Profiling of small molecules by chemical proteomics

Methods in Molecular Biology

Volumn 1394, Issue , 2016, Pages 211-218

  Huber, Kilian V M ^a   Superti Furga, Giulio ^a  

^a NONE

Author keywords

Chemical proteomics; Drug discovery; Mode of action; Target deconvolution

Indexed keywords

NATURAL PRODUCT; SMALL MOLECULE TRANSPORT AGENT; PROTEIN; PROTEOME;

COLUMN CHROMATOGRAPHY; CONTROLLED STUDY; DRUG DETERMINATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HIGH THROUGHPUT SCREENING; MASS SPECTROMETRY; NUCLEOPHILICITY; PROTEIN INTERACTION; PROTEIN PROCESSING; PROTEOMICS; ANIMAL; CHEMISTRY; HUMAN; PROCEDURES;

ANIMALS; HUMANS; PROTEINS; PROTEOME; PROTEOMICS;

EID: 84951856514     PISSN: 10643745     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-1-4939-3341-9_15     Document Type: Chapter

References (15)

1. Swinney DC, Anthony J (2011) How were new medicines discovered? Nat Rev Drug Discov 10(7):507-519
2. Schenone M, Dancik V, Wagner BK et al (2013) Target identification and mechanism of action in chemical biology and drug discovery. Nat Chem Biol 9(4):232-240
3. Sillaber C, Herrmann H, Bennett K et al (2009) Immunosuppression and atypical infections in CML patients treated with dasatinib at 140 mg daily. Eur J Clin Invest 39(12):1098-1109
4. Terstappen GC, Schlupen C, Raggiaschi R et al (2007) Target deconvolution strategies in drug discovery. Nat Rev Drug Discov 6(11):891-903
5. Brown EJ, Albers MW, Bum Shin T et al (1994) A mammalian protein targeted by G1-arresting rapamycin-receptor complex. Nature 369(6483):756-758
6. Harding MW, Galat A, Uehling DE et al (1989) A receptor for the immuno-suppressant FK506 is a cis-trans peptidyl-prolyl isomerase. Nature 341(6244):758-760
7. Taunton J, Hassig CA, Schreiber SL (1996) A mammalian histone deacetylase related to the yeast transcriptional regulator Rpd3p. Science 272(5260):408-411
8. Ito T, Ando H, Suzuki T et al (2010) Identification of a primary target of thalidomide teratogenicity. Science 327(5971): 1345-1350
9. Sun L, Wang H, Wang Z et al (2012) Mixed lineage kinase domain-like protein mediates necrosis signaling downstream of RIP3 kinase. Cell 148(1-2):213-227
10. Huber KVM, Salah E, Radic B et al (2014) Stereospecific targeting of MTH1 by (S)crizotinib as an anticancer strategy. Nature 508(7495):222-227
11. Rix U, Superti-Furga G (2009) Target profiling of small molecules by chemical proteomics. Nat Chem Biol 5(9):616-624
12. Nomura DK, Dix MM, Cravatt BF (2010) Activity-based protein profiling for biochemical pathway discovery in cancer. Nat Rev Cancer 10(9):630-638
13. Savitski MM, Reinhard FBM, Franken H et al (2014) Tracking cancer drugs in living cells by thermal profiling of the proteome. Science 346(6205):1255784
14. Huber KVM, Olek KM, Müller AC et al (2015) Proteome-wide drug and metabolite interaction mapping by thermal-stability profiling. Nat Meth 12(11):1055-1057
15. Schirle M, Bantscheff M, Kuster B (2012) Mass spectrometry-based proteomics in preclinical drug discovery. Chem Biol 19(1):72-84