Dual oxidase 2 and pancreatic adenocarcinoma: IFN-γ-mediated dual oxidase 2 overexpression results in H2O2-induced, ERKassociated up-regulation of HIF-1α and VEGF-A

Oncotarget

Volumn 7, Issue 42, 2016, Pages 68412-68433

  Wu, Yongzhong ^a   Meitzler, Jennifer L ^a   Antony, Smitha ^a   Juhasz, Agnes ^a   Lu, Jiamo ^a   Jiang, Guojian ^a   Liu, Han ^a   Hollingshead, Melinda ^a   Haines, Diana C ^b   Butcher, Donna ^b   Panter, Michaela S ^a   Roy, Krishnendu ^a   Doroshow, James H ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b FREDERICK NATIONAL LABORATORY FOR CANCER RESEARCH   (United States)

Author keywords

Angiogenesis; Dual oxidase; Hydrogen peroxide; NADPH oxidase; Pancreatic cancer

Indexed keywords

ACETYLCYSTEINE; CATALASE; DIPHENYLIODONIUM SALT; DUAL OXIDASE 2; GAMMA INTERFERON; HYDROGEN PEROXIDE; HYPOXIA INDUCIBLE FACTOR 1ALPHA; MACROGOL; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR AP 1; UNCLASSIFIED DRUG; VASCULOTROPIN A; CATION; DUAL OXIDASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BXPC-3 CELL LINE; CFPAC-1 CELL LINE; CONTROLLED STUDY; CORRELATION ANALYSIS; DUOX2 GENE; FEMALE; GENE EXPRESSION; GENE KNOCKDOWN; GENE OVEREXPRESSION; GENETIC TRANSCRIPTION; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VIVO STUDY; MAPK SIGNALING; MOUSE; NONHUMAN; PANCREAS ADENOCARCINOMA; PANCREAS ADENOMA; PANCREAS CANCER; PATHOPHYSIOLOGY; PRECANCER; PROMOTER REGION; UPREGULATION; VEGF A GENE; ADENOCARCINOMA; ANIMAL; ANTAGONISTS AND INHIBITORS; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; HEK293 CELL LINE; METABOLISM; NUDE MOUSE; PANCREAS TUMOR; PATHOLOGY; RNA INTERFERENCE; TUMOR CELL LINE; XENOGRAFT;

ADENOCARCINOMA; ANIMALS; CELL LINE, TUMOR; DUAL OXIDASES; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; GENE EXPRESSION REGULATION, NEOPLASTIC; HEK293 CELLS; HUMANS; HYDROGEN PEROXIDE; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; INTERFERON-GAMMA; MICE, NUDE; ONIUM COMPOUNDS; PANCREATIC NEOPLASMS; RNA INTERFERENCE; TRANSPLANTATION, HETEROLOGOUS; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 85019480999     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/ONCOTARGET.12032     Document Type: Article

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