Apocynin, an NADPH oxidase inhibitor, suppresses progression of prostate cancer via Rac1 dephosphorylation

Experimental and Toxicologic Pathology

Volumn 65, Issue 7-8, 2013, Pages 1035-1041

  Suzuki, Shugo ^a,b   Pitchakarn, Pornsiri ^a,c   Sato, Shinya ^a   Shirai, Tomoyuki ^a   Takahashi, Satoru ^a  

^a NAGOYA CITY UNIVERSITY GRADUATE SCHOOL OF MEDICAL SCIENCES   (Japan)

^b Nagoya City University East Medical Center   (Japan)

^c Faculty of Medicine Chiang Mai University   (Thailand)

Author keywords

Apocynin; Cancer progression; NADPH oxidase; Prostate cancer; Rac1

Indexed keywords

4 AMINO 6 [2 [[4 (DIETHYLAMINO) 1 METHYLBUTYL]AMINO] 6 METHYL 4 PYRIMIDINYL] 2 METHYLQUINOLINE; ANDROGEN; APOCYNIN; CYCLIN D1; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; RAC1 PROTEIN; REACTIVE OXYGEN METABOLITE; SUPEROXIDE; VASCULOTROPIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL; CANCER INHIBITION; CELL CYCLE ARREST; CONTROLLED STUDY; G1 PHASE CELL CYCLE CHECKPOINT; IN VITRO STUDY; IN VIVO STUDY; MALE; METASTASIS INHIBITION; NONHUMAN; OXIDATIVE STRESS; PROSTATE CANCER; PROTEIN DEPHOSPHORYLATION; PROTEIN SECRETION; PROTEIN SYNTHESIS INHIBITION; RAT;

RATTUS;

APOCYNIN; CANCER PROGRESSION; NADPH OXIDASE; PROSTATE CANCER; RAC1;

ACETOPHENONES; ANIMALS; BLOTTING, WESTERN; CELL CYCLE; CELL MOVEMENT; DISEASE PROGRESSION; ENZYME INHIBITORS; IMMUNOHISTOCHEMISTRY; IN SITU NICK-END LABELING; MALE; MICE; MICE, NUDE; NADPH OXIDASE; OXIDATIVE STRESS; PHOSPHORYLATION; PROSTATIC NEOPLASMS; RAC1 GTP-BINDING PROTEIN; RATS; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84885860674     PISSN: 09402993     EISSN: 16181433     Source Type: Journal    
DOI: 10.1016/j.etp.2013.03.002     Document Type: Article

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