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Volumn 56, Issue 7, 2013, Pages 3033-3047

Rapid discovery of a novel series of Abl kinase inhibitors by application of an integrated microfluidic synthesis and screening platform

Author keywords

[No Author keywords available]

Indexed keywords

ABELSON KINASE; ABELSON TYROSINE KINASE INHIBITOR; IMATINIB; PROTEIN TYROSINE KINASE INHIBITOR; UNCLASSIFIED DRUG;

EID: 84876244863     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm400099d     Document Type: Article
Times cited : (116)

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    • Inhibition assays with ABL1 (H396P), ABL1 (M351T), ABL1 (Q252H), ABL1 (T315I), ABL1 (Y253F), ABL2/ARG and P38α/MAPK14 were carried out by Reaction Biology Corporation, Malvern, PA, USA
    • Inhibition assays with ABL1 (H396P), ABL1 (M351T), ABL1 (Q252H), ABL1 (T315I), ABL1 (Y253F), ABL2/ARG and P38α/MAPK14 were carried out by Reaction Biology Corporation, Malvern, PA, USA.
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    • In vitro human microsomal stability and parallel artificial membrane permeability assay (PAMPA) assays were carried out by Cyprotex Discovery Ltd. Macclesfield, Cheshire, U.K.
    • In vitro human microsomal stability and parallel artificial membrane permeability assay (PAMPA) assays were carried out by Cyprotex Discovery Ltd., Macclesfield, Cheshire, U.K.


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