Effects of iodonium-class flavin dehydrogenase inhibitors on growth, reactive oxygen production, cell cycle progression, NADPH oxidase 1 levels, and gene expression in human colon cancer cells and xenografts

Free Radical Biology and Medicine

Volumn 57, Issue , 2013, Pages 162-175

  Doroshow, James H ^a   Gaur, Shikha ^b   Markel, Susan ^b   Lu, Jiamo ^a   Van Balgooy, Josephus ^b   Synold, Timothy W ^b   Xi, Bixin ^b   Wu, Xiwei ^b   Juhasz, Agnes ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b CITY OF HOPE NATIONAL MEDICAL CENTER   (United States)

Author keywords

Colon cancer; Diphenyleneiodonium; Free radicals; Gene expression; NADPH oxidase; Nox1

Indexed keywords

CYCLIN A; CYCLIN D1; CYCLIN E; DI 2 THIENYLIODONIUM; DIPHENYLIODONIUM SALT; HYDROGEN PEROXIDE; OXIDOREDUCTASE INHIBITOR; PROTEIN P27; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 1; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; AREA UNDER THE CURVE; ARTICLE; BREAST CANCER; CANCER CELL; CANCER GROWTH; CELL CYCLE PROGRESSION; CELL PROLIFERATION; COLON CANCER; COLORECTAL CANCER; CONCENTRATION RESPONSE; CONTROLLED STUDY; COVALENT BOND; DRUG EFFECT; ENZYME ACTIVITY; GENE EXPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; MALE; MAXIMUM PLASMA CONCENTRATION; MELANOMA; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROSTATE CANCER; PROSTATE CARCINOMA; TIME TO MAXIMUM PLASMA CONCENTRATION; TUMOR XENOGRAFT; UPREGULATION;

ANIMALS; CELL CYCLE; CELL LINE, TUMOR; CELL PROLIFERATION; COLONIC NEOPLASMS; CYCLINS; FLAVOPROTEINS; G1 PHASE CELL CYCLE CHECKPOINTS; GENE EXPRESSION; HUMANS; HYDROGEN PEROXIDE; MALE; MICE; NADPH OXIDASE; NEOPLASM TRANSPLANTATION; ONIUM COMPOUNDS; PROSTATIC NEOPLASMS; REACTIVE OXYGEN SPECIES; RNA, MESSENGER; THIOPHENES; TRANSPLANTATION, HETEROLOGOUS;

EID: 84874618204     PISSN: 08915849     EISSN: 18734596     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2013.01.002     Document Type: Article

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