Oxidative stress regulates vascular endothelial growth factor-A gene transcription through Sp1- and Sp3-dependent activation of two proximal GC-rich promoter elements

Journal of Biological Chemistry

Volumn 278, Issue 10, 2003, Pages 8190-8198

  Schäfer, Georgia ^a   Cramer, Thorsten ^a   Suske, Guntram ^b   Kemmner, Wolfgang ^c   Wiedenmann, Bertram ^a   Höcker, Michael ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b PHILIPPS UNIVERSITY MARBURG   (Germany)

^c MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ENZYMES; GENES; OXIDATION; TUMORS;

OXIDATIVE STRESS;

BIOCHEMISTRY;

ACETYLCYSTEINE; ANTIOXIDANT; CYTOSINE; GUANINE; HYDROGEN PEROXIDE; RAF PROTEIN; RAS PROTEIN; TRANSCRIPTION FACTOR SP1; TRANSCRIPTION FACTOR SP3; UNCLASSIFIED DRUG; VASCULOTROPIN; VASCULOTROPIN A; DNA BINDING PROTEIN; ENDOTHELIAL CELL GROWTH FACTOR; MESSENGER RNA; SP3 PROTEIN, HUMAN; TRANSCRIPTION FACTOR;

ANGIOGENESIS; ARTICLE; CONTROLLED STUDY; DROSOPHILA; ENZYME LINKED IMMUNOSORBENT ASSAY; GC RICH SEQUENCE; GENE DELETION; GENE EXPRESSION; HUMAN; HUMAN CELL; METASTASIS; MUTAGENESIS; OXIDATION REDUCTION REACTION; OXIDATIVE STRESS; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROMOTER REGION; STOMACH CANCER; TRANSCRIPTION REGULATION; TUMOR GROWTH; CELL CULTURE; GEL MOBILITY SHIFT ASSAY; GENETIC TRANSCRIPTION; GENETICS; METABOLISM; PROTEIN BINDING; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

DNA-BINDING PROTEINS; ELECTROPHORETIC MOBILITY SHIFT ASSAY; ENDOTHELIAL GROWTH FACTORS; ENZYME-LINKED IMMUNOSORBENT ASSAY; HUMANS; OXIDATIVE STRESS; PROMOTER REGIONS (GENETICS); PROTEIN BINDING; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SP1 TRANSCRIPTION FACTOR; SP3 TRANSCRIPTION FACTOR; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC; TUMOR CELLS, CULTURED; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 0037424388     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M211999200     Document Type: Article

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