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Angewandte Chemie - International Edition

Volumn 53, Issue 6, 2014, Pages 1704-1708

Seamless integration of dose-response screening and flow chemistry: Efficient generation of structure-activity relationship data of β-secretase (BACE1) inhibitors

(8) Werner, Michael a Kuratli, Christoph a Martin, Rainer E a Hochstrasser, Remo a Wechsler, David a Enderle, Thilo a Alanine, Alexander I a Vogel, Horst b

a Pharma Research and Early Development (Switzerland)

b EPFL (Switzerland)

Author keywords

biochemical assays; flow synthesis; lead discovery; medicinal chemistry; microfluidics

Indexed keywords

BIOCHEMICAL ASSAY; DRUG DISCOVERY PROCESS; FLOW SYNTHESIS; INDUSTRIAL PROCESSS; INTEGRATED PLATFORM; MEDICINAL CHEMISTRY; SEAMLESS INTEGRATION; STRUCTURE-ACTIVITY RELATIONSHIPS;

ASSAYS; AUTOMATION; MICROFLUIDICS; STRUCTURES (BUILT OBJECTS); SYNTHESIS (CHEMICAL);

INTEGRATION;

ASPARTIC PROTEINASE; BACE1 PROTEIN, HUMAN; PROTEINASE INHIBITOR; SECRETASE;

ARTICLE; AUTOMATION; BIOCHEMICAL ASSAYS; CHEMISTRY; DRUG ANTAGONISM; DRUG SCREENING; EQUIPMENT; FLOW SYNTHESIS; HUMAN; LEAD DISCOVERY; MEDICINAL CHEMISTRY; METABOLISM; METHODOLOGY; MICROFLUIDIC ANALYSIS; MICROFLUIDICS; MOLECULAR LIBRARY; PROTEIN BINDING; STRUCTURE ACTIVITY RELATION;

BIOCHEMICAL ASSAYS; FLOW SYNTHESIS; LEAD DISCOVERY; MEDICINAL CHEMISTRY; MICROFLUIDICS;

AMYLOID PRECURSOR PROTEIN SECRETASES; ASPARTIC ACID ENDOPEPTIDASES; AUTOMATION; DRUG EVALUATION, PRECLINICAL; HUMANS; MICROFLUIDIC ANALYTICAL TECHNIQUES; PROTEASE INHIBITORS; PROTEIN BINDING; SMALL MOLECULE LIBRARIES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84893486529 PISSN: 14337851 EISSN: 15213773 Source Type: Journal
DOI: 10.1002/anie.201309301 Document Type: Article

Times cited : (47)

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