IFNβ/TNFα synergism induces a non-canonical STAT2/IRF9-dependent pathway triggering a novel DUOX2 NADPH Oxidase-mediated airway antiviral response

Cell Research

Volumn 23, Issue 5, 2013, Pages 673-690

  Fink, Karin ^a,b   Martin, Lydie ^a   Mukawera, Esperance ^a   Chartier, Stéfany ^a   De Deken, Xavier ^c   Brochiero, Emmanuelle ^a,b   Miot, Françoise ^c   Grandvaux, Nathalie ^a,b  

^a CENTRE HOSPITALIER DE L UNIVERSITÉ DE MONTRÉAL   (Canada)

^b UNIVERSITÉ DE MONTRÉAL   (Canada)

^c UNIVERSITÉ LIBRE DE BRUXELLES   (Belgium)

Author keywords

antiviral; cell signaling; inflammation; innate immunity; interferon; NADPH oxidase

Indexed keywords

ALPHA BETA INTERFERON RECEPTOR; ANTIVIRUS AGENT; BETA INTERFERON; DUOX2 PROTEIN, HUMAN; HYDROGEN PEROXIDE; IFNAR1 PROTEIN, HUMAN; INTERFERON REGULATORY FACTOR 9; IRF9 PROTEIN, HUMAN; MESSENGER RNA; RECOMBINANT PROTEIN; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; SMALL CYTOPLASMIC RNA; STAT1 PROTEIN; STAT2 PROTEIN; TUMOR NECROSIS FACTOR ALPHA;

ARTICLE; AUTOCRINE EFFECT; BIOSYNTHESIS; CELL LINE; DRUG ANTAGONISM; DRUG EFFECT; DRUG POTENTIATION; GENETICS; HUMAN; INNATE IMMUNITY; METABOLISM; PARACRINE SIGNALING; RESPIRATORY SYNCYTIAL PNEUMOVIRUS; RNA INTERFERENCE; SENDAI VIRUS; SIGNAL TRANSDUCTION;

ANTIVIRAL AGENTS; AUTOCRINE COMMUNICATION; CELL LINE; DRUG SYNERGISM; HUMANS; HYDROGEN PEROXIDE; IMMUNITY, INNATE; INTERFERON-BETA; INTERFERON-STIMULATED GENE FACTOR 3, GAMMA SUBUNIT; NADPH OXIDASE; PARACRINE COMMUNICATION; RECEPTOR, INTERFERON ALPHA-BETA; RECOMBINANT PROTEINS; RESPIRATORY SYNCYTIAL VIRUSES; RNA INTERFERENCE; RNA, MESSENGER; RNA, SMALL CYTOPLASMIC; SENDAI VIRUS; SIGNAL TRANSDUCTION; STAT1 TRANSCRIPTION FACTOR; STAT2 TRANSCRIPTION FACTOR; TUMOR NECROSIS FACTOR-ALPHA;

HUMAN RESPIRATORY SYNCYTIAL VIRUS; RESPIRATORY SYNCYTIAL VIRUS;

EID: 84877101652     PISSN: 10010602     EISSN: 17487838     Source Type: Journal    
DOI: 10.1038/cr.2013.47     Document Type: Article

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