204 (2008).
    • (2008) Nature Rev. Immunol , vol.8 , pp. 193-204
    • Hammad, H.1    Lambrecht, B.N.2
  • 9
    • 38449119978 scopus 로고    scopus 로고
    • Allergic airways disease develops after an increase in allergen capture and processing in the airway mucosa
    • von Garnier, C. et al. Allergic airways disease develops after an increase in allergen capture and processing in the airway mucosa. J. Immunol. 179, 5748-5759 (2007).
    • (2007) J. Immunol , vol.179 , pp. 5748-5759
    • von Garnier, C.1
  • 11
    • 33750538236 scopus 로고    scopus 로고
    • Regulation of the T-cell response
    • Romagnani, S. Regulation of the T-cell response. Clin. Exp. Allergy 36, 1357-1366 (2006).
    • (2006) Clin. Exp. Allergy , vol.36 , pp. 1357-1366
    • Romagnani, S.1
  • 12
    • 33745288812 scopus 로고    scopus 로고
    • Emerging possibilities in the development and function of regulatory T cells
    • Wing, K., Fehervari, Z. & Sakaguchi, S. Emerging possibilities in the development and function of regulatory T cells. Int. Immunol. 18, 991-1000 (2006).
    • (2006) Int. Immunol , vol.18 , pp. 991-1000
    • Wing, K.1    Fehervari, Z.2    Sakaguchi, S.3
  • 13
    • 33745813929 scopus 로고    scopus 로고
    • Expression of interleukin (IL)-2 and IL-7 receptors discriminates between human regulatory and activated T cells
    • Seddiki, N. et al. Expression of interleukin (IL)-2 and IL-7 receptors discriminates between human regulatory and activated T cells. J. Exp. Med. 203, 1693-1700 (2006).
    • (2006) J. Exp. Med , vol.203 , pp. 1693-1700
    • Seddiki, N.1
  • 15
    • 35448956045 scopus 로고    scopus 로고
    • Larche, M. Regulatory T cells in allergy and asthma. Chest 132, 1007-1014 (2007).
    • Larche, M. Regulatory T cells in allergy and asthma. Chest 132, 1007-1014 (2007).
  • 16
    • 33947129240 scopus 로고    scopus 로고
    • H17 cells: an orphan with influence. Immunol. Cell Biol. 85, 83-84 (2007).
    • H17 cells: an orphan with influence. Immunol. Cell Biol. 85, 83-84 (2007).
  • 17
    • 34848821989 scopus 로고    scopus 로고
    • Distinct regulation of interleukin-17 in human T helper lymphocytes
    • Chen, Z., Tato, C. M., Muul, L., Laurence. A. & O'Shea, J. J. Distinct regulation of interleukin-17 in human T helper lymphocytes. Arthritis Rheum. 56, 2936-2946 (2007).
    • (2007) Arthritis Rheum , vol.56 , pp. 2936-2946
    • Chen, Z.1    Tato, C.M.2    Muul, L.3    Laurence, A.4    O'Shea, J.J.5
  • 18
    • 33751180809 scopus 로고    scopus 로고
    • IL-17 mRNA in sputum of asthmatic patients: Linking T cell driven inflammation and granulocytic influx?
    • Bullens, D. M. et al. IL-17 mRNA in sputum of asthmatic patients: linking T cell driven inflammation and granulocytic influx? Respir. Res. 7, 135 (2006).
    • (2006) Respir. Res , vol.7 , pp. 135
    • Bullens, D.M.1
  • 19
    • 34247180062 scopus 로고    scopus 로고
    • IL-17 enhances IL-1β-mediated CXCL8 release from human airway smooth muscle cells
    • Dragon, S. et al. IL-17 enhances IL-1β-mediated CXCL8 release from human airway smooth muscle cells. Am. J. Physiol. Lung Cell. Mol. Physiol. 292, L1023-L1029 (2007).
    • (2007) Am. J. Physiol. Lung Cell. Mol. Physiol , vol.292
    • Dragon, S.1
  • 21
    • 34250807106 scopus 로고    scopus 로고
    • Kelly, M., Hwang, J. M. & Kubes, P. Modulating leukocyte recruitment in inflammation. J. Allergy Clin. Immunol. 120, 3-10 (2007). An important review that describes the molecular mechanisms of the leukocyte-recruitment cascade. It includes most of the important original papers in this field.
    • Kelly, M., Hwang, J. M. & Kubes, P. Modulating leukocyte recruitment in inflammation. J. Allergy Clin. Immunol. 120, 3-10 (2007). An important review that describes the molecular mechanisms of the leukocyte-recruitment cascade. It includes most of the important original papers in this field.
  • 22
    • 34447581076 scopus 로고    scopus 로고
    • Chemokines and their receptors as potential targets for the treatment of asthma
    • Palmqvist, C., Wardlaw, A. J. & Bradding, P. Chemokines and their receptors as potential targets for the treatment of asthma. Br. J. Pharmacol. 151, 725-736 (2007).
    • (2007) Br. J. Pharmacol , vol.151 , pp. 725-736
    • Palmqvist, C.1    Wardlaw, A.J.2    Bradding, P.3
  • 23
    • 30444459034 scopus 로고    scopus 로고
    • The attraction of chemokines as a target for specific anti-inflammatory therapy
    • Pease, J. E. & Williams, T. J. The attraction of chemokines as a target for specific anti-inflammatory therapy. Br. J. Pharmacol. 147 (Suppl. 1), S212-S221 (2006).
    • (2006) Br. J. Pharmacol , vol.147 , Issue.SUPPL. 1
    • Pease, J.E.1    Williams, T.J.2
  • 24
    • 36749040998 scopus 로고    scopus 로고
    • Epithelium: At the interface of innate and adaptive immune responses
    • This review discusses recent studies that have looked at the molecular and cellular mechanisms by which epithelial cells help to shape the immune and inflammatory responses of dendritic cells, T cells and B cells, and inflammatory-cell recruitment in the context of human disease
    • Schleimer, R. P., Kato, A., Kern, R., Kuperman, D. & Avila, P. C. Epithelium: at the interface of innate and adaptive immune responses. J. Allergy Clin. Immunol. 120, 1279-1284 (2007). This review discusses recent studies that have looked at the molecular and cellular mechanisms by which epithelial cells help to shape the immune and inflammatory responses of dendritic cells, T cells and B cells, and inflammatory-cell recruitment in the context of human disease.
    • (2007) J. Allergy Clin. Immunol , vol.120 , pp. 1279-1284
    • Schleimer, R.P.1    Kato, A.2    Kern, R.3    Kuperman, D.4    Avila, P.C.5
  • 25
    • 34249337763 scopus 로고    scopus 로고
    • The epithelium takes centre stage in asthma and atopic dermatitis
    • Holgate, S. T. The epithelium takes centre stage in asthma and atopic dermatitis. Trends Immunol. 28, 248-251 (2007).
    • (2007) Trends Immunol , vol.28 , pp. 248-251
    • Holgate, S.T.1
  • 26
    • 0035984581 scopus 로고    scopus 로고
    • Asthmatic bronchial epithelium is more susceptible to oxidant-induced apoptosis
    • Bucchieri, F. et al. Asthmatic bronchial epithelium is more susceptible to oxidant-induced apoptosis. Am. J. Respir. Cell Mol. Biol. 27, 179-185 (2002).
    • (2002) Am. J. Respir. Cell Mol. Biol , vol.27 , pp. 179-185
    • Bucchieri, F.1
  • 27
    • 0037328988 scopus 로고    scopus 로고
    • Airway remodeling in asthma: New insights
    • A provocative review that discusses an alternative view of asthma pathogenesis by emphasizing the crucial role played by the airway microenvironment and by changes due to remodelling
    • Davies, D. E., Wicks, J., Powell, R. M., Puddicombe, S. M. & Holgate, S. T. Airway remodeling in asthma: new insights. J. Allergy Clin. Immunol. 111, 215-225 (2003). A provocative review that discusses an alternative view of asthma pathogenesis by emphasizing the crucial role played by the airway microenvironment and by changes due to remodelling.
    • (2003) J. Allergy Clin. Immunol , vol.111 , pp. 215-225
    • Davies, D.E.1    Wicks, J.2    Powell, R.M.3    Puddicombe, S.M.4    Holgate, S.T.5
  • 28
    • 0038108805 scopus 로고    scopus 로고
    • A second step of chemotaxis after transendothelial migration: Keratinocytes undergoing apoptosis release IFN-γ-inducible protein 10, monokine induced by IFN-γ, and IFN-γ-inducible α-chemoattractant for T cell chemotaxis toward epidermis in atopic dermatitis
    • Klunker, S. et al. A second step of chemotaxis after transendothelial migration: keratinocytes undergoing apoptosis release IFN-γ-inducible protein 10, monokine induced by IFN-γ, and IFN-γ-inducible α-chemoattractant for T cell chemotaxis toward epidermis in atopic dermatitis. J. Immunol. 171, 1078-1084 (2003).
    • (2003) J. Immunol , vol.171 , pp. 1078-1084
    • Klunker, S.1
  • 29
    • 33747779733 scopus 로고    scopus 로고
    • Illi, S. et al. Perennial allergen sensitisation early in life and chronic asthma in children: a birth cohort study. Lancet 368, 763-770 (2006). This large, prospective, multicentre study investigates the role of allergic sensitization and allergen exposure early in life and shows that sensitization to perennial allergens developing in the first 3 years of life is associated with a loss of lung function and increased the development of airway hyper-responsiveness at school age.
    • Illi, S. et al. Perennial allergen sensitisation early in life and chronic asthma in children: a birth cohort study. Lancet 368, 763-770 (2006). This large, prospective, multicentre study investigates the role of allergic sensitization and allergen exposure early in life and shows that sensitization to perennial allergens developing in the first 3 years of life is associated with a loss of lung function and increased the development of airway hyper-responsiveness at school age.
  • 30
    • 33745621611 scopus 로고    scopus 로고
    • House dust mite allergen reduction and allergy at 4 yr: Follow up of the PIAMA-study
    • Corver, K. et al. House dust mite allergen reduction and allergy at 4 yr: follow up of the PIAMA-study. Pediatr. Allergy Immunol. 17, 329-336 (2006).
    • (2006) Pediatr. Allergy Immunol , vol.17 , pp. 329-336
    • Corver, K.1
  • 31
    • 4544360627 scopus 로고    scopus 로고
    • Early life environmental control: Effect on symptoms, sensitization, and lung function at age 3 years
    • Woodcock, A. et al. Early life environmental control: effect on symptoms, sensitization, and lung function at age 3 years. Am. J. Respir. Crit. Care Med. 170, 433-439 (2004).
    • (2004) Am. J. Respir. Crit. Care Med , vol.170 , pp. 433-439
    • Woodcock, A.1
  • 32
    • 33846817376 scopus 로고    scopus 로고
    • Prevention of allergic disease during childhood by allergen avoidance: The Isle of Wight prevention study
    • Arshad, S. H., Bateman, B., Sadeghnejad, A., Gant, C. & Matthews, S. M. Prevention of allergic disease during childhood by allergen avoidance: the Isle of Wight prevention study. J. Allergy Clin. Immunol. 119, 307-313 (2007).
    • (2007) J. Allergy Clin. Immunol , vol.119 , pp. 307-313
    • Arshad, S.H.1    Bateman, B.2    Sadeghnejad, A.3    Gant, C.4    Matthews, S.M.5
  • 33
    • 0344177206 scopus 로고    scopus 로고
    • Characterization of lymphocyte responses to peanuts in normal children, peanut-allergic children, and allergic children who acquired tolerance to peanuts
    • Turcanu, V., Maleki, S. J. & Lack, G. Characterization of lymphocyte responses to peanuts in normal children, peanut-allergic children, and allergic children who acquired tolerance to peanuts. J. Clin. Invest. 111, 1065-1072 (2003).
    • (2003) J. Clin. Invest , vol.111 , pp. 1065-1072
    • Turcanu, V.1    Maleki, S.J.2    Lack, G.3
  • 34
    • 35948974348 scopus 로고    scopus 로고
    • Prevention of allergic respiratory disease in infants: Current aspects and future perspectives
    • Holt, P. G. & Sly, P. D. Prevention of allergic respiratory disease in infants: current aspects and future perspectives. Curr. Opin. Allergy Clin. Immunol. 7, 547-555 (2007).
    • (2007) Curr. Opin. Allergy Clin. Immunol , vol.7 , pp. 547-555
    • Holt, P.G.1    Sly, P.D.2
  • 35
    • 0038340259 scopus 로고    scopus 로고
    • Control of exposure to mite allergen and allergen-impermeable bed covers for adults with asthma
    • Woodcock, A. et al. Control of exposure to mite allergen and allergen-impermeable bed covers for adults with asthma. N. Engl. J. Med. 349, 225-236 (2003).
    • (2003) N. Engl. J. Med , vol.349 , pp. 225-236
    • Woodcock, A.1
  • 36
    • 0038158078 scopus 로고    scopus 로고
    • Evaluation of impermeable covers for bedding in patients with allergic rhinitis
    • Terreehorst, I. et al. Evaluation of impermeable covers for bedding in patients with allergic rhinitis. N. Engl. J. Med. 349, 237-246 (2003).
    • (2003) N. Engl. J. Med , vol.349 , pp. 237-246
    • Terreehorst, I.1
  • 37
    • 0032445151 scopus 로고    scopus 로고
    • Inflammatory mediators of asthma: An update
    • Barnes, P. J., Chung, K. F. & Page, C. P. Inflammatory mediators of asthma: an update. Pharmacol. Rev. 50, 515-596 (1998).
    • (1998) Pharmacol. Rev , vol.50 , pp. 515-596
    • Barnes, P.J.1    Chung, K.F.2    Page, C.P.3
  • 38
    • 0031842804 scopus 로고    scopus 로고
    • Transcription factors and asthma
    • Barnes, P. J. & Adcock, I. M. Transcription factors and asthma. Eur. Respir. J. 12, 221-234 (1998).
    • (1998) Eur. Respir. J , vol.12 , pp. 221-234
    • Barnes, P.J.1    Adcock, I.M.2
  • 39
    • 0141497509 scopus 로고    scopus 로고
    • How do corticosteroids work in asthma?
    • This article summarizes recent developments in our understanding of the fundamental mechanisms of gene transcription, which have led to important advances in our understanding of the molecular mechanisms by which corticosteroids suppress inflammation and provide insights into why corticosteroids fail to work in patients with steroid-resistant asthma
    • Barnes, P. J. & Adcock, I. M. How do corticosteroids work in asthma? Ann. Intern. Med. 139, 359-370 (2003). This article summarizes recent developments in our understanding of the fundamental mechanisms of gene transcription, which have led to important advances in our understanding of the molecular mechanisms by which corticosteroids suppress inflammation and provide insights into why corticosteroids fail to work in patients with steroid-resistant asthma.
    • (2003) Ann. Intern. Med , vol.139 , pp. 359-370
    • Barnes, P.J.1    Adcock, I.M.2
  • 41
    • 33646488054 scopus 로고    scopus 로고
    • Long-term inhaled corticosteroids in preschool children at high risk for asthma
    • References 40 and 41 are large, controlled, prospective studies that provide decisive evidence that early anti-inflammatory therapy with inhaled corticosteroids in pre-school children at high risk for asthma fails to modify the natural course of the disease
    • Guilbert, T. W. et al. Long-term inhaled corticosteroids in preschool children at high risk for asthma. N. Engl. J. Med. 354, 1985-1997 (2006). References 40 and 41 are large, controlled, prospective studies that provide decisive evidence that early anti-inflammatory therapy with inhaled corticosteroids in pre-school children at high risk for asthma fails to modify the natural course of the disease.
    • (2006) N. Engl. J. Med , vol.354 , pp. 1985-1997
    • Guilbert, T.W.1
  • 42
    • 0942278956 scopus 로고    scopus 로고
    • Doubling the dose of inhaled corticosteroid to prevent asthma exacerbations: Randomised controlled trial
    • Harrison, T. W., Oborne, J., Newton, S. & Tattersfield, A. E. Doubling the dose of inhaled corticosteroid to prevent asthma exacerbations: randomised controlled trial. Lancet 363, 271-275 (2004).
    • (2004) Lancet , vol.363 , pp. 271-275
    • Harrison, T.W.1    Oborne, J.2    Newton, S.3    Tattersfield, A.E.4
  • 43
    • 0242537115 scopus 로고    scopus 로고
    • Cigarette smoking impairs the therapeutic response to oral corticosteroids in chronic asthma
    • Chaudhuri, R. et al. Cigarette smoking impairs the therapeutic response to oral corticosteroids in chronic asthma. Am. J. Respir. Crit. Care Med. 168, 1308-1311 (2003).
    • (2003) Am. J. Respir. Crit. Care Med , vol.168 , pp. 1308-1311
    • Chaudhuri, R.1
  • 44
    • 0031471788 scopus 로고    scopus 로고
    • Inhaled dry-powder formoterol and salmeterol in asthmatic patients: Onset of action, duration of effect and potency
    • Palmqvist, M. et al. Inhaled dry-powder formoterol and salmeterol in asthmatic patients: onset of action, duration of effect and potency. Eur. Respir. J. 10, 2484-2489 (1997).
    • (1997) Eur. Respir. J , vol.10 , pp. 2484-2489
    • Palmqvist, M.1
  • 45
    • 24944482440 scopus 로고    scopus 로고
    • Glucocorticoid receptor nuclear translocation in airway cells after inhaled combination therapy
    • Usmani, O. S. et al. Glucocorticoid receptor nuclear translocation in airway cells after inhaled combination therapy. Am. J. Respir. Crit. Care Med. 172, 704-712 (2005).
    • (2005) Am. J. Respir. Crit. Care Med , vol.172 , pp. 704-712
    • Usmani, O.S.1
  • 46
    • 0031750702 scopus 로고    scopus 로고
    • Potential masking effects of salmeterol on airway inflammation in asthma
    • Mcivor, R. A. et al. Potential masking effects of salmeterol on airway inflammation in asthma. Am. J. Respir. Crit. Care Med. 158, 924-930 (1998).
    • (1998) Am. J. Respir. Crit. Care Med , vol.158 , pp. 924-930
    • Mcivor, R.A.1
  • 47
    • 33846036874 scopus 로고    scopus 로고
    • Comparative pharmacology of the H1 antihistamines
    • Del, C. A. et al. Comparative pharmacology of the H1 antihistamines. J. Invest. Allergol. Clin. Immunol. 16 (Suppl 1), 3-12 (2006).
    • (2006) J. Invest. Allergol. Clin. Immunol , vol.16 , Issue.SUPPL. 1 , pp. 3-12
    • Del, C.A.1
  • 48
    • 33745678960 scopus 로고    scopus 로고
    • 4, which provides evidence in favour of the theory that there is an additive therapeutic efficacy of antileukotrienes with inhaled corticosteroids in asthma.
    • 4, which provides evidence in favour of the theory that there is an additive therapeutic efficacy of antileukotrienes with inhaled corticosteroids in asthma.
  • 49
    • 0042355703 scopus 로고    scopus 로고
    • Recent advances in the management of asthma using leukotriene modifiers
    • Kemp, J. P. Recent advances in the management of asthma using leukotriene modifiers. Am. J. Respir. Med. 2, 139-156 (2003).
    • (2003) Am. J. Respir. Med , vol.2 , pp. 139-156
    • Kemp, J.P.1
  • 50
    • 33845421478 scopus 로고    scopus 로고
    • Critical appraisal of antileukotriene use in asthma management
    • Polosa, R. Critical appraisal of antileukotriene use in asthma management. Curr. Opin. Pulm. Med. 13, 24-30 (2007).
    • (2007) Curr. Opin. Pulm. Med , vol.13 , pp. 24-30
    • Polosa, R.1
  • 51
    • 34247257959 scopus 로고    scopus 로고
    • Montelukast in the treatment of allergic rhinitis: An evidence-based review
    • Nayak, A. & Langdon, R. B. Montelukast in the treatment of allergic rhinitis: an evidence-based review. Drugs 67, 887-901 (2007).
    • (2007) Drugs , vol.67 , pp. 887-901
    • Nayak, A.1    Langdon, R.B.2
  • 52
    • 34648831472 scopus 로고    scopus 로고
    • A double-blind, placebo-controlled trial of montelukast in adult atopic eczema
    • Friedmann, P. S. et al. A double-blind, placebo-controlled trial of montelukast in adult atopic eczema. Clin. Exp. Allergy 37, 1536-1540 (2007).
    • (2007) Clin. Exp. Allergy , vol.37 , pp. 1536-1540
    • Friedmann, P.S.1
  • 53
    • 33646924049 scopus 로고    scopus 로고
    • Are phosphodiesterase 4 inhibitors just more theophylline?
    • Boswell-Smith, V., Cazzola, M. & Page, C. P. Are phosphodiesterase 4 inhibitors just more theophylline? J. Allergy Clin. Immunol. 117, 1237-1243 (2006).
    • (2006) J. Allergy Clin. Immunol , vol.117 , pp. 1237-1243
    • Boswell-Smith, V.1    Cazzola, M.2    Page, C.P.3
  • 54
    • 33747750597 scopus 로고    scopus 로고
    • The mechanisms, diagnosis, and management of severe asthma in adults
    • Holgate, S. T. & Polosa, R. The mechanisms, diagnosis, and management of severe asthma in adults. Lancet. 368, 780-793 (2006).
    • (2006) Lancet , vol.368 , pp. 780-793
    • Holgate, S.T.1    Polosa, R.2
  • 55
    • 35348858861 scopus 로고    scopus 로고
    • Cyclosporin A treatment is associated with increased serum immunoglobulin E levels in a subgroup of atopic dermatitis patients
    • Hijnen, D. J., Knol, E., Bruijnzeel-Koomen, C. & de Bruin-Weller, M. Cyclosporin A treatment is associated with increased serum immunoglobulin E levels in a subgroup of atopic dermatitis patients. Dermatitis 18, 163-165 (2007).
    • (2007) Dermatitis , vol.18 , pp. 163-165
    • Hijnen, D.J.1    Knol, E.2    Bruijnzeel-Koomen, C.3    de Bruin-Weller, M.4
  • 56
    • 33645059692 scopus 로고    scopus 로고
    • H2 cytokine mRNA measurement in sputum of asthma patients
    • H2 cytokine mRNA measurement in sputum of asthma patients. Thorax 61, 202-208 (2006).
    • (2006) Thorax , vol.61 , pp. 202-208
    • Truyen, E.1
  • 57
    • 28244479315 scopus 로고    scopus 로고
    • Tumour necrosis factor (TNFα) as a novel therapeutic target in symptomatic corticosteroid-dependent asthma
    • Howarth, P. H. et al. Tumour necrosis factor (TNFα) as a novel therapeutic target in symptomatic corticosteroid-dependent asthma. Thorax 60, 1012-1018 (2005).
    • (2005) Thorax , vol.60 , pp. 1012-1018
    • Howarth, P.H.1
  • 58
    • 0033949791 scopus 로고    scopus 로고
    • TNFα dysregulation in asthma: Relationship to ongoing corticosteroid therapy
    • Waserman, S., Dolovich, J., Conway, M. & Marshall, J. S. TNFα dysregulation in asthma: relationship to ongoing corticosteroid therapy. Can. Respir. J. 7, 229-237 (2000).
    • (2000) Can. Respir. J , vol.7 , pp. 229-237
    • Waserman, S.1    Dolovich, J.2    Conway, M.3    Marshall, J.S.4
  • 59
    • 32644490529 scopus 로고    scopus 로고
    • Evidence of a role of tumor necrosis factor-α in refractory asthma
    • Berry, M. A. et al. Evidence of a role of tumor necrosis factor-α in refractory asthma. N. Engl. J. Med. 354, 697-708 (2006).
    • (2006) N. Engl. J. Med , vol.354 , pp. 697-708
    • Berry, M.A.1
  • 60
    • 14944350956 scopus 로고    scopus 로고
    • Inhaled p38α mitogen-activated protein kinase antisense oligonucleotide attenuates asthma in mice
    • Duan, W. et al. Inhaled p38α mitogen-activated protein kinase antisense oligonucleotide attenuates asthma in mice. Am. J. Respir. Crit. Care Med. 171, 571-578 (2005).
    • (2005) Am. J. Respir. Crit. Care Med , vol.171 , pp. 571-578
    • Duan, W.1
  • 61
    • 33745153836 scopus 로고    scopus 로고
    • Birrell, M. A. et al. IκB kinase-2-independent and - dependent inflammation in airway disease models: relevance of IKK-2 inhibition to the clinic. Mol. Pharmacol. 69, 1791-1800 (2006). This was the first study to examine the effect of an IKK2 inhibitor (TPCA-1) in well-validated models that mimic aspects of airway inflammation. TPCA-1 blocked the increase in NF-κB binding to DNA with an associated decrease in the release of inflammatory mediators and in the inflammatorycell burden in the lungs.
    • Birrell, M. A. et al. IκB kinase-2-independent and - dependent inflammation in airway disease models: relevance of IKK-2 inhibition to the clinic. Mol. Pharmacol. 69, 1791-1800 (2006). This was the first study to examine the effect of an IKK2 inhibitor (TPCA-1) in well-validated models that mimic aspects of airway inflammation. TPCA-1 blocked the increase in NF-κB binding to DNA with an associated decrease in the release of inflammatory mediators and in the inflammatorycell burden in the lungs.
  • 62
    • 35748951015 scopus 로고    scopus 로고
    • Wu, K., Bi, Y., Sun, K. & Wang, C. IL-10-producing type 1 regulatory T cells and allergy. Cell Mol. Immunol. 4, 269-275 (2007).
    • Wu, K., Bi, Y., Sun, K. & Wang, C. IL-10-producing type 1 regulatory T cells and allergy. Cell Mol. Immunol. 4, 269-275 (2007).
  • 63
    • 35748966479 scopus 로고    scopus 로고
    • Yin-Yang' functions of transforming growth factor-β and T regulatory cells in immune regulation
    • Wan, Y. Y. & Flavell, R. A. 'Yin-Yang' functions of transforming growth factor-β and T regulatory cells in immune regulation. Immunol. Rev. 220, 199-213 (2007).
    • (2007) Immunol. Rev , vol.220 , pp. 199-213
    • Wan, Y.Y.1    Flavell, R.A.2
  • 64
    • 0033549827 scopus 로고    scopus 로고
    • Long-term clinical efficacy of grass-pollen immunotherapy
    • Durham, S. R. et al. Long-term clinical efficacy of grass-pollen immunotherapy. N. Engl. J. Med. 341, 468-475 (1999).
    • (1999) N. Engl. J. Med , vol.341 , pp. 468-475
    • Durham, S.R.1
  • 66
    • 34047180982 scopus 로고    scopus 로고
    • Larché, M. Update on the current status of peptide immunotherapy. J. Allergy Clin. Immunol. 119, 906-909 (2007). This recent review summarizes the mechanisms by which allergen-specific immunotherapy exerts its immunological and anti-inflammatory effects. It also addresses new approaches to improve the efficacy of and decrease the incidence and severity of adverse reactions to allergen-specific immunotherapy.
    • Larché, M. Update on the current status of peptide immunotherapy. J. Allergy Clin. Immunol. 119, 906-909 (2007). This recent review summarizes the mechanisms by which allergen-specific immunotherapy exerts its immunological and anti-inflammatory effects. It also addresses new approaches to improve the efficacy of and decrease the incidence and severity of adverse reactions to allergen-specific immunotherapy.
  • 68
    • 34047192679 scopus 로고    scopus 로고
    • Comparison of allergenicity and immunogenicity of an intact allergen vaccine and commercially available allergoid products for birch pollen immunotherapy
    • Lund, L. et al. Comparison of allergenicity and immunogenicity of an intact allergen vaccine and commercially available allergoid products for birch pollen immunotherapy. Clin. Exp. Allergy 37, 564-571 (2007).
    • (2007) Clin. Exp. Allergy , vol.37 , pp. 564-571
    • Lund, L.1
  • 69
    • 33645212293 scopus 로고    scopus 로고
    • A novel adjuvant complex, tyrosine-MPL, for prophylactic and therapeutic vaccines
    • Wheeler, A. A novel adjuvant complex, tyrosine-MPL, for prophylactic and therapeutic vaccines. Vaccine 24 (Suppl. 2), 40-41 (2006).
    • (2006) Vaccine , vol.24 , Issue.SUPPL. 2 , pp. 40-41
    • Wheeler, A.1
  • 70
    • 33646391681 scopus 로고    scopus 로고
    • Biodegradable PLGA particles for improved systemic and mucosal treatment of Type I allergy
    • ix
    • Scholl, I., Kopp, T., Bohle, B. & Jensen-Jarolim, E. Biodegradable PLGA particles for improved systemic and mucosal treatment of Type I allergy. Immunol. Allergy Clin. North Am. 26, 349-364, ix (2006).
    • (2006) Immunol. Allergy Clin. North Am , vol.26 , pp. 349-364
    • Scholl, I.1    Kopp, T.2    Bohle, B.3    Jensen-Jarolim, E.4
  • 71
    • 5044237403 scopus 로고    scopus 로고
    • New approaches in immunotherapy: Allergen vaccination with immunostimulatory DNA
    • Creticos, P. S., Chen, Y. H. & Schroeder, J. T. New approaches in immunotherapy: allergen vaccination with immunostimulatory DNA. Immunol. Allergy Clin. North Am. 24, 569-581, v (2004).
    • (2004) Immunol. Allergy Clin. North Am , vol.24 , pp. 569-581
    • Creticos, P.S.1    Chen, Y.H.2    Schroeder, J.T.3
  • 72
    • 33748302777 scopus 로고    scopus 로고
    • Clinical efficacy and safety of sublingual immunotherapy with tree pollen extract in children
    • Valovirta, E., Jacobsen, L., Ljorring, C., Koivikko, A. & Savolainen, J. Clinical efficacy and safety of sublingual immunotherapy with tree pollen extract in children. Allergy, 61, 1177-1183 (2006).
    • (2006) Allergy , vol.61 , pp. 1177-1183
    • Valovirta, E.1    Jacobsen, L.2    Ljorring, C.3    Koivikko, A.4    Savolainen, J.5
  • 73
    • 34547639714 scopus 로고    scopus 로고
    • Efficacy of long-term sublingual immunotherapy as an adjunct to pharmacotherapy in house dust mite-allergic children with asthma
    • Ozdemir, C. et al. Efficacy of long-term sublingual immunotherapy as an adjunct to pharmacotherapy in house dust mite-allergic children with asthma. Pediatr. Allergy Immunol. 18, 508-515 (2007).
    • (2007) Pediatr. Allergy Immunol , vol.18 , pp. 508-515
    • Ozdemir, C.1
  • 74
    • 34047164918 scopus 로고    scopus 로고
    • Sublingual immunotherapy: The optimism and the issues
    • A recent overview that highlights the pros and cons of sublingual immunotherapy for the treatment of patients with asthma and/or rhinitis. It also addresses new approaches to improve the treatment of patients with IgE-mediated food allergy and to modify the natural course of allergic diseases
    • Pajno, G. B. Sublingual immunotherapy: the optimism and the issues. J. Allergy Clin. Immunol. 119, 796-801 (2007). A recent overview that highlights the pros and cons of sublingual immunotherapy for the treatment of patients with asthma and/or rhinitis. It also addresses new approaches to improve the treatment of patients with IgE-mediated food allergy and to modify the natural course of allergic diseases.
    • (2007) J. Allergy Clin. Immunol , vol.119 , pp. 796-801
    • Pajno, G.B.1
  • 75
    • 77955951213 scopus 로고    scopus 로고
    • Abramson, M. J., Puy, R. M. & Weiner, J. M. Allergen immunotherapy for asthma. Cochrane Database Syst. Rev. CD001186 (2003). This meta-analysis of 75 controlled trials (including a total of 3,188 participants with asthma) indicates that there is a significant reduction in asthma symptoms and medication and an improvement in bronchial hyper-reactivity after allergen immunotherapy.
    • Abramson, M. J., Puy, R. M. & Weiner, J. M. Allergen immunotherapy for asthma. Cochrane Database Syst. Rev. CD001186 (2003). This meta-analysis of 75 controlled trials (including a total of 3,188 participants with asthma) indicates that there is a significant reduction in asthma symptoms and medication and an improvement in bronchial hyper-reactivity after allergen immunotherapy.
  • 76
    • 33845219434 scopus 로고    scopus 로고
    • Immunologic response to administration of standardized dog allergen extract at differing doses
    • Lent, A. M. et al. Immunologic response to administration of standardized dog allergen extract at differing doses. J. Allergy Clin. Immunol. 118, 1249-1256 (2006).
    • (2006) J. Allergy Clin. Immunol , vol.118 , pp. 1249-1256
    • Lent, A.M.1
  • 77
    • 0037253412 scopus 로고    scopus 로고
    • A double-blind, placebo-controlled immunotherapy dose-response study with standardized cat extract
    • Ewbank, P. A. et al. A double-blind, placebo-controlled immunotherapy dose-response study with standardized cat extract. J. Allergy Clin. Immunol. 111, 155-161 (2003).
    • (2003) J. Allergy Clin. Immunol , vol.111 , pp. 155-161
    • Ewbank, P.A.1
  • 78
    • 0022337169 scopus 로고
    • Nasal challenge with ragweed pollen in hay fever patients. Effect of immunotherapy
    • Creticos, P. S. et al. Nasal challenge with ragweed pollen in hay fever patients. Effect of immunotherapy. J. Clin. Invest. 76, 2247-2253 (1985).
    • (1985) J. Clin. Invest , vol.76 , pp. 2247-2253
    • Creticos, P.S.1
  • 79
    • 31944443997 scopus 로고    scopus 로고
    • Efficacy and safety of specific immunotherapy with SQ allergen extract in treatment-resistant seasonal allergic rhinoconjunctivitis
    • Frew, A. J., Powell, R. J., Corrigan, C. J. & Durham, S. R. Efficacy and safety of specific immunotherapy with SQ allergen extract in treatment-resistant seasonal allergic rhinoconjunctivitis. J. Allergy Clin. Immunol. 117, 319-325 (2006).
    • (2006) J. Allergy Clin. Immunol , vol.117 , pp. 319-325
    • Frew, A.J.1    Powell, R.J.2    Corrigan, C.J.3    Durham, S.R.4
  • 80
    • 0030903223 scopus 로고    scopus 로고
    • Immunotherapy with a standardized Dermatophagoides pteronyssinus extract. VI. Specific immunotherapy prevents the onset of new sensitizations in children
    • Des, R. A. et al. Immunotherapy with a standardized Dermatophagoides pteronyssinus extract. VI. Specific immunotherapy prevents the onset of new sensitizations in children. J. Allergy Clin. Immunol. 99, 450-453 (1997).
    • (1997) J. Allergy Clin. Immunol , vol.99 , pp. 450-453
    • Des, R.A.1
  • 81
    • 0035726457 scopus 로고    scopus 로고
    • Prevention of new sensitizations in monosensitized subjects submitted to specific immunotherapy or not. A retrospective study
    • Purello-D'Ambrosio, F. et al. Prevention of new sensitizations in monosensitized subjects submitted to specific immunotherapy or not. A retrospective study. Clin. Exp. Allergy 31, 1295-1302 (2001).
    • (2001) Clin. Exp. Allergy , vol.31 , pp. 1295-1302
    • Purello-D'Ambrosio, F.1
  • 82
    • 0034847103 scopus 로고    scopus 로고
    • Prevention of new sensitizations in asthmatic children monosensitized to house dust mite by specific immunotherapy. A six-year follow-up study
    • Pajno, G. B., Barberio, G., De, L. F., Morabito, L. & Parmiani, S. Prevention of new sensitizations in asthmatic children monosensitized to house dust mite by specific immunotherapy. A six-year follow-up study. Clin. Exp. Allergy 31, 1392-1397 (2001).
    • (2001) Clin. Exp. Allergy , vol.31 , pp. 1392-1397
    • Pajno, G.B.1    Barberio, G.2    De, L.F.3    Morabito, L.4    Parmiani, S.5
  • 84
    • 29644440599 scopus 로고    scopus 로고
    • Polosa, R., Al-Delaimy, W. K., Russo, C., Piccillo, G. & Sarva, M. Greater risk of incident asthma cases in adults with allergic rhinitis and effect of allergen immunotherapy: a retrospective cohort study. Respir. Res. 6, 153 (2005). This retrospective cohort study shows that allergic rhinitis is an important independent risk factor for asthma and that treatment with allergen immunotherapy was significantly and inversely related to the development of new-onset asthma in adults with allergic rhinitis.
    • Polosa, R., Al-Delaimy, W. K., Russo, C., Piccillo, G. & Sarva, M. Greater risk of incident asthma cases in adults with allergic rhinitis and effect of allergen immunotherapy: a retrospective cohort study. Respir. Res. 6, 153 (2005). This retrospective cohort study shows that allergic rhinitis is an important independent risk factor for asthma and that treatment with allergen immunotherapy was significantly and inversely related to the development of new-onset asthma in adults with allergic rhinitis.
  • 85
    • 0036170801 scopus 로고    scopus 로고
    • Pollen immunotherapy reduces the development of asthma in children with seasonal rhinoconjunctivitis (the PAT study)
    • Moller, C. et al. Pollen immunotherapy reduces the development of asthma in children with seasonal rhinoconjunctivitis (the PAT study). J. Allergy Clin. Immunol. 109, 251-256 (2002).
    • (2002) J. Allergy Clin. Immunol , vol.109 , pp. 251-256
    • Moller, C.1
  • 86
    • 33745128688 scopus 로고    scopus 로고
    • Five-year follow-up on the PAT study: Specific immunotherapy and long-term prevention of asthma in children
    • Niggemann, B. et al. Five-year follow-up on the PAT study: specific immunotherapy and long-term prevention of asthma in children. Allergy 61, 855-859 (2006).
    • (2006) Allergy , vol.61 , pp. 855-859
    • Niggemann, B.1
  • 87
    • 6344246029 scopus 로고    scopus 로고
    • Effect of immunotherapy on asthma progression, BHR and sputum eosinophils in allergic rhinitis
    • Polosa, R. et al. Effect of immunotherapy on asthma progression, BHR and sputum eosinophils in allergic rhinitis. Allergy 59, 1224-1228 (2004).
    • (2004) Allergy , vol.59 , pp. 1224-1228
    • Polosa, R.1
  • 88
    • 4944266011 scopus 로고    scopus 로고
    • Coseasonal sublingual immunotherapy reduces the development of asthma in children with allergic rhinoconjunctivitis
    • Novembre, E. et al. Coseasonal sublingual immunotherapy reduces the development of asthma in children with allergic rhinoconjunctivitis. J. Allergy Clin. Immunol. 114, 851-857 (2004).
    • (2004) J. Allergy Clin. Immunol , vol.114 , pp. 851-857
    • Novembre, E.1
  • 89
    • 40049101678 scopus 로고    scopus 로고
    • IgE in allergy and asthma today
    • Gould, H. J. & Sutton, B. J. IgE in allergy and asthma today. Nature Rev. Immunol. 8, 205-217 (2008).
    • (2008) Nature Rev. Immunol , vol.8 , pp. 205-217
    • Gould, H.J.1    Sutton, B.J.2
  • 90
    • 17644441947 scopus 로고    scopus 로고
    • The effect of intravenous administration of a chimeric anti-IgE antibody on serum IgE levels in atopic subjects: Efficacy, safety and pharmacokinetics
    • Corne, J. et al. The effect of intravenous administration of a chimeric anti-IgE antibody on serum IgE levels in atopic subjects: efficacy, safety and pharmacokinetics. J. Clin. Invest. 99, 879-887 (1997).
    • (1997) J. Clin. Invest , vol.99 , pp. 879-887
    • Corne, J.1
  • 91
    • 17744376022 scopus 로고    scopus 로고
    • Anti-immunoglobulin E treatment with omalizumab in allergic diseases: An update on anti-inflammatory activity and clinical efficacy
    • Holgate, S. T., Djukanovic, R., Casale, T. & Bousquet, J. Anti-immunoglobulin E treatment with omalizumab in allergic diseases: an update on anti-inflammatory activity and clinical efficacy. Clin. Exp. Allergy 35, 408-416 (2005).
    • (2005) Clin. Exp. Allergy , vol.35 , pp. 408-416
    • Holgate, S.T.1    Djukanovic, R.2    Casale, T.3    Bousquet, J.4
  • 92
    • 0036968254 scopus 로고    scopus 로고
    • The effect of omalizumab on nasal allergic inflammation
    • Plewako, H. et al. The effect of omalizumab on nasal allergic inflammation. J. Allergy Clin. Immunol. 110, 68-71 (2002).
    • (2002) J. Allergy Clin. Immunol , vol.110 , pp. 68-71
    • Plewako, H.1
  • 93
    • 20844439555 scopus 로고    scopus 로고
    • Effect of anti-immunoglobulin E on nasal inflammation in patients with seasonal allergic rhinoconjunctivitis
    • Bez, C. et al. Effect of anti-immunoglobulin E on nasal inflammation in patients with seasonal allergic rhinoconjunctivitis. Clin. Exp. Allergy 34, 1079-1085 (2004).
    • (2004) Clin. Exp. Allergy , vol.34 , pp. 1079-1085
    • Bez, C.1
  • 94
    • 34250776613 scopus 로고    scopus 로고
    • Novel IgE peptide-based vaccine prevents the increase of IgE and down-regulates elevated IgE in rodents
    • Peng, Z. et al. Novel IgE peptide-based vaccine prevents the increase of IgE and down-regulates elevated IgE in rodents. Clin. Exp. Allergy 37, 1040-1048 (2007).
    • (2007) Clin. Exp. Allergy , vol.37 , pp. 1040-1048
    • Peng, Z.1
  • 95
    • 0036615851 scopus 로고    scopus 로고
    • Generation of therapeutic antibody responses against IgE through vaccination
    • Vernersson, M., Ledin, A., Johansson, J. & Hellman, L. Generation of therapeutic antibody responses against IgE through vaccination. FASEB J. 16, 875-877 (2002).
    • (2002) FASEB J , vol.16 , pp. 875-877
    • Vernersson, M.1    Ledin, A.2    Johansson, J.3    Hellman, L.4
  • 96
    • 25844461664 scopus 로고    scopus 로고
    • Anti-CD23 monoclonal antibody, lumiliximab, inhibited allergen-induced responses in antigen-presenting cells and T cells from atopic subjects
    • Poole, J. A., Meng, J., Reff, M., Spellman, M. C. & Rosenwasser, L. J. Anti-CD23 monoclonal antibody, lumiliximab, inhibited allergen-induced responses in antigen-presenting cells and T cells from atopic subjects. J. Allergy Clin. Immunol. 116, 780-788 (2005).
    • (2005) J. Allergy Clin. Immunol , vol.116 , pp. 780-788
    • Poole, J.A.1    Meng, J.2    Reff, M.3    Spellman, M.C.4    Rosenwasser, L.J.5
  • 97
    • 0034121883 scopus 로고    scopus 로고
    • Edwards, A. M. & Howell, J. B. The chromones: history, chemistry and clinical development. A tribute to the work of Dr R. E. C. Altounyan. Clin. Exp. Allergy 30, 756-774 (2000).
    • Edwards, A. M. & Howell, J. B. The chromones: history, chemistry and clinical development. A tribute to the work of Dr R. E. C. Altounyan. Clin. Exp. Allergy 30, 756-774 (2000).
  • 98
    • 33646901630 scopus 로고    scopus 로고
    • The role of the mast cell in the pathophysiology of asthma
    • Bradding, P., Walls, A. F. & Holgate, S. T. The role of the mast cell in the pathophysiology of asthma. J. Allergy Clin. Immunol. 117, 1277-1284 (2006).
    • (2006) J. Allergy Clin. Immunol , vol.117 , pp. 1277-1284
    • Bradding, P.1    Walls, A.F.2    Holgate, S.T.3
  • 99
    • 0029853996 scopus 로고    scopus 로고
    • Chloride transport and the actions of nedocromil sodium and cromolyn sodium in asthma 1
    • Alton, E. W. & Norris, A. A. Chloride transport and the actions of nedocromil sodium and cromolyn sodium in asthma 1. J. Allergy Clin. Immunol. 98, S102-S105 (1996).
    • (1996) J. Allergy Clin. Immunol , vol.98
    • Alton, E.W.1    Norris, A.A.2
  • 100
    • 3442890222 scopus 로고    scopus 로고
    • 2+ influx and degranulation in human lung mast cells
    • 2+ influx and degranulation in human lung mast cells. J. Allergy Clin. Immunol. 114, 66-72 (2004).
    • (2004) J. Allergy Clin. Immunol , vol.114 , pp. 66-72
    • Mark, D.S.1
  • 102
    • 13644269557 scopus 로고    scopus 로고
    • Anti-CD63 antibodies suppress IgE-dependent allergic reactions in vitro and in vivo
    • Kraft, S. et al. Anti-CD63 antibodies suppress IgE-dependent allergic reactions in vitro and in vivo. J. Exp. Med. 201, 385-396 (2005).
    • (2005) J. Exp. Med , vol.201 , pp. 385-396
    • Kraft, S.1
  • 103
    • 34247572895 scopus 로고    scopus 로고
    • New developments in FcεRI regulation, function and inhibition
    • Kraft, S. & Kinet, J. P. New developments in FcεRI regulation, function and inhibition. Nature Rev. Immunol. 7, 365-378 (2007).
    • (2007) Nature Rev. Immunol , vol.7 , pp. 365-378
    • Kraft, S.1    Kinet, J.P.2
  • 104
    • 30344435280 scopus 로고    scopus 로고
    • Inhibition of spleen tyrosine kinase prevents mast cell activation and airway hyperresponsiveness
    • Matsubara, S. et al. Inhibition of spleen tyrosine kinase prevents mast cell activation and airway hyperresponsiveness. Am. J. Respir. Crit. Care Med. 173, 56-63 (2006).
    • (2006) Am. J. Respir. Crit. Care Med , vol.173 , pp. 56-63
    • Matsubara, S.1
  • 105
    • 33748058807 scopus 로고    scopus 로고
    • Rossi, A. B. et al. Identification of the Syk kinase inhibitor R112 by a human mast cell screen. J. Allergy Clin. Immunol. 118, 749-755 (2006). References 103-105 focus on new therapeutic approaches to inhibit mast-cell activation through the modulation of Fc-receptor signalling. The use and the potential clinical application of chimeric fusion proteins, SRC tyrosine kinases and ATP-competitive SYK inhibitors are discussed.
    • Rossi, A. B. et al. Identification of the Syk kinase inhibitor R112 by a human mast cell screen. J. Allergy Clin. Immunol. 118, 749-755 (2006). References 103-105 focus on new therapeutic approaches to inhibit mast-cell activation through the modulation of Fc-receptor signalling. The use and the potential clinical application of chimeric fusion proteins, SRC tyrosine kinases and ATP-competitive SYK inhibitors are discussed.
  • 106
    • 33746646025 scopus 로고    scopus 로고
    • Mast cell inhibitor R112 is well tolerated and affects prostaglandin D2 but not other mediators, symptoms, or nasal volumes in a nasal challenge model of allergic rhinitis
    • Guyer, B. J. et al. Mast cell inhibitor R112 is well tolerated and affects prostaglandin D2 but not other mediators, symptoms, or nasal volumes in a nasal challenge model of allergic rhinitis. Allergy Asthma Proc. 27, 208-213 (2006).
    • (2006) Allergy Asthma Proc , vol.27 , pp. 208-213
    • Guyer, B.J.1
  • 107
    • 16244397342 scopus 로고    scopus 로고
    • An intranasal Syk-kinase inhibitor (R112) improves the symptoms of seasonal allergic rhinitis in a park environment
    • Meltzer, E. O., Berkowitz, R. B. & Grossbard, E. B. An intranasal Syk-kinase inhibitor (R112) improves the symptoms of seasonal allergic rhinitis in a park environment. J. Allergy Clin. Immunol. 115, 791-796 (2005).
    • (2005) J. Allergy Clin. Immunol , vol.115 , pp. 791-796
    • Meltzer, E.O.1    Berkowitz, R.B.2    Grossbard, E.B.3
  • 108
    • 33745726073 scopus 로고    scopus 로고
    • Development, migration, and survival of mast cells
    • Okayama, Y. & Kawakami, T. Development, migration, and survival of mast cells. Immunol. Res. 34, 97-115 (2006).
    • (2006) Immunol. Res , vol.34 , pp. 97-115
    • Okayama, Y.1    Kawakami, T.2
  • 109
    • 33644752698 scopus 로고    scopus 로고
    • Stem cell factor and its receptor c-Kit as targets for inflammatory diseases
    • Reber, L., Da Silva, C. A. & Frossard, N. Stem cell factor and its receptor c-Kit as targets for inflammatory diseases. Eur. J. Pharmacol. 533, 327-340 (2006).
    • (2006) Eur. J. Pharmacol , vol.533 , pp. 327-340
    • Reber, L.1    Da Silva, C.A.2    Frossard, N.3
  • 110
    • 33646858992 scopus 로고    scopus 로고
    • Inhibition of SCF attenuates peribronchial remodeling in chronic cockroach allergen-induced asthma
    • Berlin, A. A., Hogaboam, C. M. & Lukacs, N. W. Inhibition of SCF attenuates peribronchial remodeling in chronic cockroach allergen-induced asthma. Lab. Invest. 86, 557-565 (2006).
    • (2006) Lab. Invest , vol.86 , pp. 557-565
    • Berlin, A.A.1    Hogaboam, C.M.2    Lukacs, N.W.3
  • 111
    • 34248226333 scopus 로고    scopus 로고
    • The mast cell IgG receptors and their roles in tissue inflammation
    • Malbec, O. & Daeron, M. The mast cell IgG receptors and their roles in tissue inflammation. Immunol. Rev. 217, 206-221 (2007).
    • (2007) Immunol. Rev , vol.217 , pp. 206-221
    • Malbec, O.1    Daeron, M.2
  • 112
    • 0035898442 scopus 로고    scopus 로고
    • Increased severity of local and systemic anaphylactic reactions in gp49B1-deficient mice
    • Daheshia, M., Friend, D. S., Grusby, M. J., Austen, K. F. & Katz, H. R. Increased severity of local and systemic anaphylactic reactions in gp49B1-deficient mice. J. Exp. Med. 194, 227-234 (2001).
    • (2001) J. Exp. Med , vol.194 , pp. 227-234
    • Daheshia, M.1    Friend, D.S.2    Grusby, M.J.3    Austen, K.F.4    Katz, H.R.5
  • 113
    • 33644638676 scopus 로고    scopus 로고
    • IgG-blocking antibodies inhibit IgE-mediated anaphylaxis in vivo through both antigen interception and FcγRIIb cross-linking
    • Strait, R. T., Morris, S. C. & Finkelman, F. D. IgG-blocking antibodies inhibit IgE-mediated anaphylaxis in vivo through both antigen interception and FcγRIIb cross-linking. J. Clin. Invest. 116, 833-841 (2006).
    • (2006) J. Clin. Invest , vol.116 , pp. 833-841
    • Strait, R.T.1    Morris, S.C.2    Finkelman, F.D.3
  • 114
    • 0036569336 scopus 로고    scopus 로고
    • Downstream of kinase, p62(dok), is a mediator of FcγIIB inhibition of FcεRI signaling
    • Ott, V. L., Tamir, I., Niki, M., Pandolfi, P. P. & Cambier, J. C. Downstream of kinase, p62(dok), is a mediator of FcγIIB inhibition of FcεRI signaling. J. Immunol. 168, 4430-4439 (2002).
    • (2002) J. Immunol , vol.168 , pp. 4430-4439
    • Ott, V.L.1    Tamir, I.2    Niki, M.3    Pandolfi, P.P.4    Cambier, J.C.5
  • 115
    • 0035344083 scopus 로고    scopus 로고
    • gp49B1-α(v)β3 interaction inhibits antigen-induced mast cell activation
    • Castells, M. C. et al. gp49B1-α(v)β3 interaction inhibits antigen-induced mast cell activation. Nature Immunol. 2, 436-442 (2001).
    • (2001) Nature Immunol , vol.2 , pp. 436-442
    • Castells, M.C.1
  • 116
    • 34547101712 scopus 로고    scopus 로고
    • Modifications to an Fcγ-Fcvarε fusion protein alter its effectiveness in the inhibition of FcvarεRI-mediated functions
    • Allen, L. C., Kepley, C. L., Saxon, A. & Zhang, K. Modifications to an Fcγ-Fcvarε fusion protein alter its effectiveness in the inhibition of FcvarεRI-mediated functions. J. Allergy Clin. Immunol. 120, 462-468 (2007).
    • (2007) J. Allergy Clin. Immunol , vol.120 , pp. 462-468
    • Allen, L.C.1    Kepley, C.L.2    Saxon, A.3    Zhang, K.4
  • 117
    • 17644388057 scopus 로고    scopus 로고
    • A chimeric human-cat fusion protein blocks cat-induced allergy
    • Zhu, D. et al. A chimeric human-cat fusion protein blocks cat-induced allergy. Nature Med. 11, 446-449 (2005).
    • (2005) Nature Med , vol.11 , pp. 446-449
    • Zhu, D.1
  • 118
    • 0033454115 scopus 로고    scopus 로고
    • Interleukin-4 receptor in moderate atopic asthma. A phase I/II randomized, placebo-controlled trial
    • Borish, L. C. et al. Interleukin-4 receptor in moderate atopic asthma. A phase I/II randomized, placebo-controlled trial. Am. J. Respir. Crit. Care Med. 160, 1816-1823 (1999).
    • (1999) Am. J. Respir. Crit. Care Med , vol.160 , pp. 1816-1823
    • Borish, L.C.1
  • 119
    • 0034995872 scopus 로고    scopus 로고
    • Efficacy of soluble IL-4 receptor for the treatment of adults with asthma
    • Borish, L. C. et al. Efficacy of soluble IL-4 receptor for the treatment of adults with asthma. J. Allergy Clin. Immunol. 107, 963-970 (2001).
    • (2001) J. Allergy Clin. Immunol , vol.107 , pp. 963-970
    • Borish, L.C.1
  • 120
    • 0036379740 scopus 로고    scopus 로고
    • Preclinical efficacy and safety of pascolizumab (SB 240683): A humanized anti-interleukin-4 antibody with therapeutic potential in asthma
    • Hart, T. K. et al. Preclinical efficacy and safety of pascolizumab (SB 240683): a humanized anti-interleukin-4 antibody with therapeutic potential in asthma. Clin. Exp. Immunol. 130, 93-100 (2002).
    • (2002) Clin. Exp. Immunol , vol.130 , pp. 93-100
    • Hart, T.K.1
  • 121
    • 34748893102 scopus 로고    scopus 로고
    • Control of allergic reactions in mice by an active anti-murine IL-4 immunization
    • Le, B. H. et al. Control of allergic reactions in mice by an active anti-murine IL-4 immunization. Vaccine 25, 7206-7216 (2007).
    • (2007) Vaccine , vol.25 , pp. 7206-7216
    • Le, B.H.1
  • 122
    • 34248569682 scopus 로고    scopus 로고
    • Novel cytokine peptide-based vaccines: An interleukin-4 vaccine suppresses airway allergic responses in mice
    • Ma, Y. et al. Novel cytokine peptide-based vaccines: an interleukin-4 vaccine suppresses airway allergic responses in mice. Allergy 62, 675-682 (2007).
    • (2007) Allergy , vol.62 , pp. 675-682
    • Ma, Y.1
  • 123
    • 33947263596 scopus 로고    scopus 로고
    • Costimulation blockade inhibits allergic sensitization but does not affect established allergy in a murine model of grass pollen allergy
    • Linhart, B. et al. Costimulation blockade inhibits allergic sensitization but does not affect established allergy in a murine model of grass pollen allergy. J. Immunol. 178, 3924-3931 (2007).
    • (2007) J. Immunol , vol.178 , pp. 3924-3931
    • Linhart, B.1
  • 124
    • 0037775352 scopus 로고    scopus 로고
    • IL-13 effector functions
    • Wynn, T. A. IL-13 effector functions. Annu. Rev. Immunol. 21, 425-456 (2003).
    • (2003) Annu. Rev. Immunol , vol.21 , pp. 425-456
    • Wynn, T.A.1
  • 125
    • 33749499532 scopus 로고    scopus 로고
    • H2-cell- mediated responses, is a potential therapeutic target for the treatment of asthma.
    • H2-cell- mediated responses, is a potential therapeutic target for the treatment of asthma.
  • 126
    • 0032545433 scopus 로고    scopus 로고
    • Requirement for IL-13 independently of IL-4 in experimental asthma
    • Grunig, G. et al. Requirement for IL-13 independently of IL-4 in experimental asthma. Science 282, 2261-2263 (1998).
    • (1998) Science , vol.282 , pp. 2261-2263
    • Grunig, G.1
  • 127
    • 34247522910 scopus 로고    scopus 로고
    • IL-13 blockade reduces lung inflammation after Ascaris suum challenge in cynomolgus monkeys
    • Bree, A. et al. IL-13 blockade reduces lung inflammation after Ascaris suum challenge in cynomolgus monkeys. J. Allergy Clin. Immunol. 119, 1251-1257 (2007).
    • (2007) J. Allergy Clin. Immunol , vol.119 , pp. 1251-1257
    • Bree, A.1
  • 128
    • 35348909044 scopus 로고    scopus 로고
    • Wenzel, S., Wilbraham, D., Fuller, R., Getz, E. B. & Longphre, M. Effect of an interleukin-4 variant on late phase asthmatic response to allergen challenge in asthmatic patients: results of two phase 2a studies. Lancet 370, 1422-1431 (2007). This recent randomized controlled trial shows that nebulization of an IL-4 variant (pitrakinra) that potently inhibits the binding of IL-4 and IL-13 to IL-4Rα-containing complexes could markedly decrease the symptoms of experimental asthma.
    • Wenzel, S., Wilbraham, D., Fuller, R., Getz, E. B. & Longphre, M. Effect of an interleukin-4 variant on late phase asthmatic response to allergen challenge in asthmatic patients: results of two phase 2a studies. Lancet 370, 1422-1431 (2007). This recent randomized controlled trial shows that nebulization of an IL-4 variant (pitrakinra) that potently inhibits the binding of IL-4 and IL-13 to IL-4Rα-containing complexes could markedly decrease the symptoms of experimental asthma.
  • 129
    • 34548437104 scopus 로고    scopus 로고
    • Novel recombinant interleukin-13 peptide-based vaccine reduces airway allergic inflammatory responses in mice
    • Ma, Y. et al. Novel recombinant interleukin-13 peptide-based vaccine reduces airway allergic inflammatory responses in mice. Am. J. Respir. Crit. Care Med. 176, 439-445 (2007).
    • (2007) Am. J. Respir. Crit. Care Med , vol.176 , pp. 439-445
    • Ma, Y.1
  • 130
    • 34848848833 scopus 로고    scopus 로고
    • Inhibition of experimental allergic airways disease by local application of a cell-penetrating dominant-negative STAT6 peptide
    • McCusker, C. T. et al. Inhibition of experimental allergic airways disease by local application of a cell-penetrating dominant-negative STAT6 peptide. J. Immunol. 179, 2556-2564 (2007).
    • (2007) J. Immunol , vol.179 , pp. 2556-2564
    • McCusker, C.T.1
  • 131
    • 30944443047 scopus 로고    scopus 로고
    • Antisense- and RNA-interference-based therapeutic strategies in allergy
    • Popescu, F. D. Antisense- and RNA-interference-based therapeutic strategies in allergy. J. Cell Mol. Med. 9, 840-853 (2005).
    • (2005) J. Cell Mol. Med , vol.9 , pp. 840-853
    • Popescu, F.D.1
  • 132
    • 34250748567 scopus 로고    scopus 로고
    • Effect of inhaled interleukin-5 on eosinophil progenitors in the bronchi and bone marrow of asthmatic and non-asthmatic volunteers
    • Menzies-Gow, A. N., Flood-Page, P. T., Robinson, D. S. & Kay, A. B. Effect of inhaled interleukin-5 on eosinophil progenitors in the bronchi and bone marrow of asthmatic and non-asthmatic volunteers. Clin. Exp. Allergy 37, 1023-1032 (2007).
    • (2007) Clin. Exp. Allergy , vol.37 , pp. 1023-1032
    • Menzies-Gow, A.N.1    Flood-Page, P.T.2    Robinson, D.S.3    Kay, A.B.4
  • 133
    • 6644229440 scopus 로고    scopus 로고
    • Effects of an interleukin-5 blocking monoclonal antibody on eosinophils, airway hyper-responsiveness, and the late asthmatic response
    • Leckie, M. J. et al. Effects of an interleukin-5 blocking monoclonal antibody on eosinophils, airway hyper-responsiveness, and the late asthmatic response. Lancet 356, 2144-2148 (2000).
    • (2000) Lancet , vol.356 , pp. 2144-2148
    • Leckie, M.J.1
  • 134
    • 0038643527 scopus 로고    scopus 로고
    • Effect of SCH55700, a humanized anti-human interleukin-5 antibody, in severe persistent asthma: A pilot study
    • Kips, J. C. et al. Effect of SCH55700, a humanized anti-human interleukin-5 antibody, in severe persistent asthma: a pilot study. Am. J. Respir. Crit. Care Med. 167, 1655-1659 (2003).
    • (2003) Am. J. Respir. Crit. Care Med , vol.167 , pp. 1655-1659
    • Kips, J.C.1
  • 135
    • 36749065556 scopus 로고    scopus 로고
    • Flood-Page, P. et al. A study to evaluate safety and efficacy of mepolizumab in patients with moderate persistent asthma. Am. J. Respir. Crit. Care Med. 176, 1062-1071 (2007). A multicentre, randomized, double-blind, placebo-controlled study that provides conclusive evidence that treatment with an IL-5-blocking monoclonal antibody, mepolizumab, fails to give a significant clinical benefit in patients with moderate persistent asthma.
    • Flood-Page, P. et al. A study to evaluate safety and efficacy of mepolizumab in patients with moderate persistent asthma. Am. J. Respir. Crit. Care Med. 176, 1062-1071 (2007). A multicentre, randomized, double-blind, placebo-controlled study that provides conclusive evidence that treatment with an IL-5-blocking monoclonal antibody, mepolizumab, fails to give a significant clinical benefit in patients with moderate persistent asthma.
  • 136
    • 0037438409 scopus 로고    scopus 로고
    • Eosinophil's role remains uncertain as anti-interleukin-5 only partially depletes numbers in asthmatic airway
    • Flood-Page, P. T., Menzies-Gow, A. N., Kay, A. B. & Robinson, D. S. Eosinophil's role remains uncertain as anti-interleukin-5 only partially depletes numbers in asthmatic airway. Am. J. Respir. Crit. Care Med. 167, 199-204 (2003).
    • (2003) Am. J. Respir. Crit. Care Med , vol.167 , pp. 199-204
    • Flood-Page, P.T.1    Menzies-Gow, A.N.2    Kay, A.B.3    Robinson, D.S.4
  • 137
    • 0036884942 scopus 로고    scopus 로고
    • Decreased expression of membrane IL-5 receptor-α on human eosinophils: I. Loss of membrane IL-5 receptor-α on airway eosinophils and increased soluble IL-5 receptor-α in the airway after allergen challenge
    • Liu, L. Y. et al. Decreased expression of membrane IL-5 receptor-α on human eosinophils: I. Loss of membrane IL-5 receptor-α on airway eosinophils and increased soluble IL-5 receptor-α in the airway after allergen challenge. J. Immunol. 169, 6452-6458 (2002).
    • (2002) J. Immunol , vol.169 , pp. 6452-6458
    • Liu, L.Y.1
  • 138
    • 0036884097 scopus 로고    scopus 로고
    • Decreased expression of membrane IL-5 receptor-α on human eosinophils: II. IL-5 downmodulates its receptor via a proteinase-mediated process
    • Liu, L. Y. et al. Decreased expression of membrane IL-5 receptor-α on human eosinophils: II. IL-5 downmodulates its receptor via a proteinase-mediated process. J. Immunol. 169, 6459-6466 (2002).
    • (2002) J. Immunol , vol.169 , pp. 6459-6466
    • Liu, L.Y.1
  • 140
    • 85047693849 scopus 로고    scopus 로고
    • Anti-IL-5 treatment reduces deposition of ECM proteins in the bronchial subepithelial basement membrane of mild atopic asthmatics
    • Flood-Page, P. et al. Anti-IL-5 treatment reduces deposition of ECM proteins in the bronchial subepithelial basement membrane of mild atopic asthmatics. J. Clin. Invest. 112, 1029-1036 (2003).
    • (2003) J. Clin. Invest , vol.112 , pp. 1029-1036
    • Flood-Page, P.1
  • 141
    • 2942560685 scopus 로고    scopus 로고
    • Intravenous anti-IL-5 monoclonal antibody reduces eosinophils and tenascin deposition in allergen-challenged human atopic skin
    • Phipps, S., Flood-Page, P., Menzies-Gow, A., Ong, Y. E. & Kay, A. B. Intravenous anti-IL-5 monoclonal antibody reduces eosinophils and tenascin deposition in allergen-challenged human atopic skin. J. Invest. Dermatol. 122, 1406-1412 (2004).
    • (2004) J. Invest. Dermatol , vol.122 , pp. 1406-1412
    • Phipps, S.1    Flood-Page, P.2    Menzies-Gow, A.3    Ong, Y.E.4    Kay, A.B.5
  • 142
    • 34247637976 scopus 로고    scopus 로고
    • Remodeling and airway hyperresponsiveness but not cellular inflammation persist after allergen challenge in asthma
    • Kariyawasam, H. H., Aizen, M., Barkans, J., Robinson, D. S. & Kay, A. B. Remodeling and airway hyperresponsiveness but not cellular inflammation persist after allergen challenge in asthma. Am. J. Respir. Crit. Care Med. 175, 896-904 (2007).
    • (2007) Am. J. Respir. Crit. Care Med , vol.175 , pp. 896-904
    • Kariyawasam, H.H.1    Aizen, M.2    Barkans, J.3    Robinson, D.S.4    Kay, A.B.5
  • 143
    • 9144221389 scopus 로고    scopus 로고
    • Anti-interleukin-5 (mepolizumab) therapy for hypereosinophilic syndromes
    • Garrett, J. K. et al. Anti-interleukin-5 (mepolizumab) therapy for hypereosinophilic syndromes. J. Allergy Clin. Immunol. 113, 115-119 (2004).
    • (2004) J. Allergy Clin. Immunol , vol.113 , pp. 115-119
    • Garrett, J.K.1
  • 144
    • 33750494433 scopus 로고    scopus 로고
    • Anti-IL-5 (mepolizumab) therapy for eosinophilic esophagitis
    • Stein, M. L. et al. Anti-IL-5 (mepolizumab) therapy for eosinophilic esophagitis. J. Allergy Clin. Immunol. 118, 1312-1319 (2006).
    • (2006) J. Allergy Clin. Immunol , vol.118 , pp. 1312-1319
    • Stein, M.L.1
  • 145
    • 20244375866 scopus 로고    scopus 로고
    • Anti-IL-5 recombinant humanized monoclonal antibody (mepolizumab) for the treatment of atopic dermatitis
    • Oldhoff, J. M. et al. Anti-IL-5 recombinant humanized monoclonal antibody (mepolizumab) for the treatment of atopic dermatitis. Allergy 60, 693-696 (2005).
    • (2005) Allergy , vol.60 , pp. 693-696
    • Oldhoff, J.M.1
  • 146
    • 40049104660 scopus 로고    scopus 로고
    • A single dose of MEDI-528, a monoclonal antibody against interleukin-19, is well tolerated in mild and moderate asthmatics in the phase II trial MI-CP-138
    • O'Byrne, P. et al. A single dose of MEDI-528, a monoclonal antibody against interleukin-19, is well tolerated in mild and moderate asthmatics in the phase II trial MI-CP-138. Chest 132, 478 (2007).
    • (2007) Chest , vol.132 , pp. 478
    • O'Byrne, P.1
  • 147
    • 0028817164 scopus 로고
    • The effects of nebulized recombinant interferon-γ in asthmatic airways
    • Boguniewicz, M. et al. The effects of nebulized recombinant interferon-γ in asthmatic airways. J. Allergy Clin. Immunol. 95, 133-135 (1995).
    • (1995) J. Allergy Clin. Immunol , vol.95 , pp. 133-135
    • Boguniewicz, M.1
  • 148
    • 20944436592 scopus 로고    scopus 로고
    • IFNγ-enhanced allergen penetration across respiratory epithelium augments allergic inflammation
    • Reisinger, J. et al. IFNγ-enhanced allergen penetration across respiratory epithelium augments allergic inflammation. J. Allergy Clin. Immunol. 115, 973-981 (2005).
    • (2005) J. Allergy Clin. Immunol , vol.115 , pp. 973-981
    • Reisinger, J.1
  • 149
    • 0344393717 scopus 로고    scopus 로고
    • Clinical and immunological effects of low-dose IFNα treatment in patients with corticosteroid-resistant asthma
    • Simon, H. U., Seelbach, H., Ehmann, R. & Schmitz, M. Clinical and immunological effects of low-dose IFNα treatment in patients with corticosteroid-resistant asthma. Allergy 58, 1250-1255 (2003).
    • (2003) Allergy , vol.58 , pp. 1250-1255
    • Simon, H.U.1    Seelbach, H.2    Ehmann, R.3    Schmitz, M.4
  • 150
    • 33745211286 scopus 로고    scopus 로고
    • Interferon-αcon1 treatment of three patients with severe glucocorticoid-dependent asthma. Effect on disease control and systemic glucocorticosteroid dose
    • Kroegel, C. et al. Interferon-αcon1 treatment of three patients with severe glucocorticoid-dependent asthma. Effect on disease control and systemic glucocorticosteroid dose. Respiration 73, 566-570 (2006).
    • (2006) Respiration , vol.73 , pp. 566-570
    • Kroegel, C.1
  • 151
    • 17144403499 scopus 로고    scopus 로고
    • Asthmatic bronchial epithelial cells have a deficient innate immune response to infection with rhinovirus
    • Wark, P. A. et al. Asthmatic bronchial epithelial cells have a deficient innate immune response to infection with rhinovirus. J. Exp. Med. 201, 937-947 (2005).
    • (2005) J. Exp. Med , vol.201 , pp. 937-947
    • Wark, P.A.1
  • 152
    • 33748446393 scopus 로고    scopus 로고
    • Role of deficient type III interferon-λ production in asthma exacerbations
    • Contoli, M. et al. Role of deficient type III interferon-λ production in asthma exacerbations. Nature Med. 12, 1023-1026 (2006).
    • (2006) Nature Med , vol.12 , pp. 1023-1026
    • Contoli, M.1
  • 153
    • 26944489955 scopus 로고    scopus 로고
    • Exacerbations: The asthma paradox
    • Holgate, S. T. Exacerbations: the asthma paradox. Am. J. Respir. Crit. Care Med. 172, 941-943 (2005).
    • (2005) Am. J. Respir. Crit. Care Med , vol.172 , pp. 941-943
    • Holgate, S.T.1
  • 154
    • 6644223789 scopus 로고    scopus 로고
    • Effects of recombinant human interleukin-12 on eosinophils, airway hyper-responsiveness, and the late asthmatic response
    • Bryan, S. A. et al. Effects of recombinant human interleukin-12 on eosinophils, airway hyper-responsiveness, and the late asthmatic response. Lancet 356, 2149-2153 (2000).
    • (2000) Lancet , vol.356 , pp. 2149-2153
    • Bryan, S.A.1
  • 155
    • 7044277061 scopus 로고    scopus 로고
    • H2 sensitization
    • H2 sensitization. J. Leukocyte Biol. 76, 1028-1038 (2004).
    • (2004) J. Leukocyte Biol , vol.76 , pp. 1028-1038
    • Kuipers, H.1
  • 156
    • 0041652405 scopus 로고    scopus 로고
    • Interleukin-10 is a natural suppressor of cytokine production and inflammation in a murine model of allergic bronchopulmonary aspergillosis
    • Grunig, G. et al. Interleukin-10 is a natural suppressor of cytokine production and inflammation in a murine model of allergic bronchopulmonary aspergillosis. J. Exp. Med. 185, 1089-1099 (1997).
    • (1997) J. Exp. Med , vol.185 , pp. 1089-1099
    • Grunig, G.1
  • 157
    • 33846025977 scopus 로고    scopus 로고
    • Effects of adenovirus-expressing IL-10 in alleviating airway inflammation in asthma
    • Fu, C. L., Chuang, Y. H., Chau, L. Y. & Chiang, B. L. Effects of adenovirus-expressing IL-10 in alleviating airway inflammation in asthma. J. Gene Med. 8, 1393-1399 (2006).
    • (2006) J. Gene Med , vol.8 , pp. 1393-1399
    • Fu, C.L.1    Chuang, Y.H.2    Chau, L.Y.3    Chiang, B.L.4
  • 158
    • 0029070119 scopus 로고
    • A randomized, controlled trial of IL-10 in humans. Inhibition of inflammatory cytokine production and immune responses
    • Chernoff, A. E. et al. A randomized, controlled trial of IL-10 in humans. Inhibition of inflammatory cytokine production and immune responses. J. Immunol. 154, 5492-5499 (1995).
    • (1995) J. Immunol , vol.154 , pp. 5492-5499
    • Chernoff, A.E.1
  • 159
    • 34547895876 scopus 로고    scopus 로고
    • On the role of the epidermal differentiation complex in ichthyosis vulgaris, atopic dermatitis and psoriasis
    • Hoffjan, S. & Stemmler, S. On the role of the epidermal differentiation complex in ichthyosis vulgaris, atopic dermatitis and psoriasis. Br. J. Dermatol. 157, 441-449 (2007).
    • (2007) Br. J. Dermatol , vol.157 , pp. 441-449
    • Hoffjan, S.1    Stemmler, S.2
  • 160
    • 34447581118 scopus 로고    scopus 로고
    • Tillie-Leblond, I. et al. Keratinocyte growth factor improves alterations of lung permeability and bronchial epithelium in allergic rats. Eur. Respir. J. 30, 31-39 (2007). This original work in an animal model of chronic asthma shows that treatment with keratinocyte growth factor decreases lung permeability and airway inflammation in animals challenged with ovalbumin. The observed effects seem to be associated with restoration of epithelial integrity during chronic allergic asthma. These findings open new prospects for asthma therapies.
    • Tillie-Leblond, I. et al. Keratinocyte growth factor improves alterations of lung permeability and bronchial epithelium in allergic rats. Eur. Respir. J. 30, 31-39 (2007). This original work in an animal model of chronic asthma shows that treatment with keratinocyte growth factor decreases lung permeability and airway inflammation in animals challenged with ovalbumin. The observed effects seem to be associated with restoration of epithelial integrity during chronic allergic asthma. These findings open new prospects for asthma therapies.
  • 161
    • 33749030204 scopus 로고    scopus 로고
    • Growth factors as treatment options for intestinal inflammation
    • Dieckgraefe, B. K., Korzenik, J. R. & Anant, S. Growth factors as treatment options for intestinal inflammation. Ann. NY Acad. Sci. 1072, 300-306 (2006).
    • (2006) Ann. NY Acad. Sci , vol.1072 , pp. 300-306
    • Dieckgraefe, B.K.1    Korzenik, J.R.2    Anant, S.3
  • 162
    • 27144526213 scopus 로고    scopus 로고
    • Palifermin (Kepivance) for the treatment of oral mucositis in patients with hematologic malignancies requiring hematopoietic stem cell support
    • Radtke, M. L. & Kolesar, J. M. Palifermin (Kepivance) for the treatment of oral mucositis in patients with hematologic malignancies requiring hematopoietic stem cell support. J. Oncol. Pharm. Pract. 11, 121-125 (2005).
    • (2005) J. Oncol. Pharm. Pract , vol.11 , pp. 121-125
    • Radtke, M.L.1    Kolesar, J.M.2
  • 163
    • 20444365526 scopus 로고    scopus 로고
    • H2-attracting chemokines and disease severity
    • H2-attracting chemokines and disease severity. J. Immunol. 174, 8183-8190 (2005).
    • (2005) J. Immunol , vol.174 , pp. 8183-8190
    • Ying, S.1
  • 164
    • 33750835115 scopus 로고    scopus 로고
    • Non-fucosylated therapeutic antibodies as next-generation therapeutic antibodies
    • Satoh, M., Iida, S. & Shitara, K. Non-fucosylated therapeutic antibodies as next-generation therapeutic antibodies. Expert Opin. Biol. Ther. 6, 1161-1173 (2006).
    • (2006) Expert Opin. Biol. Ther , vol.6 , pp. 1161-1173
    • Satoh, M.1    Iida, S.2    Shitara, K.3
  • 165
    • 34047099762 scopus 로고    scopus 로고
    • Asthma control during the year after bronchial thermoplasty
    • Cox, G. et al. Asthma control during the year after bronchial thermoplasty N. Engl. J. Med. 356, 1327-1337 (2007).
    • (2007) N. Engl. J. Med , vol.356 , pp. 1327-1337
    • Cox, G.1
  • 166
    • 17844369481 scopus 로고    scopus 로고
    • Blocking IL-15 prevents the induction of allergen-specific T cells and allergic inflammation in vivo
    • Ruckert, R. et al. Blocking IL-15 prevents the induction of allergen-specific T cells and allergic inflammation in vivo. J. Immunol. 174, 5507-5515 (2005).
    • (2005) J. Immunol , vol.174 , pp. 5507-5515
    • Ruckert, R.1
  • 167
    • 33748515008 scopus 로고    scopus 로고
    • IL-17A induces eotaxin-1/CC chemokine ligand 11 expression in human airway smooth muscle cells: Role of MAPK (Erk1/2, JNK and p38) pathways
    • Rahman, M. S. et al. IL-17A induces eotaxin-1/CC chemokine ligand 11 expression in human airway smooth muscle cells: role of MAPK (Erk1/2, JNK and p38) pathways. J. Immunol. 177, 4064-4071 (2006).
    • (2006) J. Immunol , vol.177 , pp. 4064-4071
    • Rahman, M.S.1
  • 168
    • 33751506710 scopus 로고    scopus 로고
    • Interleukin-17 is a negative regulator of established allergic asthma
    • Schnyder-Candrian, S. et al. Interleukin-17 is a negative regulator of established allergic asthma. J. Exp. Med. 203, 2715-2725 (2006).
    • (2006) J. Exp. Med , vol.203 , pp. 2715-2725
    • Schnyder-Candrian, S.1
  • 169
    • 36749051929 scopus 로고    scopus 로고
    • Ballantyne, S. J. et al. Blocking IL-25 prevents airway hyperresponsiveness in allergic asthma. J. Allergy Clin. Immunol.120, 1234-1231 (2007). This paper shows that a neutralizing antibody specific for IL-25 can prevent airway hyper-responsiveness, which is an important feature of clinical asthma, and results in significantly decreased levels of IL-5 and IL-13 production, eosinophil infiltration, goblet-cell hyperplasia and serum IgE secretion in an experimental model of allergic asthma. These findings indicate that IL-25 is an important therapeutic target.
    • Ballantyne, S. J. et al. Blocking IL-25 prevents airway hyperresponsiveness in allergic asthma. J. Allergy Clin. Immunol.120, 1234-1231 (2007). This paper shows that a neutralizing antibody specific for IL-25 can prevent airway hyper-responsiveness, which is an important feature of clinical asthma, and results in significantly decreased levels of IL-5 and IL-13 production, eosinophil infiltration, goblet-cell hyperplasia and serum IgE secretion in an experimental model of allergic asthma. These findings indicate that IL-25 is an important therapeutic target.
  • 170
    • 34548825396 scopus 로고    scopus 로고
    • Soluble ST2 blocks interleukin-33 signaling in allergic airway inflammation
    • Hayakawa, H., Hayakawa, M., Kume, A. & Tominaga, S. Soluble ST2 blocks interleukin-33 signaling in allergic airway inflammation. J. Biol. Chem. 282, 26369-26380 (2007).
    • (2007) J. Biol. Chem , vol.282 , pp. 26369-26380
    • Hayakawa, H.1    Hayakawa, M.2    Kume, A.3    Tominaga, S.4
  • 171
    • 32044437848 scopus 로고    scopus 로고
    • IL-31: A new link between T cells and pruritus in atopic skin inflammation
    • Sonkoly, E. et al. IL-31: a new link between T cells and pruritus in atopic skin inflammation. J. Allergy Clin. Immunol. 117, 411-417 (2006).
    • (2006) J. Allergy Clin. Immunol , vol.117 , pp. 411-417
    • Sonkoly, E.1
  • 173
    • 33344455022 scopus 로고    scopus 로고
    • Thymic stromal lymphopoietin: Master switch for allergic inflammation
    • Liu, Y. J. Thymic stromal lymphopoietin: master switch for allergic inflammation. J. Exp. Med. 203, 269-273 (2006).
    • (2006) J. Exp. Med , vol.203 , pp. 269-273
    • Liu, Y.J.1
  • 174
    • 33847285312 scopus 로고    scopus 로고
    • IL-2 and IL-18 attenuation of airway hyperresponsiveness requires STAT4, IFNγ and natural killer cells
    • Matsubara, S. et al. IL-2 and IL-18 attenuation of airway hyperresponsiveness requires STAT4, IFNγ and natural killer cells. Am. J. Respir. Cell Mol. Biol. 36, 324-332 (2007).
    • (2007) Am. J. Respir. Cell Mol. Biol , vol.36 , pp. 324-332
    • Matsubara, S.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.