An integrated synthesis-purification system to accelerate the generation of compounds in pharmaceutical discovery

Journal of Flow Chemistry

Volumn 1, Issue 2, 2011, Pages 56-61

  Hochlowski, Jill ^a   Searle, Philip ^a   Tu, Noah ^a   Pan, Jeffrey ^a   Spanton, Stephen ^a   Djuric, Stevan ^a  

^a ABBOTT LABORATORIES   (United States)

Author keywords

flow synthesis; high throughput organic synthesis; high throughput purification; meso flow; segmented flow

Indexed keywords

EID: 84870266405     PISSN: 2062249X     EISSN: 20630212     Source Type: Journal    
DOI: 10.1556/jfchem.2011.00013     Document Type: Article

References (24)

1. DiMasi, J. A.; Faden, L. B. Nat. Rev. Drug Discovery 2011, 10, 23-27.
2. For examples see (a) Wang, Y.; Sarris, K.; Sauer, D. R.; Djuric, S. W. Tetrahedron Lett. 2007, 48, 5181-5184;
3. (b) Wang, Y.; Sarris, K.; Sauer, D. R.; Djuric, S. W. Tetrahedron Lett. 2007, 48, 2237-2240;
4. (c) Wang, Y.; Sauer, D. R.; Djuric, S. W. Tetrahedron Lett. 2005, 47, 105-108.
5. Hochlowski, J. E. High-Throughput Purification: Triage and Optimization. In Analysis and Purification Methods in Combinatorial Chemistry; Yan, B., Ed.; John Wiley & Sons, Inc.: Hoboken, NJ, USA, 2004; Vol. 163.
6. (a) Palmieri, A.; Ley, S. V.; Hammond, K.; Polyzos, A.; Baxendale, I. R. Tetrahedron Lett. 2009, 50, 3287-3289;
7. (b) Ley, S. V.; Baxendale, I. R. Chimia 2008, 62, 162-168;
8. (c) Baxendale I. R., Hayward J. J.; Ley S. V. Combinatorial Chemistry, High Throughput Screening, 2007, 10, 802-836.
9. (d) Baumann M., Baxendale I. R., Ley S. V. Mol. Divers 2011, 15, 613-630;
10. (e) Webb D., Jamison T. F. Chem. Sci, 2010, 1, 675-680;
11. (f) Marrea S., Jensen K. F. Chem. Soc. Rev, 2010, 39, 1183-1202;
12. (g) Valera, F. E.; Quaranta, M.; Moran, A.; Blacker, J.; Armstrong, A.; Cabral, J. T.; Blackmond, D. G. Angew. Chem. Int. Ed. 2010, 49, 2478-2485.
13. Song, H.; Chen, D. L.; Ismagilov, R. F. Angew. Chem. Int. Ed. 2006, 45, 7336-7356.
14. (a) Pickett, S. D.; Green, D. V. S.; Hunt, D. L.; Pardoe, D. A.; Hughes, I. Med. Chem. Lett. 2011, 2, 28-33;
15. (b) Wong Hawkes, S. Y. F.; Chapela, M. J. V.; Montembault, M. QSAR Comb. Sci. 2005, 24, 712-721;
16. (c) Hughes, I.; Warrington, B. H.; Wong, Y. F. Microfluidic System. WO2004089533 A1, 2004.
17. Accendo Corporation, Tucson, AZ. www.accendocorporation.com 8.
18. AutoChem Private Limited, Singapore. www.autochem.com.sg/micro-reactor. htm
19. Blom, K. F. J. Comb. Chem. 2002, 4, 295-301.
20. Hong, C.; Kiplinger, J. P.; Goetzinger, W. K.; Cole, R. O.; Laws, K. A.; Foster, M.; Schrock, A. Rapid Commun. Mass. Spectrom. 2002, 16, 544-554.
21. Spanton, S. G.; Whittern, D. Magn. Reson. Chem. 2009, 47, 1055-1061.
22. Pauli, G. F.; Jaki, B.; Lankin, D. J. Nat. Prod. 2007, 70, 589-595.
23. Tu, N. P.; Hochlowski, J. E; Djuric, S. W. Mol. Divers. 2011, Sep 17. DOI 10.1007/s11030-011-9331-4.
24. Also, see Bogdan, A. R.; Sach, N. W. Adv. Synth. Catal. 2009, 351, 849-854 for the version of this protocol without sonification.