Activation of TLR4 is required for the synergistic induction of dual oxidase 2 and dual oxidase A2 by IFN-γ and lipopolysaccharide in human pancreatic cancer cell lines

Journal of Immunology

Volumn 190, Issue 4, 2013, Pages 1859-1872

  Wu, Yongzhong ^a   Lu, Jiamo ^a   Antony, Smitha ^a   Juhasz, Agnes ^a   Liu, Han ^a   Jiang, Guojian ^a   Meitzler, Jennifer L ^a   Hollingshead, Melinda ^a   Haines, Diana C ^b   Butcher, Donna ^b   Roy, Krishnendu ^a   Doroshow, James H ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b FREDERICK NATIONAL LABORATORY FOR CANCER RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DUAL OXIDASE 2; DUAL OXIDASE A2; GAMMA INTERFERON; HYDROGEN PEROXIDE; I KAPPA B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LIPOPOLYSACCHARIDE; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 2; SMALL INTERFERING RNA; SYNAPTOTAGMIN I; TOLL LIKE RECEPTOR 4; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CANCER GROWTH; CHRONIC PANCREATITIS; CONTROLLED STUDY; CYTOKINE PRODUCTION; DISEASE SEVERITY; DNA DAMAGE; DRUG MECHANISM; ENZYME INDUCTION; EXTRACELLULAR MATRIX; FEMALE; G1 PHASE CELL CYCLE CHECKPOINT; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VIVO STUDY; MOLECULAR PATHOLOGY; MOUSE; NONHUMAN; PANCREAS CANCER; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN SYNTHESIS INHIBITION; RNA INTERFERENCE; TUMOR XENOGRAFT;

ANIMALS; CELL LINE, TUMOR; CHRONIC DISEASE; FEMALE; HUMANS; INTERFERON-GAMMA; LIPOPOLYSACCHARIDES; MEMBRANE PROTEINS; MICE; MICE, NUDE; NADPH OXIDASE; NEOPLASM TRANSPLANTATION; PANCREATIC NEOPLASMS; PANCREATITIS; RANDOM ALLOCATION; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTOR 4; TUMOR CELLS, CULTURED;

EID: 84873564101     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1201725     Document Type: Article

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