Chemical aspects of the extractive methods of ambient ionization mass spectrometry

Annual Review of Physical Chemistry

Volumn 64, Issue , 2013, Pages 481-505

  Badu Tawiah, Abraham K ^a   Eberlin, Livia S ^a   Ouyang, Zheng ^b   Cooks, R Graham ^a  

^a PURDUE UNIVERSITY   (United States)

^b PURDUE UNIVERSITY   (United States)

Author keywords

Desorption electrospray ionization (DESI); Electrospray; Ionic reactions; Ionization mechanisms; Organic reactions

Indexed keywords

BIOLOGICAL MATERIALS; CHEMICAL ANALYSIS; DESORPTION; DIAGNOSIS; ELECTROSPRAY IONIZATION; MASS SPECTROMETRY; POROUS MATERIALS; REACTION RATES;

AMBIENT IONIZATIONS; ANALYTES; CHEMICAL ASPECTS; DESORPTION ELECTROSPRAY IONIZATION; ELECTROSPRAYS; IONIC REACTION; IONIZATION MASS SPECTROMETRY; IONIZATION MECHANISMS; ORGANIC REACTION;

DROPS;

ANIMAL; ECONOMICS; ELECTROSPRAY MASS SPECTROMETRY; EQUIPMENT; EQUIPMENT DESIGN; HUMAN; METHODOLOGY; REVIEW; SYNTHESIS;

ANIMALS; CHEMISTRY TECHNIQUES, SYNTHETIC; EQUIPMENT DESIGN; HUMANS; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION;

EID: 84875997410     PISSN: 0066426X     EISSN: None     Source Type: Book Series    
DOI: 10.1146/annurev-physchem-040412-110026     Document Type: Article

References (148)

1. Munson MSB, Field FH. 1966. Chemical ionization mass spectrometry. I. General introduction. J. Am. Chem. Soc. 88:2621-30
2. Fenn JB, Mann M, Meng CK, Wong SF, Whitehouse CM. 1989. Electrospray ionization for mass spectrometry of large biomolecules. Science 246:64-71
3. Cole RB. 1997. Electrospray Ionization Mass Spectrometry: Fundamentals, Instrumentation and Applications. New York: Wiley
4. Tanaka K, Waki H, Ido Y, Akita S, Yoshida Y, Yoshida T. 1988. Protein and polymer analyses up to m/ζ 100,000 by laser ionization time-of flight mass spectrometry. Rapid Commun. Mass Spectrom. 2:151-53
5. KarasM, Hillenkamp F. 1988. Laser desorption ionization of proteins with molecular weight exceeding 10,000 Daltons. Anal. Chem. 60:2299-301
6. Cooks RG, Ouyang Z, Takats Z, Wiseman JM. 2006. Ambient mass spectrometry. Science 311:1566-70
7. Kakhniashvili DG, Bulla LA Jr, Goodman SR. 2004. The human erythrocyte proteome: analysis by ion trap mass spectrometry. Mol. Cell. Proteomics 3:501-9
8. Van Noorden R. 2007. Mass spectrometry tackles big problem. Chem. World 4(10):12
9. Blackwell A, Dodds E, Bandarian V, Wysocki VH. 2011. Revealing the quaternary structure of a heterogeneous noncovalent protein complex through surface-induced dissociation. Anal. Chem. 83:2862-65
10. Zhou M, Sandercock AM, Fraser CS, Ridlova G, Stephens E, et al. 2008. Mass spectrometry reveals modularity and a complete subunit interaction map of the eukaryotic translation factor eIF3. Proc. Natl. Acad. Sci. USA 105:18139-44
11. Uetrecht C, Versluis C, Watts NR, Roos WH,Wuite GJL, et al. 2008. High-resolution mass spectrometry of viral assemblies: molecular composition and stability of dimorphic hepatitis B virus capsids. Proc. Natl. Acad. Sci. USA 105:9216-20
12. Kondrat RW, Cooks RG, McLaughlin JL. 1978. Alkaloids in whole plant material: direct analysis by kinetic energy spectrometry. Science 199:978-80
13. Kondrat RW, Cooks RG. 1978. Direct analysis of mixtures by mass spectrometry. Anal. Chem. 50:A81
14. Song Y, Cooks RG. 2007. Reactive desorption electrospray ionization for selective detection of the hydrolysis products of toxic phosphonate esters. J. Mass Spectrom. 42:1086-92
15. Chen H, Cotte-Rodriguez I, Cooks RG. 2006. cis-Diol functional group recognition by reactive desorption electrospray ionization (DESI). Chem. Commun. 2006:597-99
16. Jackson AU, Tata A, Wu C, Perry RH, Haas G, et al. 2009. Direct analysis of Stevia leaves for diterpene glycosides by desorption electrospray ionization mass spectrometry. Analyst 134:867-74
17. Myung S,Wiseman JM, Valentine SJ, Takats Z, Cooks RG, Clemmer DE. 2006. Coupling desorption electrospray ionization (DESI) with ion mobility/mass spectrometry for analysis of protein structure: evidence for desorption of folded and denatured states. J. Phys. Chem. B 110:5045-51
18. Ifa DR, Wu C, Ouyang Z, Cooks RG. 2010. Desorption electrospray ionization and other ambient ionization methods: current progress and preview. Analyst 135:669-81
19. Fico M, Yu M, Ouyang Z, Cooks RG, Chappell WJ. 2007. Miniaturization and geometry optimization of a polymer-based rectilinear ion trap. Anal. Chem. 79:8076-82
20. Tadjimukhamedov F, Jackson AU, Nazarov EG,Ouyang Z,Cooks RG. 2010. Evaluation of a differential mobility spectrometer/miniature mass spectrometer system. J. Am. Soc. Mass Spectrom. 21:1477-81
21. Mulligan CC, Justes DR, Noll RJ, Sanders NL, Laughlin BC, Cooks RG. 2006. Direct monitoring of gaseous toxic compounds in air using a portable mass spectrometer. Analyst 131:556-67
22. Mulligan CC, Talaty NN, Cooks RG. 2006. Desorption electrospray ionization with a portable mass spectrometer: in-situ analysis of ambient surfaces. Chem. Commun. 2006:1709-11
23. Ouyang Z, Cooks RG. 2009. Miniature mass spectrometers. Annu. Rev. Anal. Chem. 2:187-214
24. Harris, GA, Galhena AS, Fernandez FM. 2011. Ambient sampling/ionization mass spectrometry: applications and current trends. Anal. Chem. 83:4508-38
25. Huanga M-Z, Chenga S-C, Choa Y-T, Shiea J. 2011. Ambient ionization mass spectrometry: A tutorial. Anal. Chim. Acta 702:1-15
26. Weston DJ. 2010. Ambient ionization mass spectrometry: current understanding of mechanistic theory; analytical performance and application areas. Analyst 135:661-68
27. Huang M-Z, Yuan C-H, Cheng S-C, Cho Y-T, Shiea J. 2010. Ambient ionization mass spectrometry. Annu. Rev. Anal. Chem. 3:43-65
28. Van Berkel GJ, Pasilis SP, Ovchinnikova O. 2008. Established and emerging atmospheric pressure surface sampling/ionization techniques for mass spectrometry. J. Mass Spectrom. 43:1161-80
29. Takats Z, Wiseman JM, Gologan B, Cooks RG. 2004. Mass spectrometry sampling under ambient conditions with desorption electrospray ionization. Science 306:471-73
30. Haddad R, Sparrapan R, Kotiaho T, Eberlin MN. 2008. Easy ambient sonic-spray ionization-membrane interface mass spectrometry for direct analysis of solution constituents. Anal. Chem. 80:898-903
31. Chan CC, Bolgar MS,Miller SA, Attygalle AB. 2010. Desorption ionization by charge exchange (DICE) for sample analysis under ambient conditions by mass spectrometry. J. Am. Soc.Mass Spectrom. 21:1554- 60
32. Chipuk JE, Brodbelt JS. 2008. Transmission mode desorption electrospray ionization. J. Am. Soc. Mass Spectrom. 19:1612-20
33. Roach PJ, Laskin J, Laskin A. 2010. Nanospray desorption electrospray ionization: an ambient method for liquid-extraction surface sampling in mass spectrometry. Analyst 135:2233-36
34. Hiraoka K, Nishidate K, Mori K, Asakawa D, Suzuki S. 2007. Development of probe electrospray using a solid needle. Rapid Commun. Mass Spectrom. 21:3139-44
35. Van Berkel GJ, KerteszV,KingRC. 2009. High-throughput mode liquidmicrojunction surface sampling probe. Anal. Chem. 81:7096-101
36. Wang H, Liu J, Cooks RG, Ouyang Z. 2010. Paper spray for direct analysis of complex mixtures using mass spectrometry. Angew. Chem. Int. Ed. Engl. 49:877-80
37. Cody RB, Laramee JA, Durst HD. 2005. Versatile new ion source for the analysis of materials in open air under ambient conditions. Anal. Chem. 77:2297-302
38. Harper JD, Charipar NA,Mulligan CC, Zhang X,Cooks RG, Ouyang Z. 2008. Low temperature plasma probe for ambient desorption ionization. Anal. Chem. 80:9097-104
39. Andrade F, Shelley J, Wetzel W, Webb M, Gamez G, et al. 2008. Atmospheric pressure chemical ionization source. 2. Desorption-ionization for the direct analysis of solid compounds. Anal. Chem. 80:2654-63
40. Takats Z, Cotte-Rodriguez I, Talaty N, Chen H, Cooks RG. 2005. Direct, trace level detection of explosives on ambient surfaces by desorption electrospray ionizationmass spectrometry. Chem. Commun. 2005:1950-52
41. Wang H, Sun W, Zhang J, Yang X, Lin T, Ding L. 2010. Desorption corona beam ionization source for mass spectrometry. Analyst 135:688-95
42. Na N, Zhao M, Zhang S, Yang C. Zhang X. 2007. Development of a dielectric barrier discharge ion source for ambient mass spectrometry. J. Am. Soc. Mass Spectrom. 18:1859-62
43. HuangMZ, Hsu HJ, Wu CI, Lin SY,Ma YL, et al. 2007. Characterization of the chemical components on the surface of different solidswith electrospray-assisted laser desorption ionizationmass spectrometry. Rapid Commun. Mass Spectrom. 21:1767-75
44. Nemes P, Vertes A. 2007. Laser ablation electrospray ionization for atmospheric pressure, in vivo, and imaging mass spectrometry. Anal. Chem. 79:8098-106
45. Rezenom YH, Dong J, Murray KK. 2008. Infrared laser-assisted desorption electrospray ionizationmass spectrometry. Analyst 133:226-32
46. Sampson JS, Muddiman DC. 2009. Atmospheric pressure infrared (10.6 μm) laser desorption electrospray ionization (IR-LDESI) coupled to a LTQ Fourier transform ion cyclotron resonance mass spectrometer. Rapid Commun. Mass Spectrom. 23:1989-92
47. Cheng S-C, Cheng T-L, Chang H-C, Shiea J. 2009. Using laser-induced acoustic desorption/ electrospray ionization mass spectrometry to characterize small organic and large biological compounds in the solid state and in solution under ambient conditions. Anal. Chem. 81:868-74
48. Chen H, Wortmann A, Zenobi R. 2007. Neutral desorption sampling coupled to extractive electrospray ionization mass spectrometry for rapid differentiation of biosamples by metabolomic fingerprinting. J. Mass Spectrom. 42:1123-35
49. Dixon RB, Sampson JS, Muddiman DC. 2009. Generation of multiply charged peptides and proteins by radio frequency acoustic desorption and ionization for mass spectrometric detection. J. Am. Soc. Mass Spectrom. 20:597-600
50. McEwen CN,McKay RG, Larsen BS. 2005. Analysis of solids, liquids, and biological tissues using solids probe introduction at atmospheric pressure on commercial LC/MS instruments. Anal. Chem. 77:7826-31
51. Galhena AS, Harris GA, Nyadong L, Murray KK, Fernandez FM. 2010. Small molecule ambient mass spectrometry imaging by infrared laser ablation metastable-induced chemical ionization. Anal. Chem. 82:2178-81
52. Schafer KC, Denes J, Albrecht K, Szaniszlo T, Balog J, et al. 2009. In vivo, in situ tissue analysis using rapid evaporative ionization mass spectrometry. Angew. Chem. Int. Ed. Engl. 48:8240-42
53. Haapala M, Pol J, Saarela V, Arvola V, Kotiaho T, et al. 2007. Desorption atmospheric pressure photoionization. Anal. Chem. 79:7867-72
54. Steeb J, Galhena AS, Nyadong L, Janata J, Fernandez FM. 2009. Beta electron-assisted direct chemical ionization (BADCI) probe for ambient mass spectrometry. Chem. Commun. 2009:4699-701
55. Chen H, Venter A, Cooks RG. 2006. Extractive electrospray ionization for direct analysis of undiluted urine, milk and other complex mixtures without sample preparation. Chem. Commun. 2006:2042-44
56. Dixon RB, Sampson JS, Hawkridge AM,Muddiman DC. 2008. Ambient aerodynamic ionization source for remote analyte sampling and mass spectrometric analysis. Anal. Chem. 80:5266-71
57. Shelley JT, Ray SJ, HieftjeGM. 2008. Laser ablation coupled to a flowing atmospheric pressure afterglow for ambient mass spectral imaging. Anal. Chem. 80:8308-13
58. Crotti S Traldi P. 2009. Aspects of the role of surfaces in ionization processes. Comb. Chem. High Throughput Screen. 12:125-36
59. Martin AN, Farquar GR, Steele PT, Jones AD, Frank M. 2009. Use of single particle aerosol mass spectrometry for the automated nondestructive identification of drugs in multicomponent samples. Anal. Chem. 81:9336-42
60. Wu J, Hughes CS, Picard P, Letarte S, Gaudreault M, et al. 2007. High-throughput cytochrome P450 inhibition assays using laser diode thermal desorption-atmospheric pressure chemical ionization-tandem mass spectrometry. Anal. Chem. 79:4657-65
61. Wetzel WC, Andrade FJ, Broekaert JAC, Hieftje GM. 2006. Overcoming interferences in inductively coupled plasma mass spectrometry via gas-flow modulation: Part 2. Correlation methods. J. Anal. At. Spectrom. 21:750-56
62. Heron SR, Wilson R, Shaffer SA, Goodlett DR, Cooper JM. 2010. Surface acoustic wave nebulization of peptides as a microfluidic interface for mass spectrometry. Anal. Chem. 82:3985-89
63. Chen T-Y, Lin J-Y, Chen J-Y, Chen Y-C. 2010. Ultrasonication-assisted spray ionization mass spectrometry for the analysis of biomolecules in solution. J. Am. Soc. Mass Spectrom. 21:1547-53
64. Basile F, Zhang S, Shin Y-S, Drolet B. 2010. Atmospheric pressure-thermal desorption (AP-TD)/ electrospray ionization-mass spectrometry for the rapid analysis of Bacillus spores. Analyst 135:797-803
65. Symonds JM, Galhena AS, Fernandez FM, Orlando TM. 2010. Microplasma discharge ionization source for ambient mass spectrometry. Anal. Chem. 82:621-27
66. Chen H, Ouyang Z, Cooks RG. 2006. Thermal production and reactions of organic ions at atmospheric pressure. Angew. Chem. Int. Ed. Engl. 45:3656-60
67. Nyadong L,Galhena AS, Fernandez FM. 2009. Desorption electrospray/ metastable-induced ionization: A flexible multimode ambient ion generation technique. Anal. Chem. 81:7788-94
68. Neidholdt EL, Beauchamp JL. 2011. Switched ferroelectric plasma ionizer (SwiFerr) for ambient mass spectrometry. Anal. Chem. 83:38-43
69. Brady JJ, Judge EJ, Levis RJ. 2009. Mass spectrometry of intact neutral macromolecules using intense non-resonant femtosecond laser vaporization with electrospray post-ionization. Rapid Commun. Mass Spectrom. 23:3151-57
70. Ratcliffe LV,Rutten FJ, Barrett DA, Whitmore T, Seymour D, et al. 2007. Surface analysis under ambient conditions using plasma-assisted desorption/ionization mass spectrometry. Anal. Chem. 79:6094-101
71. Takats Z, Wiseman JM, Cooks RG. 2005. Ambient mass spectrometry using desorption electrospray ionization (DESI): instrumentation, mechanisms and applications in forensics, chemistry, and biology. J. Mass Spectrom. 40:1261-75
72. Venter A, Sojka PE,CooksRG. 2006. Droplet dynamics and ionizationmechanisms in desorption electrospray ionization mass spectrometry. Anal. Chem. 78:8549-55
73. Costa AB, Cooks RG. 2007. Simulation of atmospheric transport and droplet-thin film collisions in desorption electrospray ionization. Chem. Commun. 2007:3915-17
74. Costa AB, Cooks RG. 2008. Simulated splashes: elucidating the mechanism of desorption electrospray ionization mass spectrometry. Chem. Phys. Lett. 464:1-8
75. Pasilis SP, Kertesz V, Van Berkel GJ. 2007. Surface scanning analysis of planar arrays of analytes with desorption electrospray ionization-mass spectrometry. Anal. Chem. 79:5956-62
76. Wood MC, Busby DK, Farnsworth PB. 2009. Microscopic imaging of glass surfaces under the effects of desorption electrospray ionization. Anal. Chem. 81:6407-15
77. Augusti R, Chen H, Eberlin LS, Nefliu M, Cooks RG. 2006. Atmospheric pressure Eberlin transacetalization reactions in the heterogeneous. Int. J. Mass Spectrom. 253:281-87
78. Girod M, Moyano E, Campbell DI,Cooks RG. 2011. Accelerated bimolecular reactions in microdroplets studied by desorption electrospray ionization mass spectrometry. Chem. Sci. 2:501-10
79. Barbara EJ, Eyler RJ, Powell HD. 2008. Reactive desorption electrospray ionization for rapid screening of guests for supramolecular inclusion complexes. Rapid Commun. Mass Spectrom. 22:4121-28
80. Huang G, Chen H, Zhang X, Cooks RG, Ouyang Z. 2007. Rapid screening of anabolic steroids in urine by reactive desorption electrospray ionization. Anal. Chem. 79:8327-32
81. Nyadong L, Green MD, De Jesus VR, Newton PN, Fernandez FM. 2007. Reactive desorption electrospray ionization linear ion trap mass spectrometry of latest-generation counterfeit antimalarials via noncovalent complex formation. Anal. Chem. 79:2150-57
82. Nefliu M, Moore C, Cooks RG. 2006. Enhanced desorption ionization using oxidizing electrosprays. J. Am. Soc. Mass Spectrom. 17:1091-95
83. Zhang Y, Yuan Z,Dewald HD, ChenH. 2011. Coupling of liquid chromatography with mass spectrometry by desorption electrospray ionization (DESI). Chem. Commun. 47:4171-73
84. ZhangY,DewaldHD,ChenH. 2011. On-linemass spectrometric analysis of proteins/peptides following electrolytic reduction of disulfide bonds. J. Proteome Res. 10:1293-304
85. Lu M, Wolff C, Cui W, Chen H. 2012. Investigation of some biologically relevant redox reactions using electrochemical mass spectrometry interfaced by desorption electrospray ionization. Anal. Bioanal. Chem. 403:355-65
86. Miao Z, Chen H, Liu P, Liu Y. 2011. Development of submillisecond time-resolved mass spectrometry using desorption electrospray ionization. Anal. Chem. 83:3994-97
87. Jackson AU, Shum T, Sokol E, Dill A, Cooks RG. 2011. Enhanced detection of olefins using ambient ionizationmass spectrometry: Ag+ adducts of biologically relevant alkenes. Anal. Bioanal. Chem. 399:367- 76
88. Green FM, Salter TL,Gilmore IS, Stokes P, O'ConnorG. 2010. The effect of electrospray solvent composition on desorption electrospray ionisation (DESI) efficiency and spatial resolution. Analyst 135:731- 37
89. Badu-Tawiah AK, Bland C, Campbell DI, Cooks RG. 2010. Non-aqueous spray solvents and solubility effects in desorption electrospray ionization. J. Am. Soc. Mass Spectrom. 21:572-79
90. Badu-Tawiah AK, Cooks RG. 2010. Enhanced ion signals in desorption electrospray ionization using surfactant spray solutions. J. Am. Soc. Mass Spectrom. 21:1423-31
91. Eberlin LS, Ferreira CR, Dill AL, Ifa DR, Cooks RG. 2011. Desorption electrospray ionization mass spectrometry for lipid characterization and biological tissue imaging. Biochim. Biophys. Acta 1811:946-60
92. Wiseman JM, Li JB. 2010. Elution, partial separation, and identification of lipids directly from tissue slices on planar chromatography media by desorption electrospray ionization mass spectrometry. Anal. Chem. 82:8866-74
93. Eberlin LS, Ferreira CR, Dill AL, Ifa DR, Cheng L, Cooks RG. 2011. Nondestructive, histologically compatible tissue imaging by desorption electrospray ionization mass spectrometry. Chembiochemistry 12:2129-32
94. Wu C, Ifa DR, Manicke NE, Cooks RG. 2009. Rapid, direct analysis of cholesterol by charge labeling in reactive desorption electrospray ionization. Anal. Chem. 81:7618-24
95. Manicke NE, Nefliu M, Wu C, Woods JW, Reiser V, et al. 2009. Imaging of lipids in atheroma by desorption electrospray ionization mass spectrometry. Anal. Chem. 81:8702-7
96. Wu C, Ifa DR, Manicke NE, Cooks RG. 2010. Molecular imaging of adrenal gland by desorption electrospray ionization mass spectrometry. Analyst 135:28-32
97. Dill AL, Eberlin LS, Ifa DR, Cooks RG. 2011. Perspectives in imaging using mass spectrometry. Chem. Commun. 47:2741-46
98. Eberlin LS, Dill AL, Golby AJ, Ligon KL, Wiseman JM, et al. 2010. Discrimination of human astrocytoma subtypes by lipid analysis using desorption electrospray ionization imaging mass spectrometry. Angew. Chem. Int. Ed. Engl. 49:5953-56
99. Eberlin LS, Liu X, Ferreira CR, Santagata S, Agar NYR, Cooks RG. 2011. DESI then MALDI mass spectrometry imaging of lipid and protein distributions in single tissue sections. Anal. Chem. 83:8366-71
100. Chin JT,Wheeler SL,Klibanov AM. 1994. Communication to the editor on protein solubility in organic solvents. Biotechnol. Bioeng. 44:140-45
101. Kertesz V, Van Berkel GJ. 2008. Improved imaging resolution in desorption electrospray ionization mass spectrometry. Rapid Commun. Mass Spectrom. 22:2639-44
102. Wiseman JM, IfaDR, Venter A, CooksRG. 2008. Ambient molecular imaging by desorption electrospray ionization mass spectrometry. Nat. Protoc. 3:517-24
103. Campbell DI, Ferreira CR, Eberlin LS, Cooks RG. 2012. Improved spatial resolution in the imaging of biological tissue using desorption electrospray ionization. Anal. Bioanal. Chem. 404:389-98
104. Perry RH, Splendore M, Chien A, Davis NK, Zare RN. 2011. Detecting reaction intermediates using DESI. in liquids on the millisecond time scale using desorption electrospray ionization. Angew. Chem. Int. Ed. Engl. 50:250-54
105. Perry RH, Brownell KR, Chingin K, Cahill TJ III, Waymouth RM, Zare RN. 2012. Transient Ru- methyl formate intermediates generated with bifunctional transfer hydrogenation catalysts. Proc. Natl. Acad. Sci. USA 109:2246-50
106. XuG, Chen B,GuoB,Heb D, Yao S. 2011. Detection of intermediates for the Eschweiler-Clarke reaction by liquid-phase reactive desorption electrospray ionization mass spectrometry. Analyst 136:2385-90
107. Badu-Tawiah AK, Cyriac J, Cooks RG. 2012. Reactions of organic ions at ambient surfaces in a solventfree environment. J. Am. Soc. Mass Spectrom. 23:842-49
108. Chen H, Eberlin LS, Nefliu M, Augusti R, Cooks RG. 2008. Organic reactions of ionic intermediates promoted by atmospheric-pressure thermal activation. Angew. Chem. Int. Ed. Engl. 47:3422-25
109. Cotte-Rodriguez I, Takats Z, Talaty N, Chen H, Cooks RG. 2005. Desorption electrospray ionization of explosives on surfaces: sensitivity and selectivity enhancement by reactive desorption electrospray ionization. Anal. Chem. 77:6755-64
110. Cotte-Rodriguez I, Cooks RG. 2006. Non-proximate detection of explosives and chemical warfare agent simulants by desorption electrospray ionization mass spectrometry. Chem. Commun. 2006:2968-70
111. Cotte-Rodriguez I,Hernandez-Soto H, Chen H, CooksRG. 2008. In-situ trace detection of peroxide explosives by desorption electrospray ionization and desorption atmospheric pressure chemical ionization. Anal. Chem. 80:1512-19
112. Badu-Tawiah AK, Campbell ID, Cooks RG. 2012. Accelerated C-N bond formation in dropcast thin films on ambient surfaces. J. Am. Soc. Mass Spectrom. 23:1077-84
113. Ohta K, Morokuma K. 1985. An MO study of SN2 reactions in hydrated gas clusters: (H2O)nOH; + CH3Cl(H2O)m →HOCH3 +Cl; + (n + m)H2O. J. Phys. Chem. 89:5845-49
114. Bohme DK, Raksit AB. 1984. Gas-phase measurements of the influence of stepwise solvation on the kinetics of nucleophilic displacement reactions with chloromethane and bromomethane at room temperature. J. Am. Chem. Soc. 106:3447-52
115. Nguyen TB, Lee PB, Updyke KM, Bones DL, Laskin J, et al. 2012. Formation of nitrogen- and sulfurcontaining light-absorbing compounds accelerated by evaporation of water from secondary organic aerosols. J. Geophys. Res. 117:D01207
116. Chen Y, Bond TC. 2010. Light absorption by organic carbon from wood combustion. Atmos. Chem. Phys. 10:1773-87
117. Strekowski RS, Remorov R, George C. 2003. Direct kinetic study of the reaction of Cl2 - radical anions with ethanol at the air-water interface. J. Phys. Chem. A 107:2497-504
118. Kuznetsova M, Lee C. 2001. Enhanced extracellular enzymatic peptide hydrolysis in the sea surface microlayer. Mar. Chem. 73:319-32
119. Jorabchi K, Smith LM. 2009. Single droplet separations and surface partition coefficient measurements using laser ablation mass spectrometry. Anal. Chem. 81:9682-88
120. Ablyazov PN, Vasilevskaya VV, Khokhlov AR. 2007. Reactions in surface microreactors: computer simulation. Colloid J. 69:265-71
121. Badu-Tawiah AK, Campbell ID, Cooks RG. 2012. Reactions of micro-solvated organic compounds at ambient surfaces: droplet velocity, charge state and solvent effects. J. Am. Soc.Mass Spectrom. 23:1077-84
122. Badu-Tawiah AK,Wu C, Cooks RG. 2011. Ambient ion soft landing. Anal. Chem. 83:2648-54
123. Dwars T, Paetzold E, Oehme G. 2005. Reactions in micellar systems. Angew. Chem. Int. Ed. Engl. 44:7174-99
124. Mason TJ. 1999. Sonochemistry. New York: Oxford Univ. Press
125. Rehman A. 2010. Methods of electrospray chemical synthesis and devices for use therein. US Patent No. 2012/0012453 A1
126. Mueller T, Badu-Tawiah AK, Cooks RG. 2012. Accelerated carbon-carbon bond-forming reactions in preparative electrospray. Angew. Chem. Int. Ed. Engl. 51:11832-35
127. Badu-Tawiah AK. 2012. Ion generation, ion collection and ionic reactions outside the mass spectrometer. PhD diss., Purdue Univ.
128. Badu-Tawiah AK, Li A, Jjunju FPM, Cooks RG. 2012. Peptide cross-linking at ambient surfaces by reactions of nanosprayed molecular cations. Angew. Chem. Int. Ed. Engl. 51:9417-21
129. Laskin J, Heath BS, Roach PJ, Cazares L, Semmes OJ. 2012. Tissue imaging using nanospray desorption electrospray ionization mass spectrometry. Anal. Chem. 84:141-48
130. Eckert PA, Roach PJ, Laskin A, Laskin J. 2012. Chemical characterization of crude petroleum using nanospray desorption electrospray ionization coupled with high-resolution mass spectrometry. Anal. Chem. 84:1517-25
131. Van Berkel GJ, Kertesz V. 2010. Electrochemistry of the electrospray ion source. In Electrospray and MALDI Mass Spectrometry: Fundamentals, Instrumentation, Practicalities, and Biological Applications, ed. RB Cole, pp. 75-122. New York: Wiley. 2nd ed.
132. Abonnene M, Qiao L, Liu BH, Girault HH. 2010. Electrochemical aspects of electrospray and later desorption/ionization for mass spectrometry. Annu. Rev. Anal. Chem. 3:230-54
133. Liu P, Lanekoff IT, Laskin J, Dewald HD, Chen H. 2012. Study of electrochemical reactions using nanospray desorption electrospray ionization mass spectrometry. Anal. Chem. 84:5737-43
134. Van Berkel GJ, KerteszV,KingRC. 2009. High-throughput mode liquidmicrojunction surface sampling probe. Anal. Chem. 81:7096-101
135. Van Berkel GJ, Kertesz V. 2009. Electrochemically initiated tagging of thiols using an electrospray ionization based liquid microjunction surface sampling probe two-electrode cell. Rapid Commun. Mass Spectrom. 23:1380-86
136. Ford MJ, Kertesz V, Van Berkel GJ. 2005. Thin-layer chromatography/ electrospray ionization triplequadrupole linear ion trap mass spectrometry system: analysis of rhodamine dyes separated on reversedphase C-8 plates. J. Mass Spectrom. 40:866-75
137. Ford MJ, Van Berkel GJ. 2004. An improved thin-layer chromatography/mass spectrometry coupling using a surface sampling probe electrospray ion trap system. Rapid Commun. Mass Spectrom. 18:1303-9
138. Van Berkel GJ, Ford MJ, Doktycz MJ, Kennel SJ. 2006. Evaluation of a surface-sampling probe electrospray mass spectrometry system for the analysis of surface-deposited and affinity-captured proteins. Rapid Commun. Mass Spectrom. 20:1144-52
139. ManickeNE, Abu-Rabie P, Spooner N, Ouyang Z, Cooks RG. 2011. Quantitative analysis of therapeutic drugs in dried blood spot samples by paper spray mass spectrometry: an avenue to therapeutic drug monitoring. J. Am. Soc. Mass Spectrom. 22:1501-7
140. Zhang Z, XuW,ManickeNE, Cooks RG, Ouyang Z. 2012. Silica coated paper substrate for paper-spray analysis of therapeutic drugs in dried blood spots. Anal. Chem. 84:931-38
141. Liu J, Wang H, Manicke NE, Lin J-M, Cooks RG, Ouyang Z. 2010. Development, characterization, and application of paper spray ionization. Anal. Chem. 82:2463-71
142. Yang Q, Wang H, Maas JD, Chappell WJ, Manicke NE, et al. 2012. Paper spray ionization devices for direct, biomedical analysis using mass spectrometry. Int. J. Mass Spectrom. 312:201-7
143. Espy RD, Muliadi AR, Ouyang Z, Cooks RG. 2012. Spray mechanism in paper spray ionization. Int. J. Mass Spectrom. 325-327:167-71
144. Li A, Wang H, Ouyang Z, Cooks RG. 2011. Paper spray ionization of polar analytes using non-polar solvents. Chem. Commun. 47:2811-13
145. Adamson AW, Slawson V. 1981. Evaporative hopping as a mechanism for surface mobility in the autoxidation of adsorbed fatty acids. J. Phys. Chem. 85:116-19
146. Liu J,Wang H, Cooks RG, Ouyang Z. 2011. Leaf spray: direct chemical analysis of plant material and living plants by mass spectrometry. Anal. Chem. 83:7608-13
147. Liu J, Cooks RG, Ouyang Z. 2011. Biological tissue diagnostics using needle biopsy and spray ionization mass spectrometry. Anal. Chem. 83:9221-25
148. Tadjimukhamedov FK, Huang G, Ouyang Z, Cooks RG. 2012. Rapid detection of urushiol allergens of Toxicodendron genus using leaf spray mass spectrometry. Analyst 137:1082-84