-
1
-
-
84921752079
-
Proteasomes. A molecular census of 26S proteasomes in intact neurons
-
Asano, Shoh, Yoshiyuki Fukuda, Florian Beck, Antje Aufderheide, Friedrich Förster, Radostin Danev, and Wolfgang Baumeister. 2015. Proteasomes. A molecular census of 26S proteasomes in intact neurons. Science 347: 439-42.
-
(2015)
Science
, vol.347
, pp. 439-442
-
-
Asano, S.1
Fukuda, Y.2
Beck, F.3
Aufderheide, A.4
Förster, F.5
Danev, R.6
Baumeister, W.7
-
2
-
-
0037507351
-
An evaluation of automated model-building procedures for protein crystallography
-
Badger, J. 2003. An evaluation of automated model-building procedures for protein crystallography. Acta Crystallogr. Sect. D. Biol. Crystallogr. 59 (Pt 5): 823-7.
-
(2003)
Acta Crystallogr. Sect. D. Biol. Crystallogr
, vol.59
, pp. 823-827
-
-
Badger, J.1
-
3
-
-
84878580683
-
Ribosome structures to near-atomic resolution from thirty thousand cryo-EM particles
-
Bai, Xiao-chen, Israel S Fernández, Greg McMullan, and Sjors H W Scheres. 2013. Ribosome structures to near-atomic resolution from thirty thousand cryo-EM particles. eLife 2: e00461.
-
(2013)
eLife
, vol.2
-
-
Bai, X.-C.1
Fernández, I.S.2
McMullan, G.3
Sjors, H.4
Scheres, W.5
-
6
-
-
83855162728
-
The structure of the eukaryotic ribosome at 3. 0 A resolution
-
Ben-Shem, A., N. Garreau de Loubresse, S. Melnikov, L. Jenner, G. Yusupova, and M. Yusupov. 2011. The structure of the eukaryotic ribosome at 3. 0 A resolution. Science 334: 1524-9.
-
(2011)
Science
, vol.334
, pp. 1524-1529
-
-
Ben-Shem, A.1
Garreau de Loubresse, N.2
Melnikov, S.3
Jenner, L.4
Yusupova, G.5
Yusupov, M.6
-
7
-
-
0001651415
-
X-ray photographs of crystalline pepsin
-
Bernal, J. D., and D. Crowfoot. 1934. X-ray photographs of crystalline pepsin. Nature 133: 794-5.
-
(1934)
Nature
, vol.133
, pp. 794-795
-
-
Bernal, J.D.1
Crowfoot, D.2
-
8
-
-
79951931431
-
Macromolecular NMR spectroscopy for the non-spectroscopist: Beyond macromolecular solution structure determination
-
Bieri, Michael, Ann H Kwan, Mehdi Mobli, Glenn F King, Joel P Mackay, and Paul R Gooley. 2011. Macromolecular NMR spectroscopy for the non-spectroscopist: beyond macromolecular solution structure determination. FEBS Journal 278: 704-15.
-
(2011)
FEBS Journal
, vol.278
, pp. 704-715
-
-
Bieri, M.1
Kwan, A.H.2
Mobli, M.3
King, G.F.4
Mackay, J.P.5
Gooley, P.R.6
-
9
-
-
53449086885
-
Neutron crystallography: Opportunities, challenges, and limitations
-
Blakeley, Matthew P., Paul Langan, Nobuo Niimura, and Alberto Podjarny. 2008. Neutron crystallography: opportunities, challenges, and limitations. Curr. Opin. Struct. Biol. 18: 593-600.
-
(2008)
Curr. Opin. Struct. Biol
, vol.18
, pp. 593-600
-
-
Blakeley, M.P.1
Langan, P.2
Niimura, N.3
Podjarny, A.4
-
10
-
-
72949097424
-
Fraud rocks protein community
-
Borrell, B. 2009. Fraud rocks protein community. Nature 462: 970.
-
(2009)
Nature
, vol.462
, pp. 970
-
-
Borrell, B.1
-
12
-
-
0345249062
-
The determination of parameters in crystal structures by means of Fourier series
-
Bragg, W. L. 1929. The determination of parameters in crystal structures by means of Fourier series. Proc. R. Soc. London, A 123: 537-59.
-
(1929)
Proc. R. Soc. London, A
, vol.123
, pp. 537-559
-
-
Bragg, W.L.1
-
13
-
-
77956006893
-
The three-dimensional organization of polyribosomes in intact human cells
-
Brandt, Florian, Lars-Anders Carlson, F Ulrich Hartl, Wolfgang Baumeister, and Kay Grünewald. 2010. The three-dimensional organization of polyribosomes in intact human cells. Mol. Cell 39: 560-9.
-
(2010)
Mol. Cell
, vol.39
, pp. 560-569
-
-
Brandt, F.1
Carlson, L.-A.2
Ulrich Hartl, F.3
Baumeister, W.4
Grünewald, K.5
-
14
-
-
84924617498
-
2.8 A resolution reconstruction of the thermoplasma acidophilum 20S proteasome using cryo-electron microscopy
-
Campbell, M. G., D. Veesler, A. Cheng, C. S. Potter, and B. Carragher. 2015. 2. 8 A resolution reconstruction of the thermoplasma acidophilum 20S proteasome using cryo-electron microscopy. Elife 4.
-
(2015)
Elife
, pp. 4
-
-
Campbell, M.G.1
Veesler, D.2
Cheng, A.3
Potter, C.S.4
Carragher, B.5
-
15
-
-
84868573207
-
Movies of ice-embedded particles enhance resolution in electron cryo-microscopy
-
Campbell, Melody G, Anchi Cheng, Axel F Brilot, Arne Moeller, Dmitry Lyumkis, David Veesler, Junhua Pan, Stephen C Harrison, Clinton S Potter, Bridget Carragher, and Nikolaus Grigorieff. 2012. Movies of ice-embedded particles enhance resolution in electron cryo-microscopy. Structure 20: 1823-8.
-
(2012)
Structure
, vol.20
, pp. 1823-1828
-
-
Campbell, M.G.1
Cheng, A.2
Brilot, A.F.3
Moeller, A.4
Lyumkis, D.5
Veesler, D.6
Pan, J.7
Harrison, S.C.8
Potter, C.S.9
Carragher, B.10
Grigorieff, N.11
-
16
-
-
48649084644
-
Structural basis for RNA-silencing suppression by Tomato aspermy virus protein 2b
-
Chen, H. Y., J. Yang, C. Lin, and Y. A. Yuan. 2008. Structural basis for RNA-silencing suppression by Tomato aspermy virus protein 2b. EMBO reports 9: 754-60.
-
(2008)
EMBO reports
, vol.9
, pp. 754-760
-
-
Chen, H.Y.1
Yang, J.2
Lin, C.3
Yuan, Y.A.4
-
17
-
-
84905590378
-
Revealing transient structures of nucleosomes as DNA unwinds
-
Chen, Yujie, Joshua M Tokuda, Traci Topping, Julie L Sutton, Steve P Meisburger, Suzette A Pabit, Lisa M Gloss, and Lois Pollack. 2014. Revealing transient structures of nucleosomes as DNA unwinds. Nucleic Acids Res. 42: 8767-76.
-
(2014)
Nucleic Acids Res
, vol.42
, pp. 8767-8776
-
-
Chen, Y.1
Tokuda, J.M.2
Topping, T.3
Sutton, J.L.4
Meisburger, S.P.5
Pabit, S.A.6
Gloss, L.M.7
Pollack, L.8
-
18
-
-
0014930077
-
Three dimensional reconstructions of spherical viruses by fourier synthesis from electron micrographs
-
Crowther, R. A., L A Amos, J T Finch, D J De Rosier, and A Klug. 1970. Three dimensional reconstructions of spherical viruses by fourier synthesis from electron micrographs. Nature 226: 421-5.
-
(1970)
Nature
, vol.226
, pp. 421-425
-
-
Crowther, R.A.1
Amos, L.A.2
Finch, D.J.T.3
De Rosier, J.4
Klug, A.5
-
19
-
-
84905251244
-
X-ray vs. NMR structure of N-terminal domain of δ-subunit of RNA polymerase
-
Demo, Gabriel, Veronika Papoušková, Jan Komárek, Pavel Kadeřávek, Olga Otrusinová, Pavel Srb, Alžbeta Rabatinová, Libor Krásný, Lukáš Žídek, Vladimír Sklenář, and Michaela Wimmerová 2014. X-ray vs. NMR structure of N-terminal domain of δ-subunit of RNA polymerase. J. Struct. Biol. 187: 174-86.
-
(2014)
J. Struct. Biol
, vol.187
, pp. 174-186
-
-
Demo, G.1
Papoušková, V.2
Komárek, J.3
Kadeřávek, P.4
Otrusinová, O.5
Srb, P.6
Rabatinová, A.7
Krásný, L.8
Žídek, L.9
Sklenář, V.10
Wimmerová, M.11
-
21
-
-
0037062977
-
NMR analysis of a 900K GroEL GroES complex
-
Fiaux, J., E. B. Bertelsen, A. L. Horwich, and K. Wuthrich. 2002. NMR analysis of a 900K GroEL GroES complex. Nature 418: 207-11.
-
(2002)
Nature
, vol.418
, pp. 207-211
-
-
Fiaux, J.1
Bertelsen, E.B.2
Horwich, A.L.3
Wuthrich, K.4
-
22
-
-
84928560614
-
Structure of the E. coli ribosome-EF-Tu complex at <3 A resolution by Cs-corrected cryo-EM
-
Fischer, Niels, Piotr Neumann, Andrey L. Konevega, Lars V. Bock, Ralf Ficner, Marina V. Rodnina, and Holger Stark. 2015. "Structure of the E. coli ribosome-EF-Tu complex at <3 A resolution by Cs-corrected cryo-EM. " Nature 520 (7548): 567-570.
-
(2015)
Nature
, vol.520
, Issue.7548
, pp. 567-570
-
-
Fischer, N.1
Neumann, P.2
Konevega, A.L.3
Bock, L.V.4
Ficner, R.5
Rodnina, M.V.6
Stark, H.7
-
23
-
-
84896774627
-
Developments in X-ray crystallographic structure determination of biological macromolecules
-
Garman, E. F. 2014. Developments in X-ray crystallographic structure determination of biological macromolecules. Science 343: 1102-8.
-
(2014)
Science
, vol.343
, pp. 1102-1108
-
-
Garman, E.F.1
-
24
-
-
38549174161
-
Filling in the gaps: Artistic license in education and outreach
-
Goodsell, D. S., and G. T. Johnson. 2007. Filling in the gaps: artistic license in education and outreach. PLoS Biology 5: e308.
-
(2007)
PLoS Biology
, vol.5
-
-
Goodsell, D.S.1
Johnson, G.T.2
-
25
-
-
84922715597
-
Super-resolution molecular and functional imaging of nanoscale architectures in life and materials science
-
Habuchi, Satoshi. 2014. Super-resolution molecular and functional imaging of nanoscale architectures in life and materials science. Front. Bioeng. Biotechnol. 2: 20.
-
(2014)
Front. Bioeng. Biotechnol
, vol.2
, pp. 20
-
-
Habuchi, S.1
-
26
-
-
0016842810
-
Three-dimensional model of purple membrane obtained by electron microscopy
-
Henderson, R., and P. N. Unwin. 1975. Three-dimensional model of purple membrane obtained by electron microscopy. Nature 257: 28-32.
-
(1975)
Nature
, vol.257
, pp. 28-32
-
-
Henderson, R.1
Unwin, P.N.2
-
27
-
-
84898624666
-
Anomalous diffraction in crystallographic phase evaluation
-
Hendrickson, W. A. 2014. Anomalous diffraction in crystallographic phase evaluation. Q. Rev. Biophys. 47: 49-93.
-
(2014)
Q. Rev. Biophys
, vol.47
, pp. 49-93
-
-
Hendrickson, W.A.1
-
28
-
-
0029644940
-
Where freedom is given, liberties are taken
-
Kleywegt, G. J., and T. A. Jones. 1995. Where freedom is given, liberties are taken. Structure 3: 535-40.
-
(1995)
Structure
, vol.3
, pp. 535-540
-
-
Kleywegt, G.J.1
Jones, T.A.2
-
29
-
-
79953734276
-
Macromolecular complexes in crystals and solutions
-
Krissinel, Evgeny. 2011. Macromolecular complexes in crystals and solutions. Acta Crystallogr. Sect. D. Biol. Crystallogr. 67 (Pt 4): 376-85.
-
(2011)
Acta Crystallogr. Sect. D. Biol. Crystallogr
, vol.67
, pp. 376-385
-
-
Krissinel, E.1
-
30
-
-
79951919101
-
Macromolecular NMR spectroscopy for the non-spectroscopist
-
Kwan, Ann H., Mehdi Mobli, Paul R Gooley, Glenn F King, and Joel P Mackay. 2011. Macromolecular NMR spectroscopy for the non-spectroscopist. FEBS Journal 278: 687-703.
-
(2011)
FEBS Journal
, vol.278
, pp. 687-703
-
-
Kwan, A.H.1
Mobli, M.2
Gooley, P.R.3
King, G.F.4
Mackay, J.P.5
-
31
-
-
69949138064
-
Neutrons for biologists: A beginner's guide, or why you should consider using neutrons
-
Lakey, J. H. 2009. Neutrons for biologists: a beginner's guide, or why you should consider using neutrons. J. R. Soc. Interface 6(Suppl_5): S567-73.
-
(2009)
J.R. Soc. Interface
, vol.6
, pp. S567-S573
-
-
Lakey, J.H.1
-
32
-
-
84886953122
-
The structure of the box C/D enzyme reveals regulation of RNA methylation
-
Lapinaite, Audrone, Bernd Simon, Lars Skjaerven, Magdalena Rakwalska-Bange, Frank Gabel, and Teresa Carlomagno. 2013. The structure of the box C/D enzyme reveals regulation of RNA methylation. Nature 502: 519-23.
-
(2013)
Nature
, vol.502
, pp. 519-523
-
-
Lapinaite, A.1
Simon, B.2
Skjaerven, L.3
Rakwalska-Bange, M.4
Gabel, F.5
Carlomagno, T.6
-
33
-
-
84884239080
-
Cryo-electron tomography: The challenge of doing structural biology in situ
-
Lučič, Vladan, Alexander Rigort, and Wolfgang Baumeister. 2013. Cryo-electron tomography: the challenge of doing structural biology in situ. J. Cell Biol. 202: 407-19.
-
(2013)
J. Cell Biol
, vol.202
, pp. 407-419
-
-
Lučič, V.1
Rigort, A.2
Baumeister, W.3
-
34
-
-
84887083603
-
An introduction to biological NMR spectroscopy
-
Marion, Dominique. 2013. An introduction to biological NMR spectroscopy. Mol. Cell. Proteomics 12: 3006-25.
-
(2013)
Mol. Cell. Proteomics
, vol.12
, pp. 3006-3025
-
-
Marion, D.1
-
35
-
-
85015556005
-
History of the electron microscope in cell biology
-
Masters, B. R. 2009. History of the electron microscope in cell biology. eLS.
-
(2009)
eLS
-
-
Masters, B.R.1
-
36
-
-
0022649552
-
Quaternary organization of the 30S ribosomal subunit of escherichia coli
-
Moore, P. B., M Capel, M Kjeldgaard, and D M Engelman. 1986. Quaternary organization of the 30S ribosomal subunit of escherichia coli. Biophys. J. 49: 13-5.
-
(1986)
Biophys. J
, vol.49
, pp. 13-15
-
-
Moore, P.B.1
Capel, M.2
Kjeldgaard, M.3
Engelman, D.M.4
-
37
-
-
84884682632
-
Collaboration gets the most out of software
-
Morin, Andrew, Ben Eisenbraun, Jason Key, Paul C Sanschagrin, Michael A Timony, Michelle Ottaviano, and Piotr Sliz. 2013. Collaboration gets the most out of software. eLife 2: 1-6.
-
(2013)
eLife
, vol.2
, pp. 1-6
-
-
Morin, A.1
Eisenbraun, B.2
Key, J.3
Sanschagrin, P.C.4
Timony, M.A.5
Ottaviano, M.6
Sliz, P.7
-
38
-
-
84878860950
-
Validation of Cryo-EM Structure of IP3R1 Channel
-
Murray, Stephen C., John Flanagan, Olga B Popova, Wah Chiu, Steven J Ludtke, and Irina I Serysheva. 2013. Validation of Cryo-EM Structure of IP3R1 Channel. Structure 21: 900-9.
-
(2013)
Structure
, vol.21
, pp. 900-909
-
-
Murray, S.C.1
Flanagan, J.2
Popova, O.B.3
Chiu, W.4
Ludtke, S.J.5
Serysheva, I.I.6
-
39
-
-
13844253947
-
SAXS and the working protein
-
Nagar, Bhushan, and John Kuriyan. 2005. SAXS and the working protein. Structure 13: 169-70.
-
(2005)
Structure
, vol.13
, pp. 169-170
-
-
Nagar, B.1
Kuriyan, J.2
-
40
-
-
84880765999
-
Measuring image resolution in optical nanoscopy
-
Nieuwenhuizen, Robert P. J., Keith A Lidke, Mark Bates, Daniela Leyton Puig, David Grünwald, Sjoerd Stallinga, and Bernd Rieger. 2013. Measuring image resolution in optical nanoscopy. Nat. Methods 10: 557-62.
-
(2013)
Nat. Methods
, vol.10
, pp. 557-562
-
-
Nieuwenhuizen, R.P.J.1
Lidke, K.A.2
Bates, M.3
Puig, D.L.4
Grünwald, D.5
Stallinga, S.6
Rieger, B.7
-
41
-
-
77749311718
-
Bridging the solution divide: Comprehensive structural analyses of dynamic RNA, DNA, and protein assemblies by small-angle X-ray scattering
-
Rambo, Robert P., and John A. Tainer. 2010. Bridging the solution divide: comprehensive structural analyses of dynamic RNA, DNA, and protein assemblies by small-angle X-ray scattering. Curr. Opin. Struct. Biol. 20: 128-37.
-
(2010)
Curr. Opin. Struct. Biol
, vol.20
, pp. 128-137
-
-
Rambo, R.P.1
Tainer, J.A.2
-
42
-
-
84877778935
-
Super-resolution in solution X-ray scattering and its applications to structural systems biology
-
Rambo, Robert P., and John A. Tainer. 2013. Super-resolution in solution X-ray scattering and its applications to structural systems biology. Annu. Rev. Biophys. 42: 415-41.
-
(2013)
Annu. Rev. Biophys
, vol.42
, pp. 415-441
-
-
Rambo, R.P.1
Tainer, J.A.2
-
43
-
-
37249065351
-
The molecular sociology of the cell
-
Robinson, Carol V., Andrej Sali, and Wolfgang Baumeister. 2007. The molecular sociology of the cell. Nature 450: 973-82.
-
(2007)
Nature
, vol.450
, pp. 973-982
-
-
Robinson, C.V.1
Sali, A.2
Baumeister, W.3
-
44
-
-
84922390208
-
Achievements and challenges in structural bioinformatics and computational biophysics
-
Samish, I., P. E. Bourne, and R. J. Najmanovich. 2015. Achievements and challenges in structural bioinformatics and computational biophysics. Bioinformatics 31: 146-50.
-
(2015)
Bioinformatics
, vol.31
, pp. 146-150
-
-
Samish, I.1
Bourne, P.E.2
Najmanovich, R.J.3
-
45
-
-
0142245541
-
X-ray microscopy: Methods and perspectives
-
Schneider, Gerd. 2003. X-ray microscopy: methods and perspectives. Anal. Bioanal. Chem. 376: 558-61.
-
(2003)
Anal. Bioanal. Chem
, vol.376
, pp. 558-561
-
-
Schneider, G.1
-
46
-
-
84888087327
-
Three-dimensional electron crystallography of protein microcrystals
-
Shi, D., B. L. Nannenga, M. G. Iadanza, and T. Gonen. 2013. Three-dimensional electron crystallography of protein microcrystals. eLife 2: e01345.
-
(2013)
eLife
, vol.2
-
-
Shi, D.1
Nannenga, B.L.2
Iadanza, M.G.3
Gonen, T.4
-
47
-
-
84908191629
-
Synchrotron-based small-angle X-ray scattering of proteins in solution
-
Skou, Soren, Richard E Gillilan, and Nozomi Ando. 2014. Synchrotron-based small-angle X-ray scattering of proteins in solution. Nat. Protoc. 9: 1727-39.
-
(2014)
Nat. Protoc
, vol.9
, pp. 1727-1739
-
-
Skou, S.1
Gillilan, R.E.2
Ando, N.3
-
48
-
-
77954580347
-
Small-angle X-ray and neutron scattering as a tool for structural systems biology
-
Svergun, Dmitri I. 2010. Small-angle X-ray and neutron scattering as a tool for structural systems biology. Biol. Chem. 391: 737-43.
-
(2010)
Biol. Chem
, vol.391
, pp. 737-743
-
-
Svergun, D.I.1
-
50
-
-
14144254537
-
Solution NMR-derived global fold of a monomeric 82-kDa enzyme
-
Tugarinov, Vitali, Wing-Yiu Choy, Vladislav Yu. Orekhov, and Lewis E. Kay. 2005. Solution NMR-derived global fold of a monomeric 82-kDa enzyme. Proc. Natl. Acad. Sci. U. S. A. 102: 622-27.
-
(2005)
Proc. Natl. Acad. Sci. U.S.A
, vol.102
, pp. 622-627
-
-
Tugarinov, V.1
Choy, W.-Y.2
Orekhov, V.Y.3
Kay, L.E.4
-
51
-
-
0031298118
-
Correction of the NMR structure of the ETS1/DNA complex
-
Werner, M. H., G. M. Clore, C. L. Fisher, R. J. Fisher, L. Trinh, J. Shiloach, and A. M. Gronenborn. 1997. Correction of the NMR structure of the ETS1/DNA complex. J. Biomol. NMR 10: 317-28.
-
(1997)
J. Biomol. NMR
, vol.10
, pp. 317-328
-
-
Werner, M.H.1
Clore, G.M.2
Fisher, C.L.3
Fisher, R.J.4
Trinh, L.5
Shiloach, J.6
Gronenborn, A.M.7
-
53
-
-
79953803622
-
ABC ATPase signature helices in Rad50 link nucleotide state to Mre11 interface for DNA repair
-
Williams, Gareth J., R. Scott Williams, Jessica S. Williams, Gabriel Moncalian, Andrew S. Arvai, Oliver Limbo, Grant Guenther, Soumita SilDas, Michal Hammel, Paul Russell, and John A. Tainer. 2011. ABC ATPase signature helices in Rad50 link nucleotide state to Mre11 interface for DNA repair. Nat. Struct. Mol. Biol. 18: 423-31.
-
(2011)
Nat. Struct. Mol. Biol
, vol.18
, pp. 423-431
-
-
Williams, G.J.1
Scott Williams, R.2
Williams, J.S.3
Moncalian, G.4
Arvai, A.S.5
Limbo, O.6
Guenther, G.7
Das, S.S.8
Hammel, M.9
Russell, P.10
Tainer, J.A.11
-
54
-
-
84886586188
-
Protein crystallography for aspiring crystallographers or how to avoid pitfalls and traps in macromolecular structure determination
-
Wlodawer, Alexander, Wladek Minor, Zbigniew Dauter, and Mariusz Jaskolski. 2013. Protein crystallography for aspiring crystallographers or how to avoid pitfalls and traps in macromolecular structure determination. FEBS Journal 280: 5705-36.
-
(2013)
FEBS Journal
, vol.280
, pp. 5705-5736
-
-
Wlodawer, A.1
Minor, W.2
Dauter, Z.3
Jaskolski, M.4
-
55
-
-
84885871508
-
Correlative cryo-electron tomography and optical microscopy of cells
-
Zhang, Peijun. 2013. Correlative cryo-electron tomography and optical microscopy of cells. Curr. Opin. Struct. Biol. 23: 763-70.
-
(2013)
Curr. Opin. Struct. Biol
, vol.23
, pp. 763-770
-
-
Zhang, P.1
-
56
-
-
73149105706
-
Insights into cleavage specificity from the crystal structure of foot-and-mouth disease virus 3C protease complexed with a peptide substrate
-
Zunszain, P. A., S. R. Knox, T. R. Sweeney, J. Yang, N. Roque-Rosell, G. J. Belsham, R. J. Leatherbarrow, and S. Curry. 2010. Insights into cleavage specificity from the crystal structure of foot-and-mouth disease virus 3C protease complexed with a peptide substrate. J. Mol. Biol. 395: 375-89.
-
(2010)
J. Mol. Biol
, vol.395
, pp. 375-389
-
-
Zunszain, P.A.1
Knox, S.R.2
Sweeney, T.R.3
Yang, J.4
Roque-Rosell, N.5
Belsham, G.J.6
Leatherbarrow, R.J.7
Curry, S.8
|