-
1
-
-
77649234756
-
How to improve R&D productivity: the pharmaceutical industry's grand challenge
-
20168317
-
Paul SM Mytelka DS Dunwiddie CT: How to improve R&D productivity: the pharmaceutical industry's grand challenge. Nat Rev Drug Discov. 2010;9(3):203-14. 20168317 10.1038/nrd3078
-
(2010)
Nat Rev Drug Discov
, vol.9
, Issue.3
, pp. 203-214
-
-
Paul, S.M.1
Mytelka, D.S.2
Dunwiddie, C.T.3
-
2
-
-
84870175062
-
Cool, or simple and cheap? Why not both?
-
23165967
-
Whitesides GM: Cool, or simple and cheap? Why not both? Lab Chip. 2013;13(1):11-3. 23165967 10.1039/c2lc90109a
-
(2013)
Lab Chip
, vol.13
, Issue.1
, pp. 11-13
-
-
Whitesides, G.M.1
-
3
-
-
85091161429
-
Enabling Chemistry Technologies and Parallel Synthesis - Accelerators of Drug Discovery Programs
-
Progress in Medicinal Chemistry,. in Press.
-
Djuric SW Bogdan A Koolman H: Enabling Chemistry Technologies and Parallel Synthesis - Accelerators of Drug Discovery Programs.Progress in Medicinal Chemistry,2016. in Press.
-
(2016)
-
-
Djuric, S.W.1
Bogdan, A.2
Koolman, H.3
-
4
-
-
82255182142
-
20 years of DNA-encoded chemical libraries
-
22083211
-
Mannocci L Leimbacher M Wichert M: 20 years of DNA-encoded chemical libraries. Chem Commun (Camb). 2011;47(48):12747-53. 22083211 10.1039/c1cc15634a
-
(2011)
Chem Commun (Camb)
, vol.47
, Issue.48
, pp. 12747-53
-
-
Mannocci, L.1
Leimbacher, M.2
Wichert, M.3
-
5
-
-
84991372938
-
From haystack to needle: Finding value with DNA encoded library technology at GSK
-
Arico-Muendel CC: From haystack to needle: Finding value with DNA encoded library technology at GSK. Med Chem Commun. 2016. 10.1039/C6MD00341A
-
(2016)
Med Chem Commun
-
-
Arico-Muendel, C.C.1
-
6
-
-
84979943840
-
Chemical Space of DNA-Encoded Libraries
-
26914744
-
Franzini RM Randolph C: Chemical Space of DNA-Encoded Libraries. J Med Chem. 2016;59(14):6629-44. 26914744 10.1021/acs.jmedchem.5b01874
-
(2016)
J Med Chem
, vol.59
, Issue.14
, pp. 6629-6644
-
-
Franzini, R.M.1
Randolph, C.2
-
7
-
-
85027924723
-
Enantioselective catalysis of photochemical reactions
-
25728854
-
Brimioulle R Lenhart D Maturi MM: Enantioselective catalysis of photochemical reactions. Angew Chem Int Ed Engl. 2015;54(13):3872-90. 25728854 10.1002/anie.201411409
-
(2015)
Angew Chem Int Ed Engl
, vol.54
, Issue.13
, pp. 3872-3890
-
-
Brimioulle, R.1
Lenhart, D.2
Maturi, M.M.3
-
8
-
-
77953959859
-
LOPHTOR: A convenient flow-based photochemical reactor
-
Vasudevan A Villamil C Trumbull J: LOPHTOR: A convenient flow-based photochemical reactor. Tetrahedron Lett. 2010;51(31):4007-9. 10.1016/j.tetlet.2010.05.119
-
(2010)
Tetrahedron Lett
, vol.51
, Issue.31
, pp. 4007-4009
-
-
Vasudevan, A.1
Villamil, C.2
Trumbull, J.3
-
9
-
-
84983070648
-
Synthesis of 4,4'-Disubstituted and Spiro-tetrahydroquinolines via Photochemical Cyclization of Acrylanilides and the First Synthesis of (±)-trans-Vabicaserin
-
Koolman HF Braje WM Haupt WH: Synthesis of 4,4'-Disubstituted and Spiro-tetrahydroquinolines via Photochemical Cyclization of Acrylanilides and the First Synthesis of (±)-trans-Vabicaserin. Synlett. 2016. 10.1055/s-0035-1562621
-
(2016)
Synlett
-
-
Koolman, H.F.1
Braje, W.M.2
Haupt, W.H.3
-
10
-
-
52149113820
-
The advent and development of organocatalysis
-
18800128
-
MacMillan DW: The advent and development of organocatalysis. Nature. 2008;455(7211):304-8. 18800128 10.1038/nature07367
-
(2008)
Nature
, vol.455
, Issue.7211
, pp. 304-308
-
-
MacMillan, D.W.1
-
11
-
-
84904797499
-
3-carbons with aryl halides
-
24903563, 4296524
-
Zuo Z Ahneman DT Chu L: Dual catalysis. Merging photoredox with nickel catalysis: coupling of α-carboxyl sp 3-carbons with aryl halides. Science. 2014;345(6195):437-40. 24903563 10.1126/science.1255525 4296524
-
(2014)
Science
, vol.345
, Issue.6195
, pp. 437-440
-
-
Zuo, Z.1
Ahneman, D.T.2
Chu, L.3
-
12
-
-
84899936504
-
Late-stage functionalization of biologically active heterocycles through photoredox catalysis
-
24677697
-
Dirocco DA Dykstra K Krska S: Late-stage functionalization of biologically active heterocycles through photoredox catalysis. Angew Chem Int Ed Engl. 2014;53(19):4802-6. 24677697 10.1002/anie.201402023
-
(2014)
Angew Chem Int Ed Engl
, vol.53
, Issue.19
, pp. 4802-4806
-
-
Dirocco, D.A.1
Dykstra, K.2
Krska, S.3
-
13
-
-
84946781041
-
Development of a Direct Photocatalytic C-H Fluorination for the Preparative Synthesis of Odanacatib
-
26484983
-
Halperin SD Kwon D Holmes M: Development of a Direct Photocatalytic C-H Fluorination for the Preparative Synthesis of Odanacatib. Org Lett. 2015;17(21):5200-3. 26484983 10.1021/acs.orglett.5b02532
-
(2015)
Org Lett
, vol.17
, Issue.21
, pp. 5200-5203
-
-
Halperin, S.D.1
Kwon, D.2
Holmes, M.3
-
14
-
-
84859941649
-
Visible-light photoredox catalysis in flow
-
22431004, 3496249
-
Tucker JW Zhang Y Jamison TF: Visible-light photoredox catalysis in flow. Angew Chem Int Ed Engl. 2012;51(17):4144-7. 22431004 10.1002/anie.201200961 3496249
-
(2012)
Angew Chem Int Ed Engl
, vol.51
, Issue.17
, pp. 4144-4147
-
-
Tucker, J.W.1
Zhang, Y.2
Jamison, T.F.3
-
15
-
-
84918805831
-
Radical C-H functionalization of heteroarenes under electrochemical control
-
25209429, 4214156
-
O'Brien AG Maruyama A Inokuma Y: Radical C-H functionalization of heteroarenes under electrochemical control. Angew Chem Int Ed Engl. 2014;53(44):11868-71. 25209429 10.1002/anie.201407948 4214156
-
(2014)
Angew Chem Int Ed Engl
, vol.53
, Issue.44
, pp. 11868-71
-
-
O'Brien, A.G.1
Maruyama, A.2
Inokuma, Y.3
-
16
-
-
84899005292
-
Total synthesis of dixiamycin B by electrochemical oxidation
-
24697810, 4004216
-
Rosen BR Werner EW O'Brien AG: Total synthesis of dixiamycin B by electrochemical oxidation. J Am Chem Soc. 2014;136(15):5571-4. 24697810 10.1021/ja5013323 4004216
-
(2014)
J Am Chem Soc
, vol.136
, Issue.15
, pp. 5571-5574
-
-
Rosen, B.R.1
Werner, E.W.2
O'Brien, A.G.3
-
17
-
-
84944810559
-
A Microflow Electrolysis Cell for Laboratory Synthesis on the Multigram Scale
-
Green RA Brown RCD Pletcher D: A Microflow Electrolysis Cell for Laboratory Synthesis on the Multigram Scale. Org Process Res Dev. 2015;19:1424-7. 10.1021/acs.oprd.5b00260
-
(2015)
Org Process Res Dev
, vol.19
, pp. 1424-1427
-
-
Green, R.A.1
Brown, R.C.D.2
Pletcher, D.3
-
18
-
-
84925595637
-
Understanding the Performance of a Microfluidic Electrolysis Cell for Routine Organic Electrosynthesis
-
Green R Brown R Pletcher D: Understanding the Performance of a Microfluidic Electrolysis Cell for Routine Organic Electrosynthesis. J Flow Chem. 2015;5(1):31-6. 10.1556/JFC-D-14-00027
-
(2015)
J Flow Chem
, vol.5
, Issue.1
, pp. 31-36
-
-
Green, R.1
Brown, R.2
Pletcher, D.3
-
19
-
-
84883420711
-
Continuous-Flow Microfluidic Electrochemical Synthesis: Investigating a New Tool for Oxidative Chemistry
-
Roth GP Stalder R Long TR: Continuous-Flow Microfluidic Electrochemical Synthesis: Investigating a New Tool for Oxidative Chemistry. J Flow Chem. 2013;3(2):34-40. 10.1556/JFC-D-13-00002
-
(2013)
J Flow Chem
, vol.3
, Issue.2
, pp. 34-40
-
-
Roth, G.P.1
Stalder, R.2
Long, T.R.3
-
20
-
-
63449118639
-
Continuous-Flow Microreactor Chemistry under High-Temperature/Pressure Conditions
-
Razzaq T Glasnov TN Kappe CO: Continuous-Flow Microreactor Chemistry under High-Temperature/Pressure Conditions. Eur J Org Chem. 2009;2009(9):1321-5. 10.1002/ejoc.200900077
-
(2009)
Eur J Org Chem
, vol.2009
, Issue.9
, pp. 1321-1325
-
-
Razzaq, T.1
Glasnov, T.N.2
Kappe, C.O.3
-
21
-
-
84931956239
-
Generation of Reactive Ketenes under Flow Conditions through Zinc-Mediated Dehalogenation
-
Hafner A Ley S: Generation of Reactive Ketenes under Flow Conditions through Zinc-Mediated Dehalogenation. Synlett. 2015;26:1470-4. 10.1055/s-0034-1380679
-
(2015)
Synlett
, vol.26
, pp. 1470-1474
-
-
Hafner, A.1
Ley, S.2
-
22
-
-
77952935876
-
Continuous flow organic synthesis under high-temperature/pressure conditions
-
20411525
-
Razzaq T Kappe CO: Continuous flow organic synthesis under high-temperature/pressure conditions. Chem Asian J. 2010;5(6):1274-89. 20411525 10.1002/asia.201000010
-
(2010)
Chem Asian J
, vol.5
, Issue.6
, pp. 1274-1289
-
-
Razzaq, T.1
Kappe, C.O.2
-
23
-
-
84987837313
-
Taming hazardous chemistry by continuous flow technology
-
27453961
-
Movsisyan M Delbeke EI Berton JK: Taming hazardous chemistry by continuous flow technology. Chem Soc Rev. 2016.45(18):4892-928. 27453961 10.1039/c5cs00902b
-
(2016)
Chem Soc Rev
, vol.45
, Issue.18
, pp. 4892-4928
-
-
Movsisyan, M.1
Delbeke, E.I.2
Berton, J.K.3
-
24
-
-
84923083164
-
Flow chemistry: intelligent processing of gas-liquid transformations using a tube-in-tube reactor
-
25611216
-
Brzozowski M O'Brien M Ley SV: Flow chemistry: intelligent processing of gas-liquid transformations using a tube-in-tube reactor. Acc Chem Res. 2015;48(2):349-62. 25611216 10.1021/ar500359m
-
(2015)
Acc Chem Res
, vol.48
, Issue.2
, pp. 349-362
-
-
Brzozowski, M.1
O'Brien, M.2
Ley, S.V.3
-
25
-
-
84885086350
-
Flash chemistry: flow chemistry that cannot be done in batch
-
24042967
-
Yoshida J Takahashi Y Nagaki A: Flash chemistry: flow chemistry that cannot be done in batch. Chem Commun (Camb). 2013;49(85):9896-904. 24042967 10.1039/c3cc44709j
-
(2013)
Chem Commun (Camb)
, vol.49
, Issue.85
, pp. 9896-9904
-
-
Yoshida, J.1
Takahashi, Y.2
Nagaki, A.3
-
26
-
-
0037238724
-
"Multi-component reactions: emerging chemistry in drug discovery" 'from xylocain to crixivan'
-
12570721
-
Hulme C Gore V: "Multi-component reactions: emerging chemistry in drug discovery" 'from xylocain to crixivan'. Curr Med Chem. 2003;10(1):51-80. 12570721 10.2174/0929867033368600
-
(2003)
Curr Med Chem
, vol.10
, Issue.1
, pp. 51-80
-
-
Hulme, C.1
Gore, V.2
-
27
-
-
84946481302
-
Multicomponent Reactions, Union of MCRs and Beyond
-
26455350
-
Zarganes-Tzitzikas T Chandgude AL Dömling A: Multicomponent Reactions, Union of MCRs and Beyond. Chem Rec. 2015;15(5):981-96. 26455350 10.1002/tcr.201500201
-
(2015)
Chem Rec
, vol.15
, Issue.5
, pp. 981-996
-
-
Zarganes-Tzitzikas, T.1
Chandgude, A.L.2
Dömling, A.3
-
28
-
-
84876244863
-
Rapid discovery of a novel series of Abl kinase inhibitors by application of an integrated microfluidic synthesis and screening platform
-
23441572
-
Desai B Dixon K Farrant E: Rapid discovery of a novel series of Abl kinase inhibitors by application of an integrated microfluidic synthesis and screening platform. J Med Chem. 2013;56(7):3033-47. 23441572 10.1021/jm400099d
-
(2013)
J Med Chem
, vol.56
, Issue.7
, pp. 3033-3047
-
-
Desai, B.1
Dixon, K.2
Farrant, E.3
-
29
-
-
84881398027
-
Integrated Synthesis and Testing of Substituted Xanthine Based DPP4 Inhibitors: Application to Drug Discovery
-
24900744, 4027231
-
Czechtizky W Dedio J Desai B: Integrated Synthesis and Testing of Substituted Xanthine Based DPP4 Inhibitors: Application to Drug Discovery. ACS Med Chem Lett. 2013;4(8):768-72. 24900744 10.1021/ml400171b 4027231
-
(2013)
ACS Med Chem Lett
, vol.4
, Issue.8
, pp. 768-772
-
-
Czechtizky, W.1
Dedio, J.2
Desai, B.3
-
30
-
-
78049355458
-
Chiral separations
-
20636046
-
Stalcup AM: Chiral separations. Annu Rev Anal Chem (Palo Alto Calif). 2010;3:341-63. 20636046 10.1146/annurev.anchem.111808.073635
-
(2010)
Annu Rev Anal Chem (Palo Alto Calif)
, vol.3
, pp. 341-363
-
-
Stalcup, A.M.1
-
31
-
-
84951856514
-
Profiling of Small Molecules by Chemical Proteomics
-
26700051
-
Huber KV Superti-Furga G: Profiling of Small Molecules by Chemical Proteomics. Methods Mol Biol. 2016;1394:211-8. 26700051 10.1007/978-1-4939-3341-9_15
-
(2016)
Methods Mol Biol
, vol.1394
, pp. 211-218
-
-
Huber, K.V.1
Superti-Furga, G.2
-
32
-
-
84975780780
-
Proteome-wide covalent ligand discovery in native biological systems
-
27309814, 4919207
-
Backus KM Correia BE Lum KM: Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016;534(7608):570-4. 27309814 10.1038/nature18002 4919207
-
(2016)
Nature
, vol.534
, Issue.7608
, pp. 570-574
-
-
Backus, K.M.1
Correia, B.E.2
Lum, K.M.3
-
33
-
-
84932611992
-
Advancing Biological Understanding and Therapeutics Discovery with Small-Molecule Probes
-
26046436, 4564295
-
Schreiber SL Kotz JD Li M: Advancing Biological Understanding and Therapeutics Discovery with Small-Molecule Probes. Cell. 2015;161(6):1252-65. 26046436 10.1016/j.cell.2015.05.023 4564295
-
(2015)
Cell
, vol.161
, Issue.6
, pp. 1252-1265
-
-
Schreiber, S.L.1
Kotz, J.D.2
Li, M.3
-
34
-
-
84949294621
-
Target engagement and drug residence time can be observed in living cells with BRET
-
26631872, 4686764
-
Robers MB Dart ML Woodroofe CC: Target engagement and drug residence time can be observed in living cells with BRET. Nat Commun. 2015;6:10091. 26631872 10.1038/ncomms10091 4686764
-
(2015)
Nat Commun
, vol.6
, pp. 10091
-
-
Robers, M.B.1
Dart, M.L.2
Woodroofe, C.C.3
-
35
-
-
84929314533
-
Know your target, know your molecule
-
25978985
-
Bunnage ME Gilbert AM Jones LH: Know your target, know your molecule. Nat Chem Biol. 2015;11(6):368-72. 25978985 10.1038/nchembio.1813
-
(2015)
Nat Chem Biol
, vol.11
, Issue.6
, pp. 368-372
-
-
Bunnage, M.E.1
Gilbert, A.M.2
Jones, L.H.3
-
36
-
-
84971232024
-
Understanding the chemically-reactive proteome
-
26726011
-
Jones LH: Understanding the chemically-reactive proteome. Mol Biosyst. 2016;12(6):1728-30. 26726011 10.1039/c5mb00760g
-
(2016)
Mol Biosyst
, vol.12
, Issue.6
, pp. 1728-1730
-
-
Jones, L.H.1
-
37
-
-
84939552495
-
Protein degradation: Prime time for PROTACs
-
26284668
-
Deshaies RJ: Protein degradation: Prime time for PROTACs. Nat Chem Biol. 2015;11(9):634-5. 26284668 10.1038/nchembio.1887
-
(2015)
Nat Chem Biol
, vol.11
, Issue.9
, pp. 634-635
-
-
Deshaies, R.J.1
-
38
-
-
84870284254
-
Rapid access to compound libraries through flow technology: fully automated synthesis of a 3-aminoindolizine library via orthogonal diversification
-
22954105
-
Lange PP James K: Rapid access to compound libraries through flow technology: fully automated synthesis of a 3-aminoindolizine library via orthogonal diversification. ACS Comb Sci. 2012;14(10):570-8. 22954105 10.1021/co300094n
-
(2012)
ACS Comb Sci
, vol.14
, Issue.10
, pp. 570-578
-
-
Lange, P.P.1
James, K.2
-
39
-
-
84870266405
-
An Integrated Synthesis-Purification System to Accelerate the Generation of Compounds in Pharmaceutical Discovery
-
Hochlowski JE Searle PA Tu NP: An Integrated Synthesis-Purification System to Accelerate the Generation of Compounds in Pharmaceutical Discovery. J Flow Chem. 2011;1(2):56-61. 10.1556/jfchem.2011.00013
-
(2011)
J Flow Chem
, vol.1
, Issue.2
, pp. 56-61
-
-
Hochlowski, J.E.1
Searle, P.A.2
Tu, N.P.3
-
40
-
-
84896272686
-
An automated synthesis-purification-sample-management platform for the accelerated generation of pharmaceutical candidates
-
24352687
-
Sutherland JD Tu NP Nemcek TA: An automated synthesis-purification-sample-management platform for the accelerated generation of pharmaceutical candidates. J Lab Autom. 2014;19(2):176-82. 24352687 10.1177/2211068213516325
-
(2014)
J Lab Autom
, vol.19
, Issue.2
, pp. 176-182
-
-
Sutherland, J.D.1
Tu, N.P.2
Nemcek, T.A.3
-
41
-
-
33846998340
-
The Development of Integrated Microfluidic Chemistry Platforms for Lead Optimisation in the Pharmaceutical Industry
-
In: June 19-21 Limerick, Ireland. p.
-
Fernandez-Suarez M Garcia-Egido E Montembault M: The Development of Integrated Microfluidic Chemistry Platforms for Lead Optimisation in the Pharmaceutical Industry.In: June 19-21, 2006; Limerick, Ireland. p.997-1002. 10.1115/ICNMM2006-96058
-
(2006)
, pp. 997-1002
-
-
Fernandez-Suarez, M.1
Garcia-Egido, E.2
Montembault, M.3
-
42
-
-
84893486529
-
Seamless integration of dose-response screening and flow chemistry: efficient generation of structure-activity relationship data of β-secretase (BACE1) inhibitors
-
24458566
-
Werner M Kuratli C Martin RE: Seamless integration of dose-response screening and flow chemistry: efficient generation of structure-activity relationship data of β-secretase (BACE1) inhibitors. Angew Chem Int Ed Engl. 2014;53(6):1704-8. 24458566 10.1002/anie.201309301
-
(2014)
Angew Chem Int Ed Engl
, vol.53
, Issue.6
, pp. 1704-1708
-
-
Werner, M.1
Kuratli, C.2
Martin, R.E.3
-
43
-
-
84922480032
-
Organic chemistry. Nanomole-scale high-throughput chemistry for the synthesis of complex molecules
-
25554781
-
Buitrago Santanilla A Regalado EL Pereira T: Organic chemistry. Nanomole-scale high-throughput chemistry for the synthesis of complex molecules. Science. 2015;347(6217):49-53. 25554781 10.1126/science.1259203
-
(2015)
Science
, vol.347
, Issue.6217
, pp. 49-53
-
-
Buitrago Santanilla, A.1
Regalado, E.L.2
Pereira, T.3
-
44
-
-
84887166938
-
Flow chemistry syntheses of natural products
-
23999700
-
Pastre JC Browne DL Ley SV: Flow chemistry syntheses of natural products. Chem Soc Rev. 2013;42(23):8849-69. 23999700 10.1039/c3cs60246j
-
(2013)
Chem Soc Rev
, vol.42
, Issue.23
, pp. 8849-8869
-
-
Pastre, J.C.1
Browne, D.L.2
Ley, S.V.3
-
45
-
-
85000936170
-
Enabling Technologies for the Future of Chemical Synthesis
-
27163040, 4827522
-
Fitzpatrick DE Battilocchio C Ley SV: Enabling Technologies for the Future of Chemical Synthesis. ACS Cent Sci. 2016;2(3):131-8. 27163040 10.1021/acscentsci.6b00015 4827522
-
(2016)
ACS Cent Sci
, vol.2
, Issue.3
, pp. 131-138
-
-
Fitzpatrick, D.E.1
Battilocchio, C.2
Ley, S.V.3
-
46
-
-
84905492988
-
Tools for chemical synthesis in microsystems
-
24865228
-
Jensen KF Reizman BJ Newman SG: Tools for chemical synthesis in microsystems. Lab Chip. 2014;14(17):3206-12. 24865228 10.1039/c4lc00330f
-
(2014)
Lab Chip
, vol.14
, Issue.17
, pp. 3206-3212
-
-
Jensen, K.F.1
Reizman, B.J.2
Newman, S.G.3
-
47
-
-
79961218749
-
Deciding whether to go with the flow: evaluating the merits of flow reactors for synthesis
-
21710673
-
Hartman RL McMullen JP Jensen KF: Deciding whether to go with the flow: evaluating the merits of flow reactors for synthesis. Angew Chem Int Ed Engl. 2011;50(33):7502-19. 21710673 10.1002/anie.201004637
-
(2011)
Angew Chem Int Ed Engl
, vol.50
, Issue.33
, pp. 7502-7519
-
-
Hartman, R.L.1
McMullen, J.P.2
Jensen, K.F.3
-
48
-
-
84922784995
-
Achieving continuous manufacturing: technologies and approaches for synthesis, workup, and isolation of drug substance. May 20-21, 2014 Continuous Manufacturing Symposium
-
25470351
-
Baxendale IR Braatz RD Hodnett BK: Achieving continuous manufacturing: technologies and approaches for synthesis, workup, and isolation of drug substance. May 20-21, 2014 Continuous Manufacturing Symposium. J Pharm Sci. 2015;104(3):781-91. 25470351 10.1002/jps.24252
-
(2015)
J Pharm Sci
, vol.104
, Issue.3
, pp. 781-791
-
-
Baxendale, I.R.1
Braatz, R.D.2
Hodnett, B.K.3
-
49
-
-
84930202202
-
Continuous-flow technology-a tool for the safe manufacturing of active pharmaceutical ingredients
-
25989203
-
Gutmann B Cantillo D Kappe CO: Continuous-flow technology-a tool for the safe manufacturing of active pharmaceutical ingredients. Angew Chem Int Ed Engl. 2015;54(23):6688-728. 25989203 10.1002/anie.201409318
-
(2015)
Angew Chem Int Ed Engl
, vol.54
, Issue.23
, pp. 6688-6728
-
-
Gutmann, B.1
Cantillo, D.2
Kappe, C.O.3
-
50
-
-
51149088558
-
The Use of DiethylaminosulfurTrifluoride (DAST) for Fluorination in a Continuous Flow Reactor
-
Baumann M Baxendale IR Ley SV: The Use of DiethylaminosulfurTrifluoride (DAST) for Fluorination in a Continuous Flow Reactor. Synlett. 2008;14:2111-2114. 10.1055/s-2008-1078026
-
(2008)
Synlett
, vol.14
, pp. 2111-2114
-
-
Baumann, M.1
Baxendale, I.R.2
Ley, S.V.3
-
51
-
-
84978975174
-
Automated library synthesis of cyclopropyl boronic esters employing diazomethane in a tube-in-tube flow reactor
-
27314279
-
Koolman HF Kantor S Bogdan AR: Automated library synthesis of cyclopropyl boronic esters employing diazomethane in a tube-in-tube flow reactor. Org Biomol Chem. 2016;14(27):6591-5. 27314279 10.1039/c6ob00715e
-
(2016)
Org Biomol Chem
, vol.14
, Issue.27
, pp. 6591-6595
-
-
Koolman, H.F.1
Kantor, S.2
Bogdan, A.R.3
-
52
-
-
71049126548
-
Escape from flatland: increasing saturation as an approach to improving clinical success
-
19827778
-
Lovering F Bikker J Humblet C: Escape from flatland: increasing saturation as an approach to improving clinical success. J Med Chem. 2009;52(21):6752-6. 19827778 10.1021/jm901241e
-
(2009)
J Med Chem
, vol.52
, Issue.21
, pp. 6752-6756
-
-
Lovering, F.1
Bikker, J.2
Humblet, C.3
-
53
-
-
84859941649
-
Visible-light photoredox catalysis in flow
-
22431004, 3496249
-
Tucker JW Zhang Y Jamison TF: Visible-light photoredox catalysis in flow. Angew Chem Int Ed Engl. 2012;51(17):4144-7. 22431004 10.1002/anie.201200961 3496249
-
(2012)
Angew Chem Int Ed Engl
, vol.51
, Issue.17
, pp. 4144-4147
-
-
Tucker, J.W.1
Zhang, Y.2
Jamison, T.F.3
-
54
-
-
84915758742
-
Batch versus flow photochemistry: a revealing comparison of yield and productivity
-
25263341
-
Elliott LD Knowles JP Koovits PJ: Batch versus flow photochemistry: a revealing comparison of yield and productivity. Chemistry. 2014;20(46):15226-32. 25263341 10.1002/chem.201404347
-
(2014)
Chemistry
, vol.20
, Issue.46
, pp. 15226-32
-
-
Elliott, L.D.1
Knowles, J.P.2
Koovits, P.J.3
-
55
-
-
84899936504
-
Late-stage functionalization of biologically active heterocycles through photoredox catalysis
-
24677697
-
Dirocco DA Dykstra K Krska S: Late-stage functionalization of biologically active heterocycles through photoredox catalysis. Angew Chem Int Ed Engl. 2014;53(19):4802-6. 24677697 10.1002/anie.201402023
-
(2014)
Angew Chem Int Ed Engl
, vol.53
, Issue.19
, pp. 4802-4806
-
-
Dirocco, D.A.1
Dykstra, K.2
Krska, S.3
-
56
-
-
84966650486
-
Exploiting plug-and-play electrochemistry for drug discovery
-
27079543
-
Gao L Teng Y: Exploiting plug-and-play electrochemistry for drug discovery. Future Med Chem. 2016;8(5):567-77. 27079543 10.4155/fmc.16.8
-
(2016)
Future Med Chem
, vol.8
, Issue.5
, pp. 567-577
-
-
Gao, L.1
Teng, Y.2
-
57
-
-
85091166954
-
-
http://syrris.com/flow-products/asia-modules/asia-flux-for-electrochemistry. Co-developed with AbbVie.
-
-
-
-
58
-
-
79952258629
-
Continuous flow thermolysis of azidoacrylates for the synthesis of heterocycles and pharmaceutical intermediates
-
21173952
-
O'Brien AG Levesque F Seeberger PH: Continuous flow thermolysis of azidoacrylates for the synthesis of heterocycles and pharmaceutical intermediates. Chem Commun (Camb). 2011;47(9):2688-90. 21173952 10.1039/c0cc04481d
-
(2011)
Chem Commun (Camb)
, vol.47
, Issue.9
, pp. 2688-2690
-
-
O'Brien, A.G.1
Levesque, F.2
Seeberger, P.H.3
-
59
-
-
84855834894
-
Highly efficient thermal cyclization reactions of alkylidene esters in continuous flow to give aromatic/heteroaromatic derivatives
-
Lengyel L Nagy TZ Sipos G: Highly efficient thermal cyclization reactions of alkylidene esters in continuous flow to give aromatic/heteroaromatic derivatives. Tetrahedron Lett. 2012;53(7):738-43. 10.1016/j.tetlet.2011.11.125
-
(2012)
Tetrahedron Lett
, vol.53
, Issue.7
, pp. 738-743
-
-
Lengyel, L.1
Nagy, T.Z.2
Sipos, G.3
-
60
-
-
84925633927
-
Synthesis of Condensed Heterocycles by the Gould-Jacobs Reaction in a Novel Three-Mode Pyrolysis Reactor
-
Lengyel LC Sipos G Sipőcz T: Synthesis of Condensed Heterocycles by the Gould-Jacobs Reaction in a Novel Three-Mode Pyrolysis Reactor. Org Process Res Dev. 2015;19(3):399-409. 10.1021/op500354z
-
(2015)
Org Process Res Dev
, vol.19
, Issue.3
, pp. 399-409
-
-
Lengyel, L.C.1
Sipos, G.2
Sipőcz, T.3
-
61
-
-
84055193467
-
Synthesis of Annulated Pyridines by Intramolecular Inverse-Electron-Demand Hetero-Diels-Alder Reaction under Superheated Continuous Flow Conditions
-
Martin RE Morawitz F Kuratli C: Synthesis of Annulated Pyridines by Intramolecular Inverse-Electron-Demand Hetero-Diels-Alder Reaction under Superheated Continuous Flow Conditions. Eur J Org Chem. 2012;2012(1):47-52. 10.1002/ejoc.201101538
-
(2012)
Eur J Org Chem
, vol.2012
, Issue.1
, pp. 47-52
-
-
Martin, R.E.1
Morawitz, F.2
Kuratli, C.3
-
62
-
-
84880567562
-
The Kondrat'eva reaction in flow: direct access to annulated pyridines
-
23805911
-
Lehmann J Alzieu T Martin RE: The Kondrat'eva reaction in flow: direct access to annulated pyridines. Org Lett. 2013;15(14):3550-3. 23805911 10.1021/ol4013525
-
(2013)
Org Lett
, vol.15
, Issue.14
, pp. 3550-3553
-
-
Lehmann, J.1
Alzieu, T.2
Martin, R.E.3
-
63
-
-
84957580234
-
Nucleophilic aromatic substitution of heterocycles using a high-temperature and high-pressure flow reactor
-
Charaschanya M Bogdan AR Wang Y: Nucleophilic aromatic substitution of heterocycles using a high-temperature and high-pressure flow reactor. Tetrahedron Lett. 2016;57(9):1035-9. 10.1016/j.tetlet.2016.01.080
-
(2016)
Tetrahedron Lett
, vol.57
, Issue.9
, pp. 1035-1039
-
-
Charaschanya, M.1
Bogdan, A.R.2
Wang, Y.3
-
64
-
-
84966269260
-
High-Temperature Boc Deprotection in Flow and Its Application in Multistep Reaction Sequences
-
27046640
-
Bogdan AR Charaschanya M Dombrowski AW: High-Temperature Boc Deprotection in Flow and Its Application in Multistep Reaction Sequences. Org Lett. 2016;18(8):1732-5. 27046640 10.1021/acs.orglett.6b00378
-
(2016)
Org Lett
, vol.18
, Issue.8
, pp. 1732-1735
-
-
Bogdan, A.R.1
Charaschanya, M.2
Dombrowski, A.W.3
-
65
-
-
85091173692
-
-
http://thalesnano.com/phoenix-flow-reactor.
-
-
-
-
66
-
-
85000936170
-
Enabling Technologies for the Future of Chemical Synthesis
-
27163040, 4827522
-
Fitzpatrick DE Battilocchio C Ley SV: Enabling Technologies for the Future of Chemical Synthesis. ACS Cent Sci. 2016;2(3):131-8. 27163040 10.1021/acscentsci.6b00015 4827522
-
(2016)
ACS Cent Sci
, vol.2
, Issue.3
, pp. 131-138
-
-
Fitzpatrick, D.E.1
Battilocchio, C.2
Ley, S.V.3
-
67
-
-
84939567633
-
Machine-Assisted Organic Synthesis
-
26193360, 4834626
-
Ley SV Fitzpatrick DE Myers RM: Machine-Assisted Organic Synthesis. Angew Chem Int Ed Engl. 2015;54(35):10122-36. 26193360 10.1002/anie.201501618 4834626
-
(2015)
Angew Chem Int Ed Engl
, vol.54
, Issue.35
, pp. 10122-36
-
-
Ley, S.V.1
Fitzpatrick, D.E.2
Myers, R.M.3
-
68
-
-
85091132093
-
-
http://www.fiercebiotech.com/r-d/race-to-build-a-robo-chemist
-
-
-
-
69
-
-
85091141932
-
-
http://blogs.sciencemag.org/pipeline/archives/2014/08/07/the_synthesis_machine
-
-
-
-
70
-
-
85091166964
-
-
http://www.pharmafile.com/news/502337/what-could-artificial-intelligence-mean-pharma
-
-
-
-
71
-
-
85091140892
-
-
http://www.cam.ac.uk/research/news/artificially-intelligent-robot-scientist-eve-could-boost-search-for-new-drugs
-
-
-
-
72
-
-
84928677852
-
FOCUS--Development of a Global Communication and Modeling Platform for Applied and Computational Medicinal Chemists
-
25816021
-
Stiefl N Gedeck P Chin D: FOCUS--Development of a Global Communication and Modeling Platform for Applied and Computational Medicinal Chemists. J Chem Inf Model. 2015;55(4):896-908. 25816021 10.1021/ci500598e
-
(2015)
J Chem Inf Model
, vol.55
, Issue.4
, pp. 896-908
-
-
Stiefl, N.1
Gedeck, P.2
Chin, D.3
-
73
-
-
84859531062
-
Illuminator: increasing synergies between medicinal and computational chemists
-
22475753
-
Gobbi A Lardy M Kim SH: Illuminator: increasing synergies between medicinal and computational chemists. In Silico Biol. 2011-2012;11(1-2):83-93. 22475753 10.3233/CI-2009-0017
-
(2011)
In Silico Biol
, vol.11
, Issue.1-2
, pp. 83-93
-
-
Gobbi, A.1
Lardy, M.2
Kim, S.H.3
-
74
-
-
84949319273
-
In silico ADME/T modelling for rational drug design
-
26328949
-
Wang Y Xing J Xu Y: In silico ADME/T modelling for rational drug design. Q Rev Biophys. 2015;48(4):488-515. 26328949 10.1017/S0033583515000190
-
(2015)
Q Rev Biophys
, vol.48
, Issue.4
, pp. 488-515
-
-
Wang, Y.1
Xing, J.2
Xu, Y.3
-
75
-
-
84969497966
-
Impact of Binding Site Comparisons on Medicinal Chemistry and Rational Molecular Design
-
27046190
-
Ehrt C Brinkjost T Koch O: Impact of Binding Site Comparisons on Medicinal Chemistry and Rational Molecular Design. J Med Chem. 2016;59(9):4121-51. 27046190 10.1021/acs.jmedchem.6b00078
-
(2016)
J Med Chem
, vol.59
, Issue.9
, pp. 4121-4151
-
-
Ehrt, C.1
Brinkjost, T.2
Koch, O.3
-
76
-
-
84979902232
-
Protein-Ligand Informatics Force Field (PLIff): Toward a Fully Knowledge Driven "Force Field" for Biomolecular Interactions
-
27353137
-
Verdonk ML Ludlow RF Giangreco I: Protein-Ligand Informatics Force Field (PLIff): Toward a Fully Knowledge Driven "Force Field" for Biomolecular Interactions. J Med Chem. 2016;59(14):6891-902. 27353137 10.1021/acs.jmedchem.6b00716
-
(2016)
J Med Chem
, vol.59
, Issue.14
, pp. 6891-6902
-
-
Verdonk, M.L.1
Ludlow, R.F.2
Giangreco, I.3
-
77
-
-
84969248247
-
Binding Mode and Induced Fit Predictions for Prospective Computational Drug Design
-
26974351
-
Grebner C Iegre J Ulander J: Binding Mode and Induced Fit Predictions for Prospective Computational Drug Design. J Chem Inf Model. 2016;56(4):774-87. 26974351 10.1021/acs.jcim.5b00744
-
(2016)
J Chem Inf Model
, vol.56
, Issue.4
, pp. 774-787
-
-
Grebner, C.1
Iegre, J.2
Ulander, J.3
-
78
-
-
85091184952
-
-
http://aws.amazon.com/solutions/case-studies/novartis/
-
-
-
-
79
-
-
79959780557
-
Software and resources for computational medicinal chemistry
-
21707404, 3413324
-
Liao C Sitzmann M Pugliese A: Software and resources for computational medicinal chemistry. Future Med Chem. 2011;3(8):1057-85. 21707404 10.4155/fmc.11.63 3413324
-
(2011)
Future Med Chem
, vol.3
, Issue.8
, pp. 1057-1085
-
-
Liao, C.1
Sitzmann, M.2
Pugliese, A.3
-
80
-
-
84948970906
-
Structural Biology: A Century-long Journey into an Unseen World
-
26740732, 4697198
-
Curry S: Structural Biology: A Century-long Journey into an Unseen World. Interdiscip Sci Rev. 2015;40(3):308-28. 26740732 10.1179/0308018815Z.000000000120 4697198
-
(2015)
Interdiscip Sci Rev
, vol.40
, Issue.3
, pp. 308-328
-
-
Curry, S.1
-
81
-
-
84942522975
-
Structure of the toxic core of α-synuclein from invisible crystals
-
26352473, 4791177
-
Rodriguez JA Ivanova MI Sawaya MR: Structure of the toxic core of α-synuclein from invisible crystals. Nature. 2015;525(7570):486-90. 26352473 10.1038/nature15368 4791177
-
(2015)
Nature
, vol.525
, Issue.7570
, pp. 486-490
-
-
Rodriguez, J.A.1
Ivanova, M.I.2
Sawaya, M.R.3
-
82
-
-
85091138990
-
Sharing Pharmaceutical Industry Data: Outlook and Opportunities
-
American Chemical Society Meeting: Sharing Pharmaceutical Industry Data: Outlook and Opportunities.Philadelphia, PA,2016.
-
(2016)
-
-
-
83
-
-
84978923182
-
In silico Exploration of the Conformational Universe of GPCRs
-
27492237
-
Rodriguez-Espigares I Kaczor AA Selent J: In silico Exploration of the Conformational Universe of GPCRs. Mol Inform. 2016;35(6-7):227-37. 27492237 10.1002/minf.201600012
-
(2016)
Mol Inform
, vol.35
, Issue.6-7
, pp. 227-237
-
-
Rodriguez-Espigares, I.1
Kaczor, A.A.2
Selent, J.3
-
84
-
-
84949520925
-
Advances in Computational Techniques to Study GPCR-Ligand Recognition
-
26538318
-
Ciancetta A Sabbadin D Federico S: Advances in Computational Techniques to Study GPCR-Ligand Recognition. Trends Pharmacol Sci. 2015;36(12):878-90. 26538318 10.1016/j.tips.2015.08.006
-
(2015)
Trends Pharmacol Sci
, vol.36
, Issue.12
, pp. 878-890
-
-
Ciancetta, A.1
Sabbadin, D.2
Federico, S.3
-
85
-
-
84978474564
-
Twenty years on: the impact of fragments on drug discovery
-
27417849
-
Erlanson DA Fesik SW Hubbard RE: Twenty years on: the impact of fragments on drug discovery. Nat Rev Drug Discov. 2016;15(9):605-19. 27417849 10.1038/nrd.2016.109
-
(2016)
Nat Rev Drug Discov
, vol.15
, Issue.9
, pp. 605-619
-
-
Erlanson, D.A.1
Fesik, S.W.2
Hubbard, R.E.3
-
86
-
-
84993661783
-
The ways and means of fragment-based drug design
-
27452339
-
Doak BC Norton RS Scanlon MJ: The ways and means of fragment-based drug design. Pharmacol Ther. 2016; pii: S0163-7258(16)30123-1. 27452339 10.1016/j.pharmthera.2016.07.003
-
(2016)
Pharmacol Ther
-
-
Doak, B.C.1
Norton, R.S.2
Scanlon, M.J.3
-
87
-
-
84923922485
-
Fragment screening by SPR and advanced application to GPCRs
-
25301577
-
Shepherd CA Hopkins AL Navratilova I: Fragment screening by SPR and advanced application to GPCRs. Prog Biophys Mol Biol. 2014;116(2-3):113-23. 25301577 10.1016/j.pbiomolbio.2014.09.008
-
(2014)
Prog Biophys Mol Biol
, vol.116
, Issue.2-3
, pp. 113-123
-
-
Shepherd, C.A.1
Hopkins, A.L.2
Navratilova, I.3
-
88
-
-
77950902962
-
Post processing of protein-compound docking for fragment-based drug discovery (FBDD): in-silico structure-based drug screening and ligand-binding pose prediction
-
20337587
-
Fukunishi Y: Post processing of protein-compound docking for fragment-based drug discovery (FBDD): in-silico structure-based drug screening and ligand-binding pose prediction. Curr Top Med Chem. 2010;10(6):680-94. 20337587 10.2174/156802610791111452
-
(2010)
Curr Top Med Chem
, vol.10
, Issue.6
, pp. 680-694
-
-
Fukunishi, Y.1
-
89
-
-
84997659194
-
Solvation thermodynamic mapping of molecular surfaces in AmberTools: GIST
-
27317094
-
Ramsey S Nguyen C Salomon-Ferrer R: Solvation thermodynamic mapping of molecular surfaces in AmberTools: GIST. J Comput Chem. 2016;37(21):2029-37. 27317094 10.1002/jcc.24417
-
(2016)
J Comput Chem
, vol.37
, Issue.21
, pp. 2029-2037
-
-
Ramsey, S.1
Nguyen, C.2
Salomon-Ferrer, R.3
-
90
-
-
84940189864
-
Evaluating Free Energies of Binding and Conservation of Crystallographic Waters Using SZMAP
-
26176600
-
Bayden AS Moustakas DT Joseph-McCarthy D: Evaluating Free Energies of Binding and Conservation of Crystallographic Waters Using SZMAP. J Chem Inf Model. 2015;55(8):1552-65. 26176600 10.1021/ci500746d
-
(2015)
J Chem Inf Model
, vol.55
, Issue.8
, pp. 1552-1565
-
-
Bayden, A.S.1
Moustakas, D.T.2
Joseph-McCarthy, D.3
-
91
-
-
84908253611
-
Analysis of factors influencing hydration site prediction based on molecular dynamics simulations
-
25252619, 4210176
-
Yang Y Hu B Lill MA: Analysis of factors influencing hydration site prediction based on molecular dynamics simulations. J Chem Inf Model. 2014;54(10):2987-95. 25252619 10.1021/ci500426q 4210176
-
(2014)
J Chem Inf Model
, vol.54
, Issue.10
, pp. 2987-2995
-
-
Yang, Y.1
Hu, B.2
Lill, M.A.3
-
92
-
-
33846524439
-
Motifs for molecular recognition exploiting hydrophobic enclosure in protein-ligand binding
-
17204562, 1783395
-
Young T Abel R Kim B: Motifs for molecular recognition exploiting hydrophobic enclosure in protein-ligand binding. Proc Natl Acad Sci U S A. 2007;104(3):808-13. 17204562 10.1073/pnas.0610202104 1783395
-
(2007)
Proc Natl Acad Sci U S A
, vol.104
, Issue.3
, pp. 808-813
-
-
Young, T.1
Abel, R.2
Kim, B.3
-
93
-
-
84969512867
-
WScore: A Flexible and Accurate Treatment of Explicit Water Molecules in Ligand-Receptor Docking
-
27054459
-
Murphy RB Repasky MP Greenwood JR: WScore: A Flexible and Accurate Treatment of Explicit Water Molecules in Ligand-Receptor Docking. J Med Chem. 2016;59(9):4364-84. 27054459 10.1021/acs.jmedchem.6b00131
-
(2016)
J Med Chem
, vol.59
, Issue.9
, pp. 4364-4384
-
-
Murphy, R.B.1
Repasky, M.P.2
Greenwood, J.R.3
-
94
-
-
84923538660
-
Accurate and reliable prediction of relative ligand binding potency in prospective drug discovery by way of a modern free-energy calculation protocol and force field
-
25625324
-
Wang L Wu Y Deng Y: Accurate and reliable prediction of relative ligand binding potency in prospective drug discovery by way of a modern free-energy calculation protocol and force field. J Am Chem Soc. 2015;137(7):2695-703. 25625324 10.1021/ja512751q
-
(2015)
J Am Chem Soc
, vol.137
, Issue.7
, pp. 2695-2703
-
-
Wang, L.1
Wu, Y.2
Deng, Y.3
-
95
-
-
79951543355
-
A water-swap reaction coordinate for the calculation of absolute protein-ligand binding free energies
-
21303099
-
Woods CJ Malaisree M Hannongbua S: A water-swap reaction coordinate for the calculation of absolute protein-ligand binding free energies. J Chem Phys. 2011;134(5): 054114. 21303099 10.1063/1.3519057
-
(2011)
J Chem Phys
, vol.134
, Issue.5
-
-
Woods, C.J.1
Malaisree, M.2
Hannongbua, S.3
-
96
-
-
84908110328
-
Rapid decomposition and visualisation of protein-ligand binding free energies by residue and by water
-
25340314
-
Woods CJ Malaisree M Michel J: Rapid decomposition and visualisation of protein-ligand binding free energies by residue and by water. Faraday Discuss. 2014;169:477-99. 25340314 10.1039/c3fd00125c
-
(2014)
Faraday Discuss
, vol.169
, pp. 477-499
-
-
Woods, C.J.1
Malaisree, M.2
Michel, J.3
-
97
-
-
84955613377
-
Insights into Protein-Ligand Interactions: Mechanisms, Models, and Methods
-
26821017, 4783878, pii: E144.
-
Du X Li Y Xia YL: Insights into Protein-Ligand Interactions: Mechanisms, Models, and Methods. Int J Mol Sci. 2016;17(2): pii: E144. 26821017 10.3390/ijms17020144 4783878
-
(2016)
Int J Mol Sci
, vol.17
, Issue.2
-
-
Du, X.1
Li, Y.2
Xia, Y.L.3
-
98
-
-
84969593568
-
Ligand-Binding Affinity Estimates Supported by Quantum-Mechanical Methods
-
27077817
-
Ryde U Söderhjelm P: Ligand-Binding Affinity Estimates Supported by Quantum-Mechanical Methods. Chem Rev. 2016;116(9):5520-66. 27077817 10.1021/acs.chemrev.5b00630
-
(2016)
Chem Rev
, vol.116
, Issue.9
, pp. 5520-5566
-
-
Ryde, U.1
Söderhjelm, P.2
-
99
-
-
34347224684
-
Calculation of protein-ligand binding affinities
-
17201676
-
Gilson MK Zhou HX: Calculation of protein-ligand binding affinities. Annu Rev Biophys Biomol Struct. 2007;36:21-42. 17201676 10.1146/annurev.biophys.36.040306.132550
-
(2007)
Annu Rev Biophys Biomol Struct
, vol.36
, pp. 21-42
-
-
Gilson, M.K.1
Zhou, H.X.2
-
100
-
-
62849109096
-
Healthy skepticism: assessing realistic model performance
-
19340931
-
Brown SP Muchmore SW Hajduk PJ: Healthy skepticism: assessing realistic model performance. Drug Discov Today. 2009;14(7-8):420-7. 19340931 10.1016/j.drudis.2009.01.012
-
(2009)
Drug Discov Today
, vol.14
, Issue.7-8
, pp. 420-427
-
-
Brown, S.P.1
Muchmore, S.W.2
Hajduk, P.J.3
-
101
-
-
4344704556
-
The Encyclopedia of Mass Spectrometry 10 Volume Set
-
Reference Source, Elsevier Press.
-
Gross ML Caprioli RM: The Encyclopedia of Mass Spectrometry 10 Volume Set.Elsevier Press.2003-2010. Reference Source
-
(2003)
-
-
Gross, M.L.1
Caprioli, R.M.2
-
102
-
-
84881131111
-
Mass Spectrometry for Drug Discovery and Drug Development
-
Reference Source, John Wiley & Sons, Inc.
-
Korfmacher WA: Mass Spectrometry for Drug Discovery and Drug Development.John Wiley & Sons, Inc.2013. Reference Source
-
(2013)
-
-
Korfmacher, W.A.1
-
103
-
-
84954546745
-
Advances in Mass Spectrometry Within Drug Discovery
-
26773070
-
Wingfield J Wilson ID: Advances in Mass Spectrometry Within Drug Discovery. J Biomol Screen. 2016;21(2):109-10. 26773070 10.1177/1087057115623454
-
(2016)
J Biomol Screen
, vol.21
, Issue.2
, pp. 109-110
-
-
Wingfield, J.1
Wilson, I.D.2
-
104
-
-
79952068768
-
Comparison of the response of four aerosol detectors used with ultra high pressure liquid chromatography
-
21315361
-
Hutchinson JP Li J Farrell W: Comparison of the response of four aerosol detectors used with ultra high pressure liquid chromatography. J Chromatogr A. 2011;1218(12):1646-55. 21315361 10.1016/j.chroma.2011.01.062
-
(2011)
J Chromatogr A
, vol.1218
, Issue.12
, pp. 1646-1655
-
-
Hutchinson, J.P.1
Li, J.2
Farrell, W.3
-
105
-
-
84919882437
-
On-line monitoring of continuous flow chemical synthesis using a portable, small footprint mass spectrometer
-
25106707
-
Bristow TW Ray AD O'Kearney-McMullan A: On-line monitoring of continuous flow chemical synthesis using a portable, small footprint mass spectrometer. J Am Soc Mass Spectrom. 2014;25(10):1794-802. 25106707 10.1007/s13361-014-0957-1
-
(2014)
J Am Soc Mass Spectrom
, vol.25
, Issue.10
, pp. 1794-1802
-
-
Bristow, T.W.1
Ray, A.D.2
O'Kearney-McMullan, A.3
-
106
-
-
85091155254
-
High performance compact mass spectrometer
-
Reference Source
-
High performance compact mass spectrometer.2016. Reference Source
-
(2016)
-
-
-
107
-
-
84875997410
-
Chemical aspects of the extractive methods of ambient ionization mass spectrometry
-
23331308
-
Badu-Tawiah AK Eberlin LS Ouyang Z: Chemical aspects of the extractive methods of ambient ionization mass spectrometry. Annu Rev Phys Chem. 2013;64:481-505. 23331308 10.1146/annurev-physchem-040412-110026
-
(2013)
Annu Rev Phys Chem
, vol.64
, pp. 481-505
-
-
Badu-Tawiah, A.K.1
Eberlin, L.S.2
Ouyang, Z.3
-
108
-
-
84876138216
-
Mass spectrometry: recent advances in direct open air surface sampling/ionization
-
23301684
-
Monge ME Harris GA Dwivedi P: Mass spectrometry: recent advances in direct open air surface sampling/ionization. Chem Rev. 2013;113(4):2269-308. 23301684 10.1021/cr300309q
-
(2013)
Chem Rev
, vol.113
, Issue.4
, pp. 2269-2308
-
-
Monge, M.E.1
Harris, G.A.2
Dwivedi, P.3
-
109
-
-
84869484006
-
Accelerated carbon-carbon bond-forming reactions in preparative electrospray
-
23042619
-
Müller T Badu-Tawiah A Cooks RG: Accelerated carbon-carbon bond-forming reactions in preparative electrospray. Angew Chem Int Ed Engl. 2012;51(47):11832-5. 23042619 10.1002/anie.201206632
-
(2012)
Angew Chem Int Ed Engl
, vol.51
, Issue.47
, pp. 11832-5
-
-
Müller, T.1
Badu-Tawiah, A.2
Cooks, R.G.3
-
110
-
-
84983095409
-
Syntheses of Isoquinoline and Substituted Quinolines in Charged Microdroplets
-
26450661
-
Banerjee S Zare RN: Syntheses of Isoquinoline and Substituted Quinolines in Charged Microdroplets. Angew Chem Int Ed Engl. 2015;54(49):14795-9. 26450661 10.1002/anie.201507805
-
(2015)
Angew Chem Int Ed Engl
, vol.54
, Issue.49
, pp. 14795-9
-
-
Banerjee, S.1
Zare, R.N.2
-
111
-
-
84919330949
-
Accelerated Hantzsch electrospray synthesis with temporal control of reaction intermediates
-
Bain RM Pulliam CJ Cooks RG: Accelerated Hantzsch electrospray synthesis with temporal control of reaction intermediates. Chem Sci. 2015;6:397-401. 10.1039/C4SC02436B
-
(2015)
Chem Sci
, vol.6
, pp. 397-401
-
-
Bain, R.M.1
Pulliam, C.J.2
Cooks, R.G.3
-
112
-
-
84954515691
-
The Evolution of MALDI-TOF Mass Spectrometry toward Ultra-High-Throughput Screening: 1536-Well Format and Beyond
-
26428484
-
Haslam C Hellicar J Dunn A: The Evolution of MALDI-TOF Mass Spectrometry toward Ultra-High-Throughput Screening: 1536-Well Format and Beyond. J Biomol Screen. 2016;21(2):176-86. 26428484 10.1177/1087057115608605
-
(2016)
J Biomol Screen
, vol.21
, Issue.2
, pp. 176-186
-
-
Haslam, C.1
Hellicar, J.2
Dunn, A.3
-
113
-
-
84954557011
-
Coupling Laser Diode Thermal Desorption with Acoustic Sample Deposition to Improve Throughput of Mass Spectrometry-Based Screening
-
26420787
-
Haarhoff Z Wagner A Picard P: Coupling Laser Diode Thermal Desorption with Acoustic Sample Deposition to Improve Throughput of Mass Spectrometry-Based Screening. J Biomol Screen. 2016;21(2):165-75. 26420787 10.1177/1087057115607184
-
(2016)
J Biomol Screen
, vol.21
, Issue.2
, pp. 165-175
-
-
Haarhoff, Z.1
Wagner, A.2
Picard, P.3
-
114
-
-
84955509834
-
Novel Acoustic Loading of a Mass Spectrometer: Toward Next-Generation High-Throughput MS Screening
-
26721821
-
Sinclair I Stearns R Pringle S: Novel Acoustic Loading of a Mass Spectrometer: Toward Next-Generation High-Throughput MS Screening. J Lab Autom. 2016;21(1):19-26. 26721821 10.1177/2211068215619124
-
(2016)
J Lab Autom
, vol.21
, Issue.1
, pp. 19-26
-
-
Sinclair, I.1
Stearns, R.2
Pringle, S.3
-
115
-
-
85091136125
-
-
http://www.agilent.com/en-us/products/mass-spectrometry/rapidfire-high-throughput-ms-systems
-
-
-
-
116
-
-
84954528369
-
Target Identification of Compounds from a Cell Viability Phenotypic Screen Using a Bead/Lysate-Based Affinity Capture Platform
-
26676096
-
Tang H Duggan S Richardson PL: Target Identification of Compounds from a Cell Viability Phenotypic Screen Using a Bead/Lysate-Based Affinity Capture Platform. J Biomol Screen. 2016;21(2):201-11. 26676096 10.1177/1087057115622431
-
(2016)
J Biomol Screen
, vol.21
, Issue.2
, pp. 201-211
-
-
Tang, H.1
Duggan, S.2
Richardson, P.L.3
-
117
-
-
84946838742
-
Imaging mass spectrometry in drug discovery and development
-
26542100
-
Oppenheimer SR Wehr AY: Imaging mass spectrometry in drug discovery and development. Bioanalysis. 2015;7(20):2609-10. 26542100 10.4155/bio.15.202
-
(2015)
Bioanalysis
, vol.7
, Issue.20
, pp. 2609-2610
-
-
Oppenheimer, S.R.1
Wehr, A.Y.2
-
118
-
-
84887783399
-
A mimetic tissue model for the quantification of drug distributions by MALDI imaging mass spectrometry
-
24024735
-
Groseclose MR Castellino S: A mimetic tissue model for the quantification of drug distributions by MALDI imaging mass spectrometry. Anal Chem. 2013;85(21):10099-106. 24024735 10.1021/ac400892z
-
(2013)
Anal Chem
, vol.85
, Issue.21
, pp. 10099-106
-
-
Groseclose, M.R.1
Castellino, S.2
-
119
-
-
79251491350
-
A quantitation method for mass spectrometry imaging
-
21259359
-
Koeniger SL Talaty N Luo Y: A quantitation method for mass spectrometry imaging. Rapid Commun Mass Spectrom. 2011;25(4):503-10. 21259359 10.1002/rcm.4891
-
(2011)
Rapid Commun Mass Spectrom
, vol.25
, Issue.4
, pp. 503-510
-
-
Koeniger, S.L.1
Talaty, N.2
Luo, Y.3
-
120
-
-
84953790341
-
Ambient Mass Spectrometry Imaging Using Direct Liquid Extraction Techniques
-
26566087
-
Laskin J Lanekoff I: Ambient Mass Spectrometry Imaging Using Direct Liquid Extraction Techniques. Anal Chem. 2016;88(1):52-73. 26566087 10.1021/acs.analchem.5b04188
-
(2016)
Anal Chem
, vol.88
, Issue.1
, pp. 52-73
-
-
Laskin, J.1
Lanekoff, I.2
-
121
-
-
84927919393
-
From Discovery to Finished Products: Innovative Applications of Surface Mass Spectrometry in Pharmaceutical Industry
-
Talaty N Gong HH Koeniger S: From Discovery to Finished Products: Innovative Applications of Surface Mass Spectrometry in Pharmaceutical Industry. Microscopy and Microanalysis. 2014;20(S3):1412-1413. 10.1017/S1431927614008794
-
(2014)
Microscopy and Microanalysis
, vol.20
, pp. 1412-1413
-
-
Talaty, N.1
Gong, H.H.2
Koeniger, S.3
-
122
-
-
84890818650
-
Ambient mass spectrometry technologies for the detection of falsified drugs
-
Culzoni MJ Dwivedi P Green MD: Ambient mass spectrometry technologies for the detection of falsified drugs. Med Chem Commun. 2014;5:9-19. 10.1039/C3MD00235G
-
(2014)
Med Chem Commun
, vol.5
, pp. 9-19
-
-
Culzoni, M.J.1
Dwivedi, P.2
Green, M.D.3
-
123
-
-
85091151542
-
-
https://www.bruker.com/products/mass-spectrometry-and-separations/lc-ms/o-tof/timstof/overview.html
-
-
-
-
124
-
-
84897524702
-
Chemical vapor deposition of aminopropyl silanes in microfluidic channels for highly efficient microchip capillary electrophoresis-electrospray ionization-mass spectrometry
-
24655020
-
Batz NG Mellors JS Alarie JP: Chemical vapor deposition of aminopropyl silanes in microfluidic channels for highly efficient microchip capillary electrophoresis-electrospray ionization-mass spectrometry. Anal Chem. 2014;86(7):3493-500. 24655020 10.1021/ac404106u
-
(2014)
Anal Chem
, vol.86
, Issue.7
, pp. 3493-3500
-
-
Batz, N.G.1
Mellors, J.S.2
Alarie, J.P.3
-
125
-
-
84959506734
-
Topographical and Chemical Imaging of a Phase Separated Polymer Using a Combined Atomic Force Microscopy/Infrared Spectroscopy/Mass Spectrometry Platform
-
26890087
-
Tai T Karacsony O Bocharova V: Topographical and Chemical Imaging of a Phase Separated Polymer Using a Combined Atomic Force Microscopy/Infrared Spectroscopy/Mass Spectrometry Platform. Anal Chem. 2016;88(5):2864-70. 26890087 10.1021/acs.analchem.5b04619
-
(2016)
Anal Chem
, vol.88
, Issue.5
, pp. 2864-2870
-
-
Tai, T.1
Karacsony, O.2
Bocharova, V.3
-
126
-
-
85091141998
-
-
https://www.fluidigm.com/products/helios
-
-
-
-
127
-
-
84965146271
-
Mass Cytometry: Single Cells, Many Features
-
27153492, 4860251
-
Spitzer MH Nolan GP: Mass Cytometry: Single Cells, Many Features. Cell. 2016;165(4):780-91. 27153492 10.1016/j.cell.2016.04.019 4860251
-
(2016)
Cell
, vol.165
, Issue.4
, pp. 780-791
-
-
Spitzer, M.H.1
Nolan, G.P.2
-
128
-
-
84926342669
-
Immunohistochemistry and mass spectrometry for highly multiplexed cellular molecular imaging
-
25730370
-
Levenson RM Borowsky AD Angelo M: Immunohistochemistry and mass spectrometry for highly multiplexed cellular molecular imaging. Lab Invest. 2015;95(4):397-405. 25730370 10.1038/labinvest.2015.2
-
(2015)
Lab Invest
, vol.95
, Issue.4
, pp. 397-405
-
-
Levenson, R.M.1
Borowsky, A.D.2
Angelo, M.3
|